quipazine has been researched along with Spinal Cord Injuries in 29 studies
Quipazine: A pharmacologic congener of serotonin that contracts smooth muscle and has actions similar to those of tricyclic antidepressants. It has been proposed as an oxytocic.
Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Severe spinal cord contusions interrupt nearly all brain projections to lumbar circuits producing leg movement." | 1.48 | Cortico-reticulo-spinal circuit reorganization enables functional recovery after severe spinal cord contusion. ( Anderson, MA; Anil, S; Asboth, L; Barraud, Q; Batti, L; Baud, L; Beauparlant, J; Courtine, G; Friedli, L; Kreider, J; Martinez-Gonzalez, C; Pagès, S; Pidpruzhnykova, G; Rey, E; Schneider, BL; Shkorbatova, P, 2018) |
| "Quipazine was particularly effective facilitating hindlimb stepping." | 1.42 | Neurochemical excitation of thoracic propriospinal neurons improves hindlimb stepping in adult rats with spinal cord lesions. ( Chopek, JW; Cowley, KC; MacNeil, BJ; Schmidt, BJ; Sutherland, S, 2015) |
| " We hypothesized that the characteristics of the spinally evoked potentials after chronic administration of both strychnine and quipazine under the influence of eEmc during standing and stepping can be used as biomarkers to predict successful motor performance." | 1.42 | Electrophysiological biomarkers of neuromodulatory strategies to recover motor function after spinal cord injury. ( Choe, J; Creagmile, J; Edgerton, VR; Gad, P; Gerasimenko, Y; Roy, RR; Zhong, H, 2015) |
| "Cervical incomplete spinal cord injuries often lead to severe and persistent impairments of sensorimotor functions and are clinically the most frequent type of spinal cord injury." | 1.37 | Motor deficits and recovery in rats with unilateral spinal cord hemisection mimic the Brown-Sequard syndrome. ( Filli, L; Schwab, ME; Weinmann, O; Zörner, B, 2011) |
| "After complete spinal cord transections that removed all supraspinal inputs in adult rats, combinations of serotonergic agonists and epidural electrical stimulation were able to acutely transform spinal networks from nonfunctional to highly functional and adaptive states as early as 1 week after injury." | 1.35 | Transformation of nonfunctional spinal circuits into functional states after the loss of brain input. ( Ao, Y; Courtine, G; Edgerton, VR; Gerasimenko, Y; Ichiyama, RM; Lavrov, I; Musienko, P; Roy, RR; Sofroniew, MV; Song, B; van den Brand, R; Yew, A; Zhong, H, 2009) |
| "Quipazine (i." | 1.35 | Dose dependence of the 5-HT agonist quipazine in facilitating spinal stepping in the rat with epidural stimulation. ( Edgerton, VR; Gerasimenko, Y; Ichiyama, RM; Jindrich, DL; Roy, RR; Zhong, H, 2008) |
| " Dose-response curves were obtained for quipazine (nonselective 5-hydroxytryptamine [5-HT] agonist; 1." | 1.33 | The serotonergic agonists quipazine, CGS-12066A, and alpha-methylserotonin alter motor activity and induce hindlimb stepping in the intact and spinal rat fetus. ( Brumley, MR; Robinson, SR, 2005) |
| " At the dosage used (0." | 1.33 | Spinal cord-transected mice learn to step in response to quipazine treatment and robotic training. ( Burdick, JW; Cai, LL; Edgerton, VR; Fong, AJ; Otoshi, CK; Reinkensmeyer, DJ; Roy, RR, 2005) |
| "Quipazine or vehicle was administered to the lumbar spinal cord using an intrathecal cannula." | 1.33 | Effect of robotic-assisted treadmill training and chronic quipazine treatment on hindlimb stepping in spinally transected rats. ( Acosta, CN; de Leon, RD, 2006) |
| "After thoracic spinal cord transection, a paraplegic syndrome occurs." | 1.32 | 5-HT1A receptors are involved in short- and long-term processes responsible for 5-HT-induced locomotor function recovery in chronic spinal rat. ( Antri, M; Barthe, JY; Mouffle, C; Orsal, D, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.45) | 18.2507 |
| 2000's | 13 (44.83) | 29.6817 |
| 2010's | 14 (48.28) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Swann-Thomsen, HE | 1 |
| Viall, DD | 1 |
| Brumley, MR | 3 |
| Ganzer, PD | 3 |
| Beringer, CR | 1 |
| Shumsky, JS | 3 |
| Nwaobasi, C | 1 |
| Moxon, KA | 3 |
| Asboth, L | 1 |
| Friedli, L | 1 |
| Beauparlant, J | 1 |
| Martinez-Gonzalez, C | 1 |
| Anil, S | 1 |
| Rey, E | 1 |
| Baud, L | 1 |
| Pidpruzhnykova, G | 1 |
| Anderson, MA | 1 |
| Shkorbatova, P | 1 |
| Batti, L | 1 |
| Pagès, S | 1 |
| Kreider, J | 1 |
| Schneider, BL | 1 |
| Barraud, Q | 1 |
| Courtine, G | 3 |
| Gerasimenko, IuP | 1 |
| Moshonkina, TR | 1 |
| Pavlova, NV | 1 |
| Tomilovskaia, ES | 1 |
| Kozlovskaia, IB | 1 |
| Chopek, JW | 2 |
| MacDonell, CW | 1 |
| Gardiner, K | 1 |
| Gardiner, PF | 1 |
| Sławińska, U | 2 |
| Miazga, K | 1 |
| Jordan, LM | 2 |
| Dugan, EA | 1 |
| Cowley, KC | 1 |
| MacNeil, BJ | 1 |
| Sutherland, S | 1 |
| Schmidt, BJ | 1 |
| Gad, P | 1 |
| Roy, RR | 6 |
| Choe, J | 1 |
| Creagmile, J | 1 |
| Zhong, H | 5 |
| Gerasimenko, Y | 3 |
| Edgerton, VR | 6 |
| Foffani, G | 1 |
| Shumsky, J | 1 |
| Knudsen, EB | 2 |
| Swann, HE | 1 |
| Kauer, SD | 1 |
| Allmond, JT | 1 |
| Ung, RV | 1 |
| Landry, ES | 2 |
| Rouleau, P | 1 |
| Lapointe, NP | 1 |
| Rouillard, C | 1 |
| Guertin, PA | 4 |
| van den Brand, R | 1 |
| Yew, A | 1 |
| Musienko, P | 1 |
| Song, B | 1 |
| Ao, Y | 1 |
| Ichiyama, RM | 3 |
| Lavrov, I | 1 |
| Sofroniew, MV | 1 |
| Ziegler, MD | 1 |
| Filli, L | 1 |
| Zörner, B | 1 |
| Weinmann, O | 1 |
| Schwab, ME | 1 |
| Majczyński, H | 1 |
| Dai, Y | 1 |
| Antri, M | 2 |
| Orsal, D | 2 |
| Barthe, JY | 2 |
| Saruhashi, Y | 1 |
| Matsusue, Y | 1 |
| Hukuda, S | 1 |
| Mouffle, C | 1 |
| Robinson, SR | 1 |
| Fong, AJ | 1 |
| Cai, LL | 1 |
| Otoshi, CK | 1 |
| Reinkensmeyer, DJ | 1 |
| Burdick, JW | 1 |
| de Leon, RD | 1 |
| Acosta, CN | 1 |
| Gerasimenko, YP | 1 |
| Lavrov, IA | 1 |
| Cai, L | 1 |
| Jindrich, DL | 1 |
| Kim, D | 1 |
| Adipudi, V | 1 |
| Shibayama, M | 1 |
| Giszter, S | 1 |
| Tessler, A | 1 |
| Murray, M | 1 |
| Simansky, KJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Study on Preliminary Safety and Efficacy of the ARC Therapy Using the ARC-IM Lumbar System to Support Mobility in People With Chronic Spinal Cord Injury[NCT05942339] | 8 participants (Anticipated) | Interventional | 2023-08-31 | Not yet recruiting | |||
| STIMO-PARKINSON: Study on Feasibility of Targeted Epidural Spinal Stimulation (TESS) to Improve Mobility in Patients With Parkinson's Disease[NCT04956770] | 2 participants (Actual) | Interventional | 2021-06-14 | Active, not recruiting | |||
| Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury[NCT04994886] | 8 participants (Anticipated) | Interventional | 2021-06-08 | Recruiting | |||
| Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury[NCT05044923] | 8 participants (Anticipated) | Interventional | 2021-12-31 | Recruiting | |||
| Epidural Electrical Stimulation to Restore Hemodynamic Stability and Trunk Control in People With Spinal Cord Injury[NCT05111093] | 20 participants (Anticipated) | Interventional | 2021-11-29 | Recruiting | |||
| Priming With High-Frequency Trans-spinal Stimulation to Augment Locomotor Benefits in Spinal Cord Injury[NCT04807764] | 45 participants (Anticipated) | Interventional | 2021-08-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
29 other studies available for quipazine and Spinal Cord Injuries
| Article | Year |
|---|---|
Acute intrathecal administration of quipazine elicits air-stepping behavior.
Topics: Animals; Animals, Newborn; Biological Availability; Blood-Brain Barrier; Injections, Spinal; Kinesis | 2021 |
Serotonin receptor and dendritic plasticity in the spinal cord mediated by chronic serotonergic pharmacotherapy combined with exercise following complete SCI in the adult rat.
Topics: Aging; Animals; Female; Neuronal Plasticity; Physical Conditioning, Animal; Quipazine; Rats; Rats, S | 2018 |
Cortico-reticulo-spinal circuit reorganization enables functional recovery after severe spinal cord contusion.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Channelrhodopsins; Disease Models, Animal; F | 2018 |
[Serotoninergic system morphofunctional aspects in control of postural and locomotion function].
Topics: Animals; Exercise Test; Gait; Hindlimb; Injections, Intraperitoneal; Ketanserin; Locomotion; Male; P | 2012 |
Daily passive cycling attenuates the hyperexcitability and restores the responsiveness of the extensor monosynaptic reflex to quipazine in the chronic spinally transected rat.
Topics: Animals; Combined Modality Therapy; Disease Models, Animal; Exercise Therapy; Female; Quipazine; Rat | 2014 |
5-HT₂ and 5-HT₇ receptor agonists facilitate plantar stepping in chronic spinal rats through actions on different populations of spinal neurons.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Electromyography; Female; Hin | 2014 |
A combination therapy of neural and glial restricted precursor cells and chronic quipazine treatment paired with passive cycling promotes quipazine-induced stepping in adult spinalized rats.
Topics: Animals; Exercise Therapy; Female; Neural Stem Cells; Neuroglia; Quipazine; Rats; Rats, Sprague-Dawl | 2015 |
Neurochemical excitation of thoracic propriospinal neurons improves hindlimb stepping in adult rats with spinal cord lesions.
Topics: Animals; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Functional Laterality; Gait | 2015 |
Electrophysiological biomarkers of neuromodulatory strategies to recover motor function after spinal cord injury.
Topics: Animals; Biomechanical Phenomena; Disease Models, Animal; Electric Stimulation Therapy; Electromyogr | 2015 |
Interactive Effects Between Exercise and Serotonergic Pharmacotherapy on Cortical Reorganization After Spinal Cord Injury.
Topics: Action Potentials; Analysis of Variance; Animals; Cerebral Cortex; Disease Models, Animal; Exercise | 2016 |
Stimulation of 5-HT2A receptors recovers sensory responsiveness in acute spinal neonatal rats.
Topics: Animals; Animals, Newborn; Female; Male; Motor Activity; Quipazine; Rats; Rats, Sprague-Dawley; Rece | 2017 |
Role of spinal 5-HT2 receptor subtypes in quipazine-induced hindlimb movements after a low-thoracic spinal cord transection.
Topics: Animals; Disease Models, Animal; Hindlimb; Male; Mice; Motor Activity; Movement; Nerve Net; Paralysi | 2008 |
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai | 2009 |
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai | 2009 |
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai | 2009 |
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai | 2009 |
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai | 2009 |
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai | 2009 |
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai | 2009 |
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai | 2009 |
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai | 2009 |
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai | 2009 |
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai | 2009 |
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai | 2009 |
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai | 2009 |
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai | 2009 |
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai | 2009 |
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai | 2009 |
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai | 2009 |
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai | 2009 |
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai | 2009 |
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai | 2009 |
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai | 2009 |
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai | 2009 |
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai | 2009 |
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai | 2009 |
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai | 2009 |
Why variability facilitates spinal learning.
Topics: Algorithms; Animals; Disease Models, Animal; Electromyography; Exercise Therapy; Female; Learning; M | 2010 |
Motor deficits and recovery in rats with unilateral spinal cord hemisection mimic the Brown-Sequard syndrome.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Apomorphine; Brown-Sequard Syndrome; Clonidine; Dis | 2011 |
The upright posture improves plantar stepping and alters responses to serotonergic drugs in spinal rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Female; Foot; Hindlimb; Locomotion; Neurons, Affere | 2012 |
Serotonergic pharmacotherapy promotes cortical reorganization after spinal cord injury.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Brain Mapping; Cerebral Corte | 2013 |
Locomotor recovery in the chronic spinal rat: effects of long-term treatment with a 5-HT2 agonist.
Topics: Animals; Drug Administration Schedule; Electromyography; Female; Hindlimb; Locomotion; Muscle Contra | 2002 |
Effects of serotonin 1A agonist on acute spinal cord injury.
Topics: Action Potentials; Analysis of Variance; Animals; In Vitro Techniques; Isoindoles; Male; Mianserin; | 2002 |
5-HT1A receptors are involved in short- and long-term processes responsible for 5-HT-induced locomotor function recovery in chronic spinal rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Biomechanical Phenomena; Electrom | 2003 |
Role of NMDA receptor activation in serotonin agonist-induced air-stepping in paraplegic mice.
Topics: Animals; Dizocilpine Maleate; Drug Synergism; Excitatory Amino Acid Antagonists; Male; Mice; Motor A | 2004 |
Synergistic activation of the central pattern generator for locomotion by l-beta-3,4-dihydroxyphenylalanine and quipazine in adult paraplegic mice.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Levodopa; Locomotion; Male; Mice; Paraple | 2004 |
Differential effects of 5-HT1 and 5-HT2 receptor agonists on hindlimb movements in paraplegic mice.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Disease Models, Animal; Drug Interactions; Exer | 2004 |
The serotonergic agonists quipazine, CGS-12066A, and alpha-methylserotonin alter motor activity and induce hindlimb stepping in the intact and spinal rat fetus.
Topics: Analysis of Variance; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Embryo, Mammalian | 2005 |
Spinal cord-transected mice learn to step in response to quipazine treatment and robotic training.
Topics: Animals; Learning; Mice; Psychomotor Performance; Quipazine; Robotics; Spinal Cord Injuries; Walking | 2005 |
Effect of robotic-assisted treadmill training and chronic quipazine treatment on hindlimb stepping in spinally transected rats.
Topics: Animals; Exercise Test; Female; Hindlimb; Quipazine; Rats; Rats, Sprague-Dawley; Robotics; Spinal Co | 2006 |
Epidural spinal cord stimulation plus quipazine administration enable stepping in complete spinal adult rats.
Topics: Animals; Behavior, Animal; Biomechanical Phenomena; Disease Models, Animal; Dose-Response Relationsh | 2007 |
Dose dependence of the 5-HT agonist quipazine in facilitating spinal stepping in the rat with epidural stimulation.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimul | 2008 |
Direct agonists for serotonin receptors enhance locomotor function in rats that received neural transplants after neonatal spinal transection.
Topics: Amphetamines; Animals; Animals, Newborn; Fenfluramine; Fetal Tissue Transplantation; Motor Activity; | 1999 |