qx-314 has been researched along with Disease Models, Animal in 17 studies
QX-314: triethyl analog of lidocaine; RN & NM refer to ion
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we investigated spontaneous pain and mechanical allodynia in a preclinical model of oral ulcerative mucositis after systemic administration of the chemotherapy drug 5-fluorouracil, using our proprietary pain assay system for conscious rats." | 7.83 | Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil. ( Goto, T; Harano, N; Hitomi, S; Inenaga, K; Inoue, H; Ito, M; Matoba, M; Miyano, K; Nodai, T; Ono, K; Uezono, Y; Watanabe, S; Yamaguchi, K, 2016) |
| " In this study, we investigated spontaneous pain and mechanical allodynia in a preclinical model of oral ulcerative mucositis after systemic administration of the chemotherapy drug 5-fluorouracil, using our proprietary pain assay system for conscious rats." | 3.83 | Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil. ( Goto, T; Harano, N; Hitomi, S; Inenaga, K; Inoue, H; Ito, M; Matoba, M; Miyano, K; Nodai, T; Ono, K; Uezono, Y; Watanabe, S; Yamaguchi, K, 2016) |
| " We concluded that only peripheral blockade of transient receptor potential vanilloid receptor 1-expressing nociceptive afferents by the QX-314/capsaicin combination was effective at reducing neuropathic allodynia and hyperalgesia." | 3.78 | Differential effects of peripheral versus central coadministration of QX-314 and capsaicin on neuropathic pain in rats. ( Cheng, J; Fox, LE; Shen, J, 2012) |
| "NaV1." | 1.42 | Genetic background modulates impaired excitability of inhibitory neurons in a mouse model of Dravet syndrome. ( Catterall, WA; Jones, CJ; Rubinstein, M; Scheuer, T; Westenbroek, RE; Yu, FH, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (17.65) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 9 (52.94) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Lee, S | 2 |
| Jo, S | 1 |
| Talbot, S | 2 |
| Zhang, HB | 1 |
| Kotoda, M | 1 |
| Andrews, NA | 1 |
| Puopolo, M | 2 |
| Liu, PW | 1 |
| Jacquemont, T | 1 |
| Pascal, M | 1 |
| Heckman, LM | 1 |
| Jain, A | 1 |
| Lee, J | 1 |
| Woolf, CJ | 3 |
| Bean, BP | 3 |
| López-Huerta, VG | 1 |
| Carrillo-Reid, L | 1 |
| Galarraga, E | 1 |
| Tapia, D | 1 |
| Fiordelisio, T | 1 |
| Drucker-Colin, R | 1 |
| Bargas, J | 1 |
| Peters, CM | 1 |
| Ririe, D | 1 |
| Houle, TT | 1 |
| Aschenbrenner, CA | 1 |
| Eisenach, JC | 1 |
| Rubinstein, M | 1 |
| Westenbroek, RE | 1 |
| Yu, FH | 1 |
| Jones, CJ | 1 |
| Scheuer, T | 1 |
| Catterall, WA | 1 |
| Abdulnour, RE | 1 |
| Burkett, PR | 1 |
| Cronin, SJ | 1 |
| Pascal, MA | 1 |
| Laedermann, C | 1 |
| Foster, SL | 1 |
| Tran, JV | 1 |
| Lai, N | 1 |
| Chiu, IM | 1 |
| Ghasemlou, N | 2 |
| DiBiase, M | 1 |
| Roberson, D | 2 |
| Von Hehn, C | 1 |
| Agac, B | 1 |
| Haworth, O | 1 |
| Seki, H | 1 |
| Penninger, JM | 1 |
| Kuchroo, VK | 1 |
| Levy, BD | 1 |
| Yamaguchi, K | 1 |
| Ono, K | 1 |
| Hitomi, S | 1 |
| Ito, M | 1 |
| Nodai, T | 1 |
| Goto, T | 1 |
| Harano, N | 1 |
| Watanabe, S | 1 |
| Inoue, H | 1 |
| Miyano, K | 1 |
| Uezono, Y | 1 |
| Matoba, M | 1 |
| Inenaga, K | 1 |
| Shen, J | 1 |
| Fox, LE | 1 |
| Cheng, J | 1 |
| Brenneis, C | 1 |
| Kistner, K | 1 |
| Segal, D | 1 |
| Sisignano, M | 1 |
| Labocha, S | 1 |
| Ferreirós, N | 1 |
| Strominger, A | 1 |
| Cobos, EJ | 1 |
| Geisslinger, G | 1 |
| Reeh, PW | 1 |
| Oliveira, MC | 1 |
| Parada, CA | 2 |
| Veiga, MC | 1 |
| Rodrigues, LR | 1 |
| Barros, SP | 1 |
| Tambeli, CH | 2 |
| Sasaki, S | 1 |
| Huda, K | 1 |
| Inoue, T | 1 |
| Miyata, M | 1 |
| Imoto, K | 1 |
| Lim, TK | 1 |
| Macleod, BA | 1 |
| Ries, CR | 1 |
| Schwarz, SK | 1 |
| Agrawal, SK | 1 |
| Fehlings, MG | 1 |
| de Curtis, M | 1 |
| Radici, C | 1 |
| Forti, M | 1 |
| Follis, FM | 1 |
| Blisard, KS | 1 |
| Varvitsiotis, PS | 1 |
| Pett, SB | 1 |
| Temes, RT | 1 |
| Wernly, JA | 1 |
| Roveroni, RC | 1 |
| Cecília, M | 1 |
| Veiga, FA | 1 |
17 other studies available for qx-314 and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Novel charged sodium and calcium channel inhibitor active against neurogenic inflammation.
Topics: Animals; Bupivacaine; Calcium; Calcium Channel Blockers; Calcium Channels, N-Type; Calcium Signaling | 2019 |
The balance of striatal feedback transmission is disrupted in a model of parkinsonism.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adrenergic Agents; Anesthetics, Local; Anim | 2013 |
Nociceptor-selective peripheral nerve block induces delayed mechanical hypersensitivity and neurotoxicity in rats.
Topics: Anesthetics, Combined; Anesthetics, Local; Animals; Behavior, Animal; Capsaicin; Disease Models, Ani | 2014 |
Genetic background modulates impaired excitability of inhibitory neurons in a mouse model of Dravet syndrome.
Topics: Action Potentials; Animals; Animals, Newborn; Biophysical Phenomena; Conditioning, Psychological; Di | 2015 |
Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation.
Topics: Airway Remodeling; Anesthetics, Local; Animals; Animals, Newborn; Capsaicin; Cytokines; Disease Mode | 2015 |
Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil.
Topics: Acetanilides; Anesthetics, Local; Animals; Anti-Bacterial Agents; Antimetabolites; Carcinosarcoma; C | 2016 |
Differential effects of peripheral versus central coadministration of QX-314 and capsaicin on neuropathic pain in rats.
Topics: Anesthetics, Local; Animals; Antipruritics; Capsaicin; Disease Models, Animal; Drug Administration R | 2012 |
Phenotyping the function of TRPV1-expressing sensory neurons by targeted axonal silencing.
Topics: Action Potentials; Anesthetics, Local; Animals; Axons; Behavior, Animal; Capsaicin; Chronic Pain; Di | 2013 |
Evidence for the involvement of endogenous ATP and P2X receptors in TMJ pain.
Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Arthralgia; Arthritis; Carrageenan; Disea | 2005 |
Impaired feedforward inhibition of the thalamocortical projection in epileptic Ca2+ channel mutant mice, tottering.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Age Factors; Animals; Calcium Channel Block | 2006 |
The quaternary lidocaine derivative, QX-314, produces long-lasting local anesthesia in animal models in vivo.
Topics: Action Potentials; Anesthesia, Local; Anesthetics, Local; Animals; Disease Models, Animal; Dose-Resp | 2007 |
The effect of the sodium channel blocker QX-314 on recovery after acute spinal cord injury.
Topics: Anesthetics, Local; Animals; Disease Models, Animal; Female; Lidocaine; Rats; Rats, Wistar; Spinal C | 1997 |
Cellular mechanisms underlying spontaneous interictal spikes in an acute model of focal cortical epileptogenesis.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Acute Disease; | 1999 |
Selective protection of gray and white matter during spinal cord ischemic injury.
Topics: Animals; Brain; Disease Models, Animal; Evaluation Studies as Topic; Excitatory Amino Acid Antagonis | 1999 |
Development of a behavioral model of TMJ pain in rats: the TMJ formalin test.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Behavior, Animal; Disease Models, Animal; Lidocaine | 2001 |