Compounds > quipazine
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quipazine and Injuries, Spinal Cord

quipazine has been researched along with Injuries, Spinal Cord in 29 studies

Quipazine: A pharmacologic congener of serotonin that contracts smooth muscle and has actions similar to those of tricyclic antidepressants. It has been proposed as an oxytocic.

Research Excerpts

ExcerptRelevanceReference
"Severe spinal cord contusions interrupt nearly all brain projections to lumbar circuits producing leg movement."1.48Cortico-reticulo-spinal circuit reorganization enables functional recovery after severe spinal cord contusion. ( Anderson, MA; Anil, S; Asboth, L; Barraud, Q; Batti, L; Baud, L; Beauparlant, J; Courtine, G; Friedli, L; Kreider, J; Martinez-Gonzalez, C; Pagès, S; Pidpruzhnykova, G; Rey, E; Schneider, BL; Shkorbatova, P, 2018)
"Quipazine was particularly effective facilitating hindlimb stepping."1.42Neurochemical excitation of thoracic propriospinal neurons improves hindlimb stepping in adult rats with spinal cord lesions. ( Chopek, JW; Cowley, KC; MacNeil, BJ; Schmidt, BJ; Sutherland, S, 2015)
" We hypothesized that the characteristics of the spinally evoked potentials after chronic administration of both strychnine and quipazine under the influence of eEmc during standing and stepping can be used as biomarkers to predict successful motor performance."1.42Electrophysiological biomarkers of neuromodulatory strategies to recover motor function after spinal cord injury. ( Choe, J; Creagmile, J; Edgerton, VR; Gad, P; Gerasimenko, Y; Roy, RR; Zhong, H, 2015)
"Cervical incomplete spinal cord injuries often lead to severe and persistent impairments of sensorimotor functions and are clinically the most frequent type of spinal cord injury."1.37Motor deficits and recovery in rats with unilateral spinal cord hemisection mimic the Brown-Sequard syndrome. ( Filli, L; Schwab, ME; Weinmann, O; Zörner, B, 2011)
"After complete spinal cord transections that removed all supraspinal inputs in adult rats, combinations of serotonergic agonists and epidural electrical stimulation were able to acutely transform spinal networks from nonfunctional to highly functional and adaptive states as early as 1 week after injury."1.35Transformation of nonfunctional spinal circuits into functional states after the loss of brain input. ( Ao, Y; Courtine, G; Edgerton, VR; Gerasimenko, Y; Ichiyama, RM; Lavrov, I; Musienko, P; Roy, RR; Sofroniew, MV; Song, B; van den Brand, R; Yew, A; Zhong, H, 2009)
"Quipazine (i."1.35Dose dependence of the 5-HT agonist quipazine in facilitating spinal stepping in the rat with epidural stimulation. ( Edgerton, VR; Gerasimenko, Y; Ichiyama, RM; Jindrich, DL; Roy, RR; Zhong, H, 2008)
" Dose-response curves were obtained for quipazine (nonselective 5-hydroxytryptamine [5-HT] agonist; 1."1.33The serotonergic agonists quipazine, CGS-12066A, and alpha-methylserotonin alter motor activity and induce hindlimb stepping in the intact and spinal rat fetus. ( Brumley, MR; Robinson, SR, 2005)
" At the dosage used (0."1.33Spinal cord-transected mice learn to step in response to quipazine treatment and robotic training. ( Burdick, JW; Cai, LL; Edgerton, VR; Fong, AJ; Otoshi, CK; Reinkensmeyer, DJ; Roy, RR, 2005)
"Quipazine or vehicle was administered to the lumbar spinal cord using an intrathecal cannula."1.33Effect of robotic-assisted treadmill training and chronic quipazine treatment on hindlimb stepping in spinally transected rats. ( Acosta, CN; de Leon, RD, 2006)
"After thoracic spinal cord transection, a paraplegic syndrome occurs."1.325-HT1A receptors are involved in short- and long-term processes responsible for 5-HT-induced locomotor function recovery in chronic spinal rat. ( Antri, M; Barthe, JY; Mouffle, C; Orsal, D, 2003)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (3.45)18.2507
2000's13 (44.83)29.6817
2010's14 (48.28)24.3611
2020's1 (3.45)2.80

Authors

AuthorsStudies
Swann-Thomsen, HE1
Viall, DD1
Brumley, MR3
Ganzer, PD3
Beringer, CR1
Shumsky, JS3
Nwaobasi, C1
Moxon, KA3
Asboth, L1
Friedli, L1
Beauparlant, J1
Martinez-Gonzalez, C1
Anil, S1
Rey, E1
Baud, L1
Pidpruzhnykova, G1
Anderson, MA1
Shkorbatova, P1
Batti, L1
Pagès, S1
Kreider, J1
Schneider, BL1
Barraud, Q1
Courtine, G3
Gerasimenko, IuP1
Moshonkina, TR1
Pavlova, NV1
Tomilovskaia, ES1
Kozlovskaia, IB1
Chopek, JW2
MacDonell, CW1
Gardiner, K1
Gardiner, PF1
Sławińska, U2
Miazga, K1
Jordan, LM2
Dugan, EA1
Cowley, KC1
MacNeil, BJ1
Sutherland, S1
Schmidt, BJ1
Gad, P1
Roy, RR6
Choe, J1
Creagmile, J1
Zhong, H5
Gerasimenko, Y3
Edgerton, VR6
Foffani, G1
Shumsky, J1
Knudsen, EB2
Swann, HE1
Kauer, SD1
Allmond, JT1
Ung, RV1
Landry, ES2
Rouleau, P1
Lapointe, NP1
Rouillard, C1
Guertin, PA4
van den Brand, R1
Yew, A1
Musienko, P1
Song, B1
Ao, Y1
Ichiyama, RM3
Lavrov, I1
Sofroniew, MV1
Ziegler, MD1
Filli, L1
Zörner, B1
Weinmann, O1
Schwab, ME1
Majczyński, H1
Dai, Y1
Antri, M2
Orsal, D2
Barthe, JY2
Saruhashi, Y1
Matsusue, Y1
Hukuda, S1
Mouffle, C1
Robinson, SR1
Fong, AJ1
Cai, LL1
Otoshi, CK1
Reinkensmeyer, DJ1
Burdick, JW1
de Leon, RD1
Acosta, CN1
Gerasimenko, YP1
Lavrov, IA1
Cai, L1
Jindrich, DL1
Kim, D1
Adipudi, V1
Shibayama, M1
Giszter, S1
Tessler, A1
Murray, M1
Simansky, KJ1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Study on Preliminary Safety and Efficacy of the ARC Therapy Using the ARC-IM Lumbar System to Support Mobility in People With Chronic Spinal Cord Injury[NCT05942339]8 participants (Anticipated)Interventional2023-08-31Not yet recruiting
STIMO-PARKINSON: Study on Feasibility of Targeted Epidural Spinal Stimulation (TESS) to Improve Mobility in Patients With Parkinson's Disease[NCT04956770]2 participants (Actual)Interventional2021-06-14Active, not recruiting
Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury[NCT04994886]8 participants (Anticipated)Interventional2021-06-08Recruiting
Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury[NCT05044923]8 participants (Anticipated)Interventional2021-12-31Recruiting
Epidural Electrical Stimulation to Restore Hemodynamic Stability and Trunk Control in People With Spinal Cord Injury[NCT05111093]20 participants (Anticipated)Interventional2021-11-29Recruiting
Priming With High-Frequency Trans-spinal Stimulation to Augment Locomotor Benefits in Spinal Cord Injury[NCT04807764]45 participants (Anticipated)Interventional2021-08-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

29 other studies available for quipazine and Injuries, Spinal Cord

ArticleYear
Acute intrathecal administration of quipazine elicits air-stepping behavior.
    Behavioural pharmacology, 2021, 06-01, Volume: 32, Issue:4

    Topics: Animals; Animals, Newborn; Biological Availability; Blood-Brain Barrier; Injections, Spinal; Kinesis

2021
Serotonin receptor and dendritic plasticity in the spinal cord mediated by chronic serotonergic pharmacotherapy combined with exercise following complete SCI in the adult rat.
    Experimental neurology, 2018, Volume: 304

    Topics: Aging; Animals; Female; Neuronal Plasticity; Physical Conditioning, Animal; Quipazine; Rats; Rats, S

2018
Cortico-reticulo-spinal circuit reorganization enables functional recovery after severe spinal cord contusion.
    Nature neuroscience, 2018, Volume: 21, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Channelrhodopsins; Disease Models, Animal; F

2018
[Serotoninergic system morphofunctional aspects in control of postural and locomotion function].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2012, Volume: 98, Issue:12

    Topics: Animals; Exercise Test; Gait; Hindlimb; Injections, Intraperitoneal; Ketanserin; Locomotion; Male; P

2012
Daily passive cycling attenuates the hyperexcitability and restores the responsiveness of the extensor monosynaptic reflex to quipazine in the chronic spinally transected rat.
    Journal of neurotrauma, 2014, Jun-15, Volume: 31, Issue:12

    Topics: Animals; Combined Modality Therapy; Disease Models, Animal; Exercise Therapy; Female; Quipazine; Rat

2014
5-HT₂ and 5-HT₇ receptor agonists facilitate plantar stepping in chronic spinal rats through actions on different populations of spinal neurons.
    Frontiers in neural circuits, 2014, Volume: 8

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Electromyography; Female; Hin

2014
A combination therapy of neural and glial restricted precursor cells and chronic quipazine treatment paired with passive cycling promotes quipazine-induced stepping in adult spinalized rats.
    The journal of spinal cord medicine, 2015, Volume: 38, Issue:6

    Topics: Animals; Exercise Therapy; Female; Neural Stem Cells; Neuroglia; Quipazine; Rats; Rats, Sprague-Dawl

2015
Neurochemical excitation of thoracic propriospinal neurons improves hindlimb stepping in adult rats with spinal cord lesions.
    Experimental neurology, 2015, Volume: 264

    Topics: Animals; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Functional Laterality; Gait

2015
Electrophysiological biomarkers of neuromodulatory strategies to recover motor function after spinal cord injury.
    Journal of neurophysiology, 2015, May-01, Volume: 113, Issue:9

    Topics: Animals; Biomechanical Phenomena; Disease Models, Animal; Electric Stimulation Therapy; Electromyogr

2015
Interactive Effects Between Exercise and Serotonergic Pharmacotherapy on Cortical Reorganization After Spinal Cord Injury.
    Neurorehabilitation and neural repair, 2016, Volume: 30, Issue:5

    Topics: Action Potentials; Analysis of Variance; Animals; Cerebral Cortex; Disease Models, Animal; Exercise

2016
Stimulation of 5-HT2A receptors recovers sensory responsiveness in acute spinal neonatal rats.
    Behavioral neuroscience, 2017, Volume: 131, Issue:1

    Topics: Animals; Animals, Newborn; Female; Male; Motor Activity; Quipazine; Rats; Rats, Sprague-Dawley; Rece

2017
Role of spinal 5-HT2 receptor subtypes in quipazine-induced hindlimb movements after a low-thoracic spinal cord transection.
    The European journal of neuroscience, 2008, Volume: 28, Issue:11

    Topics: Animals; Disease Models, Animal; Hindlimb; Male; Mice; Motor Activity; Movement; Nerve Net; Paralysi

2008
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Why variability facilitates spinal learning.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Aug-11, Volume: 30, Issue:32

    Topics: Algorithms; Animals; Disease Models, Animal; Electromyography; Exercise Therapy; Female; Learning; M

2010
Motor deficits and recovery in rats with unilateral spinal cord hemisection mimic the Brown-Sequard syndrome.
    Brain : a journal of neurology, 2011, Volume: 134, Issue:Pt 8

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Apomorphine; Brown-Sequard Syndrome; Clonidine; Dis

2011
The upright posture improves plantar stepping and alters responses to serotonergic drugs in spinal rats.
    The Journal of physiology, 2012, Apr-01, Volume: 590, Issue:7

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Female; Foot; Hindlimb; Locomotion; Neurons, Affere

2012
Serotonergic pharmacotherapy promotes cortical reorganization after spinal cord injury.
    Experimental neurology, 2013, Volume: 241

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Brain Mapping; Cerebral Corte

2013
Locomotor recovery in the chronic spinal rat: effects of long-term treatment with a 5-HT2 agonist.
    The European journal of neuroscience, 2002, Volume: 16, Issue:3

    Topics: Animals; Drug Administration Schedule; Electromyography; Female; Hindlimb; Locomotion; Muscle Contra

2002
Effects of serotonin 1A agonist on acute spinal cord injury.
    Spinal cord, 2002, Volume: 40, Issue:10

    Topics: Action Potentials; Analysis of Variance; Animals; In Vitro Techniques; Isoindoles; Male; Mianserin;

2002
5-HT1A receptors are involved in short- and long-term processes responsible for 5-HT-induced locomotor function recovery in chronic spinal rat.
    The European journal of neuroscience, 2003, Volume: 18, Issue:7

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Biomechanical Phenomena; Electrom

2003
Role of NMDA receptor activation in serotonin agonist-induced air-stepping in paraplegic mice.
    Spinal cord, 2004, Volume: 42, Issue:3

    Topics: Animals; Dizocilpine Maleate; Drug Synergism; Excitatory Amino Acid Antagonists; Male; Mice; Motor A

2004
Synergistic activation of the central pattern generator for locomotion by l-beta-3,4-dihydroxyphenylalanine and quipazine in adult paraplegic mice.
    Neuroscience letters, 2004, Mar-25, Volume: 358, Issue:2

    Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Levodopa; Locomotion; Male; Mice; Paraple

2004
Differential effects of 5-HT1 and 5-HT2 receptor agonists on hindlimb movements in paraplegic mice.
    Progress in neuro-psychopharmacology & biological psychiatry, 2004, Volume: 28, Issue:6

    Topics: Analysis of Variance; Animals; Antiparkinson Agents; Disease Models, Animal; Drug Interactions; Exer

2004
The serotonergic agonists quipazine, CGS-12066A, and alpha-methylserotonin alter motor activity and induce hindlimb stepping in the intact and spinal rat fetus.
    Behavioral neuroscience, 2005, Volume: 119, Issue:3

    Topics: Analysis of Variance; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Embryo, Mammalian

2005
Spinal cord-transected mice learn to step in response to quipazine treatment and robotic training.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Dec-14, Volume: 25, Issue:50

    Topics: Animals; Learning; Mice; Psychomotor Performance; Quipazine; Robotics; Spinal Cord Injuries; Walking

2005
Effect of robotic-assisted treadmill training and chronic quipazine treatment on hindlimb stepping in spinally transected rats.
    Journal of neurotrauma, 2006, Volume: 23, Issue:7

    Topics: Animals; Exercise Test; Female; Hindlimb; Quipazine; Rats; Rats, Sprague-Dawley; Robotics; Spinal Co

2006
Epidural spinal cord stimulation plus quipazine administration enable stepping in complete spinal adult rats.
    Journal of neurophysiology, 2007, Volume: 98, Issue:5

    Topics: Animals; Behavior, Animal; Biomechanical Phenomena; Disease Models, Animal; Dose-Response Relationsh

2007
Dose dependence of the 5-HT agonist quipazine in facilitating spinal stepping in the rat with epidural stimulation.
    Neuroscience letters, 2008, Jun-27, Volume: 438, Issue:3

    Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimul

2008
Direct agonists for serotonin receptors enhance locomotor function in rats that received neural transplants after neonatal spinal transection.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999, Jul-15, Volume: 19, Issue:14

    Topics: Amphetamines; Animals; Animals, Newborn; Fenfluramine; Fetal Tissue Transplantation; Motor Activity;

1999