Compounds > quinoxalines
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quinoxalines and Muscle Relaxation

quinoxalines has been researched along with Muscle Relaxation in 115 studies

Research

Studies (115)

TimeframeStudies, this research(%)All Research%
pre-19906 (5.22)18.7374
1990's31 (26.96)18.2507
2000's63 (54.78)29.6817
2010's15 (13.04)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Antoniali, C; Bendhack, LM; da Silva, RS; Grando, MD; Graton, ME; Potje, SR; Troiano, JA1
Blaha, I; Bustamante, S; Carballido, J; Fernandes, VS; García-Sacristán, A; Hernández, M; Martínez, AC; Martínez-Sáenz, A; Recio, P; Ribeiro, AS; Serrano-Margüello, D; Vázquez-Alba, D1
Breslin, JW; Kurtz, KH; Moor, AN; Souza-Smith, FM1
Busch, M; Busch, R; Dörr, M; Eckerle, LG; Felix, SB; Gross, S; Hertrich, I; Rauch, BH; Reinke, Y; Riad, A; Stasch, JP1
Fukamoto, A; Hotta, Y; Ieda, N; Kataoka, T; Kawade, Y; Kimura, K; Maeda, Y; Nakagawa, H1
Brouckaert, P; Buys, E; Dhaese, I; Lefebvre, RA; Sips, P; Vanneste, G1
Dehpour, AR; Ghahremani, MH; Ghasemi, M; Karimollah, AR1
Chen, J; Chen, X; Liu, J; Wang, T; Xiao, H; Yang, J; Ye, Z; Yin, C1
Kito, Y; Suzuki, H1
Jokanović, M; Micov, A; Savić, V; Simić, M; Stepanović, JM; Stepanović-Petrović, RM; Tokic-Vujosević, Z; Tomić, MA1
Antunes, E; De Nucci, G; Mónica, FZ; Morganti, RP; Toque, HA1
Altun, A; Bagcivan, I; Durmus, N; Sarac, B; Sencan, M; Turan, M1
Man, RY; Ng, KF; Vanhoutte, PM; Wong, ES1
Bak, YO; Choi, BR; Jeon, JH; Kim, HK; Lee, SW; Park, JK; So, I; Zhao, C1
Cosyns, SM; Lefebvre, RA1
Ishii, K; Moriuchi, H; Nakahara, T; Sakamoto, K; Yunoki, M1
Borsotto, M; Gallego, D; Gil, V; Heurteaux, C; Jiménez, M; Martínez-Cutillas, M; Moha Ou Maati, H; Peyronnet, R1
Chen, Y; Chitapanarux, T; Melton, AC; Soon, RK; Wu, J; Yee, HF1
Abacioğlu, N; Ademoğlu, F; Başgut, B; Cakici, I1
Beranova, P; Boucher, JL; Callizot, N; Chalupsky, K; Entlicher, G; Mansuy, D; Muller, B; Schott, C; Stoclet, JC; Vetrovsky, P1
Cellek, S; Hobbs, AJ; Kalsi, JS; Kell, PD; Moncada, S; Ralph, DJ; Rees, RW; Royle, M1
Elphick, MR; Melarange, R1
Cao, J; Inoue, M; Kitazawa, T; Taneike, T1
Abete, P; Cipolletta, E; De Santis, D; Ferrara, N; Iaccarino, G; Leosco, D; Pisani, E; Rengo, F; Sorriento, D; Trimarco, B; Trimarco, V1
Crescioli, C; Fazzini, A; Filippi, S; Ledda, F; Maggi, M; Natali, A; Riffaud, JP; Vannelli, GB1
Chen, KH; Chen, SJ; Webb, RC; Wu, CC; Yen, MH1
Hobbs, AJ; MacAllister, RJ; Madhani, M; Scotland, RS1
Ozdem, SS; Sadan, G; Tasatargil, A1
Anderson, TJ; Ellis, A; Pannirselvam, M; Triggle, CR1
Jun, CH; Lee, TS; Sohn, UD1
De Godoy, M; Li, F; Rattan, S1
Antunes, E; Baracat, JS; De Nucci, G; de Oliveira, JF; Fregonesi, A; Okuyama, CE; Priviero, FB; Rodrigues Netto, N; Teixeira, CE1
Gonick, HC; Merlic, CA; Shelkovnikov, S1
Khalil, RA; Orshal, JM1
Boussery, K; Delaey, C; Van de Voorde, J1
Bawankule, DU; Chanda, D; Krishna, AV; Mishra, SK; Prakash, VR; Sardar, KK; Sathishkumar, K1
Angelini, GD; Jeremy, JY; Jones, R; Persad, R; Shukla, N1
Elmedal Laursen, B; Mulvany, MJ; Simonsen, U1
Boddy, G; Cho, WJ; Daniel, EE; El-Yazbi, AF; Schulz, R1
Antunes, E; Baracat, JS; Claudino, MA; De Nucci, G; Priviero, FB; Teixeira, CE; Webb, RC1
Amato, A; Feo, S; Mulè, F; Serio, R; Zizzo, MG1
Barthó, L; Benkó, R; Magyar, K; Rumbus, Z; Tóvölgyi, Z; Undi, S; Wolf, M1
Adaikan, PG; Lau, LC1
Broadley, KJ; Gudka, N; Hamrouni, AM1
Kim, M; Perrino, BA1
Albani, M; Gougoulias, N; Kouvelas, D1
Antal, A; Barthó, L; Benkó, R; Cseke, L; Horváth, OP; Illényi, L; Kassai, M; Kelemen, D; Magyar, K; Undi, S; Vereczkei, A; Wolf, M1
Baggio, CH; Cipriani, TR; da Silva-Santos, JE; de Souza, LM; Freitas, CS; Graça, C; Marques, MC; Pontarolo, R; Rattmann, YD; Rieck, L; Sassaki, GL1
Jiang, B; Wang, R; Wu, L1
Anand-Srivastava, MB; Bassil, M; Li, Y1
Abou-Gharbia, M; Freed, ME; McCaully, RJ; Silver, PJ; Wendt, RL1
Dyamenahalli, U; Haworth, SG; Stuart-Smith, K; Tulloh, RM1
Butler, A; Connor, HE; O'Shaughnessy, CT; Worton, SP1
Block, F; Schwarz, M1
Cellek, S; Kasakov, L; Moncada, S1
Ciampoli, D; Johnson, PJ; Stebbing, MJ; Young, HM1
Drewett, JG; Herzig, TC; Knych, ET; Olson, LJ1
Brien, JF; Hussain, AS; Marks, GS; Nakatsu, K1
Barber, DA; Miller, VM1
Cantabrana, B; Hidalgo, A; Menéndez Antolin, L; Pérez Vallina, JR; Sánchez, M1
Faraci, FM; Heistad, DD; Maeda, N; Shesely, EG; Sigmund, CD1
Gustafsson, LE; Hallén, K; Iversen, HH; Olgart, C; Wiklund, NP1
Katusic, ZS; Onoue, H1
Bayguinov, O; Sanders, KM1
Li, L; Paakkari, I; Vaali, K; Vapaatalo, H1
Contreras, J; García-Sacristán, A; Hernández, M; López, PG; Prieto, D; Recio, P1
Kendall, DA; Roberts, RE; Tomlinson, AE; Wilson, VG1
Hiley, CR; White, R1
Lefebvre, RA1
Ruiz, E; Tejerina, T1
Hwang, TL; Teng, CM; Wu, CC1
Cellek, S; Moncada, S1
Cohen, RA; Griswold, MC; Komalavilas, P; Lincoln, TM; Weisbrod, RM; Yaghoubi, M1
Vanover, KE1
Galle, J; Hatzelmann, A; Hübner, U; Schmidt, HH; Wagner, B; Wanner, C; Zabel, U1
Kendall, DA; Roberts, RE; Wilson, VG1
Gibson, A; O'Kane, K1
Sanders, KM; Shuttleworth, CW; Sweeney, KM1
Koshita, M; Nakahira, Y; Suzuki, H; Takano, H1
Ekblad, E1
Costa, G; Garcia-Pascual, A; Labadia, A; Triguero, D1
Buus, NH; Mulvany, MJ; Pilegaard, HK; Simonsen, U1
Costa, G; García-Pascual, A; Jiménez, E; Labadía, A; Triguero, D1
Cocks, TM; Selemidis, S1
Dick, JM; Lefebvre, RA1
Hata, F; Nakagawa, M; Niioka, S; Nishio, H; Okishio, Y; Takeuchi, T; Yamaji, M1
Kurowski, S; Vemulapalli, S2
Clouse, WD; Hurt, RD; Miller, VM; Rud, KS1
Chen, SJ; Lin, CI; Wu, CC; Yang, SN; Yen, MH1
Ikeo, T; Inoue, H; Kikkawa, K; Mochida, H; Noto, T; Takagi, M; Yano, K1
Baccari, MC; Calamai, F1
Conklin, JL; Kooy, N; Murray, JA; Uc, A1
Gloviczki, P; Landis, ME; Miller, VM; Ray, EC1
Benezech, V; Bonnet, P; Chapat, J; Deleuze-Masquefa, C; Elliott, K; Escale, R; Fabreguettes, J; Laurent, F; Michel, A; Parra, S; Pocock, T; Small, R; Subra, G; Vidal, J1
Ahn, D; Chung, S; Kwon, S; Nam, T; Yeon, D1
Dikmen, A; Döndaş, N; Ergün, Y; Oğülener, N1
Bendhack, LM; Ceron, PI; Cremonez, DC; Tedesco, AC1
Brioni, JD; Hsieh, GC; Kolasa, T; Sullivan, JP1
Fernández, E; Jiménez, M; Tanović, A1
Buxton, IL; Kaiser, RA; Malmquist, NA; Tichenor, S1
Fujita, A; Hata, F; Morimoto, H; Sugimoto, K; Takeuch, T1
Bessard, G; Bréant, D; Caron, F; Corompt, E; Devillier, P1
Gao, Y; Moessinger, A; Raj, JU; Sander, FC; Souici, AC; Tolsa, JF1
Ball, SL; Duncan, A; Martin, W; McPate, MJ; Nelli, S; Rafique, KM; Shahidullah, M; Strachan, PD1
Cellek, S; Moncada, S; Ziessen, T1
Allescher, HD; Folmer, R; Kurjak, M; Schusdziarra, V; Storr, M1
Bowes, TJ; Daniel, EE; Jury, J1
Lefebvre, RA; Smits, GJ1
Cantor, EH; Davey, DD; Erhardt, PW; Greenberg, SS; Ingebretsen, WR; Wiggins, J1
Flavahan, NA; Shimokawa, H; Vanhoutte, PM2
Hollier, LH; Miller, VM; Reigel, MM; Vanhoutte, PM1
Miller, VM; Vanhoutte, PM1
Bullock, GR; Taylor, SG; Weston, AH1

Other Studies

115 other study(ies) available for quinoxalines and Muscle Relaxation

ArticleYear
Endothelial modulation of a nitric oxide donor complex-induced relaxation in normotensive and spontaneously hypertensive rats.
    Life sciences, 2018, May-15, Volume: 201

    Topics: Animals; Coordination Complexes; Dose-Response Relationship, Drug; Endothelium, Vascular; Guanylate Cyclase; Male; Mesenteric Arteries; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Oxadiazoles; Potassium Channel Blockers; Quinoxalines; Rats; Rats, Inbred SHR; Ruthenium; Vascular Resistance; Vasodilation

2018
Underlying mechanisms involved in progesterone-induced relaxation to the pig bladder neck.
    European journal of pharmacology, 2014, Jan-15, Volume: 723

    Topics: Animals; Calcium; Cyclooxygenase Inhibitors; Female; Guanylate Cyclase; In Vitro Techniques; Indomethacin; Male; Muscle Relaxation; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Potassium; Potassium Channel Blockers; Potassium Channels; Progesterone; Quinoxalines; Receptors, Progesterone; Swine; Urinary Bladder; Urothelium

2014
Involvement of H1 and H2 receptors and soluble guanylate cyclase in histamine-induced relaxation of rat mesenteric collecting lymphatics.
    Microcirculation (New York, N.Y. : 1994), 2014, Volume: 21, Issue:7

    Topics: Animals; Cimetidine; Endothelium, Lymphatic; Guanylate Cyclase; Histamine H1 Antagonists; Histamine H2 Antagonists; Lymphatic Vessels; Male; Mesentery; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Pyrilamine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Histamine H1; Receptors, Histamine H2; Soluble Guanylyl Cyclase

2014
The soluble guanylate cyclase stimulator riociguat and the soluble guanylate cyclase activator cinaciguat exert no direct effects on contractility and relaxation of cardiac myocytes from normal rats.
    European journal of pharmacology, 2015, Nov-15, Volume: 767

    Topics: Animals; Benzoates; Calcium; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Female; Guanylate Cyclase; Isoproterenol; Muscle Relaxation; Myocardial Contraction; Myocytes, Cardiac; Oxadiazoles; Pyrazoles; Pyrimidines; Quinoxalines; Rats; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Thionucleotides; Verapamil

2015
Light-controlled relaxation of the rat penile corpus cavernosum using NOBL-1, a novel nitric oxide releaser.
    Investigative and clinical urology, 2016, Volume: 57, Issue:3

    Topics: Animals; Guanylate Cyclase; Male; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penis; Phosphodiesterase 5 Inhibitors; Photic Stimulation; Quinoxalines; Rats, Wistar; Vardenafil Dihydrochloride

2016
Involvement of soluble guanylate cyclase alpha(1) and alpha(2), and SK(Ca) channels in NANC relaxation of mouse distal colon.
    European journal of pharmacology, 2008, Jul-28, Volume: 589, Issue:1-3

    Topics: Animals; Apamin; Blotting, Western; Colon; Cyclic GMP; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Female; Gastrointestinal Motility; Guanylate Cyclase; Male; Mice; Mice, Knockout; Muscle Relaxation; Muscle, Smooth; Myenteric Plexus; Neural Inhibition; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Potassium Channel Blockers; Protein Subunits; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Small-Conductance Calcium-Activated Potassium Channels; Soluble Guanylyl Cyclase; Vasoactive Intestinal Peptide

2008
Inhibition by lithium of the nitrergic relaxation of rat anococcygeus muscle.
    Nitric oxide : biology and chemistry, 2009, Volume: 20, Issue:1

    Topics: Analysis of Variance; Animals; Arginine; Electric Stimulation; Lithium Chloride; Male; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitrergic Neurons; Nitric Oxide; Nitric Oxide Synthase Type I; Nitroprusside; Oxadiazoles; Phenylephrine; Quinoxalines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction

2009
The relaxation mechanisms of tetrandrine on the rabbit corpus cavernosum tissue in vitro.
    Natural product research, 2009, Volume: 23, Issue:2

    Topics: 4-Aminopyridine; Animals; Benzylisoquinolines; Drugs, Chinese Herbal; Enzyme Inhibitors; Glyburide; In Vitro Techniques; Indomethacin; Male; Muscle Relaxation; Muscle, Smooth; Nitroarginine; Oxadiazoles; Penis; Potassium Channel Blockers; Potassium Chloride; Quinoxalines; Rabbits; Stephania tetrandra; Tetraethylammonium

2009
Properties of Rikkunshi-to (TJ-43)-induced relaxation of rat gastric fundus smooth muscles.
    American journal of physiology. Gastrointestinal and liver physiology, 2010, Volume: 298, Issue:5

    Topics: Animals; Apamin; Drugs, Chinese Herbal; Enprostil; Gastric Fundus; Hesperidin; Membrane Potentials; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Potassium; Pyrimidinones; Quinoxalines; Rats; Thiazoles; Verapamil

2010
Comparison of vasorelaxant effect and tolerance profile of a novel isosorbide-5-mononitrate derivative with its stereoisomer and parent drug on rat mesenteric artery.
    Arzneimittel-Forschung, 2010, Volume: 60, Issue:4

    Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Electrophoresis, Capillary; Endothelium, Vascular; In Vitro Techniques; Isosorbide Dinitrate; Magnetic Resonance Spectroscopy; Male; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Oxadiazoles; Phenylephrine; Quinoxalines; Rats; Rats, Wistar; Spectrophotometry, Infrared; Stereoisomerism; Vasoconstrictor Agents; Vasodilator Agents

2010
Mechanisms of relaxant activity of the nitric oxide-independent soluble guanylyl cyclase stimulator BAY 41-2272 in rat tracheal smooth muscle.
    European journal of pharmacology, 2010, Oct-25, Volume: 645, Issue:1-3

    Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Trachea

2010
Investigation of relaxant effects of new agents affecting nitric oxide/cyclic guanosine monophosphate pathway on sheep oddi sphincter.
    Pancreas, 2010, Volume: 39, Issue:6

    Topics: Animals; Carbachol; Cyclic GMP; Dose-Response Relationship, Drug; Guanylate Cyclase; In Vitro Techniques; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; Sheep; Sphincter of Oddi; Triazenes

2010
Dexmedetomidine induces both relaxations and contractions, via different {alpha}2-adrenoceptor subtypes, in the isolated mesenteric artery and aorta of the rat.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 335, Issue:3

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Aorta; Brimonidine Tartrate; Clonidine; Dexmedetomidine; Endothelium, Vascular; In Vitro Techniques; Indomethacin; Male; Mesenteric Arteries; Models, Biological; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Naphthalenes; NG-Nitroarginine Methyl Ester; Pertussis Toxin; Prazosin; Propionates; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Thromboxane

2010
The role of capillarisin from Artemisia capillaris on penile erection.
    Phytotherapy research : PTR, 2012, Volume: 26, Issue:6

    Topics: Animals; Artemisia; Chromones; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Evaluation, Preclinical; Ethanol; Male; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Penile Erection; Penis; Phenylephrine; Phosphodiesterase 5 Inhibitors; Plant Extracts; Quinoxalines; Rabbits; Radioimmunoassay; Signal Transduction

2012
Mechanism of relaxation and interaction with nitric oxide of the soluble guanylate cyclase stimulator BAY 41-2272 in mouse gastric fundus and colon.
    European journal of pharmacology, 2012, Jul-05, Volume: 686, Issue:1-3

    Topics: Animals; Colon; Cyclic GMP; Enzyme Inhibitors; Gastric Fundus; Guanylate Cyclase; In Vitro Techniques; Isometric Contraction; Male; Mice; Mice, Inbred C57BL; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase

2012
The relaxant action of nicorandil in bovine tracheal smooth muscle.
    Pharmacology, 2012, Volume: 89, Issue:5-6

    Topics: Animals; Cattle; Cromakalim; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth; Nicorandil; Nitroprusside; Oxadiazoles; Peptides; Quinoxalines; Trachea; Vasodilator Agents

2012
Relative contribution of SKCa and TREK1 channels in purinergic and nitrergic neuromuscular transmission in the rat colon.
    American journal of physiology. Gastrointestinal and liver physiology, 2012, Aug-01, Volume: 303, Issue:3

    Topics: Animals; Apamin; Colon; Cysteine; Male; Methionine; Muscle Relaxation; Nitroarginine; Nitroprusside; Oxadiazoles; Peptides; Potassium Channel Blockers; Potassium Channels, Tandem Pore Domain; Quinoxalines; Rats; Rats, Sprague-Dawley; Small-Conductance Calcium-Activated Potassium Channels; Synaptic Transmission

2012
Inducible NOS mediates CNP-induced relaxation of intestinal myofibroblasts.
    American journal of physiology. Gastrointestinal and liver physiology, 2013, Apr-01, Volume: 304, Issue:7

    Topics: Animals; Cyclic GMP; Guanylate Cyclase; Humans; Mice; Muscle Relaxation; Myofibroblasts; Natriuretic Peptide, C-Type; Nitric Oxide Synthase Type II; Nitroarginine; omega-N-Methylarginine; Oxadiazoles; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase

2013
The mechanisms of peroxynitrite-induced relaxations in isolated rat anococcygeus muscle.
    Pharmacology, 2002, Volume: 66, Issue:1

    Topics: Animals; Antioxidants; Glyburide; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Peroxynitrous Acid; Potassium Channel Blockers; Quinoxalines; Rats

2002
Involvement of NO in the endothelium-independent relaxing effects of N(omega)-hydroxy-L-arginine and other compounds bearing a C=NOH function in the rat aorta.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:2

    Topics: Animals; Aorta, Thoracic; Arginine; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indicators and Reagents; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NADPH-Ferrihemoprotein Reductase; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Organic Cation Transport Proteins; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar

2002
BAY41-2272, a novel nitric oxide independent soluble guanylate cyclase activator, relaxes human and rabbit corpus cavernosum in vitro.
    The Journal of urology, 2003, Volume: 169, Issue:2

    Topics: Animals; Guanylate Cyclase; Humans; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Penis; Pyrazoles; Pyridines; Quinoxalines; Rabbits

2003
Comparative analysis of nitric oxide and SALMFamide neuropeptides as general muscle relaxants in starfish.
    The Journal of experimental biology, 2003, Volume: 206, Issue:Pt 5

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic GMP; Muscle Relaxation; Neuropeptides; Nitric Oxide; Oxadiazoles; Quinoxalines; Radioimmunoassay; Starfish; Stomach

2003
5-HT7 receptor-mediated relaxation of the oviduct in nonpregnant proestrus pigs.
    European journal of pharmacology, 2003, Feb-14, Volume: 461, Issue:2-3

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Binding, Competitive; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrous Cycle; Female; Guanylate Cyclase; Imidazoles; In Vitro Techniques; Isoproterenol; Muscle Relaxation; Neuropeptides; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Oviducts; Oxadiazoles; Pituitary Adenylate Cyclase-Activating Polypeptide; Purinones; Quinoxalines; Radioligand Assay; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Swine; Tritium; Vasoactive Intestinal Peptide

2003
Exercise restores beta-adrenergic vasorelaxation in aged rat carotid arteries.
    American journal of physiology. Heart and circulatory physiology, 2003, Volume: 285, Issue:1

    Topics: Acetylcholine; Adrenergic beta-Agonists; Animals; Blotting, Western; Body Weight; Brimonidine Tartrate; Carotid Arteries; Cells, Cultured; Cytosol; Endothelium, Vascular; Enzyme Inhibitors; Isoproterenol; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; omega-N-Methylarginine; Organ Size; Physical Conditioning, Animal; Quinoxalines; Rats; Rats, Inbred WKY; Receptors, Adrenergic, beta; Vasodilator Agents

2003
Effects of NCX 4050, a new NO donor, in rabbit and human corpus cavernosum.
    International journal of andrology, 2003, Volume: 26, Issue:2

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 5; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Humans; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Penile Erection; Penis; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Quinoxalines; Rabbits; Sildenafil Citrate; Sulfones

2003
Abnormal activation of Na+-K+ pump in aortas from rats with endotoxaemia.
    Naunyn-Schmiedeberg's archives of pharmacology, 2003, Volume: 368, Issue:1

    Topics: Animals; Aorta, Thoracic; Endotoxemia; Enzyme Inhibitors; Escherichia coli; In Vitro Techniques; Lipopolysaccharides; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Ouabain; Oxadiazoles; Phenylephrine; Potassium Channels, Inwardly Rectifying; Quinoxalines; Rats; Rats, Inbred WKY; Sodium-Potassium-Exchanging ATPase; Time Factors

2003
Vascular natriuretic peptide receptor-linked particulate guanylate cyclases are modulated by nitric oxide-cyclic GMP signalling.
    British journal of pharmacology, 2003, Volume: 139, Issue:7

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Aorta, Thoracic; Atrial Natriuretic Factor; Cyclic GMP; Dose-Response Relationship, Drug; Drug Antagonism; Drug Synergism; Guanylate Cyclase; Male; Mesenteric Arteries; Mice; Mice, Inbred Strains; Mice, Knockout; Muscle Relaxation; Natriuretic Peptide, C-Type; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrogen Oxides; Nitroglycerin; Oxadiazoles; Phenylephrine; Polysaccharides; Quinoxalines; Receptors, Atrial Natriuretic Factor; Signal Transduction; Spermine

2003
The effects of selective phosphodiesterase III and V inhibitors on adrenergic and non-adrenergic, non-cholinergic relaxation responses of guinea-pig pulmonary arteries.
    Autonomic & autacoid pharmacology, 2003, Volume: 23, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenosine; Animals; Arginine; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Synergism; Electric Stimulation; Guinea Pigs; Histamine; Isoproterenol; Male; Milrinone; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitroprusside; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pulmonary Artery; Purinones; Quinoxalines; Receptors, Adrenergic; Receptors, Cholinergic; Signal Transduction; Tetrodotoxin; Theophylline

2003
Catalase has negligible inhibitory effects on endothelium-dependent relaxations in mouse isolated aorta and small mesenteric artery.
    British journal of pharmacology, 2003, Volume: 140, Issue:7

    Topics: Acetylcholine; Animals; Aorta, Thoracic; Apamin; Cardiovascular Agents; Catalase; Charybdotoxin; Diabetes Mellitus, Type 2; Endothelium, Vascular; Enzyme Inhibitors; Hydrogen Peroxide; Indomethacin; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Potassium Channel Blockers; Potassium Chloride; Quinoxalines; Tetraethylammonium; Vasodilator Agents

2003
NO/cyclic GMP pathway mediates the relaxation of feline lower oesophageal sphincter.
    Autonomic & autacoid pharmacology, 2003, Volume: 23, Issue:3

    Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cats; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Esophagogastric Junction; In Vitro Techniques; Indomethacin; Male; Methylene Blue; Molsidomine; Muscle Relaxation; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Oxadiazoles; Quinoxalines; Signal Transduction; Vasoactive Intestinal Peptide

2003
Role of adenylate and guanylate cyclases in beta1-, beta2-, and beta3-adrenoceptor-mediated relaxation of internal anal sphincter smooth muscle.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 308, Issue:3

    Topics: Adenine; Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blotting, Western; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; GTP-Binding Proteins; Guanylate Cyclase; Indoles; Male; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Procaterol; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Receptors, Adrenergic, beta-3; Suramin; Xamoterol

2004
Nitric oxide release from human corpus cavernosum induced by a purified scorpion toxin.
    Urology, 2004, Volume: 63, Issue:1

    Topics: Adolescent; Adult; Child; Cyclic GMP; Drug Evaluation, Preclinical; Electric Stimulation; Enzyme Inhibitors; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neurotoxins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Penis; Phenylephrine; Piperazines; Priapism; Purines; Quinoxalines; Scorpion Venoms; Second Messenger Systems; Sildenafil Citrate; Sodium Channel Blockers; Sulfones; Tetrodotoxin

2004
Influence of nitric oxide donors and peroxynitrite on the contractile effect and concentration of norepinephrine.
    Life sciences, 2004, Apr-23, Volume: 74, Issue:23

    Topics: Animals; Aorta, Thoracic; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Donors; Norepinephrine; Oxadiazoles; Peroxynitrous Acid; Quinoxalines; Rats; Rats, Sprague-Dawley

2004
Interleukin-6 impairs endothelium-dependent NO-cGMP-mediated relaxation and enhances contraction in systemic vessels of pregnant rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2004, Volume: 286, Issue:6

    Topics: Acetylcholine; Animals; Blotting, Western; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Estradiol; Female; Interleukin-6; Isometric Contraction; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oxadiazoles; Phenylephrine; Pregnancy; Pregnancy, Animal; Progesterone; Quinoxalines; Rats; Rats, Sprague-Dawley; Vasodilator Agents

2004
The vasorelaxing effect of CGRP and natriuretic peptides in isolated bovine retinal arteries.
    Investigative ophthalmology & visual science, 2005, Volume: 46, Issue:4

    Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Cattle; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Isometric Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Natriuretic Peptides; Nitroarginine; Oxadiazoles; Peptide Fragments; Potassium Channel Blockers; Potassium Channels; Quinoxalines; Regional Blood Flow; Retinal Artery; Vasodilation

2005
BAY 41-2272 [5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyrimidin-4-ylamine]-induced dilation in ovine pulmonary artery: role of sodium pump.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:1

    Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Ouabain; Oxadiazoles; Pulmonary Artery; Pyrazoles; Pyridines; Quinoxalines; Rubidium Radioisotopes; Serotonin; Sheep; Sodium-Potassium-Exchanging ATPase; Vasoconstriction; Vasodilation

2005
Effect of sildenafil citrate and a nitric oxide donating sildenafil derivative, NCX 911, on cavernosal relaxation and superoxide formation in hypercholesterolaemic rabbits.
    European journal of pharmacology, 2005, Jul-11, Volume: 517, Issue:3

    Topics: Acetophenones; Allopurinol; Animals; Carbachol; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypercholesterolemia; In Vitro Techniques; Male; Muscle Relaxation; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Onium Compounds; Oxadiazoles; Penis; Phosphodiesterase Inhibitors; Piperazines; Purines; Quinoxalines; Rabbits; Rotenone; Sildenafil Citrate; Sulfones; Superoxides; Uncoupling Agents; Xanthine Oxidase

2005
Involvement of guanylyl cyclase, protein kinase A and Na+ K+ ATPase in relaxations of bovine isolated bronchioles induced by GEA 3175, an NO donor.
    Pulmonary pharmacology & therapeutics, 2006, Volume: 19, Issue:3

    Topics: Animals; Bronchi; Calcium; Cattle; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Guanylate Cyclase; In Vitro Techniques; Molsidomine; Muscle Relaxation; Nitric Oxide; Nitric Oxide Donors; Ouabain; Oxadiazoles; Peptides; Potassium; Quinoxalines; S-Nitrosoglutathione; Serotonin; Sodium-Potassium-Exchanging ATPase; Thionucleotides; Triazoles

2006
Impact of caveolin-1 knockout on NANC relaxation in circular muscles of the mouse small intestine compared with longitudinal muscles.
    American journal of physiology. Gastrointestinal and liver physiology, 2006, Volume: 290, Issue:2

    Topics: Animals; Apamin; Autonomic Nervous System; Caveolin 1; Immunohistochemistry; In Vitro Techniques; Jejunum; Male; Mice; Mice, Knockout; Microscopy, Electron; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Nitroprusside; Oxadiazoles; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; Synaptic Transmission; Tetrodotoxin

2006
Stimulation of soluble guanylyl cyclase by BAY 41-2272 relaxes anococcygeus muscle: interaction with nitric oxide.
    European journal of pharmacology, 2006, Jan-13, Volume: 530, Issue:1-2

    Topics: Animals; Carbachol; Carbolines; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroglycerin; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Tadalafil; Tetrodotoxin

2006
Evidence for a role of inducible nitric oxide synthase in gastric relaxation of mdx mice.
    Neurogastroenterology and motility, 2006, Volume: 18, Issue:6

    Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Imines; Male; Mice; Mice, Inbred mdx; Muscle Relaxation; Muscle, Smooth; Muscular Dystrophy, Duchenne; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Organ Culture Techniques; Oxadiazoles; Quinoxalines; Receptors, Vasoactive Intestinal Peptide; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stomach; Vasoactive Intestinal Peptide

2006
P(2) purinoceptors account for the non-nitrergic NANC relaxation in the rat ileum.
    Naunyn-Schmiedeberg's archives of pharmacology, 2006, Volume: 373, Issue:4

    Topics: Animals; Electric Stimulation; Enzyme Inhibitors; Female; Guanylate Cyclase; Ileum; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Nitric Oxide Synthase; Nitroarginine; Nitroglycerin; Nitroprusside; Oxadiazoles; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Quinoxalines; Rats; Rats, Wistar; Receptors, Purinergic P2; Tetrodotoxin

2006
Mechanisms of direct relaxant effect of sildenafil, tadalafil and vardenafil on corpus cavernosum.
    European journal of pharmacology, 2006, Jul-17, Volume: 541, Issue:3

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Calcium; Carbolines; Dose-Response Relationship, Drug; Imidazoles; Male; Muscle Relaxation; Muscle, Smooth; Norepinephrine; Oxadiazoles; Penis; Phosphodiesterase Inhibitors; Piperazines; Purines; Quinoxalines; Rabbits; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Verapamil

2006
Investigation of the mechanism for the relaxation of rat duodenum mediated via M1 muscarinic receptors.
    Autonomic & autacoid pharmacology, 2006, Volume: 26, Issue:3

    Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Bicuculline; Dose-Response Relationship, Drug; Duodenum; Elapid Venoms; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Muscarinic Agonists; Muscarinic Antagonists; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Oxadiazoles; Penicillamine; Pirenzepine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Suramin

2006
CaM kinase II activation and phospholamban phosphorylation by SNP in murine gastric antrum smooth muscles.
    American journal of physiology. Gastrointestinal and liver physiology, 2007, Volume: 292, Issue:4

    Topics: Animals; Benzylamines; Calcium Signaling; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indoles; Mice; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Phosphorylation; Potassium Channel Blockers; Pyloric Antrum; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Soluble Guanylyl Cyclase; Sulfonamides

2007
Protective effect of PNQX on motor units and muscle property after sciatic nerve crush in neonatal rats.
    Pharmacological research, 2007, Volume: 55, Issue:5

    Topics: Animals; Animals, Newborn; Axotomy; Disease Models, Animal; Excitatory Amino Acid Antagonists; Female; Male; Motor Neurons; Muscle Contraction; Muscle Fatigue; Muscle Relaxation; Muscle Strength; Muscle, Skeletal; Neuroprotective Agents; Organ Size; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Sciatic Nerve; Sciatic Neuropathy; Time Factors

2007
P2 purinoceptor antagonists inhibit the non-adrenergic, non-cholinergic relaxation of the human colon in vitro.
    Neuroscience, 2007, Jun-15, Volume: 147, Issue:1

    Topics: Adenosine Triphosphate; Colon, Sigmoid; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Guanylate Cyclase; Humans; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth; Myenteric Plexus; Neurotransmitter Agents; Nitrergic Neurons; Nitric Acid; Nitric Oxide; Nitroarginine; Oxadiazoles; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Quinoxalines; Receptors, Purinergic P2; Statistics, Nonparametric; Suramin

2007
In vivo assessment of safety and mechanisms underlying in vitro relaxation induced by Mikania laevigata Schultz Bip. ex Baker in the rat trachea.
    Journal of ethnopharmacology, 2007, Jul-25, Volume: 112, Issue:3

    Topics: 4-Aminopyridine; Acetylcholine; Animals; Brazil; Coumarins; Dose-Response Relationship, Drug; Female; Gas Chromatography-Mass Spectrometry; Glyburide; In Vitro Techniques; Male; Mice; Mikania; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Oxadiazoles; Plant Extracts; Potassium Channel Blockers; Quinoxalines; Rats; Rats, Wistar; Tetraethylammonium; Toxicity Tests, Acute; Toxicity Tests, Chronic; Trachea

2007
Sulphonylureas induced vasorelaxation of mouse arteries.
    European journal of pharmacology, 2007, Dec-22, Volume: 577, Issue:1-3

    Topics: Adamantane; Animals; Arteries; Endothelium, Vascular; Glyburide; In Vitro Techniques; KATP Channels; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Morpholines; Muscle Relaxation; Muscle, Smooth, Vascular; Oxadiazoles; Phenylephrine; Potassium Channel Blockers; Quinoxalines; Sulfonylurea Compounds; Vascular Resistance; Vasoconstrictor Agents

2007
Peroxynitrite inhibits the expression of G(i)alpha protein and adenylyl cyclase signaling in vascular smooth muscle cells.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 294, Issue:2

    Topics: Adenylyl Cyclase Inhibitors; Animals; Aorta, Thoracic; Blotting, Western; Carbazoles; Cells, Cultured; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Indoles; Mitogen-Activated Protein Kinases; Muscle Relaxation; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxadiazoles; Peroxynitrous Acid; Quinoxalines; Rats; Receptor, Angiotensin, Type 1; Receptors, Atrial Natriuretic Factor; Signal Transduction

2008
Tetrahydropyrrolo[1,2-a]quinoxalines and tetrahydropyrrolo[1,2-a]pyrido[3,2-a]pyrazines: vascular smooth muscle relaxants and antihypertensive agents.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

    Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Chemical Phenomena; Chemistry; Female; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mass Spectrometry; Muscle Relaxation; Muscle, Smooth, Vascular; Neuromuscular Depolarizing Agents; Optical Rotation; Pyrazines; Pyrroles; Quinoxalines; Rabbits; Spectrophotometry, Infrared; Structure-Activity Relationship

1984
Adrenoceptor-stimulated endothelium-dependent relaxation in porcine intrapulmonary arteries.
    Pulmonary pharmacology, 1994, Volume: 7, Issue:5

    Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Arginine; Brimonidine Tartrate; Dose-Response Relationship, Drug; Endothelium, Vascular; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Prazosin; Pulmonary Artery; Quinoxalines; Swine; Yohimbine

1994
Sensory nerve-mediated relaxation of guinea-pig isolated pulmonary artery: prejunctional modulation by alpha 2-adrenoceptor agonists but not sumatriptan.
    British journal of pharmacology, 1993, Volume: 109, Issue:1

    Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcitonin Gene-Related Peptide; Electric Stimulation; Guinea Pigs; Histamine; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Neuromuscular Junction; Neurons, Afferent; Piperazines; Pulmonary Artery; Pyrrolidines; Quinoxalines; Substance P; Sulfonamides; Sumatriptan; Vasoconstrictor Agents; Yohimbine

1993
N-methyl-D-aspartate (NMDA)-mediated muscle relaxant action of dextromethorphan in rats.
    Neuroreport, 1993, Volume: 4, Issue:7

    Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Dextromethorphan; Electric Stimulation; Electromyography; H-Reflex; Injections, Intraperitoneal; Injections, Spinal; Male; Muscle Relaxation; Muscles; N-Methylaspartate; Quinoxalines; Rats; Rats, Wistar; Reflex, Stretch

1993
Inhibition of nitrergic relaxations by a selective inhibitor of the soluble guanylate cyclase.
    British journal of pharmacology, 1996, Volume: 118, Issue:1

    Topics: Animals; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Oxadiazoles; Quinoxalines; Rabbits; Solubility; Synaptic Transmission

1996
Inhibitory transmission to the longitudinal muscle of the mouse caecum is mediated largely by nitric oxide acting via soluble guanylyl cyclase.
    Journal of the autonomic nervous system, 1996, Nov-06, Volume: 61, Issue:2

    Topics: Animals; Cecum; Electric Stimulation; Enzyme Inhibitors; Guanylate Cyclase; Histocytochemistry; Immunohistochemistry; Mice; Mice, Inbred DBA; Muscle Relaxation; Muscle, Smooth; NADPH Dehydrogenase; Neural Inhibition; Neurotransmitter Agents; Nitric Oxide; Nitroprusside; omega-N-Methylarginine; Oxadiazoles; Oxyhemoglobins; Quinoxalines; Solubility; Vasodilator Agents

1996
Selective guanylyl cyclase inhibitor reverses nitric oxide-induced vasorelaxation.
    Hypertension (Dallas, Tex. : 1979), 1997, Volume: 29, Issue:1 Pt 2

    Topics: Animals; Aorta; COS Cells; Cyclic GMP; Guanosine Triphosphate; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Nitroso Compounds; Oxadiazoles; Oxidation-Reduction; Phenylephrine; Quinoxalines; Rats; Rats, Sprague-Dawley; Xanthine; Xanthine Oxidase; Xanthines

1997
The soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one (ODQ) inhibits relaxation of rabbit aortic rings induced by carbon monoxide, nitric oxide, and glyceryl trinitrate.
    Canadian journal of physiology and pharmacology, 1997, Volume: 75, Issue:8

    Topics: Animals; Aorta; Carbon Monoxide; Enzyme Inhibitors; Guanylate Cyclase; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Oxadiazoles; Quinoxalines; Rabbits

1997
Gender differences in endothelium-dependent relaxations do not involve NO in porcine coronary arteries.
    The American journal of physiology, 1997, Volume: 273, Issue:5

    Topics: Adrenergic alpha-Agonists; Animals; Bradykinin; Brimonidine Tartrate; Calcimycin; Cholesterol; Coronary Vessels; Endothelium, Vascular; Estradiol; Female; In Vitro Techniques; Indomethacin; Isometric Contraction; Lipoproteins; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Ovariectomy; Progesterone; Prostaglandins; Quinoxalines; Sex Characteristics; Sexual Maturation; Swine; Testosterone

1997
Nitric oxide and cyclic nucleotides participate in the relaxation of diclofenac on rat uterine smooth muscle.
    General pharmacology, 1998, Volume: 30, Issue:1

    Topics: Adenylyl Cyclases; Animals; Cyclic GMP; Cyclooxygenase Inhibitors; Diclofenac; Drug Interactions; Enzyme Inhibitors; Female; GTP-Binding Proteins; Molsidomine; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Nucleotides, Cyclic; omega-N-Methylarginine; Oxadiazoles; Pertussis Toxin; Quinoxalines; Rats; Rats, Wistar; Sensitivity and Specificity; Sulfonamides; Uterine Contraction; Uterus; Vanadates; Vasodilator Agents; Virulence Factors, Bordetella

1998
Responses of carotid artery in mice deficient in expression of the gene for endothelial NO synthase.
    The American journal of physiology, 1998, Volume: 274, Issue:2

    Topics: Acetylcholine; Animals; Carotid Arteries; Endothelium, Vascular; Enzyme Inhibitors; Gene Deletion; Gene Targeting; Heterozygote; Homozygote; Mice; Mice, Mutant Strains; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Oxadiazoles; Quinoxalines; Vasodilator Agents

1998
Blockade of nitrergic neuroeffector transmission in guinea-pig colon by a selective inhibitor of soluble guanylyl cyclase.
    Acta physiologica Scandinavica, 1998, Volume: 162, Issue:1

    Topics: Animals; Colon; Electrophysiology; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Oxadiazoles; Quinoxalines; Solubility; Synaptic Transmission

1998
The effect of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) and charybdotoxin (CTX) on relaxations of isolated cerebral arteries to nitric oxide.
    Brain research, 1998, Feb-23, Volume: 785, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Bradykinin; Cerebral Arteries; Charybdotoxin; Colforsin; Cyclic GMP; Dogs; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Hydrazines; In Vitro Techniques; Isometric Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitrogen Oxides; Oxadiazoles; Quinoxalines; Uridine Triphosphate

1998
Dissociation between electrical and mechanical responses to nitrergic stimulation in the canine gastric fundus.
    The Journal of physiology, 1998, Jun-01, Volume: 509 ( Pt 2)

    Topics: Animals; Arginine; Atropine; Calcium; Cytosol; Dogs; Electric Stimulation; Female; Gastric Fundus; Guanylate Cyclase; In Vitro Techniques; Male; Membrane Potentials; Muscle Relaxation; Muscle, Smooth; Nicardipine; Nitric Oxide; Nitroprusside; Oxadiazoles; Oxyhemoglobins; Phentolamine; Propranolol; Quaternary Ammonium Compounds; Quinoxalines; Stomach; Synaptic Transmission; Time Factors

1998
Involvement of bradykinin B1 and B2 receptors in relaxation of mouse isolated trachea.
    British journal of pharmacology, 1998, Volume: 123, Issue:7

    Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Dinoprostone; Enzyme Inhibitors; Female; Guanylate Cyclase; In Vitro Techniques; Indomethacin; Male; Mice; Mice, Inbred BALB C; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Oxadiazoles; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Bradykinin; Trachea

1998
Nitrergic relaxation of the horse corpus cavernosum. Role of cGMP.
    European journal of pharmacology, 1998, Jun-12, Volume: 351, Issue:1

    Topics: Adenosine Triphosphate; Animals; Calcium; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Horses; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; NADPH Dehydrogenase; Nerve Fibers; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Penis; Potassium Channels; Quinoxalines; Tetrodotoxin

1998
Alpha2-adrenoceptor-mediated contractions of the porcine isolated ear artery: evidence for a cyclic AMP-dependent and a cyclic AMP-independent mechanism.
    British journal of pharmacology, 1998, Volume: 124, Issue:6

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenergic alpha-Agonists; Angiotensin II; Animals; Arteries; Brimonidine Tartrate; Colforsin; Cyclic AMP; Ear; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Nitroprusside; Quinoxalines; Receptors, Adrenergic, alpha-2; Swine

1998
Modulation of relaxation to levcromakalim by S-nitroso-N-acetylpenicillamine (SNAP) and 8-bromo cyclic GMP in the rat isolated mesenteric artery.
    British journal of pharmacology, 1998, Volume: 124, Issue:6

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cromakalim; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Relaxation; Oxadiazoles; Penicillamine; Quinoxalines; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine

1998
Influence of a selective guanylate cyclase inhibitor, and of the contraction level, on nitrergic relaxations in the gastric fundus.
    British journal of pharmacology, 1998, Volume: 124, Issue:7

    Topics: Animals; Chymotrypsin; Electric Stimulation; Enzyme Inhibitors; Gastric Fundus; Guanylate Cyclase; Muscle Contraction; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar

1998
Relaxant effects of L-citrulline in rabbit vascular smooth muscle.
    British journal of pharmacology, 1998, Volume: 125, Issue:1

    Topics: Animals; Aorta; Cells, Cultured; Citrulline; Cyclic GMP; Dexamethasone; Endothelium, Vascular; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Polysaccharides; Potassium Channels; Purinones; Quinoxalines; Rabbits

1998
Comparison of two soluble guanylyl cyclase inhibitors, methylene blue and ODQ, on sodium nitroprusside-induced relaxation in guinea-pig trachea.
    British journal of pharmacology, 1998, Volume: 125, Issue:6

    Topics: Animals; Cyclic GMP; Drug Interactions; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; Methylene Blue; Mice; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Oxadiazoles; Quinoxalines; Signal Transduction; Solubility; Trachea; Vasodilator Agents

1998
Nitrergic neurotransmission mediates the non-adrenergic non-cholinergic responses in the clitoral corpus cavernosum of the rabbit.
    British journal of pharmacology, 1998, Volume: 125, Issue:8

    Topics: Animals; Arginine; Clitoris; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Female; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Penile Erection; Penis; Purinones; Quinoxalines; Rabbits; Synaptic Transmission; Tetrodotoxin

1998
Evidence that additional mechanisms to cyclic GMP mediate the decrease in intracellular calcium and relaxation of rabbit aortic smooth muscle to nitric oxide.
    British journal of pharmacology, 1998, Volume: 125, Issue:8

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Angiotensin II; Animals; Aorta; Calcium; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Manganese; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Oxadiazoles; Phosphodiesterase Inhibitors; Protein Kinase C; Purinones; Quinoxalines; Rabbits; Thionucleotides; Vasoconstrictor Agents; Vasodilator Agents

1998
Interaction of ethanol with excitatory amino acid receptor antagonists in mice.
    European journal of pharmacology, 1999, Mar-05, Volume: 368, Issue:2-3

    Topics: Animals; Ataxia; Behavior, Animal; Benzodiazepines; Central Nervous System Depressants; Chlordiazepoxide; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Excitatory Amino Acid Antagonists; Hypnotics and Sedatives; Isoquinolines; Male; Mice; Muscle Relaxation; Pentobarbital; Piperazines; Pregnanolone; Psychomotor Performance; Quinoxalines; Receptors, Glutamate; Tetrazoles

1999
Effects of the soluble guanylyl cyclase activator, YC-1, on vascular tone, cyclic GMP levels and phosphodiesterase activity.
    British journal of pharmacology, 1999, Volume: 127, Issue:1

    Topics: Animals; Aorta, Thoracic; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indazoles; Isoenzymes; Kinetics; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Oxadiazoles; Phosphoric Diester Hydrolases; Quinoxalines; Rabbits; Vasodilator Agents

1999
A study of NPY-mediated contractions of the porcine isolated ear artery.
    British journal of pharmacology, 1999, Volume: 127, Issue:1

    Topics: Adenylyl Cyclases; Adrenergic alpha-Agonists; Angiotensin II; Animals; Brimonidine Tartrate; Colforsin; Cyclic AMP; Ear, External; In Vitro Techniques; Isometric Contraction; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Neuropeptide Y; Nitroprusside; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Neuropeptide Y; Regional Blood Flow; Swine; Vasoconstrictor Agents; Vasodilator Agents

1999
Characterisation of nitrergic transmission in the isolated anococcygeus muscle of the female mouse.
    European journal of pharmacology, 1999, Jul-14, Volume: 377, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Catechols; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Estrus; Female; Guanylate Cyclase; In Vitro Techniques; Mice; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Phosphodiesterase Inhibitors; Purinones; Quinoxalines; Synaptic Transmission; Vasoactive Intestinal Peptide; Vasodilator Agents

1999
Evidence that nitric oxide acts as an inhibitory neurotransmitter supplying taenia from the guinea-pig caecum.
    British journal of pharmacology, 1999, Volume: 127, Issue:6

    Topics: Animals; Cecum; Dimethylphenylpiperazinium Iodide; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; In Vitro Techniques; Muscle Relaxation; Neurotransmitter Agents; Nicotinic Agonists; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Nitroprusside; Oxadiazoles; Quinoxalines; Tetrodotoxin; Vasodilator Agents

1999
Pranidipine enhances relaxation produced by endothelium-derived relaxing factor in carotid artery.
    European journal of pharmacology, 1999, Dec-03, Volume: 385, Issue:2-3

    Topics: Acetylcholine; Animals; Calcium Channel Blockers; Carotid Arteries; Dihydropyridines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Membrane Potentials; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroarginine; Nitroprusside; Norepinephrine; Oxadiazoles; Potassium; Quinoxalines; Vasoconstrictor Agents; Vasodilator Agents

1999
Pharmacological evidence for both neuronal and smooth muscular PAC1 receptors and a VIP-specific receptor in rat colon.
    Regulatory peptides, 1999, Dec-23, Volume: 85, Issue:2-3

    Topics: Animals; Apamin; Colon; Female; Indazoles; Muscle Relaxation; Muscle, Smooth; Myenteric Plexus; Neuropeptides; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Pituitary Adenylate Cyclase-Activating Polypeptide; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I; Receptors, Pituitary Hormone; Receptors, Vasoactive Intestinal Peptide; Tetrodotoxin; Vasoactive Intestinal Peptide

1999
Effects of superoxide anion generators and thiol modulators on nitrergic transmission and relaxation to exogenous nitric oxide in the sheep urethra.
    British journal of pharmacology, 2000, Volume: 129, Issue:1

    Topics: Animals; Ascorbate Oxidase; Benzoates; Ditiocarb; Electric Stimulation; Enzyme Inhibitors; Female; Guanylate Cyclase; Imidazoles; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Oxadiazoles; Quinoxalines; Sheep; Sulfhydryl Compounds; Superoxide Dismutase; Superoxides; Synaptic Transmission; Urethra

2000
Nitric oxide, prostanoid and non-NO, non-prostanoid involvement in acetylcholine relaxation of isolated human small arteries.
    British journal of pharmacology, 2000, Volume: 129, Issue:1

    Topics: Acetylcholine; Adenylyl Cyclase Inhibitors; Animals; Arteries; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Enzyme Inhibitors; Humans; In Vitro Techniques; Male; Membrane Potentials; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Norepinephrine; Oxadiazoles; Oxyhemoglobins; Penicillamine; Potassium; Prostaglandins; Quinoxalines; Rats; Rats, Wistar; Regional Blood Flow; S-Nitroso-N-Acetylpenicillamine; Skin; Vasoconstrictor Agents

2000
Spontaneous photo-relaxation of urethral smooth muscle from sheep, pig and rat and its relationship with nitrergic neurotransmission.
    The Journal of physiology, 2000, Feb-01, Volume: 522 Pt 3

    Topics: Adenine; Animals; Citrulline; Cold Temperature; Culture Techniques; Electric Stimulation; Enzyme Inhibitors; Female; Light; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Oxadiazoles; Oxyhemoglobins; Phosphodiesterase Inhibitors; Photic Stimulation; Potassium; Purinones; Quinoxalines; Rats; Rats, Wistar; Sheep; Superoxides; Swine; Synaptic Transmission; Tetrodotoxin; Thiourea; Time Factors; Urethra

2000
Nitrergic relaxation of the mouse gastric fundus is mediated by cyclic GMP-dependent and ryanodine-sensitive mechanisms.
    British journal of pharmacology, 2000, Volume: 129, Issue:7

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Animals; Caffeine; Calcium Channel Blockers; Cyclic GMP; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Gastric Fundus; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Muscle Relaxation; Muscle, Smooth; Nifedipine; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Oxadiazoles; Quinoxalines; Ryanodine

2000
Interplay between nitric oxide and vasoactive intestinal polypeptide in the pig gastric fundus smooth muscle.
    European journal of pharmacology, 2000, Jun-02, Volume: 397, Issue:2-3

    Topics: Adenine; Adenylyl Cyclase Inhibitors; Amidines; Animals; Arginine; Benzylamines; Carbazoles; Colforsin; Cyclic AMP; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gastric Fundus; In Vitro Techniques; Indoles; Isoquinolines; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroarginine; Oxadiazoles; Protein Kinase Inhibitors; Pyrroles; Quinoxalines; Sulfonamides; Swine; Thionucleotides; Vasoactive Intestinal Peptide

2000
1H-[1,2,4] oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) inhibits cyclic GMP-PKG pathway-independent nonadrenergic, noncholinergic relaxation in longitudinal muscle of the rectum of Wistar-ST rats.
    Japanese journal of pharmacology, 2000, Volume: 82, Issue:2

    Topics: Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Relaxation; Neuropeptides; Nitroarginine; Oxadiazoles; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Quinoxalines; Rats; Rats, Wistar; Rectum; Vasoactive Intestinal Peptide

2000
Sildenafil relaxes rabbit clitoral corpus cavernosum.
    Life sciences, 2000, May-26, Volume: 67, Issue:1

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Clitoris; Electric Stimulation; Female; Guanylate Cyclase; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Phosphodiesterase Inhibitors; Piperazines; Purines; Quinoxalines; Rabbits; Sildenafil Citrate; Sulfones; Synaptic Transmission; Tetrodotoxin

2000
Short-term treatment with transdermal nicotine affects the function of canine saphenous veins.
    Vascular medicine (London, England), 2000, Volume: 5, Issue:2

    Topics: Administration, Cutaneous; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcimycin; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Isometric Contraction; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nicotine; Nitric Oxide; omega-N-Methylarginine; Potassium Chloride; Quinoxalines; Saphenous Vein

2000
Abnormal activation of K(+) channels in aortic smooth muscle of rats with endotoxic shock: electrophysiological and functional evidence.
    British journal of pharmacology, 2000, Volume: 131, Issue:2

    Topics: Animals; Aorta; Apamin; Benzimidazoles; Charybdotoxin; Drug Interactions; Enzyme Inhibitors; Glyburide; Hypoglycemic Agents; Hypotension; Lipopolysaccharides; Male; Membrane Potentials; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Oxadiazoles; Pinacidil; Potassium Channels; Quinoxalines; Rats; Rats, Inbred WKY; Shock, Septic; Tetraethylammonium; Vasodilation; Vasodilator Agents

2000
Pharmacological profile of T-1032, a novel specific phosphodiesterase type 5 inhibitor, in isolated rat aorta and rabbit corpus cavernosum.
    European journal of pharmacology, 2001, Jan-05, Volume: 411, Issue:1-2

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta, Thoracic; Arginine; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Isoproterenol; Isoquinolines; Male; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitroprusside; Oxadiazoles; Papaverine; Penis; Phenylephrine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Pyridines; Quinoxalines; Rabbits; Rats; Rats, Wistar; Sildenafil Citrate; Sulfones; Tetrodotoxin; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents

2001
Modulation of nitrergic relaxant responses by peptides in the mouse gastric fundus.
    Regulatory peptides, 2001, Apr-02, Volume: 98, Issue:1-2

    Topics: Animals; Apamin; Carbachol; Cholinergic Agonists; Chymotrypsin; Electric Stimulation; Enzyme Inhibitors; Gastric Fundus; Guanylate Cyclase; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle Relaxation; Neuropeptides; Neurotransmitter Agents; Nitroarginine; Oxadiazoles; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Quinoxalines; Vasoactive Intestinal Peptide

2001
Effect of peroxynitrite on motor function of the opossum esophagus.
    Digestive diseases and sciences, 2001, Volume: 46, Issue:1

    Topics: Animals; Enzyme Inhibitors; Esophagitis; Esophagogastric Junction; Female; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Nitrates; Opossums; Oxadiazoles; Oxidants; Oxyhemoglobins; Quinoxalines; Tyrosine

2001
Effects of dietary L-arginine on structure and function of flow-restricted vein grafts.
    Journal of vascular surgery, 2001, Volume: 33, Issue:4

    Topics: Adrenergic alpha-Agonists; Amino Acids; Animals; Arginine; Blood Flow Velocity; Brimonidine Tartrate; Calcimycin; Constriction, Pathologic; Dietary Supplements; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; Femoral Artery; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Quinoxalines; Saphenous Vein; Vascular Patency

2001
Imidazo[1,2-a]quinoxalines: synthesis and cyclic nucleotide phosphodiesterase inhibitory activity.
    European journal of medicinal chemistry, 2001, Volume: 36, Issue:3

    Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Cardiotonic Agents; Cattle; Enzyme Inhibitors; Guinea Pigs; Inhibitory Concentration 50; Isoenzymes; Magnetic Resonance Spectroscopy; Male; Muscle Relaxation; Muscle, Smooth; Nitriles; Pyrazines; Quinoxalines; Structure-Activity Relationship

2001
Mechanism of carbon monoxide-induced relaxation in the guinea pig ileal smooth muscle.
    The Journal of veterinary medical science, 2001, Volume: 63, Issue:4

    Topics: Animals; Calcium; Calcium Channels; Carbon Monoxide; Cyclic GMP; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Patch-Clamp Techniques; Potassium Chloride; Quinoxalines; Signal Transduction

2001
The influence of nitric oxide donors on the responses to nitrergic nerve stimulation in the mouse duodenum.
    European journal of pharmacology, 2001, Jun-08, Volume: 421, Issue:2

    Topics: Animals; Dose-Response Relationship, Drug; Duodenum; Electric Stimulation; Enzyme Inhibitors; Ethylmaleimide; Female; Hemoglobins; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Nitroglycerin; Nitroprusside; Oxadiazoles; Quinoxalines; Thiazines

2001
The relaxation induced by S-nitroso-glutathione and S-nitroso-N-acetylcysteine in rat aorta is not related to nitric oxide production.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 298, Issue:2

    Topics: Acetylcysteine; Animals; Aorta, Thoracic; Endothelium, Vascular; Enzyme Inhibitors; Glutathione; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroso Compounds; Oxadiazoles; Phenylephrine; Potassium Channel Blockers; Potassium Chloride; Quinoxalines; Rats; Rats, Wistar; Ryanodine; S-Nitrosoglutathione; Thapsigargin; Vasoconstrictor Agents; Vasodilation

2001
Phentolamine mesylate relaxes rabbit corpus cavernosum by a nonadrenergic, noncholinergic mechanism.
    Fundamental & clinical pharmacology, 2001, Volume: 15, Issue:1

    Topics: Adrenergic alpha-Antagonists; Animals; Cyclic GMP-Dependent Protein Kinases; Electric Stimulation; Enzyme Activation; Enzyme Inhibitors; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Penis; Phentolamine; Quinoxalines; Rabbits; Tetrodotoxin

2001
Dual mechanism of action of nicorandil on rabbit corpus cavernosal smooth muscle tone.
    International journal of impotence research, 2001, Volume: 13, Issue:4

    Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Animals; Enzyme Activation; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nicorandil; Nitroprusside; Oxadiazoles; Penis; Phenylephrine; Potassium Channels; Quinoxalines; Rabbits; Vasodilator Agents

2001
Actions of NO donors and endogenous nitrergic transmitter on the longitudinal muscle of rat ileum in vitro: mechanisms involved.
    Life sciences, 2001, Jul-27, Volume: 69, Issue:10

    Topics: Animals; Apamin; Atropine; Calcium Channels; Charybdotoxin; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Ileum; Molsidomine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nifedipine; Nitric Oxide; Nitroprusside; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Tetrodotoxin

2001
NO-induced relaxation of labouring and non-labouring human myometrium is not mediated by cyclic GMP.
    British journal of pharmacology, 2001, Volume: 134, Issue:1

    Topics: Charybdotoxin; Cyclic GMP; Cysteine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanylate Cyclase; Humans; In Vitro Techniques; Labor, Obstetric; Molsidomine; Muscle Relaxation; Muscle, Smooth; Myometrium; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Oxadiazoles; Oxytocin; Penicillamine; Peptides; Pregnancy; Quinoxalines; S-Nitrosothiols; Scorpion Venoms; Time Factors; Uterus

2001
Mechanism of a nitric oxide donor NOR 1-induced relaxation in longitudinal muscle of rat proximal colon.
    Japanese journal of pharmacology, 2001, Volume: 86, Issue:4

    Topics: Animals; Calcium; Carbachol; Colon; Culture Techniques; Cyclic GMP; DNA-Binding Proteins; Dose-Response Relationship, Drug; Male; Models, Biological; Muscle Contraction; Muscle Relaxation; Muscle, Skeletal; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Thapsigargin; Thionucleotides

2001
Relaxation and modulation of cyclic AMP production in response to atrial natriuretic peptides in guinea pig tracheal smooth muscle.
    European journal of pharmacology, 2001, Nov-02, Volume: 430, Issue:2-3

    Topics: Adenylyl Cyclases; Animals; Apamin; Atrial Natriuretic Factor; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Natriuretic Peptide, C-Type; Nitroprusside; Oxadiazoles; Peptide Fragments; Peptides; Phosphodiesterase Inhibitors; Potassium Channel Blockers; Quinoxalines; Rolipram; Trachea

2001
Differential responses of newborn pulmonary arteries and veins to atrial and C-type natriuretic peptides.
    American journal of physiology. Heart and circulatory physiology, 2002, Volume: 282, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Atrial Natriuretic Factor; Cyclic GMP; Gene Expression Regulation; Guanylate Cyclase; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Natriuretic Peptide, C-Type; Nitric Oxide; Oxadiazoles; Pulmonary Artery; Pulmonary Veins; Quinoxalines; Receptors, Atrial Natriuretic Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sheep; Transcription, Genetic

2002
Role of catalase in the smooth muscle relaxant actions of sodium azide and cyanamide.
    European journal of pharmacology, 2002, Jan-18, Volume: 435, Issue:1

    Topics: Amitrole; Animals; Aorta; Catalase; Cattle; Cyanamide; Electrochemistry; Enzyme Inhibitors; Hemoglobins; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitrites; Nitrogen Oxides; Oxadiazoles; Penis; Quinoxalines; Rats; Rats, Wistar; Sodium Azide; Spectrophotometry

2002
Characterization of the non-nitrergic NANC relaxation responses in the rabbit vaginal wall.
    British journal of pharmacology, 2002, Volume: 135, Issue:2

    Topics: Adrenergic Fibers; Animals; Cholinergic Fibers; Chymotrypsin; Electric Stimulation; Enzyme Inhibitors; Female; In Vitro Techniques; Muscle Relaxation; Neuropeptides; Nitrergic Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxadiazoles; Perfusion; Quinoxalines; Rabbits; Rats; Rats, Sprague-Dawley; Vagina

2002
Okadaic acid inhibits relaxant neural transmission in rat gastric fundus in vitro.
    Acta physiologica Scandinavica, 2002, Volume: 175, Issue:1

    Topics: Animals; Carbazoles; Electric Stimulation; Enzyme Inhibitors; Gastric Fundus; Gastrointestinal Agents; Hydrazines; In Vitro Techniques; Indoles; Male; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Nitrogen Oxides; Okadaic Acid; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoprotein Phosphatases; Purinones; Pyrroles; Quinoxalines; Rats; Rats, Wistar; Synaptic Transmission; Vasoactive Intestinal Peptide

2002
Roles of guanylate cyclase in responses to myogenic and neural nitric oxide in canine lower esophageal sphincter.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 301, Issue:3

    Topics: Animals; Dogs; Enzyme Inhibitors; Esophagogastric Junction; Female; Guanylate Cyclase; Male; Muscle Relaxation; Muscle Tonus; Nerve Fibers; Nitric Oxide; Oxadiazoles; Patch-Clamp Techniques; Potassium Channel Blockers; Quinoxalines; Tetraethylammonium Compounds

2002
Modulation of non-adrenergic non-cholinergic inhibitory neurotransmission in rat gastric fundus by the alpha 2-adrenoceptor agonist, UK-14,304.
    British journal of pharmacology, 1992, Volume: 107, Issue:1

    Topics: Adrenergic alpha-Agonists; Animals; Autonomic Nervous System; Brimonidine Tartrate; Electric Stimulation; Gastric Fundus; In Vitro Techniques; Male; Muscle Relaxation; Nitric Oxide; Prazosin; Quinoxalines; Rats; Rats, Wistar; Synaptic Transmission; Vasoactive Intestinal Peptide; Yohimbine

1992
Novel compounds possessing potent cAMP and cGMP phosphodiesterase inhibitory activity. Synthesis and cardiovascular effects of a series of imidazo[1,2-a]quinoxalinones and imidazo[1,5-a]quinoxalinones and their aza analogues.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:9

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aza Compounds; Cardiotonic Agents; Dogs; Heart; Imidazoles; In Vitro Techniques; Molecular Structure; Muscle Relaxation; Muscle, Smooth, Vascular; Quinoxalines

1991
Natural course of the impairment of endothelium-dependent relaxations after balloon endothelium removal in porcine coronary arteries. Possible dysfunction of a pertussis toxin-sensitive G protein.
    Circulation research, 1989, Volume: 65, Issue:3

    Topics: Adenosine Diphosphate; Animals; Antihypertensive Agents; Blood Platelets; Bradykinin; Brimonidine Tartrate; Calcimycin; Coronary Vessels; Dinoprost; Endothelium, Vascular; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Pertussis Toxin; Potassium Chloride; Quinoxalines; Serotonin; Swine; Thrombin; Virulence Factors, Bordetella

1989
Pertussis toxin inhibits endothelium-dependent relaxations to certain agonists in porcine coronary arteries.
    The Journal of physiology, 1989, Volume: 408

    Topics: Adenylate Cyclase Toxin; Animals; Brimonidine Tartrate; Coronary Vessels; Endothelium, Vascular; Male; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Oxyhemoglobins; Pertussis Toxin; Platelet Aggregation; Quinoxalines; Serotonin; Swine; Thrombin; Virulence Factors, Bordetella

1989
Endothelium-dependent responses in autogenous femoral veins grafted into the arterial circulation of the dog.
    The Journal of clinical investigation, 1987, Volume: 80, Issue:5

    Topics: Acetylcholine; Adenosine Diphosphate; Adrenergic alpha-Agonists; Animals; Arachidonic Acid; Arachidonic Acids; Arteries; Brimonidine Tartrate; Calcimycin; Dogs; Endothelium; Femoral Vein; Indomethacin; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Quinoxalines; Thrombin

1987
Endothelial alpha 2-adrenoceptors in canine pulmonary and systemic blood vessels.
    European journal of pharmacology, 1985, Nov-26, Volume: 118, Issue:1-2

    Topics: Animals; Antihypertensive Agents; Brimonidine Tartrate; Dogs; Endothelium; Female; In Vitro Techniques; Isometric Contraction; Lung; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Pulmonary Artery; Pulmonary Veins; Quinoxalines; Receptors, Adrenergic, alpha

1985
Influence of the vascular endothelium on agonist-induced contractions and relaxations in rat aorta.
    British journal of pharmacology, 1986, Volume: 89, Issue:4

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Antihypertensive Agents; Aorta, Thoracic; Brimonidine Tartrate; Cyclic GMP; Endothelium; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Prostaglandin Endoperoxides, Synthetic; Quinoxalines; Rats; Rats, Inbred Strains

1986