quinoxalines has been researched along with Seizures in 112 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.79) | 18.7374 |
| 1990's | 62 (55.36) | 18.2507 |
| 2000's | 25 (22.32) | 29.6817 |
| 2010's | 22 (19.64) | 24.3611 |
| 2020's | 1 (0.89) | 2.80 |
| Authors | Studies |
|---|---|
| Folbergrová, J; Haugvicová, R; Kubová, H; Mareš, P | 1 |
| Abulkhair, HS; Ahmed, HEA; Akl, EN; Bayoumi, AH; El-Adl, K; El-Morsy, A; El-Zoghbi, MS; Elmeligie, S; Ghiaty, A; Hassan, MH; Zayed, MF | 1 |
| Hensch, TK; Jensen, FE; Lippman-Bell, JJ; Sun, H; Takesian, AE; Wang, TT | 1 |
| Gray, WP; Pringle, A; Sadek, AR; Seifert, G; Shtaya, A; Steinhäuser, C; Zaben, M | 1 |
| Jensen, FE; Klein, P; Kothari, N; Pollard, J; Rakhade, SN; Sudhalter, J; Theilhaber, J | 1 |
| Jackson, MC; Jensen, FE; Joseph, A; Klein, PM; Lippman-Bell, JJ; Obeid, M; Rakhade, SN | 1 |
| Erken, G; Erken, HA; Genç, O; Koç, ER; Korkut, O; Simşek, H; Yavuz, O | 1 |
| Gmiro, VE; Serdyuk, SE; Veselkina, OS | 1 |
| Arbab-Zadeh, A; Garg, J; Krishnamoorthy, P; Lavie, CJ; Lichstein, E; Sharma, A; Sochor, O; Thakar, S | 1 |
| Breschi, GL; de Curtis, M; Gnatkovsky, V; Taverna, S; Uva, L | 1 |
| Amaral-Martins, F; Campos, AC; de Oliveira, AC; Fiebich, BL; Lima, IV; Miranda, AS; Moraes, MF; Santos, RP; Sousa, LP; Teixeira, AL; Teixeira, MM; Vago, JP; Vieira, ÉL; Vieira, LB | 1 |
| Bankstahl, M; Klein, S; Löscher, W; Römermann, K; Twele, F | 1 |
| Avoli, M; Hamidi, S; Herrington, R; Lévesque, M | 1 |
| Doty, DJ; Fujinami, RS; Hanak, TJ; Libbey, JE; Wilcox, KS | 1 |
| Chung, HJ; Jewett, KA; Lee, KY; Man, HY; Tsai, NP; Zhu, J | 1 |
| Soares, C | 1 |
| Bonde, S; Ekdahl, CT; Iosif, RE; Jakubs, K; Kokaia, M; Kokaia, Z; Lindvall, O | 1 |
| Itoh, K; Watanabe, M | 1 |
| Adeola, M; Loo, M; Patil, T; Poles, A; Raffa, RB; Rawls, SM; Raymondi, N; Thomas, T | 1 |
| Bortolatto, CF; Jesse, CR; Nogueira, CW; Savegnago, L; Wilhelm, EA | 1 |
| Aas, P; Enger, S; Myhrer, T | 1 |
| Avoli, M; Carriero, G; de Curtis, M; Gnatkovsky, V; Uva, L | 1 |
| Schauwecker, PE | 1 |
| Catarzi, D; Colotta, V; Filacchioni, G; Lenzi, O; Lingenhöhl, K; Ofner, S; Poli, D; Varano, F | 1 |
| Alfaro, JM; Burgos, JS; Ripoll-Gómez, J | 1 |
| Gutiérrez, R; Treviño, M; Vivar, C | 1 |
| Aas, P; Enger, S; Jonassen, M; Myhrer, T | 1 |
| Ayyad, RR; Elhelby, AA; Zayed, MF | 1 |
| Behl, B; Henn, C; Hofmann, HP; Lubisch, W; Reeb, J; Regner, F; Vierling, M | 1 |
| Kamata, A; Kaneko, S; Murakami, T; Okada, M; Wada, K; Zhu, G | 1 |
| Rubaj, A; Sieklucka-Dziuba, M; Zgodziński, W | 1 |
| Alessandrl, MG; Ferrucci, M; Fornai, F; Giorgi, FS; Lazzeri, G; Lenzi, P; Murri, L; Pizzanelli, C | 1 |
| Carpes, MJ; Correia, CR; Mello, CF; Roehrs, C; Rubin, MA; Sauzem, PD; Sinhorin, VD; Zimmer, MF | 1 |
| Chimirri, A; De Sarro, A; De Sarro, G; Ferreri, G; Gareri, P; Gitto, R; Russo, E | 1 |
| Jensen, FE; Koh, S; Simpson, JN; Tibayan, FD | 1 |
| Huang, YG; Jiang, W; Wolfe, K; Xiao, L; Zhang, X; Zhang, ZJ | 1 |
| Chan, MH; Chen, HH; Ko, CH; Lin, YR | 1 |
| Barkoczy, J; Gigler, G; Gressens, P; Harsing, LG; Kapus, G; Kertesz, S; Levay, G; Medja, F; Spedding, M; Szenasi, G; Villa, P; Williamson, T | 1 |
| Banerjee, SB; Dias, BG; Ladiwala, U; Rajendran, R; Tole, S; Vaidya, VA | 1 |
| Avila, TT; Fischer, A; Jorge, RS; Leke, R; Oliveira, DL; Portela, LV; Schmidt, AP; Souza, DO; Wofchuk, S | 1 |
| Akil, O; Clause, A; Edwards, RH; Glowatzki, E; Grant, L; Kandler, K; Lustig, LR; Noebels, JL; Seal, RP; Weber, CM; Yi, E; Yoo, J | 1 |
| Gerardy-Schahn, R; Pekcec, A; Potschka, H; Weinhold, B | 1 |
| Klitgaard, H; Laudrup, P | 1 |
| Aguglia, U; Bertorelli, R; De Sarro, A; De Sarro, G; Ongini, E | 1 |
| Lees, GJ; Leong, W | 1 |
| Abe, S; Akazawa, K; Nakamura, M | 1 |
| Honoré, T; Jacobsen, P; Swedberg, MD | 1 |
| Kubová, H; Mares, P; Vachová, D; Velísek, L | 1 |
| Donevan, SD; Rogawski, MA; Yamaguchi, S | 1 |
| Czuczwar, SJ; Kleinrok, Z; Turski, WA; Zarnowski, T | 1 |
| De Sarro, A; De Sarro, G; Nava, F; Renne, S | 1 |
| Ammendola, D; De Sarro, A; De Sarro, G; Nava, F | 1 |
| Folbergrová, J | 2 |
| Baubichon, D; Blanchet, G; Burckhart, MF; Carpentier, P; Lallement, G; Pernot-Marino, I | 1 |
| Hönack, D; Löscher, W | 1 |
| Brady, RJ; Smith, KL; Swann, JW | 1 |
| Starr, BS; Starr, MS | 1 |
| Gwag, BJ; Sessler, FM; Springer, JE | 1 |
| Baubichon, D; Blanchet, G; Carpentier, P; Foquin-Tarricone, A; Lallement, G; Pernot-Marino, I; Piras, A | 1 |
| Berg, M; Bruhn, T; Diemer, NH; Johansen, FF | 1 |
| Furuya, T; Hidaka, K; Kawasaki, S; Kubota, H; Murase, K; Ohmori, J; Okada, M; Sakamoto, S; Shimizu-Sasamata, M; Togami, J | 1 |
| Bagetta, G; Dolly, JO; Nair, S; Nistico, G | 1 |
| Keana, JF; Lutfy, K; Weber, E; Woodward, RM | 1 |
| Craggs, M; Dürmüller, N; Meldrum, BS | 1 |
| Steppuhn, KG; Turski, L | 1 |
| Baubichon, D; Blanchet, G; Carpentier, P; Delamanche, IS; Denoyer, M; Lallement, G; Pernot-Marino, I | 1 |
| al-Zubaidy, Z; Chapman, AG; Meldrum, BS | 1 |
| Borowicz, KK; Czuczwar, SJ; Kleinrok, Z; Turski, WA; Tutka, P; Zarnowski, T | 1 |
| Guastella, J; Huettner, JE; Keana, JF; Tran, M; Weber, E; Woodward, RM | 1 |
| Hatanaka, K; Kawasaki-Yatsugi, S; Koshiya, K; Murase, K; Ohmori, J; Okada, M; Sakamoto, S; Shimizu-Sasamata, M; Togami, J; Usuda, S; Yatsugi, S | 1 |
| Ishida, N; Kanai, H; Kato, N; Takazawa, A; Yamauchi, T; Yamazaki, O | 1 |
| Belonga, KL; Carter, DB; Im, WB; Jacobsen, EJ; Petke, JD; Sethy, VH; Stelzer, LS; Tang, AH; VonVoigtlander, PF | 1 |
| Holmes, GL; Liu, Z; Mikati, M; Sarkisian, M; Stafstrom, CE; Tandon, P; Werner, SJ; Yang, Y | 1 |
| Carter, DB; Im, HK; Im, WB; Jacobsen, EJ; McGee, JE; Mickelson, JW; Petke, JD; Schreur, PJ; Sethy, VH; Tang, AH | 1 |
| Gale, K; Halonen, T; Sahibzada, N; Tortorella, A | 1 |
| Shiraishi, K | 2 |
| Kawaguchi, K; Simon, RP | 1 |
| Abdel-Rahman, MS; Barat, SA | 1 |
| Dorandeu, F; Fosbraey, P; Lallement, G; Pernot-Marino, I; Tattersall, JE; Wetherell, J | 1 |
| Ikonomidou, C; Turski, L | 1 |
| Ashby, CR; Katsumori, H; Minabe, Y; Osawa, M | 1 |
| Brackett, RL; Kanthasamy, AG; Matsumoto, RR | 1 |
| Blaszczak, P; Turski, WA | 1 |
| Braisted, JC; Chavko, M; Harabin, AL; Outsa, NJ | 1 |
| Begnini, J; de Bastiani, J; de Mello, CF; Fialho, DB; Jurach, A; Lima, TT; Ribeiro, MC; Wajner, M | 1 |
| Cassidy, RM; Gale, K | 1 |
| Higashiyama, A; Ishida, N; Kato, N; Yasuda, S | 1 |
| Auberson, YP; Bischoff, S; Moretti, R; Schmutz, M; Veenstra, SJ | 1 |
| Greene, JR; McMath, H; Mellanby, J; Mudher, AK; Perry, VH | 1 |
| Belonga, KL; Carter, DB; Im, HK; Im, WB; Jacobsen, EJ; Mickelson, JW; Petke, JD; Sethy, VH; Stelzer, LS; Tang, AH; TenBrink, RE; VonVoigtlander, PF; Zhong, WZ | 1 |
| Drejer, J; Gouliaev, AH; Jensen, LH; Mathiesen, C; Moller, A; Nielsen, EO; Varming, T; Wätjen, F | 1 |
| Becker, KJ; Brambrink, AM; Hanley, DF; Koehler, RC; Martin, LJ; Traystman, RJ | 1 |
| Matsumoto, RR; Nour, M; Pouw, B | 1 |
| Folbergrová, J; Haugvicová, R; Mares, P | 1 |
| Bohme, GA; Boireau, A; Cheve, M; Damour, D; Debono, MW; Genevois-Borella, A; Imperato, A; Jimonet, P; Mignani, S; Pratt, J; Randle, JC; Ribeill, Y; Stutzmann, JM; Vuilhorgne, M | 1 |
| Aguilar-Veiga, E; Galán-Valiente, J; Sierra-Marcuño, G; Sierra-Paredes, G; Vazquez-Illanes, MD | 1 |
| Higashiyama, A; Ishida, N; Kato, N; Morinobu, S; Yasuda, S | 1 |
| Schweitzer, JS; Stringer, JL; Wang, H; Xiong, ZQ | 1 |
| Burton, FH; Campbell, KM; McGrath, MJ; Parks, CR | 1 |
| Johnston, MV; McDonald, JW; Trescher, WH | 1 |
| Ammendola, D; De Sarro, A; De Sarro, G; Trimarchi, GR | 1 |
| Calder, LD; Karler, R | 1 |
| Taylor, CP; Vartanian, MG | 1 |
| Andrew, M; Farley, JM; Ho, IK; Oden, G; Rockhold, RW | 1 |
| Chapman, AG; Meldrum, BS; Smith, SE | 1 |
| Calder, LD; Karler, R; Turkanis, SA | 1 |
| Freed, WJ; Jurson, PA | 1 |
| Furshpan, EJ; Koroshetz, WJ | 1 |
| Drejer, J; Honoré, T; Jensen, LH; Sheardown, MJ; Stidsen, CE | 1 |
| Frenk, H; Liban, A; Teichberg, VI; Urca, G | 1 |
1 review(s) available for quinoxalines and Seizures
| Article | Year |
|---|---|
Cardiovascular adverse events associated with smoking-cessation pharmacotherapies.
Topics: Benzazepines; Bupropion; Chest Pain; Dose-Response Relationship, Drug; Humans; Hypertension; Nicotinic Agonists; Practice Guidelines as Topic; Quinoxalines; Randomized Controlled Trials as Topic; Seizures; Smoking Cessation; Smoking Prevention; Tachycardia; Varenicline | 2015 |
111 other study(ies) available for quinoxalines and Seizures
| Article | Year |
|---|---|
Do stereoisomers of homocysteic acid exhibit different convulsant action in immature rats?
Topics: 2-Amino-5-phosphonovalerate; Animals; Benzodiazepines; Dizocilpine Maleate; Homocysteine; Male; Quinoxalines; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Stereoisomerism | 2019 |
In vivo- and in silico-driven identification of novel synthetic quinoxalines as anticonvulsants and AMPA inhibitors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Mice; Molecular Docking Simulation; Molecular Structure; Pentylenetetrazole; Quinoxalines; Seizures; Structure-Activity Relationship | 2021 |
Early Seizures Prematurely Unsilence Auditory Synapses to Disrupt Thalamocortical Critical Period Plasticity.
Topics: Animals; Auditory Perception; Cerebral Cortex; Female; Male; Mice, Inbred C57BL; Neuronal Plasticity; Quinoxalines; Receptors, AMPA; Seizures; Synapses; Thalamus | 2018 |
AMPA receptors and seizures mediate hippocampal radial glia-like stem cell proliferation.
Topics: Animals; Animals, Newborn; Benzodiazepines; Cell Death; Cell Proliferation; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Kainic Acid; Ki-67 Antigen; Male; Membrane Potentials; Nerve Tissue Proteins; Neuroglia; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Seizures; Stem Cells | 2018 |
Gene expression profiling of a hypoxic seizure model of epilepsy suggests a role for mTOR and Wnt signaling in epileptogenesis.
Topics: Animals; Biomarkers; Cell Proliferation; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation, Developmental; Hypoxia; Neurogenesis; Neurons; Oligodendroglia; Organ Specificity; Quinoxalines; Rats; Seizures; Time Factors; TOR Serine-Threonine Kinases; Wnt Signaling Pathway | 2013 |
AMPA receptor antagonist NBQX attenuates later-life epileptic seizures and autistic-like social deficits following neonatal seizures.
Topics: Aging; Animals; Animals, Newborn; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Hippocampus; Male; Neurons; Quinoxalines; Rats; Rats, Long-Evans; Receptors, AMPA; Seizures | 2013 |
Single dose varenicline may trigger epileptic activity.
Topics: Animals; Benzazepines; Brain; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Male; Nicotinic Agonists; Quinoxalines; Rats; Rats, Wistar; Seizures; Varenicline | 2014 |
Combined blockade of NMDA and AMPA receptors prevents acute kainate seizures and chronic kainate lethality in rats.
Topics: Adamantane; Amines; Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Injections, Intramuscular; Kainic Acid; Male; Memantine; N-Methylaspartate; Neuroprotective Agents; Pentylenetetrazole; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Survival Analysis | 2014 |
Synchronous inhibitory potentials precede seizure-like events in acute models of focal limbic seizures.
Topics: 4-Aminopyridine; Action Potentials; Animals; Bicuculline; Computer Simulation; Convulsants; Disease Models, Animal; Electric Stimulation; Entorhinal Cortex; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Guinea Pigs; In Vitro Techniques; Models, Biological; Neural Inhibition; Potassium Channel Blockers; Quinoxalines; Seizures | 2015 |
PI3Kγ deficiency enhances seizures severity and associated outcomes in a mouse model of convulsions induced by intrahippocampal injection of pilocarpine.
Topics: Animals; Calcium; Calcium-Binding Proteins; Class Ib Phosphatidylinositol 3-Kinase; Cytokines; Disease Models, Animal; Doublecortin Domain Proteins; Enzyme Inhibitors; Glutamic Acid; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Microtubule-Associated Proteins; Muscarinic Agonists; Neuropeptides; Pilocarpine; Prefrontal Cortex; Quinoxalines; Reaction Time; Seizures; Synaptosomes; Thiazolidinediones; Time Factors | 2015 |
The AMPA receptor antagonist NBQX exerts anti-seizure but not antiepileptogenic effects in the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Chronic Disease; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Female; Hippocampus; Kainic Acid; Mice; Nitriles; Phenytoin; Pyridones; Quinoxalines; Receptors, AMPA; Seizures; Status Epilepticus | 2015 |
Interneurons spark seizure-like activity in the entorhinal cortex.
Topics: 4-Aminopyridine; Action Potentials; Animals; Disease Models, Animal; Entorhinal Cortex; Excitatory Amino Acid Antagonists; Glutamic Acid; Interneurons; Male; Piperazines; Quinoxalines; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures; Tissue Culture Techniques | 2016 |
NBQX, a highly selective competitive antagonist of AMPA and KA ionotropic glutamate receptors, increases seizures and mortality following picornavirus infection.
Topics: Analysis of Variance; Animals; Excitatory Amino Acid Antagonists; Hippocampus; Male; Mice; Mice, Inbred C57BL; Picornaviridae Infections; Plant Lectins; Quinoxalines; Seizures | 2016 |
Epilepsy-associated gene Nedd4-2 mediates neuronal activity and seizure susceptibility through AMPA receptors.
Topics: 14-3-3 Proteins; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Animals; Animals, Newborn; Blotting, Western; Cells, Cultured; Endosomal Sorting Complexes Required for Transport; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Genetic Predisposition to Disease; HEK293 Cells; Humans; Lysine; Male; Mice, Knockout; Microscopy, Confocal; Mutation, Missense; Nedd4 Ubiquitin Protein Ligases; Neurons; Quinoxalines; Receptors, AMPA; Seizures; Ubiquitin-Protein Ligases | 2017 |
First in class.
Topics: Benzazepines; Humans; Psychoses, Substance-Induced; Quinoxalines; Receptors, Nicotinic; Seizures; Smoking Cessation; United States; United States Food and Drug Administration; Varenicline | 2008 |
Inflammation regulates functional integration of neurons born in adult brain.
Topics: Analysis of Variance; Animals; Calcium-Binding Proteins; Dendritic Spines; Dose-Response Relationship, Radiation; Ectodysplasins; Electric Stimulation; Electroencephalography; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Green Fluorescent Proteins; Hippocampus; In Vitro Techniques; Inflammation; Inhibitory Postsynaptic Potentials; Lipopolysaccharides; Lysine; Male; Microfilament Proteins; Microscopy, Confocal; Neurogenesis; Neurons; Patch-Clamp Techniques; Quinoxalines; Rats; Rats, Sprague-Dawley; Seizures; Tetrodotoxin; Time Factors | 2008 |
Paradoxical facilitation of pentylenetetrazole-induced convulsion susceptibility in mice lacking neuronal nitric oxide synthase.
Topics: Animals; Convulsants; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Gene Expression Regulation; Imidazoles; Indazoles; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type I; Pentylenetetrazole; Quinoxalines; Seizures | 2009 |
Topiramate antagonizes NMDA- and AMPA-induced seizure-like activity in planarians.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fructose; N-Methylaspartate; Neuroprotective Agents; Planarians; Quinoxalines; Seizures; Topiramate | 2009 |
Anticonvulsant and antioxidant effects of 3-alkynyl selenophene in 21-day-old rats on pilocarpine model of seizures.
Topics: Animals; Anticonvulsants; Antioxidants; Brain; Diazepam; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Organoselenium Compounds; Pentylenetetrazole; Pilocarpine; Quinoxalines; Rats; Rats, Wistar; Seizures; Time Factors; Treatment Outcome | 2009 |
Roles of perirhinal and posterior piriform cortices in control and generation of seizures: a microinfusion study in rats exposed to soman.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Electroencephalography; GABA Agonists; Male; Muscarinic Antagonists; Muscimol; Procyclidine; Quinoxalines; Rats; Rats, Wistar; Scopolamine; Seizures; Soman; Statistics, Nonparametric | 2010 |
Independent epileptiform discharge patterns in the olfactory and limbic areas of the in vitro isolated Guinea pig brain during 4-aminopyridine treatment.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Brain; Cerebral Cortex; Entorhinal Cortex; Epilepsy; Excitatory Amino Acid Antagonists; Guinea Pigs; Hippocampus; In Vitro Techniques; Limbic System; Periodicity; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Time Factors | 2010 |
Neuroprotection by glutamate receptor antagonists against seizure-induced excitotoxic cell death in the aging brain.
Topics: Age Factors; Analysis of Variance; Animals; Brain; Cell Count; Cell Death; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fluorescent Antibody Technique; Kainic Acid; Mice; Neurons; Neuroprotective Agents; Quinoxalines; Seizures; Severity of Illness Index; Species Specificity | 2010 |
Pharmacological characterization of some selected 4,5-dihydro-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates and 3-hydroxyquinazoline-2,4-diones as (S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)-propionic acid receptor antagonists.
Topics: Animals; Anticonvulsants; Mice; Oocytes; Quinazolines; Quinoxalines; Rats; Receptors, AMPA; Seizures | 2010 |
Kainate administered to adult zebrafish causes seizures similar to those in rodent models.
Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Quinoxalines; Rats; Receptors, Glutamate; Seizures; Zebrafish | 2011 |
Excitation-inhibition balance in the CA3 network--neuronal specificity and activity-dependent plasticity.
Topics: Animals; CA3 Region, Hippocampal; Convulsants; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Antagonists; Kindling, Neurologic; Male; Nerve Net; Neuronal Plasticity; Neurons; Pentylenetetrazole; Quinoxalines; Rats; Rats, Wistar; Seizures; Synaptic Transmission; Valine | 2011 |
Enhanced efficacy of anticonvulsants when combined with levetiracetam in soman-exposed rats.
Topics: Animals; Anticonvulsants; Antidotes; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cyclopentanes; Disease Models, Animal; Drug Therapy, Combination; Lethal Dose 50; Levetiracetam; Male; Motor Activity; Muscimol; Nicotinic Antagonists; Piracetam; Procyclidine; Quinoxalines; Rats; Rats, Wistar; Reaction Time; Seizures; Soman; Time Factors | 2011 |
Synthesis and biological evaluation of some novel quinoxaline derivatives as anticonvulsant agents.
Topics: Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Indicators and Reagents; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice; Pentylenetetrazole; Phenobarbital; Quinoxalines; Seizures; Structure-Activity Relationship | 2011 |
Pyrrolylquinoxalinediones carrying a piperazine residue represent highly potent and selective ligands to the homomeric kainate receptor GluR5.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Ligands; Mice; Molecular Structure; N-Methylaspartate; Piperazines; Quinoxalines; Receptors, Kainic Acid; Seizures; Structure-Activity Relationship; Substrate Specificity | 2002 |
Impaired M-current and neuronal excitability.
Topics: Age Factors; Animals; Bicuculline; Central Nervous System; Data Interpretation, Statistical; Electroencephalography; Epilepsy, Benign Neonatal; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Hippocampus; Humans; Indoles; Infant, Newborn; Male; Mice; Mice, Knockout; Microdialysis; Mutation; Neurons; Potassium Channel Blockers; Potassium Channels; Pyridines; Quinoxalines; Rats; Rats, Wistar; Seizures; Synaptic Transmission | 2002 |
The epileptogenic effect of seizures induced by hypoxia: the role of NMDA and AMPA/KA antagonists.
Topics: Animals; Avoidance Learning; Bicuculline; Brain Chemistry; Dizocilpine Maleate; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; gamma-Aminobutyric Acid; Hypoxia; Mice; N-Methylaspartate; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures | 2003 |
A damage to locus coeruleus neurons converts sporadic seizures into self-sustaining limbic status epilepticus.
Topics: Animals; Benzylamines; Bicuculline; Biogenic Monoamines; Cerebellum; Dopamine beta-Hydroxylase; Drug Interactions; Electroencephalography; Excitatory Amino Acid Antagonists; Extracellular Space; Frontal Lobe; GABA Antagonists; Hippocampus; Immunohistochemistry; Kindling, Neurologic; Locus Coeruleus; Male; Neurons; Neurotoxins; Norepinephrine; Olfactory Pathways; Quinoxalines; Rats; Rats, Sprague-Dawley; Seizures; Staining and Labeling; Status Epilepticus; Time Factors | 2003 |
D,L-cis-2,3-Pyrrolidine dicarboxylate alters [3H]-L-glutamate binding and induces convulsions in mice.
Topics: Animals; Behavior, Animal; Brain Chemistry; Convulsants; Dicarboxylic Acids; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Membranes; Mice; Neuroprotective Agents; Pyrrolidines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Seizures; Stereoisomerism; Structure-Activity Relationship | 2003 |
Comparative anticonvulsant activity of N-acetyl-1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives in rodents.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred DBA; Mice, Inbred ICR; Quinoxalines; Receptors, AMPA; Seizures | 2004 |
NBQX or topiramate treatment after perinatal hypoxia-induced seizures prevents later increases in seizure-induced neuronal injury.
Topics: Animals; Anticonvulsants; Brain; Cell Death; Disease Models, Animal; DNA Fragmentation; Fructose; Hippocampus; Hypoxia, Brain; In Situ Nick-End Labeling; Kainic Acid; Male; Neurons; Neuroprotective Agents; Quinoxalines; Rats; Rats, Long-Evans; Receptors, AMPA; Seizures; Topiramate | 2004 |
Ionotropic glutamate receptor antagonists inhibit the proliferation of granule cell precursors in the adult brain after seizures induced by pentylenetrazol.
Topics: Animals; Cell Count; Cell Proliferation; Dentate Gyrus; Dizocilpine Maleate; Down-Regulation; Excitatory Amino Acid Antagonists; Male; Neurons; Pentylenetetrazole; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Seizures; Stem Cells | 2004 |
Differential inhibitory effects of honokiol and magnolol on excitatory amino acid-evoked cation signals and NMDA-induced seizures.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Biphenyl Compounds; Calcium; Cells, Cultured; Cerebellum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Ion Channels; Lignans; Mice; N-Methylaspartate; Neurons; Platelet Aggregation Inhibitors; Potassium Chloride; Quinoxalines; Rats; Rats, Sprague-Dawley; Seizures; Sodium | 2005 |
The effects of AMPA receptor antagonists in models of stroke and neurodegeneration.
Topics: Animals; Animals, Newborn; Anticonvulsants; Benzodiazepines; Brain; Brain Ischemia; Cell Survival; Chickens; Cortical Spreading Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Excitatory Amino Acid Antagonists; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred Strains; Motor Neurons; Nerve Degeneration; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Retina; Seizures; Stroke | 2005 |
Recruitment of the Sonic hedgehog signalling cascade in electroconvulsive seizure-mediated regulation of adult rat hippocampal neurogenesis.
Topics: Animals; Autoradiography; Bromodeoxyuridine; Cell Count; Dizocilpine Maleate; Electroshock; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Hedgehog Proteins; Hippocampus; Immunohistochemistry; In Situ Hybridization; Male; Neurons; Organogenesis; Patched Receptors; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Seizures; Signal Transduction; Smoothened Receptor; Stem Cells; Time Factors; Trans-Activators; Veratrum Alkaloids | 2005 |
Methotrexate induces seizure and decreases glutamate uptake in brain slices: prevention by ionotropic glutamate receptors antagonists and adenosine.
Topics: Adenosine; Animals; Brain; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Methotrexate; Mice; Neuroprotective Agents; Quinoxalines; Seizures | 2006 |
Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3.
Topics: Acoustic Stimulation; Amino Acid Transport Systems, Acidic; Animals; Animals, Newborn; Calcium; Disease Models, Animal; Electric Stimulation; Electroencephalography; Excitatory Amino Acid Antagonists; Glutamic Acid; Hair Cells, Auditory; Hearing Loss, Sensorineural; Membrane Potentials; Membrane Proteins; Mice; Mice, Knockout; Microscopy, Electron, Transmission; Neurons; Quinoxalines; Reflex, Startle; Seizures; Spiral Ganglion | 2008 |
Deficiency of neural cell adhesion molecule or its polysialylation modulates pharmacological effects of the AMPA receptor antagonist NBQX.
Topics: Analysis of Variance; Animals; Ataxia; Behavior, Animal; Disease Models, Animal; Excitatory Amino Acid Antagonists; Female; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Cell Adhesion Molecules; Pentylenetetrazole; Quinoxalines; Seizures; Sialyltransferases | 2008 |
Metabotropic and ionotropic excitatory amino acid receptor agonists induce different behavioral effects in mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cycloleucine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ibotenic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Receptors, Glutamate; Seizures | 1993 |
Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Felbamate; Female; Glycine; Injections, Intraperitoneal; Injections, Intraventricular; Kynurenic Acid; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Phenylcarbamates; Propylene Glycols; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Serine; Stereoisomerism; Synaptic Transmission | 1994 |
NBQX prevents contralateral but not ipsilateral seizure-induced cytotoxicity of kainate but not AMPA-reversal at high doses of NBQX.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Death; Dose-Response Relationship, Drug; Hippocampus; Kainic Acid; Neurons; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Seizures | 1994 |
AMPA-, but not NMDA-, receptor blocker, NBQX, prevents seizure induction in magnesium-deficient rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Magnesium Deficiency; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures | 1995 |
Anticonvulsant, anxiolytic and discriminative effects of the AMPA antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline (NBQX).
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Diazepam; Excitatory Amino Acid Antagonists; Female; Male; Mice; Mice, Inbred DBA; Morphine; Phencyclidine; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Seizures | 1995 |
Kainate/AMPA receptor antagonists are anticonvulsant against the tonic hindlimb component of pentylenetetrazol-induced seizures in developing rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Anticonvulsants; Behavior, Animal; Epilepsy, Tonic-Clonic; Hindlimb; Male; Muscle Tonus; Pentylenetetrazole; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Seizures; Synaptic Transmission | 1995 |
Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBOX in maximal electroshock and chemoconvulsant seizure models.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Hindlimb; Kainic Acid; Male; Mice; Pentylenetetrazole; Quinoxalines; Receptors, AMPA; Receptors, Kainic Acid; Seizures | 1993 |
2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(F)quinoxaline enhances the protective activity of common antiepileptic drugs against maximal electroshock-induced seizures in mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Ataxia; Avoidance Learning; Behavior, Animal; Drug Synergism; Electroshock; Male; Memory; Mice; Motor Activity; Psychomotor Performance; Quinoxalines; Seizures | 1993 |
Fenbufen pretreatment potentiates the anticonvulsant activity of CPPene and NBQX in DBA/2 mice.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Drug Synergism; Injections, Intraperitoneal; Injections, Intraventricular; Mice; Motor Activity; Phenylbutyrates; Piperazines; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures | 1994 |
Effects of some excitatory amino acid antagonists on imipenem-induced seizures in DBA/2 mice.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Anticonvulsants; Dizocilpine Maleate; Excitatory Amino Acids; Glutamine; Imipenem; Kynurenic Acid; Mice; Mice, Inbred DBA; Muscimol; Piperazines; Piperidines; Quinoxalines; Seizures | 1995 |
NMDA and not non-NMDA receptor antagonists are protective against seizures induced by homocysteine in neonatal rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Animals, Newborn; Anticonvulsants; Dizocilpine Maleate; Glutamates; Homocysteine; Male; Neuroprotective Agents; Quinoxalines; Rats; Rats, Wistar; Receptors, Amino Acid; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures | 1994 |
Modulation of soman-induced neuropathology with an anticonvulsant regimen.
Topics: Animals; Anticonvulsants; Atropine; Hippocampus; Male; Olfactory Pathways; Phencyclidine; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Seizures; Soman | 1994 |
Effects of the non-NMDA antagonists NBQX and the 2,3-benzodiazepine GYKI 52466 on different seizure types in mice: comparison with diazepam and interactions with flumazenil.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Excitatory Amino Acid Antagonists; Flumazenil; Male; Mice; Muscle Relaxants, Central; Pentylenetetrazole; Quinoxalines; Receptors, AMPA; Reflex; Seizures; Synaptic Transmission | 1994 |
Localized excitatory synaptic interactions mediate the sustained depolarization of electrographic seizures in developing hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Dendrites; Evoked Potentials; GABA Antagonists; Hippocampus; In Vitro Techniques; Kynurenic Acid; Membrane Potentials; Pyramidal Tracts; Quinoxalines; Rats; Seizures; Synapses; Tetrodotoxin | 1993 |
Glutamate-dopamine interactions in the production of pilocarpine motor seizures in the mouse.
Topics: 2-Amino-5-phosphonovalerate; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Dizocilpine Maleate; Dopamine Agents; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Mice; Mice, Inbred Strains; Pilocarpine; Piperazines; Pyrrolidinones; Quinoxalines; Receptors, AMPA; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Seizures | 1993 |
Neurotrophic factor mRNA expression in dentate gyrus is increased following in vivo stimulation of the angular bundle.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain-Derived Neurotrophic Factor; Electric Stimulation; Female; Gene Expression Regulation; Hippocampus; Long-Term Potentiation; Nerve Growth Factors; Nerve Tissue Proteins; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Seizures; Tetany | 1994 |
Coadministration of atropine, NBQX and TCP against soman-induced seizures.
Topics: Animals; Atropine; Drug Synergism; Electroencephalography; Male; Phencyclidine; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Seizures; Soman | 1994 |
Kainic acid-induced seizures and brain damage in the rat: different effects of NMDA- and AMPA receptor antagonists.
Topics: Animals; Behavior, Animal; Brain; Dizocilpine Maleate; Drug Synergism; Kainic Acid; Male; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Survival Rate | 1993 |
6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione hydrochloride (YM90K) and related compounds: structure-activity relationships for the AMPA-type non-NMDA receptor.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Binding Sites; Brain; Imidazoles; Male; Mice; Mice, Inbred DBA; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Structure-Activity Relationship | 1994 |
Hippocampal damage produced in rats by alpha-dendrotoxin--a selective K+ channel blocker--involves non-NMDA receptor activation.
Topics: Animals; Elapid Venoms; Electroencephalography; Hippocampus; Male; Nerve Degeneration; Potassium Channel Blockers; Quinoxalines; Rats; Rats, Wistar; Seizures | 1994 |
Inhibition of clonic seizure-like excitatory effects induced by intrathecal morphine using two NMDA receptor antagonists: MK-801 and ACEA-1011.
Topics: Analgesics; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; In Vitro Techniques; Injections, Intraperitoneal; Injections, Spinal; Male; Mice; Morphine; Motor Activity; Oocytes; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Seizures; Xenopus laevis | 1994 |
The effect of the non-NMDA receptor antagonist GYKI 52466 and NBQX and the competitive NMDA receptor antagonist D-CPPene on the development of amygdala kindling and on amygdala-kindled seizures.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Electric Stimulation; Kindling, Neurologic; Male; Piperazines; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures | 1994 |
Diazepam dependence prevented by glutamate antagonists.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Diazepam; Drug Tolerance; Electroencephalography; Electromyography; Excitatory Amino Acid Antagonists; Male; Mice; Mice, Inbred Strains; Motor Activity; Muscle Tonus; Piperazines; Quinoxalines; Seizures; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1993 |
Neuroprotective activity of glutamate receptor antagonists against soman-induced hippocampal damage: quantification with an omega 3 site ligand.
Topics: Animals; Autoradiography; Benzoxazines; Brain; Brain Diseases; Excitatory Amino Acid Antagonists; Hippocampus; Isoquinolines; Ligands; Male; Oxazines; Phencyclidine; Quinoxalines; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Seizures; Soman | 1993 |
Aniracetam reverses the anticonvulsant action of NBQX and GYKI 52466 in DBA/2 mice.
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Dose-Response Relationship, Drug; Mice; Mice, Inbred DBA; Piperazines; Pyrrolidinones; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Seizures | 1993 |
Influence of combined treatment with NMDA and non-NMDA receptor antagonists on electroconvulsions in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Drug Combinations; Electroshock; Male; Mice; Mice, Inbred Strains; Motor Activity; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures | 1995 |
Pharmacology of 5-chloro-7-trifluoromethyl-1,4-dihydro-2,3-quinoxalinedione: a novel systemically active ionotropic glutamate receptor antagonist.
Topics: Analgesics; Animals; Anticonvulsants; Brain; Cells, Cultured; Cloning, Molecular; Excitatory Amino Acid Antagonists; Mice; Neurons; Quinoxalines; Rats; Receptors, Glutamate; RNA, Messenger; Seizures; Xenopus laevis | 1995 |
YM90K: pharmacological characterization as a selective and potent alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor antagonist.
Topics: Animals; Anticonvulsants; Brain Ischemia; Cerebral Infarction; Corpus Striatum; Gerbillinae; Ischemia; Male; Mice; Mice, Inbred DBA; Quinoxalines; Radioligand Assay; Rats; Rats, Inbred F344; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Seizures | 1996 |
Potent and long-lasting anticonvulsant effects of 1-naphthylacetyl spermine, an analogue of Joro spider toxin, against amygdaloid kindled seizures in rats.
Topics: Amygdala; Animals; Anticoagulants; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography; Excitatory Amino Acid Antagonists; Kindling, Neurologic; Male; Neurotoxins; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Seizures; Spermine; Spider Venoms | 1996 |
3-Phenyl-substituted imidazo[1,5-alpha]quinoxalin-4-ones and imidazo[1,5-alpha]quinoxaline ureas that have high affinity at the GABAA/benzodiazepine receptor complex.
Topics: Animals; Anticonvulsants; Benzodiazepines; Cell Membrane; Cerebral Cortex; Drug Synergism; Ethanol; Imidazoles; Ligands; Male; Mice; Molecular Conformation; Molecular Structure; Pentylenetetrazole; Quinoxalines; Rats; Receptors, GABA; Seizures; Structure-Activity Relationship; Substance-Related Disorders | 1996 |
Long-term effects of excitatory amino acid antagonists NBQX and MK-801 on the developing brain.
Topics: Animals; Animals, Newborn; Brain; Dizocilpine Maleate; Evaluation Studies as Topic; Excitatory Amino Acid Antagonists; Exploratory Behavior; Infusion Pumps, Implantable; Injections, Intraperitoneal; Male; Maze Learning; Neuroprotective Agents; Pilot Projects; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures | 1996 |
High-affinity alpha-aminobutyric acid A/benzodiazepine ligands: synthesis and structure-activity relationship studies of a new series of tetracyclic imidazoquinoxalines.
Topics: Animals; Cell Line; Humans; Ligands; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Membrane Potentials; Mice; Molecular Conformation; Nucleopolyhedroviruses; Quinoxalines; Rats; Receptors, GABA-A; Recombinant Proteins; Seizures; Spectrophotometry, Infrared; Spodoptera; Structure-Activity Relationship | 1996 |
A crucial role of the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid subtype of glutamate receptors in piriform and perirhinal cortex for the initiation and propagation of limbic motor seizures.
Topics: Animals; Male; Motor Cortex; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Seizures | 1997 |
A new non-NMDA antagonist modifies the local cerebral glucose utilization in kainate-induced generalized seizure.
Topics: Animals; Anticonvulsants; Brain; Dizocilpine Maleate; Glucose; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Seizures | 1997 |
Deep prepiriform cortex modulates neuronal cell death in global ischemia.
Topics: Animals; Brain Ischemia; Cell Count; Cell Death; Excitatory Amino Acid Antagonists; Hippocampus; Male; Microinjections; Neurons; Neuroprotective Agents; Olfactory Pathways; Premedication; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures; Stereotaxic Techniques | 1997 |
Decreased cocaine- and lidocaine-induced seizure response by dextromethorphan and DNQX in rat.
Topics: Anesthetics, Local; Animals; Cocaine; Dextromethorphan; Excitatory Amino Acid Antagonists; Incidence; Injections, Intravenous; Lidocaine; Male; Narcotics; Quinoxalines; Rats; Rats, Sprague-Dawley; Seizures | 1997 |
Effects of excitatory amino acid antagonists on dendrotoxin-induced increases in neurotransmitter release and epileptiform bursting in rat hippocampus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; Action Potentials; Animals; Aspartic Acid; Dizocilpine Maleate; Elapid Venoms; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Neurotoxins; Neurotransmitter Agents; Potassium Channels; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 1997 |
Anticonvulsant action of both NMDA and non-NMDA receptor antagonists against seizures induced by homocysteine in immature rats.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Anticonvulsants; Behavior, Animal; Brain Chemistry; Dizocilpine Maleate; Dose-Response Relationship, Drug; Energy Metabolism; Excitatory Amino Acid Antagonists; Glutamates; Homocysteine; Male; Neuroprotective Agents; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 1997 |
A new nonNMDA antagonist modifies the local cerebral glucose utilization in kainate-induced generalized seizure.
Topics: Animals; Autoradiography; Brain; Deoxyglucose; Excitatory Amino Acid Antagonists; Glucose; Hippocampus; Kainic Acid; Male; Nerve Net; Neuroprotective Agents; Pyramidal Cells; Quinoxalines; Rats; Rats, Sprague-Dawley; Seizures | 1997 |
Pharmacology of the AMPA antagonist 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo-(F)-quinoxaline.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Brain Injuries; Brain Ischemia; Cerebral Cortex; Convulsants; Excitatory Amino Acid Antagonists; Exploratory Behavior; Kindling, Neurologic; Male; Mice; Mice, Inbred Strains; Neuroprotective Agents; Quinoxalines; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Rats, Wistar; Seizures | 1997 |
Acute effects of various GABA receptor agonists and glutamate antagonists on focal hippocampal seizures in freely moving rats elicited by low-frequency stimulation.
Topics: Animals; Anticonvulsants; Ataxia; Carbamazepine; Diazepam; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; GABA Agonists; Hippocampus; Kynurenic Acid; Male; Muscimol; Pipecolic Acids; Quinoxalines; Rats; Rats, Wistar; Seizures | 1998 |
Novel NMDA/glycine site antagonists attenuate cocaine-induced behavioral toxicity.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Excitatory Amino Acid Antagonists; Male; Mice; Quinoxalines; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Seizures | 1997 |
Excitatory amino acid antagonists alleviate convulsive and toxic properties of lindane in mice.
Topics: Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Felbamate; Hexachlorocyclohexane; Insecticides; Lethal Dose 50; Male; Mice; Phenylcarbamates; Propylene Glycols; Quinoxalines; Seizures | 1998 |
Role of cerebral blood flow in seizures from hyperbaric oxygen exposure.
Topics: Analysis of Variance; Animals; Cerebrovascular Circulation; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hyperbaric Oxygenation; Ketamine; Male; Nitric Oxide Synthase; Nitroarginine; Quinoxalines; Rats; Rats, Sprague-Dawley; Reaction Time; Seizures | 1998 |
Pharmacological evidence for GABAergic and glutamatergic involvement in the convulsant and behavioral effects of glutaric acid.
Topics: Animals; Behavior, Animal; Convulsants; Corpus Striatum; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Agonists; gamma-Aminobutyric Acid; Glutamates; Glutarates; Injections; Male; Muscimol; Quinoxalines; Rats; Rats, Wistar; Seizures; Stereotyped Behavior | 1998 |
Mediodorsal thalamus plays a critical role in the development of limbic motor seizures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Bicuculline; Brain Mapping; Carbon Radioisotopes; Deoxyglucose; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Limbic System; Male; Muscimol; Quinoxalines; Rats; Rats, Sprague-Dawley; Seizures; Thalamus; Time Factors; Vigabatrin | 1998 |
[Running fit and generalized tonic-clonic seizure are differently controlled by different subtype receptors in the brainstem].
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Benzothiadiazines; Brain Stem; Dizocilpine Maleate; Epilepsy, Tonic-Clonic; Excitatory Amino Acid Agonists; Inferior Colliculi; N-Methylaspartate; Neuroprotective Agents; Propylthiouracil; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Seizures | 1998 |
5-Aminomethylquinoxaline-2,3-diones. Part I: A novel class of AMPA receptor antagonists.
Topics: Animals; Excitatory Amino Acid Antagonists; Mice; Quinoxalines; Receptors, AMPA; Seizures | 1998 |
Heparin injection into the adult rat hippocampus induces seizures in the absence of macroscopic abnormalities.
Topics: Animals; Bicuculline; Drug Combinations; Electrophysiology; Heparin; Hippocampus; In Vitro Techniques; Male; Neurons; Quinoxalines; Rats; Rats, Wistar; Receptors, Neurotransmitter; Seizures; Swine; Synapses | 1999 |
Piperazine imidazo[1,5-a]quinoxaline ureas as high-affinity GABAA ligands of dual functionality.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Biological Availability; Cell Line; Cerebellum; Convulsants; Cyclic GMP; Drug Evaluation, Preclinical; GABA Agonists; Imidazoles; In Vitro Techniques; Ligands; Male; Mice; Models, Molecular; Molecular Conformation; Pentylenetetrazole; Piperazines; Quinoxalines; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Structure-Activity Relationship; Urea | 1999 |
SPD 502: a water-soluble and in vivo long-lasting AMPA antagonist with neuroprotective activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Binding, Competitive; Cell Membrane; Cells, Cultured; Cerebral Cortex; Electroshock; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glycine; Isoquinolines; Kainic Acid; Kinetics; Male; Membrane Potentials; Mice; Mice, Inbred Strains; Molecular Structure; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Pipecolic Acids; Pyrroles; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Seizures; Stereoisomerism; Tetrahydroisoquinolines | 1999 |
Effects of the AMPA receptor antagonist NBQX on outcome of newborn pigs after asphyxic cardiac arrest.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Blood Pressure; Brain; Brain Stem; Carbon Dioxide; Cardiopulmonary Resuscitation; Consciousness; Electron Transport Complex IV; Epinephrine; Excitatory Amino Acid Antagonists; Heart Arrest; Humans; Infant, Newborn; Neurons; Oxygen; Partial Pressure; Purkinje Cells; Quinoxalines; Receptors, AMPA; Seizures; Swine | 1999 |
Effects of AMPA/kainate glutamate receptor antagonists on cocaine-induced convulsions and lethality in mice.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Cocaine; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Male; Mice; Quinoxalines; Receptors, AMPA; Receptors, Kainic Acid; Seizures | 1999 |
Behavioral and metabolic changes in immature rats during seizures induced by homocysteic acid: the protective effect of NMDA and non-NMDA receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Cerebral Cortex; Disease Models, Animal; Dizocilpine Maleate; Electroencephalography; Energy Metabolism; Epilepsy; Excitatory Amino Acid Antagonists; Glucose; Homocysteine; Injections, Intraventricular; Male; Neuroprotective Agents; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 2000 |
8-Methylureido-4,5-dihydro-4-oxo-10H-imidazo[1,2-a]indeno[1,2-e]pyrazines: highly potent in vivo AMPA antagonists.
Topics: Animals; Anticonvulsants; Excitatory Amino Acid Antagonists; Isoquinolines; Mice; Oocytes; Pyrazines; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Tetrazoles; Xenopus laevis | 2000 |
Effect of ionotropic glutamate receptors antagonists on the modifications in extracellular glutamate and aspartate levels during picrotoxin seizures: a microdialysis study in freely moving rats.
Topics: Animals; Anti-Anxiety Agents; Aspartic Acid; Benzodiazepines; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Hippocampus; Male; Microdialysis; Picrotoxin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Seizures | 2000 |
Characterization of audiogenic-like seizures in naive rats evoked by activation of AMPA and NMDA receptors in the inferior colliculus.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Suckling; Benzothiadiazines; Dizocilpine Maleate; Drug Administration Routes; Excitatory Amino Acid Antagonists; Female; Hypothyroidism; Inferior Colliculi; Injections, Intraventricular; Male; Maternal Exposure; N-Methylaspartate; Propylthiouracil; Proto-Oncogene Proteins c-fos; Quinoxalines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Seizures | 2000 |
pH Sensitivity of non-synaptic field bursts in the dentate gyrus.
Topics: Animals; Calcium; Dentate Gyrus; Electrophysiology; Epilepsy; Excitatory Amino Acid Antagonists; Gap Junctions; Hydrogen-Ion Concentration; Hypnotics and Sedatives; In Vitro Techniques; Male; Octanols; Oleic Acids; Periodicity; Potassium; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Seizures; Synapses; Synaptic Transmission | 2000 |
Glutamatergic drugs exacerbate symptomatic behavior in a transgenic model of comorbid Tourette's syndrome and obsessive-compulsive disorder.
Topics: Animals; Cerebral Cortex; Comorbidity; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Humans; Limbic System; Male; Mice; Mice, Inbred BALB C; Mice, Transgenic; Motor Activity; Obsessive-Compulsive Disorder; Quinoxalines; Seizures; Tourette Syndrome | 2000 |
Susceptibility of brain to AMPA induced excitotoxicity transiently peaks during early postnatal development.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Brain; Brain Injuries; Diazepam; Dizocilpine Maleate; Female; Ibotenic Acid; Male; N-Methylaspartate; Neurotoxins; Organ Specificity; Phenytoin; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Seizures | 1992 |
Repeated treatment with quinolones potentiates the seizures induced by aminophylline in genetically epilepsy-prone rats.
Topics: Aminophylline; Animals; Cerebral Cortex; Disease Models, Animal; Drug Synergism; Electroencephalography; Epilepsy; Quinoxalines; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; Seizures | 1992 |
Excitatory amino acids and the actions of cocaine.
Topics: Animals; Caffeine; Cocaine; Dextromethorphan; Dizocilpine Maleate; Haloperidol; Male; Mice; Mice, Inbred Strains; Motor Activity; N-Methylaspartate; Pipecolic Acids; Quinoxalines; Rats; Rats, Inbred Strains; Seizures; Stereoisomerism; Stereotyped Behavior | 1992 |
Probenecid pretreatment enhances anticonvulsant action of NBQX in mice.
Topics: Animals; Anticonvulsants; Ataxia; Drug Synergism; Injections, Intravenous; Male; Mice; Motor Activity; Probenecid; Quinoxalines; Seizures | 1992 |
Glutamate receptor antagonists block cocaine-induced convulsions and death.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Anticonvulsants; Cocaine; Death; Dextrorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamates; Kynurenic Acid; Male; Mice; Mice, Inbred ICR; Piperazines; Quinoxalines; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Time Factors | 1991 |
The anticonvulsant effect of the non-NMDA antagonists, NBQX and GYKI 52466, in mice.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Female; Ibotenic Acid; Male; Mice; Mice, Inbred DBA; Postural Balance; Quinoxalines; Seizures | 1991 |
DNQX blockade of amphetamine behavioral sensitization.
Topics: Amphetamine; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Haloperidol; Kainic Acid; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Quinoxalines; Seizures; Stereotyped Behavior | 1991 |
A slight anticonvulsant effect of CNQX and DNQX as measured by homocysteine- and quisqualate-induced seizures.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Anticonvulsants; Female; Homocysteine; Mice; Oxadiazoles; Quinoxalines; Quisqualic Acid; Seizures | 1990 |
Seizure-like activity and glutamate receptors in hippocampal neurons in culture.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cells, Cultured; Electrophysiology; Glutamates; Hippocampus; Neurons; Quinoxalines; Receptors, Glutamate; Receptors, Neurotransmitter; Seizures; Tetrodotoxin | 1990 |
A potent antagonist of the strychnine insensitive glycine receptor has anticonvulsant properties.
Topics: Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Cortical Spreading Depression; Female; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Pregnancy; Pyrrolidinones; Quinoxalines; Rats; Receptors, Glycine; Receptors, Neurotransmitter; Seizures; Strychnine | 1989 |
Absence of side-effects in the anticonvulsant action of cortically applied antagonists of N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Dipeptides; Morphine; N-Methylaspartate; Picrotoxin; Quinoxalines; Rats; Rats, Inbred Strains; Seizures; Strychnine; Valine | 1986 |