quinuclidines has been researched along with Acute Confusional Senile Dementia in 37 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (13.51) | 18.7374 |
| 1990's | 11 (29.73) | 18.2507 |
| 2000's | 10 (27.03) | 29.6817 |
| 2010's | 10 (27.03) | 24.3611 |
| 2020's | 1 (2.70) | 2.80 |
| Authors | Studies |
|---|---|
| Bali, ZK; Bruszt, N; Hernádi, I; Nagy, LV; Tadepalli, SA | 1 |
| Bakshi, R; Cahill, CM; Rogers, JT; Wong, A; Xia, N | 1 |
| Hashimoto, K | 1 |
| Matera, C; Tata, AM | 1 |
| Deardorff, WJ; Grossberg, GT; Shobassy, A | 1 |
| Lilja, AM; Malmsten, L; Marutle, A; Nordberg, A; Ögren, SO; Röjdner, J; Verkhratsky, A; Voytenko, L | 1 |
| Babri, S; Mahmoudi, J; Sadigh-Eteghad, S; Talebi, M | 1 |
| Hajós, GP; Hajós, M; Kelley, C; Koenig, G; Leventhal, L; Nagy, D; Stoiljkovic, M | 1 |
| Berry, S; Gault, LM; Lenz, RA; Meier, A; Othman, AA; Pritchett, Y; Ritchie, CW; Robieson, WZ; Tang, Q | 1 |
| Anderson, DJ; Bitner, RS; Browman, K; Buccafusco, J; Bunnelle, WH; Decker, MW; Drescher, KU; Gopalakrishnan, M; Kohlhaas, KL; Markosyan, S; Marsh, KC; Nikkel, AL; Radek, R | 1 |
| Lilja, AM; Marutle, A; Nordberg, A; Porras, O; Storelli, E | 1 |
| Eschweiler, G; Gonzalez-Agosti, C; Hager, K; Hampel, H; Heuser, I; Hock, C; Maddalena, A; Müller-Spahn, F; Müller-Thomsen, T; Nitsch, RM; Oertel, W; Raschig, A; Signorell, A; Wienrich, M | 1 |
| Bar-Ner, N; Brandeis, R; Egozi, I; Fisher, A; Haring, R; Kliger-Spatz, M; Marcovitch, I; Natan, N; Pittel, Z; Sonego, H | 1 |
| Brandão, ML; De Souza Silva, MA; Dere, E; Huston, JP; Kart-Teke, E | 1 |
| Laakso, K; Paljärvi, L; Rinne, JK; Rinne, JO; Rinne, UK | 1 |
| Brandeis, R; Fisher, A; Gurwitz, D; Haring, R; Heldman, E; Karton, Y; Marciano, D; Meshulam, H; Pittel, Z; Segall, Y | 1 |
| Barg, Y; Brandeis, R; Fisher, A; Ginzburg, I; Gurwitz, D; Haring, R; Heldman, E; Karton, Y; Klimowsky, S; Korczyn, AD; Marciano, D; Meshulam, H; Pinkas-Kramarski, R; Pittel, Z; Sadot, E; Treves, TA; Verchovsky, R; Vogel, Z | 1 |
| Bromidge, SM; Brown, F; Cassidy, F; Clark, MS; Dabbs, S; Hadley, MS; Hawkins, J; Loudon, JM; Naylor, CB; Orlek, BS; Riley, GJ | 1 |
| Cilia, J; Harries, MH; Hunter, AJ; Samson, NA | 1 |
| Boulay, SF; Cohen, VI; Danesh, RA; McPherson, DW; Rayeq, MR; Reba, RC; Sood, VK; Zeeberg, BR | 1 |
| Fisher, A; Fitten, LJ; Halgren, E; O'Neill, J; Ortiz, F; Siembieda, DW | 1 |
| Adamus, WS; Leonard, JP; Tröger, W | 1 |
| Bergström, KA; Farde, L; Halldin, C; Hiltunen, J; Karlsson, P; Knapp, FF; Larsson, S; McPherson, D; Nobuhara, K; Okubo, Y; Savonen, A; Schnell, PO; Swahn, CG | 1 |
| Bergström, KA; Farde, L; Hall, H; Halldin, C; Hiltunen, J; Karlsson, P; Larsson, SA; McPherson, DW; Nobuhara, K; Pauli, S; Savonen, A; Schnell, PO; Sedvall, G; Swahn, CG | 1 |
| Greischel, A; Leusch, A; Roth, W; Tröger, W | 1 |
| Deng, M; Growdon, JH; Nitsch, RM; Schoenfeld, D; Tennis, M | 1 |
| Deng, M; Growdon, JH; Heuser, I; Hock, C; Maddalena, A; Naber, D; Nitsch, RM; Oertel, W; Raschig, A; von der Kammer, H; Wienrich, M | 1 |
| Böhme, TM; Dannhardt, G; Keim, C; Lambrecht, G; Mutschler, E | 1 |
| Ensinger, HA; Gaida, W; Hammer, R; Meier, D; Raschig, A; Walland, A; Wienrich, M | 1 |
| Beach, TG; Fisher, A; Potter, PE; Sue, LI; Walker, DG | 1 |
| Bird, ED; Enna, SJ; Reisine, TD; Spokes, E; Yamamura, HI | 1 |
| Brandeis, R; Fisher, A; Gurwitz, D; Haring, R; Heldman, E; Karton, I; Levy, A; Pittel, Z; Sapir, M | 1 |
| Berman, KF; Braun, AR; Chase, TN; Coppola, R; Gibson, RE; Jones, DW; Mann, U; Reba, RC; Sunderland, T; Weinberger, DR | 1 |
| Brandeis, R; Dachir, S; Fisher, A; Grunfeld, Y; Heldman, E; Karton, I; Levy, A; Pittel, Z; Sapir, M | 1 |
| Brandeis, R; Dachir, S; Fisher, A; Heldman, E; Karton, I; Levy, A; Pittel, Z; Sapir, M | 1 |
| Albert, M; Eckelman, WC; Gibson, RE; Hill, TC; Holman, BL; Reba, RC | 1 |
| Adem, A; Nordberg, A; Slanina, P | 1 |
7 review(s) available for quinuclidines and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Targeting the Iron-Response Elements of the mRNAs for the Alzheimer's Amyloid Precursor Protein and Ferritin to Treat Acute Lead and Manganese Neurotoxicity.
Topics: 5' Untranslated Regions; Acute Disease; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Down Syndrome; Ferritins; Humans; Iron; Iron-Regulatory Proteins; Lead Poisoning, Nervous System; Manganese Poisoning; Mice; Muscarinic Agonists; Neurons; Protein Biosynthesis; Quinuclidines; Rats; Response Elements; RNA, Messenger; Thiophenes | 2019 |
Pharmacological approaches to targeting muscarinic acetylcholine receptors.
Topics: Alzheimer Disease; Animals; Humans; Muscarinic Agonists; Pyridines; Quinuclidines; Receptors, Muscarinic; Sjogren's Syndrome; Thiadiazoles; Thiophenes | 2014 |
Safety and clinical effects of EVP-6124 in subjects with Alzheimer's disease currently or previously receiving an acetylcholinesterase inhibitor medication.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Clinical Trials, Phase III as Topic; Humans; Nicotinic Agonists; Quinuclidines; Thiophenes | 2015 |
M1 muscarinic agonists can modulate some of the hallmarks in Alzheimer's disease: implications in future therapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cell Death; Disease Models, Animal; Down-Regulation; Humans; Memory Disorders; Mice; Muscarinic Agonists; Oxidative Stress; Piperidines; Quinuclidines; Receptor, Muscarinic M1; Spiro Compounds; tau Proteins; Thiazoles; Thiophenes | 2003 |
Progress in medicinal chemistry of novel selective muscarinic agonists.
Topics: Acetylcholine; Alzheimer Disease; Animals; Chemistry, Pharmaceutical; Humans; Parasympathomimetics; Protein Conformation; Quinuclidines; Receptors, Muscarinic; Thiophenes | 1993 |
M1 agonists for the treatment of Alzheimer's disease. Novel properties and clinical update.
Topics: Alzheimer Disease; Animals; Clinical Trials as Topic; GTP-Binding Proteins; Humans; Ligands; Muscarinic Agonists; Nerve Growth Factors; PC12 Cells; Phosphorylation; Pyridines; Quinuclidines; Rats; Receptors, Cholinergic; Signal Transduction; tau Proteins; Thiadiazoles; Thiophenes | 1996 |
AF102B: rational treatment strategy for Alzheimer's disease: recent advances.
Topics: Alzheimer Disease; Humans; Parasympathomimetics; Quinuclidines; Thiophenes | 1990 |
5 trial(s) available for quinuclidines and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
ABT-126 monotherapy in mild-to-moderate Alzheimer's dementia: randomized double-blind, placebo and active controlled adaptive trial and open-label extension.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Cholinergic Agonists; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Indans; Male; Mental Status Schedule; Middle Aged; Piperidines; Quinuclidines; Thiadiazoles; Treatment Outcome | 2016 |
Treatment with the selective muscarinic m1 agonist talsaclidine decreases cerebrospinal fluid levels of A beta 42 in patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Double-Blind Method; Female; Humans; Male; Middle Aged; Muscarinic Agonists; Peptide Fragments; Placebos; Quinuclidines; Receptor, Muscarinic M1 | 2003 |
M1 agonists for the treatment of Alzheimer's disease. Novel properties and clinical update.
Topics: Alzheimer Disease; Animals; Clinical Trials as Topic; GTP-Binding Proteins; Humans; Ligands; Muscarinic Agonists; Nerve Growth Factors; PC12 Cells; Phosphorylation; Pyridines; Quinuclidines; Rats; Receptors, Cholinergic; Signal Transduction; tau Proteins; Thiadiazoles; Thiophenes | 1996 |
Phase I clinical trials with WAL 2014, a new muscarinic agonist for the treatment of Alzheimer's disease.
Topics: Administration, Oral; Adult; Alzheimer Disease; Blood Pressure; Brain; Dose-Response Relationship, Drug; Electroencephalography; Heart Rate; Humans; Male; Muscarinic Agonists; Quinuclidines; Receptor, Muscarinic M1; Receptors, Muscarinic; Salivation; Single-Blind Method | 1995 |
Treatment with the selective muscarinic agonist talsaclidine decreases cerebrospinal fluid levels of total amyloid beta-peptide in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Double-Blind Method; Humans; Muscarinic Agonists; Placebos; Quinuclidines | 2000 |
26 other study(ies) available for quinuclidines and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Potentiation of cognitive enhancer effects of Alzheimer's disease medication memantine by alpha7 nicotinic acetylcholine receptor agonist PHA-543613 in the Morris water maze task.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Animals; Bridged Bicyclo Compounds, Heterocyclic; Memantine; Morris Water Maze Test; Nootropic Agents; Quinuclidines; Rats | 2021 |
Tropisetron and its targets in Alzheimer's disease.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Animals; Humans; Indoles; Inflammation; Nicotinic Agonists; Quinuclidines; Serotonin Antagonists; Thiophenes; Tropisetron | 2015 |
Neural Stem Cell Transplant-Induced Effect on Neurogenesis and Cognition in Alzheimer Tg2576 Mice Is Inhibited by Concomitant Treatment with Amyloid-Lowering or Cholinergic α7 Nicotinic Receptor Drugs.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Carbamates; Cell Proliferation; Cognition; Doublecortin Protein; Female; Hippocampus; Humans; Male; Maze Learning; Memory; Mice; Nerve Regeneration; Neural Stem Cells; Neurogenesis; Nicotinic Agonists; Physostigmine; Quinuclidines; Stem Cell Transplantation | 2015 |
Effect of alpha-7 nicotinic acetylcholine receptor activation on beta-amyloid induced recognition memory impairment. Possible role of neurovascular function.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Amyloid beta-Peptides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cholinesterase Inhibitors; Disease Models, Animal; Galantamine; Laser-Doppler Flowmetry; Male; Memory Disorders; Mice, Inbred BALB C; Neuropsychological Tests; Neurovascular Coupling; Peptide Fragments; Quinuclidines; Recognition, Psychology; Reproducibility of Results; Time Factors; Treatment Outcome | 2015 |
Hippocampal network dynamics in response to α7 nACh receptors activation in amyloid-β overproducing transgenic mice.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cognition; Female; Gamma Rhythm; Hippocampus; Male; Mice, Transgenic; Molecular Targeted Therapy; Nerve Net; Quinuclidines; Theta Rhythm; Thiophenes | 2016 |
In vivo pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107: preclinical considerations in Alzheimer's disease.
Topics: Acetylcholine; alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Avoidance Learning; Behavior, Animal; Cognition; Cyclic AMP Response Element-Binding Protein; Donepezil; Electroencephalography; Extracellular Signal-Regulated MAP Kinases; Glycogen Synthase Kinase 3; Indans; Indoles; Macaca mulatta; Male; Mice; Mice, Knockout; Nicotinic Agonists; Nootropic Agents; Phosphorylation; Piperidines; Psychomotor Performance; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Recognition, Psychology; Social Perception; tau Proteins | 2010 |
Functional interactions of fibrillar and oligomeric amyloid-β with alpha7 nicotinic receptors in Alzheimer's disease.
Topics: Aged; alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Benzazepines; Carbamates; Cell Line, Tumor; Cells, Cultured; Frontal Lobe; Humans; Neurons; Nicotinic Agonists; PC12 Cells; Quinoxalines; Quinuclidines; Rats; Receptors, Nicotinic; Varenicline | 2011 |
Reinstatement of episodic-like memory in rats by neurokinin-1 receptor antagonism.
Topics: Alzheimer Disease; Animals; Discrimination Learning; Dose-Response Relationship, Drug; Exploratory Behavior; Male; Memory; Motor Activity; Neurokinin-1 Receptor Antagonists; Piperidines; Psychomotor Performance; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Statistics, Nonparametric | 2007 |
Reduction in muscarinic receptor binding in limbic areas of Alzheimer brain.
Topics: Aged; Alzheimer Disease; Brain; Humans; Quinuclidines; Quinuclidinyl Benzilate; Receptors, Muscarinic | 1984 |
Design of [R-(Z)]-(+)-alpha-(methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitri le (SB 202026), a functionally selective azabicyclic muscarinic M1 agonist incorporating the N-methoxy imidoyl nitrile group as a novel ester bioisostere.
Topics: Alzheimer Disease; Animals; Binding Sites; Blood Pressure; Brain; CHO Cells; Cricetinae; Electroencephalography; Heart Rate; Humans; Imines; Magnetic Resonance Spectroscopy; Male; Models, Molecular; Molecular Structure; Muscarinic Agonists; Protein Binding; Quinuclidines; Rats; Rats, Inbred Strains; Receptor, Muscarinic M1; Receptors, Muscarinic; Recombinant Proteins; Stereoisomerism; Tremor | 1997 |
The profile of sabcomeline (SB-202026), a functionally selective M1 receptor partial agonist, in the marmoset.
Topics: Alzheimer Disease; Animals; Blood Pressure; Callithrix; Female; Imines; Learning; Male; Memory; Muscarinic Agonists; Parasympathomimetics; Pattern Recognition, Visual; Quinuclidines; Receptor, Muscarinic M1; Receptors, Muscarinic; Succinimides | 1998 |
In vivo competition studies of Z-(-,-)-[125I]IQNP against 3-quinuclidinyl 2-(5-bromothienyl)-2-thienylglycolate (BrQNT) demonstrating in vivo m2 muscarinic subtype selectivity for BrQNT.
Topics: Alzheimer Disease; Animals; Autoradiography; Binding, Competitive; Brain; Bromine Radioisotopes; Cryoultramicrotomy; Glycolates; Male; Quinuclidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptors, Muscarinic; Sensitivity and Specificity; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon | 1998 |
Reduction of motoric agitation and restlessness by AF102B and tacrine in the macaque.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Female; Macaca radiata; Male; Motor Activity; Muscarinic Agonists; Pilot Projects; Psychomotor Agitation; Quinuclidines; Tacrine; Thiophenes | 1999 |
Iodine-123 labelled Z-(R,R)-IQNP: a potential radioligand for visualization of M(1 )and M(2) muscarinic acetylcholine receptors in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Brain; Iodine Radioisotopes; Ligands; Macaca fascicularis; Male; Muscarinic Antagonists; Quinuclidines; Receptors, Muscarinic; Tomography, Emission-Computed, Single-Photon | 1999 |
Z-IQNP: a potential radioligand for SPECT imaging of muscarinic acetylcholine receptors in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Autoradiography; Binding, Competitive; Brain; Humans; Iodine Radioisotopes; Macaca fascicularis; Quinuclidines; Radioligand Assay; Receptors, Muscarinic; Stereoisomerism; Tomography, Emission-Computed, Single-Photon | 2000 |
Pharmacokinetics of the M1-agonist talsaclidine in mouse, rat, rabbit and monkey, and extrapolation to man.
Topics: Alzheimer Disease; Animals; Blood Proteins; Carbon Radioisotopes; Female; Haplorhini; Humans; Kinetics; Male; Metabolic Clearance Rate; Mice; Muscarinic Agonists; Protein Binding; Quinuclidines; Rabbits; Rats; Species Specificity | 2000 |
The selective muscarinic M1 agonist AF102B decreases levels of total Abeta in cerebrospinal fluid of patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Female; Humans; Male; Quinuclidines; Thiophenes | 2000 |
Design and pharmacology of quinuclidine derivatives as M2-selective muscarinic receptor ligands.
Topics: Alzheimer Disease; Humans; In Vitro Techniques; Ligands; Quinuclidines; Radiopharmaceuticals; Receptor, Muscarinic M2; Receptors, Muscarinic; Tomography, Emission-Computed | 2001 |
Pharmacodynamic profile of the M1 agonist talsaclidine in animals and man.
Topics: Adrenergic beta-Antagonists; Adult; Alzheimer Disease; Animals; Bronchial Spasm; Dose-Response Relationship, Drug; Electroencephalography; Female; Guinea Pigs; Heart; Humans; Imines; In Vitro Techniques; Male; Middle Aged; Muscarinic Agonists; Muscle, Smooth; Neurons; Propanolamines; Quinuclidines; Rabbits; Rats; Receptors, Muscarinic | 2001 |
Reduction of cerebrospinal fluid amyloid beta after systemic administration of M1 muscarinic agonists.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cerebrospinal Fluid; Female; Muscarinic Agonists; Neurons; Peptide Fragments; Piperidines; Quinuclidines; Rabbits; Receptor, Muscarinic M1; Receptors, Muscarinic; Thiazoles; Thiophenes | 2001 |
Pre- and postsynaptic neurochemical alterations in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Caudate Nucleus; Choline O-Acetyltransferase; Dementia; Frontal Lobe; gamma-Aminobutyric Acid; Hippocampus; Humans; Middle Aged; Putamen; Quinuclidines; Receptors, Neurotransmitter; Spiperone; Synapses | 1978 |
(+-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine, an M1 selective cholinergic agonist, attenuates cognitive dysfunctions in an animal model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Binding, Competitive; Cognition Disorders; Copper; Disease Models, Animal; Male; Memory; Mice; Motor Activity; Parasympathomimetics; Pilocarpine; Quinuclidines; Quinuclidinyl Benzilate; Receptors, Muscarinic; Thiophenes | 1991 |
Cerebral muscarinic receptors in primary degenerative dementia as evaluated by SPECT with iodine-123-labeled QNB.
Topics: Alzheimer Disease; Brain; Dementia; Humans; Quinuclidines; Quinuclidinyl Benzilate; Receptors, Muscarinic; Tomography, Emission-Computed | 1990 |
(+-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3') quinuclidine (AF102B): a new M1 agonist attenuates cognitive dysfunctions in AF64A-treated rats.
Topics: Alzheimer Disease; Animals; Aziridines; Behavior, Animal; Choline; Cognition Disorders; Disease Models, Animal; Drug Design; Male; Molecular Structure; Parasympathomimetics; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Thiophenes | 1989 |
Muscarinic acetylcholine receptors in Alzheimer's disease. In vivo imaging with iodine 123-labeled 3-quinuclidinyl-4-iodobenzilate and emission tomography.
Topics: Alzheimer Disease; Amphetamines; Brain; Cerebrovascular Circulation; Humans; Iodine Radioisotopes; Iofetamine; Male; Middle Aged; Quinuclidines; Quinuclidinyl Benzilate; Radioligand Assay; Receptors, Muscarinic; Tomography, Emission-Computed | 1985 |
A muscarinic receptor type in human lymphocytes: a comparison of 3H-QNB binding to intact lymphocytes and lysed lymphocyte membranes.
Topics: Adult; Alzheimer Disease; Cell Membrane; Humans; In Vitro Techniques; Lymphocyte Activation; Lymphocytes; Quinuclidines; Quinuclidinyl Benzilate; Receptors, Muscarinic; Receptors, Nicotinic; Tritium | 1986 |