quinuclidines has been researched along with Disease Models, Animal in 88 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (2.27) | 18.7374 |
| 1990's | 6 (6.82) | 18.2507 |
| 2000's | 27 (30.68) | 29.6817 |
| 2010's | 44 (50.00) | 24.3611 |
| 2020's | 9 (10.23) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Jing, G; Kong, Q; Ming, T; Song, X; Wu, X; Yuan, M | 1 |
| Chiang, MSR; Clarke, J; Kayatekin, C; Park, H; Richards, AM; Sardi, SP; Shihabuddin, LS; Viel, C; Wang, B | 1 |
| Gao, C; Guo, Y; Han, R; Li, J; Qiao, X; Sun, L; Sun, X; Zhang, G | 1 |
| Ma, C; Wang, C; Wang, P; Zhao, H | 1 |
| Feng, Z; Kang, Y; Li, Y; Wen, H; Zheng, J; Zhu, J | 1 |
| Böhm, M; Distler, JHW; Flis, D; Stegemann, A; Steinbrink, K; Ziolkowski, W | 1 |
| Chang, Y; Li, Y; Liu, Z; Yu, J; Yu, L | 1 |
| Cai, S; Chang, JT; Davies, PJ; Echeverria, G; Feng, N; Giuliani, V; Guo, L; Heffernan, TP; Jiang, Y; Liu, X; Ma, X; Marszalek, JR; Moulder, S; Piwnica-Worms, H; Powell, RT; Qi, Y; Redwood, A; Stephan, C; Symmans, WF; Tu, Y; Vellano, CP; White, JB; Zhang, X; Zhou, X | 1 |
| Böhm, M; Del Rey, A; Raker, V; Stegemann, A; Steinbrink, K | 1 |
| Flores, JJ; Krafft, PR; Lekic, T; McBride, D; Rolland, WB; Zhang, JH | 1 |
| Ma, J; Yang, Y; Zhao, L | 1 |
| Cao, D; Kang, B; Meng, Y; Ning, H; Wang, H; Xie, S | 1 |
| Haruki, N; Hori, M; Inomata, T; Ohgoda, M; Tsukamoto, A | 1 |
| Gao, Y; Lin, D; Ma, J; Tan, H; Wang, Y | 1 |
| Mohapatra, DP; Shepherd, AJ; Shutov, LP; Usachev, YM; Warwick, CA | 1 |
| Han, L; Liao, Z; Shi, T; Tong, R; Xiao, H | 1 |
| Bangari, DS; Cao, J; Cheng, SH; Leonard, JP; Marshall, J; Nietupski, JB; Park, H; Randall, K; Silvescu, C; Tietz, D; Wang, B; Wilper, T; Ying, X | 1 |
| Andruszkow, H; Andruszkow, J; Greven, J; Hildebrand, F; Hofman, M; Kobbe, P; Kolejewska, A; Lammers, T; Möckel, D; Poeze, M; Rabenschlag, F; Teuben, MPJ | 1 |
| Fischer, L; Parada, CA; Perin-Martins, A; Tambeli, CH; Teixeira, JM | 1 |
| Caner, B; Klebe, D; Krafft, PR; Rolland, WB; Tang, J; Zhang, JH | 1 |
| Kusukawa, J; Nakamura, M; Saga, T; Tabira, Y; Takahashi, N; Watanabe, K; Yamaki, K | 1 |
| Parachikova, AI; Pedersen, CS; Plath, N; Sørensen, DB | 1 |
| Chen, K; Li, JJ; Wang, YL; Wang, YP; Xiao, F; Zhan, J; Zhang, ZZ | 1 |
| Bali, ZK; Bruszt, N; Csurgyók, R; Hernádi, I; Horváth, H; Inkeller, J | 1 |
| Chen, Y; Liu, L; Mo, LQ; Mou, M; Ren, CH; Wu, GM; Zhou, J | 1 |
| Atzori, M; Cheng, D; Cuevas-Olguin, R; Flores, G; Galindo Charles, L; Garcia-Oscos, F; Housini, M; Kilgard, MP; Lopez, D; Peña, D; Rose-John, S; Saderi, N; Salgado Burgos, H; Salgado Delgado, R | 1 |
| Akdemir, A; Bozdag, M; Carta, F; Isik, S; Lanzi, C; Masini, E; Scozzafava, A; Supuran, CT; Vullo, D | 1 |
| Babri, S; Mahmoudi, J; Sadigh-Eteghad, S; Shanehbandi, D; Talebi, M | 1 |
| Ashe, KM; Bangari, DS; Budman, E; Cheng, SH; Desnick, RJ; Leonard, JP; Marshall, J; Nietupski, JB; Scheule, RK; Siegel, CS; Wang, B | 1 |
| Dodam, JR; Grobman, M; Krumme, S; Outi, H; Reinero, CR | 1 |
| Camargo, LL; Costa, SK; Denadai-Souza, A; Fernandes, E; Grant, A; Lima, C; Mesquita, FP; Muscará, MN; Schenka, A; Soares, AG; Yshii, LM | 1 |
| Cao, HJ; Chen, KY; Ge, J; Pei, L; Yu, DM; Zhang, TZ; Zhou, J | 1 |
| Chan, ZL; Chen, ZR; Chng, WJ; Chooi, JY; Li, XL; Zhou, J | 1 |
| Lin, D; Ma, J; Wang, Z; Xue, Y | 1 |
| Babri, S; Mahmoudi, J; Sadigh-Eteghad, S; Talebi, M | 1 |
| Shu, Y; Yang, Y; Zhang, P | 1 |
| Allaire, A; Bangari, DS; Budman, E; Cheng, SH; Cromwell, MA; Grabowski, GA; Leonard, JP; Marshall, J; Nietupski, JB; Park, H; Sun, Y; Wang, B | 1 |
| Akbarali, HI; AlSharari, SD; Bagdas, D; Cabral, GA; Carroll, FI; Damaj, MI; Lichtman, PA; McGee, EA; Raborn, ES | 1 |
| Akiyama, I; Hayashi, S; Kadowaki, M; Nakashima, A; Ono, Y; Osuga, Y; Saito, S; Shima, T; Ushijima, A; Yamada-Nomoto, K; Yoshino, O | 1 |
| Bo, J; Gu, X; Huo, W; Lei, Y; Liu, Y; Ma, Z; Sun, R; Zhang, W; Zhang, Z | 1 |
| Adamson, L; Hayward, A; Neill, JC | 1 |
| Cheng, SH; Clarke, J; Dodge, JC; Makino, E; Marshall, J; Olszewski, MA; Park, H; Richards, AM; Sardi, SP; Shihabuddin, LS; Sidman, RL; Treleaven, CM; Viel, C; Wang, B | 1 |
| Antunes, E; Camargo, EA; de Nucci, G; Ferreira, T; Landucci, EC; Ribela, MT | 1 |
| Bilbe, G; Chaperon, F; Enz, A; Feuerbach, D; Gentsch, C; Hoyer, D; Lingenhoehl, K; McAllister, K; Nozulak, J; Olpe, HR; Vassout, A | 1 |
| De Jonghe, BC; Horn, CC | 1 |
| Dong, CM; Shi, H | 1 |
| Miyata, K; Ohtake, A; Sasamata, M; Sato, S | 1 |
| Li, SL; Ma, ZF; Ouyang, YH; Song, W; Zhao, N | 1 |
| Nishimura, H; Saga, T; Yakeishi, A; Yamaki, K | 1 |
| Fujino, T; Kageyama, A; Nozawa, Y; Yamada, S; Yoshida, A | 1 |
| Alt, J; Cantoreggi, S; Li, Y; Pietra, C; Rojas, C; Sebastiani, S; Slusher, BS; Stathis, M; Thomas, AG; Zhang, J | 1 |
| Appleyard, CB; Chen, Z; Coppola, D; Isidro, AA; Pagán, B; Ren, Y; Wu, J | 1 |
| Caballero, F; Elena, M; Fernández, A; Fernández-Checa, JC; García-Ruiz, C; Llacuna, L; Martínez, L; Matías, N; Montfort, CV; Morales, A; Rimola, A | 1 |
| Kang, YQ; Leng, YF; Wang, T; Xue, X; Zhang, Y | 1 |
| Akino, H; Aoki, Y; Ito, H; Nagase, K; Tanase, K; Yokoyama, O | 1 |
| Chen, S; Gou, X; Huang, Y; Li, X; Wang, F; Wang, Q; Xiong, L; Xu, N; Yang, Q; Zhang, Q | 1 |
| Carroll, FI; Damaj, MI; Freitas, K; Negus, SS | 1 |
| Advenier, C; Alt, XE; D'Agostino, B; Daoui, S; Gallelli, L; Rossi, F | 1 |
| Amemiya, T; Fujimura, M; Ishiura, Y; Kurashima, K; Myou, S; Nobata, K; Nonomura, A | 1 |
| Bar-Ner, N; Brandeis, R; Egozi, I; Fisher, A; Haring, R; Kliger-Spatz, M; Marcovitch, I; Natan, N; Pittel, Z; Sonego, H | 1 |
| Boyce, S; Clarke, D; Fisher, A; O'Connor, D; Pike, A; Rupniak, NM; Watt, A | 1 |
| Alessandri, AL; Castro, MS; Klein, A; Pinho, V; Souza, DG; Teixeira, MM | 1 |
| Nies, M; Ro, JY; Zhang, Y | 1 |
| Bánvölgyi, A; Berki, T; Brain, SD; Clark, N; Grant, AD; Helyes, Z; Pálinkás, L; Pintér, E; Pozsgai, G; Szolcsányi, J | 1 |
| Chen, B; Hu, DH; Tao, K; Wang, BT | 1 |
| Bitel, M; Chodorowski, Z; Ciechanownicz, R; Korolkiewicz, RP; Petrusewicz, J; Sein-Anand, J | 1 |
| Bradesi, S; Ennes, HS; Kokkotou, E; Marvizon, JC; Mayer, EA; McLean, P; McRoberts, JA; Mittal, Y; Ohning, G; Patierno, S; Pothoulakis, C; Simeonidis, S; Sternini, C | 1 |
| Hauer-Jensen, M; Kulkarni, A; Qiu, X; Wang, J | 1 |
| Amato, A; Faussone-Pellegrini, MS; Mulè, F; Serio, R; Vannucchi, MG | 1 |
| Fabry, Z; Johnson, MJ; Karman, J; Lee, J; Ling, C; Reinke, EK; Sandor, M; Weinstock, JV | 1 |
| Kim, JH; Lee, SE | 1 |
| Appleyard, CB; Morales, M; Santiago, C | 1 |
| Colli, E; Digesu, GA; Olivieri, L | 1 |
| Kawana, S; Yamaoka, J | 1 |
| Jia, BH; Lei, LR; Wang, YL | 1 |
| Hanaue, N; Kizu, Y; Takaki, S; Takakura, K; Takeda, I; Tonogi, M; Yamane, GY | 1 |
| Advenier, C; Emonds-Alt, X; Girard, V; Yavo, JC | 1 |
| Inoue, H; Koshihara, Y; Nagata, N | 1 |
| Cao, X; Cheng, G; Huang, X; Li, K; Yu, Z | 1 |
| Meurs, H; Schuiling, M; Zaagsma, J; Zuidhof, AB | 1 |
| Löfgren, O; Lundeberg, T; Qi, Y | 1 |
| Campbell, EA; Cruwys, S; Fox, AJ; Gentry, C; Kidd, B; Patel, S; Urban, L | 1 |
| Ikeda, K; Kobayashi, S; Miyata, K; Suzuki, M; Yamada, T | 1 |
| Kakuta, H; Moritani, H; Shikama, H; Ugawa, T | 1 |
| McNamara, JO | 1 |
| Brandeis, R; Fisher, A; Gurwitz, D; Haring, R; Heldman, E; Karton, I; Levy, A; Pittel, Z; Sapir, M | 1 |
| Brandeis, R; Dachir, S; Fisher, A; Heldman, E; Karton, I; Levy, A; Pittel, Z; Sapir, M | 1 |
3 review(s) available for quinuclidines and Disease Models, Animal
| Article | Year |
|---|---|
The forefront for novel therapeutic agents based on the pathophysiology of lower urinary tract dysfunction: ameliorative effect of solifenacin succinate (Vesicare), a bladder-selective antimuscarinic agent, on overactive bladder symptoms, especially urgen
Topics: Adenosine Triphosphate; Afferent Pathways; Animals; Disease Models, Animal; Humans; Muscarinic Antagonists; Muscle Contraction; Quinuclidines; Rats; Receptors, Muscarinic; Solifenacin Succinate; Tetrahydroisoquinolines; Urinary Bladder, Overactive | 2010 |
M1 muscarinic agonists can modulate some of the hallmarks in Alzheimer's disease: implications in future therapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cell Death; Disease Models, Animal; Down-Regulation; Humans; Memory Disorders; Mice; Muscarinic Agonists; Oxidative Stress; Piperidines; Quinuclidines; Receptor, Muscarinic M1; Spiro Compounds; tau Proteins; Thiazoles; Thiophenes | 2003 |
Overactive bladder treatments in early phase clinical trials.
Topics: Animals; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Disease Models, Animal; Drugs, Investigational; Guanidines; Humans; Mice; Muscarinic Antagonists; Quinuclidines; Receptors, Muscarinic; Sensitivity and Specificity; Severity of Illness Index; Solifenacin Succinate; Tetrahydroisoquinolines; Urinary Bladder, Overactive | 2007 |
1 trial(s) available for quinuclidines and Disease Models, Animal
| Article | Year |
|---|---|
Acute neurokinin-1 receptor antagonism fails to dampen airflow limitation or airway eosinophilia in an experimental model of feline asthma.
Topics: Animals; Asthma; Cat Diseases; Cats; Cross-Over Studies; Disease Models, Animal; Eosinophilia; Immunotherapy, Active; Prospective Studies; Quinuclidines; Receptors, Neurokinin-1 | 2016 |
84 other study(ies) available for quinuclidines and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Tumor necrosis factor α‑induced protein 8‑like 2 contributes to penehyclidine hydrochloride pretreatment against lipopolysaccharide‑induced acute lung injury in a mouse model.
Topics: Acute Lung Injury; Animals; Apoptosis; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Inflammation; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Lung; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; NF-kappa B; Quinuclidines; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2021 |
Preclinical pharmacology of glucosylceramide synthase inhibitor venglustat in a GBA-related synucleinopathy model.
Topics: Animals; Carbamates; Disease Models, Animal; Glucosylceramidase; Glucosylceramides; Glucosyltransferases; Hippocampus; Mice; Mice, Inbred C57BL; Mutation; Parkinson Disease; Quinuclidines; Synucleinopathies | 2021 |
α7 Nicotinic Acetylcholine Receptor Mediates the Neuroprotection of Remote Ischemic Postconditioning in a Rat Model of Asphyxial Cardiac Arrest.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Asphyxia; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Heart Arrest; Hippocampus; Humans; Hypoxia, Brain; Ischemic Postconditioning; Male; Neuroprotection; NF-kappa B; Quinuclidines; Rats; Signal Transduction; STAT3 Transcription Factor; Treatment Outcome | 2020 |
Smoking Attenuates Efficacy of Penehyclidine Hydrochloride in Acute Respiratory Distress Syndrome Induced by Lipopolysaccharide in Rats.
Topics: Animals; Blood Gas Analysis; Cigarette Smoking; Disease Models, Animal; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Lung; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Quinuclidines; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Signal Transduction; Treatment Outcome | 2019 |
Prevention of renal ischemia and reperfusion injury by penehyclidine hydrochloride through autophagy activation.
Topics: Adenine; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Autophagy; Beclin-1; Caspase 3; Cell Proliferation; Disease Models, Animal; Ischemia; Kidney; Male; Quinuclidines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sirolimus | 2020 |
The α7 Nicotinic Acetylcholine Receptor: A Promising Target for the Treatment of Fibrotic Skin Disorders.
Topics: Adenoviridae; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bleomycin; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Collagen; Disease Models, Animal; Drug Evaluation, Preclinical; Fibroblasts; Fibrosis; Genetic Vectors; Humans; Male; Mice; Primary Cell Culture; Quinuclidines; Receptor, Transforming Growth Factor-beta Type I; Scleroderma, Systemic; Skin | 2020 |
Penehyclidine hydrochloride inhibits renal ischemia/reperfusion-induced acute lung injury by activating the Nrf2 pathway.
Topics: Acute Lung Injury; Animals; Apoptosis; Disease Models, Animal; Gene Knockout Techniques; Humans; Kidney; Kidney Diseases; Lung; Macrophages, Alveolar; Male; NF-E2-Related Factor 2; Oxidative Stress; Quassins; Quinuclidines; Rats; Rats, Transgenic; Reactive Oxygen Species; Reperfusion Injury; Signal Transduction; tert-Butylhydroperoxide | 2020 |
Pharmacologic profiling of patient-derived xenograft models of primary treatment-naïve triple-negative breast cancer.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Drug Repositioning; Female; Heterografts; High-Throughput Screening Assays; Humans; Kinesins; Mice, Inbred NOD; Mice, SCID; Molecular Targeted Therapy; Neoplasm Transplantation; Quinuclidines; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays | 2020 |
Expression of the α7 Nicotinic Acetylcholine Receptor Is Critically Required for the Antifibrotic Effect of PHA-543613 on Skin Fibrosis.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bleomycin; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Fibrosis; Hydroxyproline; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Quinuclidines; Skin Diseases; Transforming Growth Factor beta1 | 2022 |
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Blood Transfusion, Autologous; Brain Injuries; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Hemorrhage; Collagenases; Disease Models, Animal; Humans; Inflammation; Janus Kinase 2; Mice; Neurons; Peroxidase; Quinuclidines; Rats; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha; Tyrphostins | 2017 |
Penehyclidine hydrochloride preconditioning provides cardiac protection in a rat model of myocardial ischemia/reperfusion injury via the mechanism of mitochondrial dynamics mechanism.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Cardiotonic Agents; Disease Models, Animal; Gene Expression Regulation; Heart; Ischemic Preconditioning; Male; Mitochondria; Mitochondrial Dynamics; Myocardial Reperfusion Injury; Oxidative Stress; Quinuclidines; Rats; Rats, Wistar; RNA, Messenger | 2017 |
Effects of haloperidol, olanzapine, ziprasidone, and PHA-543613 on spatial learning and memory in the Morris water maze test in naïve and MK-801-treated mice.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Haloperidol; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Olanzapine; Piperazines; Quinuclidines; Schizophrenia; Spatial Learning; Thiazoles; Treatment Outcome | 2017 |
The anti-inflammatory action of maropitant in a mouse model of acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Neurokinin-1 Receptor Antagonists; Pancreatitis; Peroxidase; Quinuclidines; Receptors, Neurokinin-1; Substance P | 2018 |
Penehyclidine hydrochloride preconditioning provides pulmonary and systemic protection in a rat model of lung ischaemia reperfusion injury.
Topics: Animals; Apoptosis; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Inflammation Mediators; Ischemic Preconditioning; Lung; Male; NF-kappa B; Oxidative Stress; Quinuclidines; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2018 |
Mechanisms underlying mechanical sensitization induced by complement C5a: the roles of macrophages, TRPV1, and calcitonin gene-related peptide receptors.
Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Complement C5a; Dipeptides; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Macrophages; Male; Mice; Mice, Inbred C57BL; Nerve Growth Factor; Pain Measurement; Piperidines; Quinazolines; Quinuclidines; Receptors, Calcitonin Gene-Related Peptide; Repressor Proteins; TRPA1 Cation Channel; TRPV Cation Channels | 2019 |
Mechanism of penehyclidine hydrochloride on a dysmenorrhea rat model.
Topics: Animals; Behavior, Animal; Calcium; Disease Models, Animal; Dysmenorrhea; Estradiol; Female; Oxytocin; Pain; Quinuclidines; Rats, Sprague-Dawley; Receptor, Muscarinic M3; Toll-Like Receptor 3; Toll-Like Receptor 4; Uterus | 2019 |
Substrate Reduction Therapy for Sandhoff Disease through Inhibition of Glucosylceramide Synthase Activity.
Topics: Animals; beta-Hexosaminidase beta Chain; Brain; Carbamates; Disease Models, Animal; Enzyme Inhibitors; Female; Glucosyltransferases; Ligands; Liver; Male; Mass Spectrometry; Mice; Mice, Knockout; Molecular Imaging; Quinuclidines; Receptors, GABA; Sandhoff Disease; Sphingolipids | 2019 |
Effect of neurokinin-1-receptor blockage on fracture healing in rats.
Topics: Animals; Collagen Type I; Collagen Type II; Disease Models, Animal; Femoral Fractures; Fracture Healing; Gene Expression Regulation, Neoplastic; Male; Neurokinin-1 Receptor Antagonists; Osteocalcin; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Substance P; Treatment Outcome | 2019 |
Mechanisms underlying transient receptor potential ankyrin 1 (TRPA1)-mediated hyperalgesia and edema.
Topics: Acetanilides; Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Extremities; Gene Expression Regulation; Hyperalgesia; Male; Oligodeoxyribonucleotides, Antisense; Peptide Fragments; Peroxidase; Piperazines; Purines; Quinuclidines; Rats; Rats, Wistar; Serotonin Antagonists; TRPA1 Cation Channel; TRPC Cation Channels | 2013 |
PHA-543613 preserves blood-brain barrier integrity after intracerebral hemorrhage in mice.
Topics: Aconitine; Androstadienes; Animals; beta Catenin; Blood-Brain Barrier; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Hemorrhage; Claudin-3; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Mice; Mice, Inbred Strains; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinuclidines; Receptors, Nicotinic; Signal Transduction; Wortmannin | 2013 |
An immunohistochemistry-based study on aquaporin (AQP)-1, 3, 4, 5 and 8 in the parotid glands, submandibular glands and sublingual glands of Sjögren's syndrome mouse models chronically administered cevimeline.
Topics: Animals; Aquaporin 1; Aquaporin 3; Aquaporin 4; Aquaporin 5; Aquaporins; Disease Models, Animal; Immunohistochemistry; Mice; Muscarinic Agonists; Parotid Gland; Quinuclidines; Salivation; Sjogren's Syndrome; Sublingual Gland; Submandibular Gland; Thiophenes; Time Factors | 2013 |
PCP-induced deficits in murine nest building activity: employment of an ethological rodent behavior to mimic negative-like symptoms of schizophrenia.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Benzofurans; Disease Models, Animal; Excitatory Amino Acid Antagonists; Hyperkinesis; Male; Mice; Mice, Inbred C57BL; Phencyclidine; Quinuclidines; Rotarod Performance Test; Schizophrenia; Schizophrenic Psychology; Social Behavior; Thiophenes | 2014 |
Penehyclidine hydrochloride decreases pulmonary microvascular permeability by upregulating beta arrestins in a murine cecal ligation and puncture model.
Topics: Acute Lung Injury; Animals; Arrestins; beta-Arrestins; Capillary Permeability; Cecum; Cholinergic Antagonists; Disease Models, Animal; Female; Ligation; Lung; Mice, Inbred Strains; Microcirculation; NF-kappa B; Pulmonary Circulation; Quinuclidines; Random Allocation; Up-Regulation; Wounds, Stab | 2015 |
Differential effects of α7 nicotinic receptor agonist PHA-543613 on spatial memory performance of rats in two distinct pharmacological dementia models.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cholinergic Agonists; Cholinergic Antagonists; Dementia; Disease Models, Animal; Dizocilpine Maleate; Drug Administration Routes; Excitatory Amino Acid Antagonists; Male; Maze Learning; Quinuclidines; Rats; Rats, Wistar; Scopolamine; Spatial Memory | 2015 |
Penehyclidine hydrochloride postconditioning on lipopolysaccharide-induced acute lung injury by inhibition of inflammatory factors in a rodent model.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Drug Evaluation, Preclinical; Interleukin-6; Lipopolysaccharides; Lung; Male; NF-kappa B; Peroxidase; Pulmonary Gas Exchange; Quinuclidines; Rats, Sprague-Dawley; Sepsis; Tumor Necrosis Factor-alpha | 2015 |
Activation of the anti-inflammatory reflex blocks lipopolysaccharide-induced decrease in synaptic inhibition in the temporal cortex of the rat.
Topics: Animals; Anti-Inflammatory Agents; Biophysics; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Electric Stimulation; In Vitro Techniques; Inflammation; Inhibitory Postsynaptic Potentials; Lipopolysaccharides; Neurons; Patch-Clamp Techniques; Quinuclidines; Rats; Rats, Sprague-Dawley; Synapses; Temporal Lobe; Vagus Nerve Stimulation | 2015 |
Synthesis of a new series of dithiocarbamates with effective human carbonic anhydrase inhibitory activity and antiglaucoma action.
Topics: Animals; Antihypertensive Agents; Carbon Disulfide; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Disease Models, Animal; Glaucoma; Humans; Intraocular Pressure; Male; Molecular Docking Simulation; Morpholines; Piperazines; Piperidines; Quinuclidines; Rabbits; Structure-Activity Relationship; Substrate Specificity; Sulfonamides; Thiocarbamates; Thiophenes | 2015 |
Selective activation of α7 nicotinic acetylcholine receptor by PHA-543613 improves Aβ25-35-mediated cognitive deficits in mice.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Amyloid beta-Peptides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cholinesterase Inhibitors; Cognition Disorders; Disease Models, Animal; Galantamine; Gene Expression Regulation; Male; Maze Learning; Mice; Mice, Inbred BALB C; Nicotinic Agonists; Nicotinic Antagonists; Peptide Fragments; Psychomotor Performance; Quinuclidines; RNA, Messenger; Time Factors | 2015 |
Efficacy of Enzyme and Substrate Reduction Therapy with a Novel Antagonist of Glucosylceramide Synthase for Fabry Disease.
Topics: alpha-Galactosidase; Animals; Blood-Brain Barrier; Carbamates; Disease Models, Animal; Fabry Disease; Glucosyltransferases; Glycolipids; Humans; Mice; Quinuclidines; Sphingolipids; Trihexosylceramides | 2015 |
Peripheral neurokinin-1 receptors contribute to kaolin-induced acute monoarthritis in rats.
Topics: Animals; Animals, Newborn; Antidiarrheals; Arthritis; Capsaicin; Cytokines; Disease Models, Animal; Edema; Enzyme Inhibitors; Hyperalgesia; Indomethacin; Kaolin; Knee Joint; Male; Pain Measurement; Peroxidase; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Synovial Fluid | 2015 |
Protective effect of penehyclidine hydrochloride on lipopolysaccharide-induced acute kidney injury in rat.
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Creatinine; Cytokines; Disease Models, Animal; Kidney; Lipopolysaccharides; Male; Occludin; Protective Agents; Quinuclidines; Rats; Zonula Occludens-1 Protein | 2015 |
PRIMA-1met (APR-246) inhibits growth of colorectal cancer cells with different p53 status through distinct mechanisms.
Topics: Animals; Caco-2 Cells; Cell Proliferation; Colorectal Neoplasms; Disease Models, Animal; HT29 Cells; Humans; Mice; Mice, Inbred NOD; Mice, SCID; Quinuclidines; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2015 |
Penehyclidine Hydrochloride Preconditioning Provides Cardioprotection in a Rat Model of Myocardial Ischemia/Reperfusion Injury.
Topics: Animals; Apoptosis; Cardiotonic Agents; Cytokines; Disease Models, Animal; Inflammation Mediators; Ischemic Preconditioning; Male; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxidative Stress; Quinuclidines; Rats; Rats, Wistar | 2015 |
Effect of alpha-7 nicotinic acetylcholine receptor activation on beta-amyloid induced recognition memory impairment. Possible role of neurovascular function.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Amyloid beta-Peptides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cholinesterase Inhibitors; Disease Models, Animal; Galantamine; Laser-Doppler Flowmetry; Male; Memory Disorders; Mice, Inbred BALB C; Neuropsychological Tests; Neurovascular Coupling; Peptide Fragments; Quinuclidines; Recognition, Psychology; Reproducibility of Results; Time Factors; Treatment Outcome | 2015 |
Neuroprotective effects of penehyclidine hydrochloride against cerebral ischemia/reperfusion injury in mice.
Topics: Analysis of Variance; Animals; Blood-Brain Barrier; Brain Edema; Brain Infarction; Capillary Permeability; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione Peroxidase; In Situ Nick-End Labeling; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Neurologic Examination; Neuroprotective Agents; Quinuclidines; Reperfusion Injury; Superoxide Dismutase; Time Factors | 2016 |
CNS-accessible Inhibitor of Glucosylceramide Synthase for Substrate Reduction Therapy of Neuronopathic Gaucher Disease.
Topics: Administration, Oral; Animals; Carbamates; Central Nervous System; Disease Models, Animal; Enzyme Inhibitors; Gaucher Disease; Glucosyltransferases; Glycolipids; Humans; Inositol; Liver; Lysosomes; Mice; Quinuclidines; Tissue Distribution; Treatment Outcome | 2016 |
Sex Differences and Drug Dose Influence the Role of the α7 Nicotinic Acetylcholine Receptor in the Mouse Dextran Sodium Sulfate-Induced Colitis Model.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Bridged Bicyclo Compounds, Heterocyclic; Colitis; Dextran Sulfate; Disease Models, Animal; Female; Inflammation; Isoxazoles; Male; Mice; Mice, Knockout; Phenylurea Compounds; Quinuclidines | 2017 |
Alpha-7 nicotinic acetylcholine receptor (nAChR) agonist inhibits the development of endometriosis by regulating inflammation.
Topics: Aconitine; Adult; alpha7 Nicotinic Acetylcholine Receptor; Animals; Ascitic Fluid; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Endometriosis; Endometrium; Female; Gene Expression Regulation; Humans; Interleukin-1beta; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Mice; Nicotine; Primary Cell Culture; Quinuclidines; RNA, Messenger; Severity of Illness Index; Signal Transduction | 2016 |
Spinal activation of alpha7-nicotinic acetylcholine receptor attenuates posttraumatic stress disorder-related chronic pain via suppression of glial activation.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bridged Bicyclo Compounds, Heterocyclic; Cholinergic Agents; Chronic Pain; Comorbidity; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Neuroglia; Quinuclidines; Random Allocation; Rats, Sprague-Dawley; Spinal Cord; Stress Disorders, Post-Traumatic; Touch | 2017 |
Partial agonism at the α7 nicotinic acetylcholine receptor improves attention, impulsive action and vigilance in low attentive rats.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Attention; Attention Deficit Disorder with Hyperactivity; Choice Behavior; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Impulsive Behavior; Male; Photic Stimulation; Quinuclidines; Rats; Rats, Transgenic; Thiadiazoles | 2017 |
Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models.
Topics: alpha-Synuclein; Animals; Carbamates; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Glucosyltransferases; Humans; Mice; Mutation; Parkinson Disease; Protein Aggregation, Pathological; Quinuclidines; tau Proteins; Ubiquitin | 2017 |
Role of substance P and bradykinin in acute pancreatitis induced by secretory phospholipase A2.
Topics: Acute Disease; Amylases; Animals; Bradykinin; Bradykinin B2 Receptor Antagonists; Disease Models, Animal; Lung; Male; Neurokinin-1 Receptor Antagonists; Pancreas; Pancreatitis; Peroxidase; Phospholipases A2, Secretory; Piperidines; Pneumonia; Quinuclidines; Rats; Rats, Wistar; Receptor, Bradykinin B2; Receptors, Neurokinin-1; Substance P; Tumor Necrosis Factor-alpha | 2008 |
The selective nicotinic acetylcholine receptor alpha7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain.
Topics: Acoustic Stimulation; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Carbamates; Cognition; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Epilepsy; Evoked Potentials, Auditory; Exploratory Behavior; Hippocampus; Male; Mice; Mice, Inbred DBA; Nicotine; Nicotinic Agonists; Pain; Pain Threshold; Quinuclidines; Rats; Receptors, Nicotinic; Sensory Gating; Social Behavior; Time Factors | 2009 |
Chemotherapy agent cisplatin induces 48-h Fos expression in the brain of a vomiting species, the house musk shrew (Suncus murinus).
Topics: Amygdala; Animals; Antiemetics; Antineoplastic Agents; Area Postrema; Brain; Cisplatin; Disease Models, Animal; Female; Isoquinolines; Mesencephalon; Palonosetron; Proto-Oncogene Proteins c-fos; Quinuclidines; Receptors, Serotonin, 5-HT3; Serotonin 5-HT3 Receptor Antagonists; Serotonin Antagonists; Shrews; Solitary Nucleus; Time Factors; Vomiting | 2009 |
[The effect of penehyclidine hydrochloride on the expression of inflammatory factor in rat with sepsis-associated lung injury].
Topics: Animals; Disease Models, Animal; HMGB1 Protein; Lung; Lung Injury; Male; Quinuclidines; Random Allocation; Rats; Rats, Sprague-Dawley; Sepsis | 2009 |
[Effect of penehyclidine hydrochloride on tumor necrosis factor-alpha in liver and spleen in mice with acute organophosphorus pesticide poisoning].
Topics: Acute Disease; Animals; Disease Models, Animal; Liver; Male; Mice; Mice, Inbred BALB C; Organophosphate Poisoning; Poisoning; Quinuclidines; RNA, Messenger; Spleen; Tumor Necrosis Factor-alpha | 2010 |
Effects of cevimeline on the immunolocalization of aquaporin-5 and the ultrastructure of salivary glands in Sjögren's syndrome model mice.
Topics: Animals; Aquaporin 5; Disease Models, Animal; Female; Immunohistochemistry; Mice; Mice, Inbred BALB C; Mice, Inbred MRL lpr; Microscopy, Electron; Muscarinic Agonists; Quinuclidines; Sjogren's Syndrome; Submandibular Gland; Thiophenes | 2009 |
Loss of muscarinic and purinergic receptors in urinary bladder of rats with hydrochloric acid-induced cystitis.
Topics: Adenosine Triphosphate; Animals; Benzhydryl Compounds; Benzofurans; Cresols; Cystitis; Disease Models, Animal; Down-Regulation; Female; Hydrochloric Acid; Mandelic Acids; N-Methylscopolamine; Organophosphonates; Phenols; Phenylpropanolamine; Pirenzepine; Polycyclic Compounds; Pyridoxal Phosphate; Pyrrolidines; Quinuclidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Receptors, Purinergic; Solifenacin Succinate; Tetrahydroisoquinolines; Tolterodine Tartrate; Urinary Bladder; Urination; Urodynamics | 2010 |
The antiemetic 5-HT3 receptor antagonist Palonosetron inhibits substance P-mediated responses in vitro and in vivo.
Topics: Action Potentials; Animals; Antiemetics; Antineoplastic Agents; Calcium; Cell Line; Cisplatin; Disease Models, Animal; Dose-Response Relationship, Drug; Isoquinolines; Male; Neurokinin-1 Receptor Antagonists; Neurons; Nodose Ganglion; Palonosetron; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin 5-HT3 Receptor Antagonists; Substance P; Vomiting | 2010 |
Effect of a neurokinin-1 receptor antagonist in a rat model of colitis-associated colon cancer.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Immunohistochemistry; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2010 |
Targeting cholesterol at different levels in the mevalonate pathway protects fatty liver against ischemia-reperfusion injury.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Cholesterol, Dietary; Choline; Choline Deficiency; Disease Models, Animal; Disease Susceptibility; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Fatty Liver; Glutathione; Heptanoic Acids; Lipotropic Agents; Liver; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; Mitochondria; Obesity; Pyrroles; Quinuclidines; Reperfusion Injury | 2011 |
[Preventive effects of ischemic postconditioning and penehyclidine hydrochloride on gastric against ischemia-reperfusion injury in rats].
Topics: Animals; Disease Models, Animal; Gastric Mucosa; Ischemia; Ischemic Postconditioning; Male; Quinuclidines; Rats; Rats, Wistar; Reperfusion Injury; Stomach Diseases | 2011 |
Co-administration of an α(1) -blocker improves the efficacy and safety of antimuscarinic agents in rats with detrusor overactivity.
Topics: Adrenergic alpha-1 Receptor Antagonists; Analysis of Variance; Animals; Disease Models, Animal; Diterpenes; Drug Therapy, Combination; Female; Infarction, Middle Cerebral Artery; Muscarinic Antagonists; Muscle Contraction; Organ Size; Quinuclidines; Rats; Rats, Sprague-Dawley; Solifenacin Succinate; Statistics, Nonparametric; Sulfonamides; Tamsulosin; Tetrahydroisoquinolines; Urinary Bladder; Urinary Bladder, Overactive | 2011 |
Electroacupuncture pretreatment attenuates cerebral ischemic injury through α7 nicotinic acetylcholine receptor-mediated inhibition of high-mobility group box 1 release in rats.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Brain Injuries; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cells, Cultured; Cerebral Cortex; Cerebral Infarction; Disease Models, Animal; Electroacupuncture; Embryo, Mammalian; Gene Expression Regulation; Glucose; HMGB1 Protein; Hypoxia; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Injections, Intraventricular; L-Lactate Dehydrogenase; Male; Neurons; Neuroprotective Agents; Phosphopyruvate Hydratase; Protein Binding; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Statistics, Nonparametric; Tetrazolium Salts; Thiazoles | 2012 |
In vivo pharmacological interactions between a type II positive allosteric modulator of α7 nicotinic ACh receptors and nicotinic agonists in a murine tonic pain model.
Topics: Acute Pain; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Behavior, Animal; Body Temperature Regulation; Bridged Bicyclo Compounds, Heterocyclic; Choline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Isoxazoles; Male; Mice; Mice, Inbred ICR; Motor Activity; Nicotine; Nicotinic Agonists; Nociceptive Pain; Pain Measurement; Phenylurea Compounds; Quinuclidines | 2013 |
Tachykinins and airway microvascular leakage induced by HCl intra-oesophageal instillation.
Topics: Animals; Asthma; Capillary Permeability; Disease Models, Animal; Esophagus; Female; Gastroesophageal Reflux; Guinea Pigs; Hydrochloric Acid; Instillation, Drug; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rabbits; Receptors, Neurokinin-1; Receptors, Neurokinin-3 | 2002 |
Airway eosinophil accumulation on sensory neuropeptide release in a guinea pig model of distilled-water-induced bronchoconstriction.
Topics: Aerosols; Animals; Bronchi; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Disease Models, Animal; Eosinophils; Guinea Pigs; Immunization, Passive; Male; Methacholine Chloride; Piperidines; Platelet Activating Factor; Quinuclidines; Substance P; Water | 2003 |
P-Glycoprotein efflux reduces the brain concentration of the substance P (NK1 receptor) antagonists SR140333 and GR205171: a comparative study using mdr1a-/- and mdr1a+/+ mice.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain Chemistry; Disease Models, Animal; Genes, MDR; Male; Mice; Mice, Knockout; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Stereoisomerism; Tetrazoles | 2003 |
Mechanisms underlying the inhibitory effects of tachykinin receptor antagonists on eosinophil recruitment in an allergic pleurisy model in mice.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophils; Female; Mice; Mice, Inbred BALB C; Piperidines; Pleurisy; Quinuclidines; Receptors, Tachykinin | 2003 |
Substance P does not play a critical role in neurogenic inflammation in the rat masseter muscle.
Topics: Analgesics; Animals; Capsaicin; Disease Models, Animal; Edema; Inflammation Mediators; Male; Masseter Muscle; Mustard Plant; Neurogenic Inflammation; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Plant Extracts; Plant Oils; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P | 2005 |
Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model.
Topics: Adjuvants, Immunologic; Animals; Calcitonin Gene-Related Peptide; Cytokines; Dermatitis, Allergic Contact; Disease Models, Animal; Diterpenes; Ear Diseases; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Oxazolone; Piperidines; Quinuclidines; Time Factors; TRPV Cation Channels | 2005 |
[The influence of non-peptide NK1 receptor antagonist L-703, 606 on the early tissue edema formation in rats with deep partial-thickness scald].
Topics: Animals; Burns; Capillary Permeability; Disease Models, Animal; Edema; Neurokinin-1 Receptor Antagonists; Quinuclidines; Rats; Rats, Sprague-Dawley | 2005 |
Salutary effects of tachykinin receptor antagonists in a rat model of postoperative ileus.
Topics: Anesthetics, Inhalation; Animals; Antipsychotic Agents; Benzamides; Disease Models, Animal; Ether; Gastrointestinal Motility; Ileus; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Postoperative Complications; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin | 2006 |
The role of neurokinin 1 receptors in the maintenance of visceral hyperalgesia induced by repeated stress in rats.
Topics: Animals; Base Sequence; Blotting, Western; Disease Models, Animal; Electrodes, Implanted; Electromyography; Gastrointestinal Motility; Gene Expression Regulation; Hyperalgesia; Male; Molecular Sequence Data; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sensitivity and Specificity; Stress, Physiological | 2006 |
Calcitonin gene-related peptide and substance P regulate the intestinal radiation response.
Topics: Adenosine; Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Disease Models, Animal; Gene Expression Profiling; Intestines; Male; Multivariate Analysis; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Radiation Injuries, Experimental; Rats; Rats, Sprague-Dawley; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Reverse Transcriptase Polymerase Chain Reaction; Substance P; X-Rays | 2006 |
Altered tachykinergic influence on gastric mechanical activity in mdx mice.
Topics: Animals; Benzamides; Disease Models, Animal; Enzyme Inhibitors; Gastrointestinal Motility; Immunohistochemistry; Male; Manometry; Mice; Mice, Inbred mdx; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Muscular Dystrophy, Duchenne; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Organ Culture Techniques; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Stomach; Tachykinins | 2006 |
Substance P receptor mediated maintenance of chronic inflammation in EAE.
Topics: Animals; Anti-Inflammatory Agents; CD4-Positive T-Lymphocytes; Chronic Disease; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Encephalomyelitis, Autoimmune, Experimental; Female; Immunity, Cellular; Immunosuppression Therapy; Interferon-gamma; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Myelin Proteins; Myelin-Associated Glycoprotein; Myelin-Oligodendrocyte Glycoprotein; Neuroimmunomodulation; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Substance P | 2006 |
Involvement of substance P and calcitonin gene-related peptide in development and maintenance of neuropathic pain from spinal nerve injury model of rat.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Disease Models, Animal; Dose-Response Relationship, Drug; Lidocaine; Male; Neuralgia; Pain Measurement; Peptide Fragments; Quinuclidines; Rats; Rats, Sprague-Dawley; Spinal Nerves; Substance P; Time Factors | 2007 |
Chronic inflammation alters the contribution of neurokinin receptor subtypes to epithelial function in rat colon.
Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipsychotic Agents; Benzamides; Colitis; Disease Models, Animal; Indomethacin; Intestinal Mucosa; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Stereoisomerism; Substance P; Tetrodotoxin; Trinitrobenzenesulfonic Acid | 2008 |
A transient unresponsive state of self-scratching behaviour is induced in mice by skin-scratching stimulation.
Topics: Analgesics, Non-Narcotic; Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; Male; Mice; Mice, Inbred ICR; Peptide Fragments; Physical Stimulation; Pruritus; Quinuclidines; Self Stimulation; Signal Transduction; Skin Physiological Phenomena; Substance P | 2007 |
[Protective effect of penehyclidine hydrochloride on lung injury in mice with sepsis and its mechanism].
Topics: Animals; Disease Models, Animal; Female; Lung; Lung Injury; Malondialdehyde; Mice; Nitric Oxide Synthase; Quinuclidines; Random Allocation; Sepsis; Superoxide Dismutase | 2007 |
Effect of cevimeline on radiation-induced salivary gland dysfunction and AQP5 in submandibular gland in mice.
Topics: Animals; Aquaporin 5; Disease Models, Animal; Female; Fluorescent Antibody Technique; Mice; Mice, Inbred ICR; Muscarinic Agonists; Quinuclidines; Radiation Dosage; Reverse Transcriptase Polymerase Chain Reaction; Saliva; Secretory Rate; Submandibular Gland; Submandibular Gland Diseases; Thiophenes; Time Factors; X-Rays; Xerostomia | 2007 |
The tachykinin NK2 receptor antagonist SR 48968 inhibits citric acid-induced airway hyperresponsiveness in guinea pigs.
Topics: Acetylcholine; Aerosols; Animals; Benzamides; Bronchial Hyperreactivity; Bronchoconstriction; Capsaicin; Citrates; Citric Acid; Codeine; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guinea Pigs; Injections, Intraperitoneal; Injections, Intravenous; Male; Narcotics; Piperidines; Protease Inhibitors; Quinuclidines; Receptors, Neurokinin-2; Receptors, Tachykinin; Stereoisomerism; Tachykinins; Thiorphan | 1996 |
Effect of the tachykinin receptor antagonists, SR 140333, FK 888, and SR 142801, on capsaicin-induced mouse ear oedema.
Topics: Animals; Binding Sites; Capsaicin; Dipeptides; Disease Models, Animal; Ear Diseases; Edema; Indoles; Injections, Intravenous; Lethal Dose 50; Male; Mice; Piperidines; Quinuclidines; Receptors, Tachykinin; Skin; Stereoisomerism; Structure-Activity Relationship; Substance P | 1996 |
Neurokinin-1 receptor antagonist SR140333: a novel type of drug to treat cerebral ischemia.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley | 1997 |
Involvement of tachykinin NK1 receptor in the development of allergen-induced airway hyperreactivity and airway inflammation in conscious, unrestrained guinea pigs.
Topics: Allergens; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Consciousness; Cross-Over Studies; Disease Models, Animal; Female; Follow-Up Studies; Guinea Pigs; Histamine; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Random Allocation; Receptors, Neurokinin-1; Respiratory Function Tests | 1999 |
Inhibitory effects of tachykinin receptor antagonists on thermally induced inflammatory reactions in a rat model.
Topics: Animals; Burns; Disease Models, Animal; Edema; Follow-Up Studies; Inflammation; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Skin Diseases; Substance P | 1999 |
Oral anti-hyperalgesic and anti-inflammatory activity of NK(1) receptor antagonists in models of inflammatory hyperalgesia of the guinea-pig.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Female; Freund's Adjuvant; Guinea Pigs; Humans; Hyperalgesia; Indoles; Isoindoles; Male; Naphthalenes; Neurokinin-1 Receptor Antagonists; Piperidines; Proline; Quinuclidines | 2000 |
Effects of YM905, a novel muscarinic M3-receptor antagonist, on experimental models of bowel dysfunction in vivo.
Topics: Animals; Bethanechol; Cholera Toxin; Colonic Diseases, Functional; Defecation; Diarrhea; Dinoprostone; Disease Models, Animal; Intestines; Isoquinolines; Male; Muscarinic Antagonists; Neostigmine; Nicotine; Quinuclidines; Rats; Receptor, Muscarinic M3; Receptors, Muscarinic; Serotonin; Solifenacin Succinate; Stress, Physiological; Tetrahydroisoquinolines | 2001 |
Experimental model of escape phenomenon in hamsters and the effectiveness of YM-53601 in the model.
Topics: Animals; Anticholesteremic Agents; Cholesterol; Cricetinae; Dietary Fats; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mesocricetus; Pravastatin; Quinuclidines | 2002 |
Selective alterations of regional beta-adrenergic receptor binding in the kindling model of epilepsy.
Topics: Alprenolol; Amygdala; Animals; Benzilates; Disease Models, Animal; Male; Quinuclidines; Rats; Receptors, Adrenergic; Receptors, Adrenergic, beta; Receptors, Cholinergic; Receptors, Muscarinic; Seizures | 1978 |
(+-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine, an M1 selective cholinergic agonist, attenuates cognitive dysfunctions in an animal model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Binding, Competitive; Cognition Disorders; Copper; Disease Models, Animal; Male; Memory; Mice; Motor Activity; Parasympathomimetics; Pilocarpine; Quinuclidines; Quinuclidinyl Benzilate; Receptors, Muscarinic; Thiophenes | 1991 |
(+-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3') quinuclidine (AF102B): a new M1 agonist attenuates cognitive dysfunctions in AF64A-treated rats.
Topics: Alzheimer Disease; Animals; Aziridines; Behavior, Animal; Choline; Cognition Disorders; Disease Models, Animal; Drug Design; Male; Molecular Structure; Parasympathomimetics; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Thiophenes | 1989 |