qx-314 has been researched along with Ache in 17 studies
QX-314: triethyl analog of lidocaine; RN & NM refer to ion
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we investigated spontaneous pain and mechanical allodynia in a preclinical model of oral ulcerative mucositis after systemic administration of the chemotherapy drug 5-fluorouracil, using our proprietary pain assay system for conscious rats." | 7.83 | Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil. ( Goto, T; Harano, N; Hitomi, S; Inenaga, K; Inoue, H; Ito, M; Matoba, M; Miyano, K; Nodai, T; Ono, K; Uezono, Y; Watanabe, S; Yamaguchi, K, 2016) |
| "The aim of this study was to determine whether systemic administration of QX-314 reduces bone cancer pain through selective inhibition of transient receptor potential vanilloid subfamily 1 (TRPV1)-expressing afferents." | 7.83 | Systemic QX-314 Reduces Bone Cancer Pain through Selective Inhibition of Transient Receptor Potential Vanilloid Subfamily 1-expressing Primary Afferents in Mice. ( Fuseya, S; Kawamata, M; Kawamata, T; Minemura, H; Yamamoto, K; Yamaori, S, 2016) |
| " In this study, we asked whether PSD increases tonic nociception in the formalin test, decreases the antinociceptive effect of morphine administered into the periaqueductal gray matter (PAG), and disrupts endogenous descending pain modulation." | 3.83 | The Pronociceptive Effect of Paradoxical Sleep Deprivation in Rats: Evidence for a Role of Descending Pain Modulation Mechanisms. ( Arase, M; Bertolini, JF; Fischer, L; Lima, MMS; Pontarolla, FM; Tobaldini, G; Tomim, DH, 2016) |
| " In this study, we investigated spontaneous pain and mechanical allodynia in a preclinical model of oral ulcerative mucositis after systemic administration of the chemotherapy drug 5-fluorouracil, using our proprietary pain assay system for conscious rats." | 3.83 | Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil. ( Goto, T; Harano, N; Hitomi, S; Inenaga, K; Inoue, H; Ito, M; Matoba, M; Miyano, K; Nodai, T; Ono, K; Uezono, Y; Watanabe, S; Yamaguchi, K, 2016) |
| "The aim of this study was to determine whether systemic administration of QX-314 reduces bone cancer pain through selective inhibition of transient receptor potential vanilloid subfamily 1 (TRPV1)-expressing afferents." | 3.83 | Systemic QX-314 Reduces Bone Cancer Pain through Selective Inhibition of Transient Receptor Potential Vanilloid Subfamily 1-expressing Primary Afferents in Mice. ( Fuseya, S; Kawamata, M; Kawamata, T; Minemura, H; Yamamoto, K; Yamaori, S, 2016) |
| "We conducted experiments in rats to determine optimal concentrations and ratios of lidocaine and QX-314 that produce the greatest degree and duration of pain-selective block when administered nearby the sciatic nerve: reduction in the response to noxious mechanical (pinch) and to radiant heat stimuli, with minimal disruption in motor function (grip strength)." | 3.77 | Targeting of sodium channel blockers into nociceptors to produce long-duration analgesia: a systematic study and review. ( Bean, BP; Binshtok, AM; Blasl, F; Roberson, DP; Woolf, CJ, 2011) |
| "We tested whether it is possible to selectively block pain signals in the orofacial area by delivering the permanently charged lidocaine derivative QX-314 into nociceptors via TPRV1 channels." | 3.76 | Selectively targeting pain in the trigeminal system. ( Ahn, DK; Bean, BP; Binshtok, AM; Chung, G; Hwang, SJ; Jung, SJ; Kang, Y; Kim, HY; Kim, JS; Kim, K; Lee, MK; Li, HY; Oh, SB; Park, CK; Woolf, CJ, 2010) |
| " We tested the possibility of selectively blocking the excitability of primary sensory nociceptor (pain-sensing) neurons by introducing the charged, membrane-impermeant lidocaine derivative QX-314 through the pore of the noxious-heat-sensitive TRPV1 channel." | 3.74 | Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers. ( Bean, BP; Binshtok, AM; Woolf, CJ, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (11.76) | 18.2507 |
| 2000's | 6 (35.29) | 29.6817 |
| 2010's | 8 (47.06) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, S | 1 |
| Jo, S | 1 |
| Talbot, S | 1 |
| Zhang, HB | 1 |
| Kotoda, M | 1 |
| Andrews, NA | 1 |
| Puopolo, M | 1 |
| Liu, PW | 1 |
| Jacquemont, T | 1 |
| Pascal, M | 1 |
| Heckman, LM | 1 |
| Jain, A | 1 |
| Lee, J | 1 |
| Woolf, CJ | 5 |
| Bean, BP | 4 |
| Kanda, H | 1 |
| Yang, Y | 2 |
| Duan, S | 1 |
| Kogure, Y | 1 |
| Wang, S | 1 |
| Iwaoka, E | 1 |
| Ishikawa, M | 1 |
| Takeda, S | 1 |
| Sonoda, H | 1 |
| Mizuta, K | 1 |
| Aoki, S | 1 |
| Yamamoto, S | 1 |
| Noguchi, K | 1 |
| Dai, Y | 1 |
| Blake, KJ | 1 |
| Baral, P | 1 |
| Voisin, T | 1 |
| Lubkin, A | 1 |
| Pinho-Ribeiro, FA | 1 |
| Adams, KL | 1 |
| Roberson, DP | 2 |
| Ma, YC | 1 |
| Otto, M | 1 |
| Torres, VJ | 1 |
| Chiu, IM | 1 |
| Tomim, DH | 1 |
| Pontarolla, FM | 1 |
| Bertolini, JF | 1 |
| Arase, M | 1 |
| Tobaldini, G | 1 |
| Lima, MMS | 1 |
| Fischer, L | 1 |
| Yamaguchi, K | 1 |
| Ono, K | 1 |
| Hitomi, S | 1 |
| Ito, M | 1 |
| Nodai, T | 1 |
| Goto, T | 1 |
| Harano, N | 1 |
| Watanabe, S | 1 |
| Inoue, H | 1 |
| Miyano, K | 1 |
| Uezono, Y | 1 |
| Matoba, M | 1 |
| Inenaga, K | 1 |
| Fuseya, S | 1 |
| Yamamoto, K | 1 |
| Minemura, H | 1 |
| Yamaori, S | 1 |
| Kawamata, T | 1 |
| Kawamata, M | 1 |
| McCoy, DD | 1 |
| Palkar, R | 1 |
| Ongun, S | 1 |
| McKemy, DD | 1 |
| Bonjardim, LR | 1 |
| da Silva, AP | 1 |
| Gameiro, GH | 1 |
| Tambeli, CH | 2 |
| Ferraz de Arruda Veiga, MC | 1 |
| Kim, HY | 1 |
| Kim, K | 1 |
| Li, HY | 1 |
| Chung, G | 1 |
| Park, CK | 1 |
| Kim, JS | 1 |
| Jung, SJ | 1 |
| Lee, MK | 1 |
| Ahn, DK | 1 |
| Hwang, SJ | 1 |
| Kang, Y | 1 |
| Binshtok, AM | 3 |
| Oh, SB | 1 |
| Blasl, F | 1 |
| Lim, TK | 1 |
| Macleod, BA | 1 |
| Ries, CR | 1 |
| Schwarz, SK | 1 |
| McCleskey, EW | 1 |
| Taylor, BK | 1 |
| Peterson, MA | 1 |
| Basbaum, AI | 1 |
| Omana-Zapata, I | 1 |
| Khabbaz, MA | 1 |
| Hunter, JC | 1 |
| Bley, KR | 1 |
| Roveroni, RC | 1 |
| Parada, CA | 1 |
| Cecília, M | 1 |
| Veiga, FA | 1 |
17 other studies available for qx-314 and Ache
| Article | Year |
|---|---|
Novel charged sodium and calcium channel inhibitor active against neurogenic inflammation.
Topics: Animals; Bupivacaine; Calcium; Calcium Channel Blockers; Calcium Channels, N-Type; Calcium Signaling | 2019 |
Atractylodin Produces Antinociceptive Effect through a Long-Lasting TRPA1 Channel Activation.
Topics: Analgesics; Animals; Calcium; Calcium Channels; Furans; Ganglia, Spinal; HEK293 Cells; Humans; Isoth | 2021 |
Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314.
Topics: Anesthetics, Local; Animals; Bacterial Toxins; Gene Knockdown Techniques; Lidocaine; Methicillin-Res | 2018 |
The Pronociceptive Effect of Paradoxical Sleep Deprivation in Rats: Evidence for a Role of Descending Pain Modulation Mechanisms.
Topics: Animals; Bicuculline; Lidocaine; Male; Morphine; Motor Activity; Nociception; Pain; Pain Measurement | 2016 |
Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil.
Topics: Acetanilides; Anesthetics, Local; Animals; Anti-Bacterial Agents; Antimetabolites; Carcinosarcoma; C | 2016 |
Systemic QX-314 Reduces Bone Cancer Pain through Selective Inhibition of Transient Receptor Potential Vanilloid Subfamily 1-expressing Primary Afferents in Mice.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Bone Neoplasms; Cyclic AMP Response Element-Binding P | 2016 |
Cellular permeation of large molecules mediated by TRPM8 channels.
Topics: Anesthetics, Local; Animals; Cell Line; Ganglia, Spinal; Humans; Lidocaine; Nociceptors; Pain; Rats; | 2017 |
Nociceptive behavior induced by mustard oil injection into the temporomandibular joint is blocked by a peripheral non-opioid analgesic and a central opioid analgesic.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Inflammatory Agents, | 2009 |
Selectively targeting pain in the trigeminal system.
Topics: Action Potentials; Analysis of Variance; Anesthetics, Local; Animals; Capsaicin; Electric Stimulatio | 2010 |
Targeting of sodium channel blockers into nociceptors to produce long-duration analgesia: a systematic study and review.
Topics: Analgesics; Animals; Drug Delivery Systems; Lidocaine; Male; Nociceptors; Pain; Rats; Sensory Recept | 2011 |
The quaternary lidocaine derivative, QX-314, produces long-lasting local anesthesia in animal models in vivo.
Topics: Action Potentials; Anesthesia, Local; Anesthetics, Local; Animals; Disease Models, Animal; Dose-Resp | 2007 |
Neuroscience: a local route to pain relief.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Capsaicin; Cell Membrane Permeability; Electric Cond | 2007 |
Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Capsaicin; Cell Membrane Permeability; Electric Cond | 2007 |
Chillies: out of the frying pan and into the clinic?
Topics: Analgesics, Non-Narcotic; Anesthetics, Local; Animals; Capsaicin; Drug Interactions; Humans; Lidocai | 2007 |
Persistent cardiovascular and behavioral nociceptive responses to subcutaneous formalin require peripheral nerve input.
Topics: Anesthesia; Anesthetics, Local; Animals; Behavior, Animal; Blood Pressure; Dose-Response Relationshi | 1995 |
QX-314 inhibits ectopic nerve activity associated with neuropathic pain.
Topics: Action Potentials; Anesthetics, Local; Animals; Blood Pressure; Heart Rate; Lidocaine; Male; Pain; R | 1997 |
Development of a behavioral model of TMJ pain in rats: the TMJ formalin test.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Behavior, Animal; Disease Models, Animal; Lidocaine | 2001 |