quinoxalines has been researched along with Muscle Contraction in 163 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (14.72) | 18.7374 |
| 1990's | 66 (40.49) | 18.2507 |
| 2000's | 59 (36.20) | 29.6817 |
| 2010's | 13 (7.98) | 24.3611 |
| 2020's | 1 (0.61) | 2.80 |
| Authors | Studies |
|---|---|
| Alsufyani, HA; Docherty, JR; McCormick, PA | 1 |
| Acharya, A; Chaudhari, U; Hengstler, JG; Hescheler, J; Nemade, H; Papadopoulos, S; Sachinidis, A | 1 |
| Birulina, YG; Gusakova, SV; Kovalev, IV; Nosarev, AV; Petrova, IV; Rydchenko, VS; Smagliy, LV; Yartseva, YO | 1 |
| Gajdus, M; Grzesk, G; Malinowski, B; Szadujkis-Szadurska, K; Szadujkis-Szadurski, L; Wicinski, M | 1 |
| Gashev, AA; Gasheva, OY; Zawieja, DC | 1 |
| Abd Elmageed, ZY; Abdel-Mageed, AB; Gur, S; Hellstrom, WJ; Kadowitz, PJ; Pankey, E; Rezk, B; Sikka, SC | 1 |
| Acheson, AG; Dashwood, MR; Eames, T; Gruss, H; Henry, Y; Rayment, SJ; Scholefield, JH; Simpson, JA; Wilson, VG | 1 |
| Baccari, MC; Francini, F; Garella, R; Idrizaj, E; Nistri, S; Squecco, R | 1 |
| Adachi, T; Fujisawa, S; Hongoh, M; Ohba, T; Ono, K; Shimbo, T | 1 |
| Antunes, E; Priviero, FB; Teixeira, CE; Toque, HA; Webb, RC; Zemse, SM | 1 |
| Chen, QZ; Gao, PJ; Guo, SJ; Han, WQ; Wu, LY; Zhu, DL | 1 |
| Antunes, E; De Nucci, G; Mónica, FZ; Morganti, RP; Toque, HA | 1 |
| Man, RY; Ng, KF; Vanhoutte, PM; Wong, ES | 1 |
| Deng, J; Feng, E; Huang, H; Jiang, H; Li, H; Li, J; Liu, H; Liu, X; Ma, S; Miao, L; Shen, X; Zhang, Y; Zhu, J; Zhu, W | 1 |
| Leite-Moreira, AF; Pinho, M; Pires, AL; Seica, R; Sena, CM | 1 |
| Mathias, R; von der Weid, PY | 1 |
| Carter, RW; Kanagy, NL | 1 |
| Beretta, C; Carcano, R; Cavalli, M | 1 |
| Castillo, C; Castillo, EF; Gil-Gastelum, O; Larios, FJ; Valencia, I | 1 |
| Castillo, C; Castillo, EF; Gil-Gastelum, O; López, O; Medina, R | 1 |
| Brioni, JD; Hsieh, GC; Moreland, RB; O'Neill, AB; Sullivan, JP | 1 |
| Artigues-Varin, C; Mulder, P; Richard, V; Thuillez, C; Varin, R | 1 |
| Barbara, G; Baschiera, F; Blandizzi, C; Breschi, MC; Colucci, R; De Giorgio, R; De Ponti, F; Del Tacca, M; Fornai, M | 1 |
| Chen, KH; Chen, SJ; Webb, RC; Wu, CC; Yen, MH | 1 |
| Ishiguro, S; Miyamoto, A; Nishio, A; Takagi, T; Yamazaki, Y | 1 |
| Carlin, AM; Kerkar, S; Steffes, CP; Tyburski, JG; Williams, M; Wilson, RF | 1 |
| Antunes, E; Baracat, JS; De Nucci, G; de Oliveira, JF; Fregonesi, A; Okuyama, CE; Priviero, FB; Rodrigues Netto, N; Teixeira, CE | 1 |
| Gillespie, JI | 1 |
| Gonick, HC; Merlic, CA; Shelkovnikov, S | 1 |
| Khalil, RA; Orshal, JM | 1 |
| Bouthillier, J; Fortin, JP; Marceau, F; Morissette, G; Otis, S | 1 |
| Mahesh, R; Pandi, PV; Perumal, RV | 1 |
| Duenes, JA; Sarr, MG; Ueno, T; Zarroug, AE | 1 |
| Bendhack, LM; Sendão Oliveira, AP | 1 |
| Atkinson, J; Giummelly, P; Mansard, A; Wang, C | 1 |
| Ertunc, M; Onur, R; Sara, Y | 1 |
| Ekerhovd, E; Norström, A | 1 |
| Bawankule, DU; Chanda, D; Krishna, AV; Mishra, SK; Prakash, VR; Sardar, KK; Sathishkumar, K | 1 |
| Ahn, DS; Chung, SS; Lee, HG; Lee, YH; Nam, TS | 1 |
| Amato, A; Corti, A; Mulè, F; Serio, R | 1 |
| Anctil, M; Pelletier, C; Poulain, I | 1 |
| Elmedal, B; Mulvany, MJ; Simonsen, U | 1 |
| Asada, Y; Kobayashi, H; Nao-i, N; Ohkura, M; Okano, M; Sawada, A; Tanaka, N; Uchikawa, Y; Wada, A; Yamamoto, R | 1 |
| Angeli, P; Buccioni, M; Giardinà, D; Gulini, U; Marucci, G; Melchiorre, C; Sagratini, G; Testa, R | 1 |
| Antunes, E; Baracat, JS; Claudino, MA; De Nucci, G; Priviero, FB; Teixeira, CE; Webb, RC | 1 |
| Abraham, NG; Bolognesi, M; Di Pascoli, M; Rodella, L; Sacerdoti, D; Turkseven, S | 1 |
| García, L; Grandoso, L; Pineda, J; Ugedo, L | 1 |
| Allison, BD; Barrett, T; Deng, X; Freedman, J; Hack, M; Hoey, K; King, C; Lagaud, G; Li, L; McAtee, LC; Morton, M; Phuong, VK; Pippel, M; Prendergast, C; Rabinowitz, MH; Rizzolio, MC; Rosen, M; Shankley, NP; Venkatesan, H; Woods, C; Wu, X | 1 |
| Richter, A; Sander, SE | 1 |
| Albani, M; Gougoulias, N; Kouvelas, D | 1 |
| Bendhack, LM; Rocha, ML | 1 |
| Cambridge, D | 1 |
| Chapleo, CB; Doxey, JC; Myers, PL | 1 |
| Shepperson, NB | 1 |
| Bogaert, MG; Lefebvre, RA; Verplanken, PA | 1 |
| Beckeringh, JJ; De Jonge, A; Thoolen, MJ; Timmermans, PB; Van Zwieten, PA; Wilffert, B | 1 |
| Cullinan, GJ; Fleisch, JH; Haisch, KD; Marshall, WS; Rinkema, LE; Schmidt, MJ; Spaethe, SM | 1 |
| Hicks, PE | 1 |
| Aburto, T; Deth, RC; Jinsi, A; Zhu, Q | 1 |
| Deth, RC; Jinsi, A | 1 |
| Galligan, JJ | 1 |
| Butler, A; Connor, HE; O'Shaughnessy, CT; Worton, SP | 1 |
| Abel, PW; Balasubramaniam, A; Conlon, JM; Porter, JE | 1 |
| Andersson, RG; Grundström, N; Johansson-Rydberg, IG | 1 |
| Guo, HY; Lorenz, RR; Vanhoutte, PM | 1 |
| Guimarães, S; Nunes, JP | 1 |
| Dodds, WJ; Lang, IM; Sarna, SK | 1 |
| Driessen, B; Starke, K; von Kügelgen, I | 1 |
| Hill, JM; Kaufman, MP; Pickar, JG | 1 |
| de Groat, WC; Sugaya, K | 1 |
| Deth, RC; Waen-Safranchik, VI | 1 |
| MacLean, MR; McCulloch, KM; McGrath, JC | 1 |
| Vanhoutte, PM; Wood, MB; Ye, Z | 1 |
| Nott, MW; Rand, MJ; Thaina, P | 2 |
| Calderó, JM; Del Castillo, JC; Del Río, J; Lasheras, B; Monge, A; Palop, JA; Roca, J; Romero, G | 1 |
| Flavahan, NA | 1 |
| Brown, DR; Malone, ED; Trent, AM; Turner, TA | 1 |
| Bryant, CE; Clarke, KW | 1 |
| Berjón, A; Del Río, J; Lasheras, B; Montañés, R; Ramírez, MJ; Roca, J; Romero, G | 1 |
| Deth, RC; Jinsi, A; Paradise, J | 1 |
| Adreani, CM; Hill, JM; Kaufman, MP | 1 |
| Boulanger, CM; Illiano, S; Marsault, R; Taddei, S; Vanhoutte, PM | 1 |
| Coupar, IM; Liu, L | 2 |
| Bertaccini, G; Poli, E; Pozzoli, C | 1 |
| Hansen, J; Thomas, GD; Victor, RG | 1 |
| Poli, E; Pozzoli, C | 1 |
| Furukawa, T; Morishita, H | 1 |
| Cellek, S; Moncada, S | 1 |
| Goldstein, I; Huang, YH; Moreland, RB; Traish, AM | 1 |
| Franck, H; Sanders, KM; Shuttleworth, CW; Sweeney, KM | 1 |
| Kanagy, NL | 1 |
| Campbell, WB; Jin, MW; Li, PL | 1 |
| Hebeiss, K; Kilbinger, H | 1 |
| Canning, BJ; Fischer, A | 1 |
| Gustafsson, LE; Hallén, K; Iversen, HH; Olgart, C; Wiklund, NP | 1 |
| Gallant, CM; Goldstein, I; Gupta, S; Moreland, RB; Traish, A; Yang, S | 1 |
| Kwan, CY; Mo, FM | 1 |
| Hole, K; Svendsen, F; Tjølsen, A | 1 |
| He, GW; Yang, CQ | 1 |
| Contreras, J; García-Sacristán, A; Hernández, M; López, PG; Prieto, D; Recio, P | 1 |
| Kendall, DA; Roberts, RE; Tomlinson, AE; Wilson, VG | 1 |
| Lefebvre, RA | 1 |
| Chen, SJ; Wu, CC; Yen, MH | 1 |
| Caudill, TK; Kanagy, NL; Resta, TC; Walker, BR | 1 |
| Ali, A; Cheng, HY; Ting, KN; Wilson, VG | 1 |
| Cena, C; Di Stilo, A; Ermondi, G; Gasco, A; Gasco, AM; Visentin, S | 1 |
| Galle, J; Hatzelmann, A; Hübner, U; Schmidt, HH; Wagner, B; Wanner, C; Zabel, U | 1 |
| Kendall, DA; Roberts, RE; Wilson, VG | 1 |
| D'Angelo, S; Mulè, F; Serio, R | 1 |
| Daly, CJ; Mackenzie, JF; McGrath, JC; Naghadeh, MA; Pediani, JD | 1 |
| Alves-Do-Prado, W; Ambiel, CR; Silva, HM | 1 |
| Koshita, M; Nakahira, Y; Suzuki, H; Takano, H | 1 |
| Landis, ME; Miller, VM; Ray, EC | 1 |
| Costa, G; Garcia-Pascual, A; Labadia, A; Triguero, D | 1 |
| Kitazawa, T; Maezono, Y; Taneike, T | 1 |
| Jonas, M; Mundey, MK; Scholefield, JH; Wilson, VG; Worthley, T | 1 |
| Clark, E; Conklin, JL; Murray, JA; Shahin, W | 1 |
| Baccari, MC; Calamai, F | 1 |
| Diamond, J; Hennan, JK | 1 |
| De Groat, WC; Yoshiyama, M | 1 |
| Gloviczki, P; Landis, ME; Miller, VM; Ray, EC | 1 |
| Kamata, K; Suenaga, H | 2 |
| Dikmen, A; Döndaş, N; Ergün, Y; Oğülener, N | 1 |
| Gonzalez, A; Sarna, SK | 1 |
| Bogers, JJ; De Man, JG; De Winter, BY; Herman, AG; Moreels, TG; Pelckmans, PA; Van Marck, EA | 1 |
| Bornstein, J; Johnson, P; Stebbing, M; Vremec, M | 1 |
| Brioni, JD; Hsieh, GC; Kolasa, T; Sullivan, JP | 1 |
| Fernández, E; Jiménez, M; Tanović, A | 1 |
| Allescher, HD; Geisler, F; Neuhuber, WL; Schusdziarra, V; Storr, M | 1 |
| Borsody, MK; Komuro, T; Macdonald, RL; Marton, LS; Ono, S; Paik, E; Weir, BK; Zhang, ZD | 1 |
| Fujita, A; Hata, F; Morimoto, H; Sugimoto, K; Takeuch, T | 1 |
| Hashimoto, A; Imaizumi, T; Kambe, T; Kishi, M; Mori, T; Nakazawa, T; Orito, K | 1 |
| Bessard, G; Bréant, D; Caron, F; Corompt, E; Devillier, P | 1 |
| Pikov, V; Wrathall, JR | 1 |
| Cawthorne, MA; Kelly, J; Roberts, SP; Sennitt, MV | 1 |
| Manca, P; Mulè, A; Peana, A; Pirisino, G; Savelli, F | 1 |
| Dunn, WR; McGrath, JC; Wilson, VG | 1 |
| Blackburn, TP; Chapman, H; Demarinis, RM; Edwards, R; Hieble, JP; Roberts, SP; Shah, DH; Sulpizio, AC; Wood, MD; Young, P | 1 |
| Bültmann, R; Starke, K; von Kügelgen, I | 1 |
| Lepor, H | 1 |
| Appell, KC; Babb, BE; Goswami, R; Hall, PL; Lawrence, KB; Logan, ME; Przyklek-Elling, R; Tomczuk, BE; Venepalli, BR; Yanni, JM | 1 |
| Hayashi, S; Ishima, T; Kano, S; Kimura, K; Matsuzaki, T; Miura, A; Ukai, Y | 1 |
| MacLean, MR; McGrath, JC | 1 |
| Calvete, J; Hayes, R; Sever, PS; Thom, S | 1 |
| Baumann, M; Gup, DI; Lepor, H; Shapiro, E | 1 |
| Alden, BM; Matherne, GP; Nakamura, KT; Robillard, JE; Rusch, NJ | 1 |
| Flavahan, NA; Shimokawa, H; Vanhoutte, PM | 1 |
| Downing, OA; Stein, W; Wilson, KA; Wilson, VG | 1 |
| Calvete, J; Hayes, R; Martin, G; Sever, P; Thom, S | 1 |
| Doxey, JC; Roach, AG; Samuel, J | 1 |
| Honda, K; Miyata-Osawa, A; Shiono, K; Takenaka, T; Terai, M | 1 |
| Lattimer, N; Rhodes, KF | 1 |
| Greenwood, B; Read, NW | 1 |
| Bond, RA; Charlton, KG; Clarke, DE | 1 |
| Itoh, H; Kohli, JD; Rajfer, SI | 1 |
| Broadley, KJ; Williamson, KL | 1 |
| Rhodes, KF; Waterfall, JF | 1 |
| Guimarães, S; Moura, D; Paiva, MQ | 1 |
| Daly, CJ; McGrath, JC; Wilson, VG | 1 |
| Bullock, GR; Taylor, SG; Weston, AH | 1 |
1 review(s) available for quinoxalines and Muscle Contraction
| Article | Year |
|---|---|
Role of alpha-adrenergic blockers in the treatment of benign prostatic hyperplasia.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Brimonidine Tartrate; Carbachol; Humans; Male; Muscle Contraction; Phenylephrine; Prazosin; Prostatic Hyperplasia; Quinoxalines | 1990 |
1 trial(s) available for quinoxalines and Muscle Contraction
| Article | Year |
|---|---|
Human vascular smooth muscle responses mediated by alpha 2 mechanisms in vivo and in vitro.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Arteries; Brimonidine Tartrate; Dioxanes; Doxazosin; Forearm; Humans; Idazoxan; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha | 1985 |
161 other study(ies) available for quinoxalines and Muscle Contraction
| Article | Year |
|---|---|
Both α
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Animals; Dose-Response Relationship, Drug; Male; Muscle Contraction; Norepinephrine; Phenylephrine; Piperazines; Prazosin; Quinazolines; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Spleen; Thymine; Yohimbine | 2021 |
Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells.
Topics: Anthracyclines; Antineoplastic Agents; Apoptosis; Benzothiazoles; Calcium Channels; Calcium-Binding Proteins; Cell Death; Cells, Cultured; Cytoskeletal Proteins; Down-Regulation; Etoposide; Gene Expression; Humans; MicroRNAs; Mitochondria, Heart; Muscle Contraction; Myocytes, Cardiac; Pluripotent Stem Cells; Quinoxalines; Spiro Compounds; Toluene; Up-Regulation | 2018 |
Role of Carbon Monoxide in the Mechanisms of Action of Extracellular ATP on Contractile Activity of Vascular Smooth Muscle Cells.
Topics: Adenosine Triphosphate; Animals; Aorta; Carbon Monoxide; Cells, Cultured; Endothelium; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Organometallic Compounds; Oxadiazoles; Phenylephrine; Protoporphyrins; Purinergic P2X Receptor Agonists; Purinergic P2Y Receptor Agonists; Quinoxalines; Rats; Rats, Wistar; Receptors, Purinergic P2X; Receptors, Purinergic P2Y | 2019 |
Role of endothelium, acetylocholine and calcium ions in Bay K8644- and KCl-induced contraction.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Animals; Arteries; Calcium; Calcium Channel Agonists; Calcium Channels; Endothelium, Vascular; Guanylate Cyclase; Ions; Male; Muscle Contraction; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Potassium Chloride; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2013 |
Cyclic guanosine monophosphate and the dependent protein kinase regulate lymphatic contractility in rat thoracic duct.
Topics: Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Guanylate Cyclase; Isoenzymes; Lymphatic Vessels; Male; Muscle Contraction; Nitric Oxide; Oxadiazoles; Protein Kinase Inhibitors; Quinoxalines; Rats; Rats, Sprague-Dawley; Thoracic Duct | 2013 |
Imatinib mesylate (Gleevec) induces human corpus cavernosum relaxation by inhibiting receptor tyrosine kinases (RTKs): identification of new RTK targets.
Topics: Adult; Aged; Apamin; Benzamides; Enzyme Activation; Erectile Dysfunction; Humans; Imatinib Mesylate; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Oxadiazoles; Penis; Phosphorylation; Piperazines; Potassium Channel Blockers; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrimidines; Quinoxalines; Receptor Protein-Tyrosine Kinases; Tetraethylammonium | 2013 |
Dual effects of α2 -adrenoceptors in modulating myogenic tone in sheep isolated internal anal sphincter.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Anal Canal; Animals; Brimonidine Tartrate; Clonidine; Dexmedetomidine; Muscle Contraction; Prazosin; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha; Sheep; Tissue Culture Techniques | 2014 |
Relaxin Affects Smooth Muscle Biophysical Properties and Mechanical Activity of the Female Mouse Colon.
Topics: Animals; Biophysical Phenomena; Calcium; Calcium Channels, L-Type; Carbazoles; Colon; Cyclic GMP-Dependent Protein Kinases; Female; Gastrointestinal Motility; Guanylate Cyclase; KATP Channels; Membrane Potentials; Mice; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Myocytes, Smooth Muscle; Oxadiazoles; Patch-Clamp Techniques; Potassium Channels, Voltage-Gated; Quinoxalines; Receptors, G-Protein-Coupled; Relaxin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sarcolemma | 2015 |
In vitro effect of nicorandil on the carbachol-induced contraction of the lower esophageal sphincter of the rat.
Topics: Animals; Carbachol; Diazoxide; Dose-Response Relationship, Drug; Esophageal Sphincter, Lower; Glyburide; In Vitro Techniques; KATP Channels; Muscle Contraction; NG-Nitroarginine Methyl Ester; Nicorandil; Oxadiazoles; Peptides; Pinacidil; Potassium; Quinoxalines; Rats | 2016 |
Effect of the phosphodiesterase 5 inhibitors sildenafil, tadalafil and vardenafil on rat anococcygeus muscle: functional and biochemical aspects.
Topics: Animals; Carbolines; Drug Evaluation, Preclinical; Enzyme Inhibitors; Guanylate Cyclase; Imidazoles; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitroglycerin; Oxadiazoles; Penile Erection; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Purines; Quinoxalines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2009 |
N-acetylcysteine-induced vasodilation involves voltage-gated potassium channels in rat aorta.
Topics: Acetylcysteine; Animals; Calcium; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Guanylate Cyclase; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Oxadiazoles; Phenylephrine; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Protein Kinase C; Quinoxalines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Vasoconstrictor Agents; Vasodilation | 2009 |
Mechanisms of relaxant activity of the nitric oxide-independent soluble guanylyl cyclase stimulator BAY 41-2272 in rat tracheal smooth muscle.
Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Trachea | 2010 |
Dexmedetomidine induces both relaxations and contractions, via different {alpha}2-adrenoceptor subtypes, in the isolated mesenteric artery and aorta of the rat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Aorta; Brimonidine Tartrate; Clonidine; Dexmedetomidine; Endothelium, Vascular; In Vitro Techniques; Indomethacin; Male; Mesenteric Arteries; Models, Biological; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Naphthalenes; NG-Nitroarginine Methyl Ester; Pertussis Toxin; Prazosin; Propionates; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Thromboxane | 2010 |
Design and synthesis of small molecule RhoA inhibitors: a new promising therapy for cardiovascular diseases?
Topics: Animals; Aorta, Thoracic; Brain; Cinnamates; Drug Design; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Propanols; Quinolines; Quinoxalines; Rats; Rats, Sprague-Dawley; rhoA GTP-Binding Protein; Small Molecule Libraries; Stereoisomerism; Structure-Activity Relationship; Vasoconstrictor Agents; Vasodilator Agents | 2011 |
Intermedin elicits a negative inotropic effect in rat papillary muscles mediated by endothelial-derived nitric oxide.
Topics: Adrenomedullin; Animals; Calcitonin Gene-Related Peptide; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Heart; Microvessels; Muscle Contraction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Papillary Muscles; Peptide Fragments; Quinoxalines; Rats; Rats, Wistar; Troponin I | 2012 |
Involvement of the NO-cGMP-K(ATP) channel pathway in the mesenteric lymphatic pump dysfunction observed in the guinea pig model of TNBS-induced ileitis.
Topics: Animals; ATP-Binding Cassette Transporters; Disease Models, Animal; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; Guinea Pigs; Hypoglycemic Agents; Ileitis; Inflammation Mediators; KATP Channels; Lymphatic Vessels; Muscle Contraction; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Potassium Channels, Inwardly Rectifying; Quinoxalines; Receptors, Drug; Sulfonylurea Receptors; Trinitrobenzenesulfonic Acid; Up-Regulation | 2013 |
Tyrosine kinases regulate intracellular calcium during alpha(2)-adrenergic contraction in rat aorta.
Topics: Adrenergic alpha-Agonists; Animals; Aorta; Brimonidine Tartrate; Calcium; Enzyme Inhibitors; Flavonoids; Hypertension; Male; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Quinazolines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Tyrphostins | 2002 |
Different contractile effects of alpha1- and alpha2-adrenergic agonists on horse isolated common digital artery smooth muscle ring preparations in vitro.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Brimonidine Tartrate; Calcium; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Endothelin Receptor Antagonists; Endothelium, Vascular; Horses; Imidazoles; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Oligopeptides; Peptides, Cyclic; Phenylephrine; Piperidines; Quinoxalines | 2002 |
Endothelial inhibitory modulation on the contractile responses to alpha 2-adrenergic agonists.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Brimonidine Tartrate; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxymetazoline; Quinoxalines; Rats; Rats, Wistar | 2002 |
Vasocontractile effects of alpha 2-adrenergic agonists associated with intracellular calcium release.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Brimonidine Tartrate; Calcium; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Oxymetazoline; Phenylephrine; Quinoxalines; Rats; Rats, Wistar; Vasoconstriction | 2002 |
YC-1 potentiates the nitric oxide/cyclic GMP pathway in corpus cavernosum and facilitates penile erection in rats.
Topics: Animals; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indazoles; Male; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Nitroprusside; Oxadiazoles; Penile Erection; Penis; Phenylephrine; Quinoxalines; Rabbits; Rats; Rats, Wistar; Signal Transduction; Vasoconstrictor Agents; Vasodilator Agents | 2003 |
Alpha2-adrenoceptor ligands inhibit alpha1-adrenoceptor-mediated contraction of isolated rat arteries.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Arteries; Azepines; Brimonidine Tartrate; Clonidine; Idazoxan; In Vitro Techniques; Ligands; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Oxazoles; Prostaglandins; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Rilmenidine; Yohimbine | 2002 |
Altered prejunctional modulation of intestinal cholinergic and noradrenergic pathways by alpha2-adrenoceptors in the presence of experimental colitis.
Topics: Acetylcholine; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Brimonidine Tartrate; Colitis; Colon; Dinitrofluorobenzene; Electric Stimulation; Enteric Nervous System; Gastrointestinal Motility; Gastrointestinal Transit; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Reverse Transcriptase Polymerase Chain Reaction; Yohimbine | 2003 |
Abnormal activation of Na+-K+ pump in aortas from rats with endotoxaemia.
Topics: Animals; Aorta, Thoracic; Endotoxemia; Enzyme Inhibitors; Escherichia coli; In Vitro Techniques; Lipopolysaccharides; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Ouabain; Oxadiazoles; Phenylephrine; Potassium Channels, Inwardly Rectifying; Quinoxalines; Rats; Rats, Inbred WKY; Sodium-Potassium-Exchanging ATPase; Time Factors | 2003 |
Enhancement of endotoxin-induced vascular hyporeactivity to phenylephrine in the thoracic aortas of Mg-deficient rats ex vivo.
Topics: Amidines; Animals; Aorta, Thoracic; Benzylamines; Diet; Dose-Response Relationship, Drug; Enzyme Inhibitors; Escherichia coli; In Vitro Techniques; Injections, Intraperitoneal; Interleukin-1; Lipopolysaccharides; Magnesium Deficiency; Male; Muscle Contraction; Muscle, Smooth, Vascular; Oxadiazoles; Phenylephrine; Quinoxalines; Rats; Rats, Wistar; Receptors, Tumor Necrosis Factor; RNA, Messenger; Tumor Necrosis Factor-alpha | 2003 |
The roles of cyclic adenosine monophosphate- and cyclic guanosine monophosphate-dependent protein kinase pathways in hydrogen peroxide-induced contractility of microvascular lung pericytes.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Analysis of Variance; Animals; Cell Survival; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Hydrogen Peroxide; Isoquinolines; Lung; Male; Muscle Contraction; Oxadiazoles; Pericytes; Quinoxalines; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Sepsis; Sulfonamides | 2003 |
Nitric oxide release from human corpus cavernosum induced by a purified scorpion toxin.
Topics: Adolescent; Adult; Child; Cyclic GMP; Drug Evaluation, Preclinical; Electric Stimulation; Enzyme Inhibitors; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neurotoxins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Penis; Phenylephrine; Piperazines; Priapism; Purines; Quinoxalines; Scorpion Venoms; Second Messenger Systems; Sildenafil Citrate; Sodium Channel Blockers; Sulfones; Tetrodotoxin | 2004 |
Noradrenaline inhibits autonomous activity in the isolated guinea pig bladder.
Topics: Action Potentials; Adrenergic alpha-Agonists; Animals; Autonomic Nervous System; Brimonidine Tartrate; Electric Stimulation; Female; Guinea Pigs; Imidazoles; Muscle Contraction; Norepinephrine; Quinoxalines; Receptors, Adrenergic; Urinary Bladder | 2004 |
Influence of nitric oxide donors and peroxynitrite on the contractile effect and concentration of norepinephrine.
Topics: Animals; Aorta, Thoracic; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Donors; Norepinephrine; Oxadiazoles; Peroxynitrous Acid; Quinoxalines; Rats; Rats, Sprague-Dawley | 2004 |
Interleukin-6 impairs endothelium-dependent NO-cGMP-mediated relaxation and enhances contraction in systemic vessels of pregnant rats.
Topics: Acetylcholine; Animals; Blotting, Western; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Estradiol; Female; Interleukin-6; Isometric Contraction; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oxadiazoles; Phenylephrine; Pregnancy; Pregnancy, Animal; Progesterone; Quinoxalines; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 2004 |
A novel nonpeptide antagonist of the kinin B1 receptor: effects at the rabbit receptor.
Topics: Animals; Aorta, Thoracic; Blotting, Western; Bradykinin B1 Receptor Antagonists; Cell Line; Chlorocebus aethiops; COS Cells; Epitopes; Genes, myc; Image Cytometry; In Vitro Techniques; Microscopy, Confocal; Muscle Contraction; Muscle, Smooth, Vascular; Protein Folding; Quinoxalines; Rabbits; Receptor, Bradykinin B1; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sulfones | 2004 |
Pharmacophore based synthesis of 3-chloroquinoxaline-2-carboxamides as serotonin3 (5-HT3) receptor antagonist.
Topics: Animals; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Structure; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Quinoxalines; Serotonin; Serotonin 5-HT3 Receptor Antagonists; Serotonin Antagonists; Structure-Activity Relationship | 2004 |
Nitrergic mechanisms mediating inhibitory control of longitudinal smooth muscle contraction in mouse small intestine.
Topics: Animals; Atropine; Electric Stimulation; Enzyme Inhibitors; Gastrointestinal Motility; Guanylate Cyclase; Ileum; Jejunum; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Phentolamine; Propranolol; Quinoxalines | 2004 |
Relaxation induced by acetylcholine involves endothelium-derived hyperpolarizing factor in 2-kidney 1-clip hypertensive rat carotid arteries.
Topics: Acetylcholine; Animals; Biological Factors; Carotid Arteries; Cyclic GMP; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Epoprostenol; Hemoglobins; Hypertension, Renovascular; Indomethacin; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroarginine; Oxadiazoles; Potassium Channel Blockers; Potassium Chloride; Quinoxalines; Rats; Rats, Wistar; Vasodilator Agents | 2004 |
Decreased aortic smooth muscle contraction in a rat model of multibacterial sepsis.
Topics: Animals; Aorta; Disease Models, Animal; Endothelial Cells; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Sepsis; Soluble Guanylyl Cyclase | 2004 |
The role of nitric oxide on contractile impairment during endotoxemia in rat diaphragm muscle.
Topics: Animals; Caffeine; Diaphragm; Endotoxemia; Enzyme Inhibitors; Guanidines; In Vitro Techniques; Indazoles; Lipopolysaccharides; Male; Muscle Contraction; Neuromuscular Nondepolarizing Agents; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Ryanodine; Tubocurarine; Vasodilator Agents; Verapamil | 2004 |
Involvement of a nitric oxide-cyclic guanosine monophosphate pathway in control of fallopian tube contractility.
Topics: Adult; Cyclic GMP; Enzyme Inhibitors; Fallopian Tubes; Female; Guanylate Cyclase; Humans; In Vitro Techniques; Methylene Blue; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Oxadiazoles; Quinoxalines; Spermine | 2004 |
BAY 41-2272 [5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyrimidin-4-ylamine]-induced dilation in ovine pulmonary artery: role of sodium pump.
Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Ouabain; Oxadiazoles; Pulmonary Artery; Pyrazoles; Pyridines; Quinoxalines; Rubidium Radioisotopes; Serotonin; Sheep; Sodium-Potassium-Exchanging ATPase; Vasoconstriction; Vasodilation | 2005 |
Inhibition of carbachol-evoked oscillatory currents by the NO donor sodium nitroprusside in guinea-pig ileal myocytes.
Topics: Animals; Caffeine; Carbachol; Chelating Agents; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Egtazic Acid; Guinea Pigs; Ileum; In Vitro Techniques; Membrane Potentials; Muscarinic Agonists; Muscle Contraction; Myocytes, Smooth Muscle; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Patch-Clamp Techniques; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Quinoxalines; Type C Phospholipases | 2005 |
Inhibitory influence of chromogranin A N-terminal fragment (vasostatin-1) on the spontaneous contractions of rat proximal colon.
Topics: Animals; Apamin; Calreticulin; Chromogranin A; Chromogranins; Colon; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gastrointestinal Tract; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Peptide Fragments; Peptides; Pressure; Protein Structure, Tertiary; Quinoxalines; Rats; Rats, Wistar; Recombinant Proteins; Tetrodotoxin; Time Factors | 2005 |
Nitric oxide modulates peristaltic muscle activity associated with fluid circulation in the sea pansy Renilla koellikeri.
Topics: Animals; Anthozoa; Body Fluids; California; Guanidines; Immunohistochemistry; Indazoles; Muscle Contraction; Muscles; Neurites; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Peristalsis; Phosphodiesterase Inhibitors; Purinones; Quinoxalines | 2005 |
Dual impact of a nitric oxide donor, GEA 3175, in human pulmonary smooth muscle.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Albuterol; Bronchi; Bronchodilator Agents; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Peptides; Pulmonary Artery; Quinoxalines; Triazoles; Vasoconstrictor Agents; Vasodilation | 2005 |
Relaxant effect of adrenomedullin on bovine isolated iris sphincter muscle under resting conditions.
Topics: Adrenomedullin; Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Cattle; Dideoxyadenosine; Enzyme Inhibitors; Female; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Nitroarginine; Oxadiazoles; Peptide Fragments; Peptides; Pupil; Quinoxalines; Signal Transduction | 2005 |
(+)-Cyclazosin, a selective alpha1B-adrenoceptor antagonist: functional evaluation in rat and rabbit tissues.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Binding, Competitive; Clonidine; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Methoxamine; Molecular Structure; Muscle Contraction; Norepinephrine; Quinazolines; Quinoxalines; Rabbits; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Vas Deferens; Vasoconstriction | 2005 |
Stimulation of soluble guanylyl cyclase by BAY 41-2272 relaxes anococcygeus muscle: interaction with nitric oxide.
Topics: Animals; Carbachol; Carbolines; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroglycerin; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Tadalafil; Tetrodotoxin | 2006 |
Chronic CO levels have [corrected] a beneficial effect on vascular relaxation in diabetes.
Topics: Acetylcholine; Animals; Aorta; Biliverdine; Blotting, Western; Carbon Monoxide; Chromium; Densitometry; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Endothelium, Vascular; Femoral Artery; Guanylate Cyclase; Heme; Immunohistochemistry; Male; Mesoporphyrins; Muscle Contraction; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Organometallic Compounds; Oxadiazoles; Oxidative Stress; Protoporphyrins; Pyrazines; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Time Factors | 2006 |
Acute and long-term administration of citalopram desensitizes alpha2-adrenoceptors in the rat vas deferens.
Topics: Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Animals; Brimonidine Tartrate; Citalopram; Dose-Response Relationship, Drug; Drug Administration Schedule; Duloxetine Hydrochloride; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Selective Serotonin Reuptake Inhibitors; Serotonin; Thiophenes; Vas Deferens | 2006 |
Identification and optimization of anthranilic sulfonamides as novel, selective cholecystokinin-2 receptor antagonists.
Topics: Animals; Binding, Competitive; Biological Availability; Dogs; Drug Stability; Gallbladder; Gastric Acid; Guinea Pigs; Humans; In Vitro Techniques; Male; Microsomes, Liver; Morpholines; Muscle Contraction; Muscle, Smooth; ortho-Aminobenzoates; Quinoxalines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Stereoisomerism; Stomach; Structure-Activity Relationship; Sulfonamides | 2006 |
Effects of intrastriatal injections of glutamate receptor antagonists on the severity of paroxysmal dystonia in the dtsz mutant.
Topics: Animals; Basal Ganglia; Caudate Nucleus; Cricetinae; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Dystonia; Excitatory Amino Acid Antagonists; Microinjections; Movement; Muscle Contraction; Mutation; Posture; Putamen; Pyrrolidinones; Quinoxalines; Reaction Time; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Severity of Illness Index; Valine | 2007 |
Protective effect of PNQX on motor units and muscle property after sciatic nerve crush in neonatal rats.
Topics: Animals; Animals, Newborn; Axotomy; Disease Models, Animal; Excitatory Amino Acid Antagonists; Female; Male; Motor Neurons; Muscle Contraction; Muscle Fatigue; Muscle Relaxation; Muscle Strength; Muscle, Skeletal; Neuroprotective Agents; Organ Size; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Sciatic Nerve; Sciatic Neuropathy; Time Factors | 2007 |
Endothelial nitric oxide has inhibitory effects on rhythmic contractions in the aortas of sinoaortic deafferented rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Arginine; Autonomic Denervation; Blood Pressure; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Heart Rate; Indomethacin; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Oxadiazoles; Oxyhemoglobins; Phenylephrine; Quinoxalines; Rats | 2007 |
UK-14,304, a potent and selective alpha2-agonist for the characterisation of alpha-adrenoceptor subtypes.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Guinea Pigs; Ileum; Imidazoles; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Pulmonary Artery; Quinoxalines; Rabbits; Receptors, Adrenergic; Receptors, Adrenergic, alpha | 1981 |
Synthesis of some potential antihypertensive phthalazinyl- and quinoxalinylguanidines.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Chemical Phenomena; Chemistry; Desoxycorticosterone; Guanidines; Heart Rate; Hypertension; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Phthalazines; Quinoxalines; Rats | 1982 |
Alpha 2-adrenoceptor agonists potentiate responses mediated by alpha 1-adrenoceptors in the cat nictitating membrane.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Brimonidine Tartrate; Cats; Clonidine; Female; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Nictitating Membrane; Norepinephrine; Phenylephrine; Quinolizines; Quinoxalines; Receptors, Adrenergic, alpha | 1984 |
Pharmacological characterization of alpha adrenoceptors in the rat gastric fundus.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Electric Stimulation; Female; Gastric Fundus; In Vitro Techniques; Methacholine Compounds; Muscle Contraction; Norepinephrine; Phenylephrine; Quinoxalines; Rats; Receptors, Adrenergic, alpha | 1984 |
The contractions induced in rat and guinea-pig aortic strips by the alpha 2-adrenoceptor selective agonists B-HT 920 and UK 14,304 are mediated by alpha 1-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Animals; Aorta; Azepines; Brimonidine Tartrate; Dose-Response Relationship, Drug; Gallopamil; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Species Specificity; Yohimbine | 1984 |
Pharmacologic analysis of two novel inhibitors of leukotriene (slow reacting substance) release.
Topics: Aminoquinolines; Animals; Calcimycin; Cromolyn Sodium; Guinea Pigs; Histamine Release; Ileum; Lung; Male; Muscle Contraction; Muscle, Smooth; Peritoneal Cavity; Quinoxalines; Rats; Rats, Inbred Strains; SRS-A | 1984 |
alpha-adrenoreceptor-mediated phasic and tonic activity in rat portal vein in vitro.
Topics: Animals; Brimonidine Tartrate; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Portal Vein; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha | 1983 |
Involvement of protein kinase C activation in alpha 2-adrenoceptor-mediated contractions of rabbit saphenous vein.
Topics: Adrenergic alpha-Agonists; Alkaloids; Animals; Brimonidine Tartrate; Calcium; Diglycerides; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Inositol Phosphates; Male; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Phosphatidic Acids; Phospholipase D; Protein Kinase C; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha-2; Saphenous Vein; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Alpha 2-adrenoceptor-mediated vasoconstriction requires a tyrosine kinase.
Topics: Animals; Aorta; Brimonidine Tartrate; Cinnamates; Dose-Response Relationship, Drug; Genistein; Hydroquinones; Isoflavones; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Protein-Tyrosine Kinases; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Saphenous Vein; Vasoconstriction | 1995 |
Differential inhibition of cholinergic and noncholinergic neurogenic contractions by mu opioid and alpha-2 adrenergic agonists in guinea pig ileum.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Choline; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Motor Neurons; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Neurotransmitter Uptake Inhibitors; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Opioid, mu; Substance P; Synaptic Transmission | 1993 |
Sensory nerve-mediated relaxation of guinea-pig isolated pulmonary artery: prejunctional modulation by alpha 2-adrenoceptor agonists but not sumatriptan.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcitonin Gene-Related Peptide; Electric Stimulation; Guinea Pigs; Histamine; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Neuromuscular Junction; Neurons, Afferent; Piperazines; Pulmonary Artery; Pyrrolidines; Quinoxalines; Substance P; Sulfonamides; Sumatriptan; Vasoconstrictor Agents; Yohimbine | 1993 |
Differential actions of lamprey peptide methionine-tyrosine at Y1 and Y2 neuropeptide Y receptors.
Topics: Amino Acid Sequence; Animals; Brimonidine Tartrate; Guinea Pigs; In Vitro Techniques; Male; Mesenteric Arteries; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Peptides; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Vas Deferens | 1994 |
Pertussis toxin attenuates presynaptic inhibition of cholinergic but not nonadrenergic noncholinergic contraction in guinea pig airways.
Topics: Animals; Brimonidine Tartrate; Bronchi; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guinea Pigs; Male; Muscle Contraction; Parasympathetic Nervous System; Pertussis Toxin; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Trachea; Virulence Factors, Bordetella | 1995 |
Anisodamine at higher concentrations in inhibiting alpha-adrenergic responses in isolated canine blood vessels.
Topics: Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Dogs; Dose-Response Relationship, Drug; Femoral Artery; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Quinoxalines; Saphenous Vein; Solanaceous Alkaloids | 1993 |
Chloroethylclonidine irreversibly activates postjunctional alpha 2-adrenoceptors in the dog saphenous vein.
Topics: Adrenergic alpha-Agonists; Alkylating Agents; Animals; Brimonidine Tartrate; Clonidine; Cocaine; Dogs; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Neuromuscular Junction; Phenylephrine; Quinoxalines; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Saphenous Vein | 1993 |
Pharyngeal, esophageal, and proximal gastric responses associated with vomiting.
Topics: Adrenergic alpha-Agonists; Animals; Apomorphine; Brimonidine Tartrate; Dogs; Electromyography; Esophagus; Female; Intestine, Small; Male; Models, Biological; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Nerve Block; Pharynx; Quinoxalines; Stomach; Vagus Nerve; Vomiting | 1993 |
Neural ATP release and its alpha 2-adrenoceptor-mediated modulation in guinea-pig vas deferens.
Topics: Adenosine Triphosphate; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurons; Norepinephrine; Prazosin; Purinergic P2 Receptor Antagonists; Quinoxalines; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Purinergic P2; Suramin; Vas Deferens; Yohimbine | 1993 |
Blockade of non-NMDA receptors attenuates reflex pressor response to static contraction.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Biphenyl Compounds; Blood Pressure; Cats; Heart Rate; Hypnotics and Sedatives; Injections, Spinal; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Piperazines; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Time Factors | 1994 |
Effects of MK-801 and CNQX, glutamate receptor antagonists, on bladder activity in neonatal rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neural Pathways; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Reflex; Spinal Cord; Urinary Bladder | 1994 |
Effects of wortmannin on alpha-1/alpha-2 adrenergic receptor-mediated contractile responses in rabbit vascular tissues.
Topics: Androstadienes; Animals; Aorta, Thoracic; Brimonidine Tartrate; Calcium; Dose-Response Relationship, Drug; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Potassium Chloride; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Saphenous Vein; Wortmannin | 1994 |
Influences of the endothelium and hypoxia on alpha 1- and alpha 2-adrenoceptor-mediated responses in the rabbit isolated pulmonary artery.
Topics: Adrenergic alpha-Agonists; Animals; Arginine; Brimonidine Tartrate; Endothelium, Vascular; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Norepinephrine; Oxygen; Phenylephrine; Pulmonary Artery; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha; Vasoconstriction | 1993 |
Alpha-adrenergic receptor responsiveness in vascular smooth muscle of canine bone.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Dogs; Dose-Response Relationship, Drug; Female; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha; Regional Blood Flow; Tibia; Yohimbine | 1993 |
Inhibition by alpha 2-adrenoceptor agonists of contractions of rabbit isolated colon elicited by pelvic nerve stimulation.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Atropine; Clonidine; Colon; Drug Resistance; Imidazoles; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Pelvis; Quinoxalines; Rabbits | 1993 |
Novel antagonists of 5-HT3 receptors. Synthesis and biological evaluation of piperazinylquinoxaline derivatives.
Topics: Animals; Brain; Female; Guinea Pigs; Male; Muscle Contraction; Muscle, Smooth; Piperazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Serotonin Antagonists; Structure-Activity Relationship | 1993 |
Lysophosphatidylcholine modifies G protein-dependent signaling in porcine endothelial cells.
Topics: Adenosine Diphosphate; Animals; Bradykinin; Brimonidine Tartrate; Coronary Vessels; Dinoprost; Endothelium, Vascular; Female; Fluorides; GTP-Binding Proteins; Lysophosphatidylcholines; Male; Muscle Contraction; Pertussis Toxin; Quinoxalines; Serotonin; Signal Transduction; Swine; Virulence Factors, Bordetella | 1993 |
Influence of adrenergic and cholinergic mediators on the equine jejunum in vitro.
Topics: Acetylcholine; Adrenergic Agonists; Adrenergic Antagonists; Animals; Atropine; Brimonidine Tartrate; Calcium Channel Blockers; Cholinergic Agonists; Cholinergic Antagonists; Dose-Response Relationship, Drug; Horses; Isoproterenol; Jejunum; Muscle Contraction; Muscle, Smooth; Norepinephrine; Oxymetazoline; Parasympathetic Nervous System; Phentolamine; Phenylephrine; Prazosin; Quinoxalines; Sympathetic Nervous System; Tetrodotoxin; Verapamil; Yohimbine | 1996 |
The actions of medetomidine may not be mediated exclusively by alpha 2-adrenoceptors in the equine saphenous vein.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Brimonidine Tartrate; Dose-Response Relationship, Drug; Electric Stimulation; Endothelium, Vascular; Female; Horses; Imidazoles; Male; Medetomidine; Muscle Contraction; Muscle, Smooth, Vascular; Neuromuscular Junction; Norepinephrine; Phenylephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-2; Saphenous Vein; Structure-Activity Relationship | 1996 |
Pharmacological properties of quinoxaline derivatives as a new class of 5-HT3 receptor antagonists.
Topics: Animals; Antiemetics; Esophagus; Female; Ferrets; Gastric Emptying; Guinea Pigs; Male; Mice; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Myenteric Plexus; Quinoxalines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Serotonin; Reflex; Serotonin Antagonists | 1996 |
A tyrosine kinase regulates alpha-adrenoceptor-stimulated contraction and phospholipase D activation in the rat aorta.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Brimonidine Tartrate; Calcium Channel Agonists; Dose-Response Relationship, Drug; Enzyme Activation; Genistein; Isoflavones; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Pertussis Toxin; Phospholipase D; Potassium; Protein-Tyrosine Kinases; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Virulence Factors, Bordetella | 1996 |
Intrathecal blockade of both NMDA and non-NMDA receptors attenuates the exercise pressor reflex in cats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Blood Pressure; Cats; Decerebrate State; Excitatory Amino Acid Antagonists; Heart Rate; Injections, Spinal; Mechanoreceptors; Muscle Contraction; Muscle, Skeletal; Physical Exertion; Quinoxalines; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Reflex, Stretch; Respiratory Mechanics; Stereotaxic Techniques; Sympathetic Nervous System; Synaptic Transmission | 1996 |
Rilmenidine activates postjunctional alpha 1- and alpha 2-adrenoceptors in the canine saphenous vein.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Calcium Channel Blockers; Clonidine; Dihydropyridines; Dogs; Female; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Isotope Labeling; Male; Medetomidine; Muscle Contraction; Muscle, Smooth; Osmolar Concentration; Oxazoles; Phenoxybenzamine; Prazosin; Protein Binding; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Saphenous Vein; Tritium; Yohimbine | 1996 |
A simple method for measuring the effects of drugs on intestinal longitudinal and circular muscle.
Topics: Animals; Atropine; Brimonidine Tartrate; Clonidine; Electric Stimulation; Female; Guinea Pigs; Hexamethonium; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Quinoxalines; Rats; Rats, Wistar; Tetrodotoxin | 1996 |
Interaction between histamine H3 receptors and other prejunctional receptor systems in the isolated guinea pig duodenum.
Topics: Acetylcholine; Adenosine; Animals; Brimonidine Tartrate; Duodenum; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Methylhistamines; Muscle Contraction; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Histamine H3; Receptors, Purinergic P1 | 1997 |
ATP-sensitive potassium channels mediate contraction-induced attenuation of sympathetic vasoconstriction in rat skeletal muscle.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Female; Femoral Artery; Humans; Muscle Contraction; Muscle, Skeletal; Potassium Channels; Quinoxalines; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sympathetic Nervous System; Vasoconstriction | 1997 |
Histamine H3 receptors do not modulate reflex-evoked peristaltic motility in the isolated guinea-pig ileum.
Topics: Animals; Brimonidine Tartrate; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Perfusion; Peristalsis; Quinoxalines; Receptors, Histamine H3; Reflex | 1997 |
Existence of dopamine D1 receptor on the sympathetic nerve endings in the guinea-pig vas deferens.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenosine Triphosphate; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Brimonidine Tartrate; Dopamine Agonists; Dopamine Antagonists; Electric Stimulation; Guinea Pigs; Idazoxan; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Presynaptic Terminals; Quinoxalines; Receptors, Dopamine D1; Spiperone; Synaptic Transmission; Vas Deferens | 1997 |
Nitrergic control of peripheral sympathetic responses in the human corpus cavernosum: a comparison with other species.
Topics: Animals; Electric Stimulation; Guanethidine; Humans; Male; Mice; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Nitroarginine; Norepinephrine; Oxadiazoles; Oxyhemoglobins; Penis; Quinoxalines; Rabbits; Rats; Species Specificity; Sympathetic Nervous System | 1997 |
Characterisation of pre- and post-synaptic alpha-adrenoceptors in modulation of the rat ileum longitudinal and circular muscle activities.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Brimonidine Tartrate; Clonidine; Electric Stimulation; Idazoxan; Ileum; In Vitro Techniques; Muscle Contraction; Oxymetazoline; Phentolamine; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Receptors, Presynaptic | 1997 |
Expression of functional alpha2-adrenergic receptor subtypes in human corpus cavernosum and in cultured trabecular smooth muscle cells.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Binding, Competitive; Brimonidine Tartrate; Cells, Cultured; Colforsin; Cyclic AMP; Humans; Idazoxan; Male; Muscle Contraction; Muscle, Smooth; Penis; Quinoxalines; Radioisotopes; Receptors, Adrenergic, alpha-2; Ribonucleases; RNA, Messenger; Yohimbine | 1997 |
Effects of a novel guanylate cyclase inhibitor on nitric oxide-dependent inhibitory neurotransmission in canine proximal colon.
Topics: Animals; Colon; Cyclic GMP; Dogs; Electric Stimulation; Enzyme Inhibitors; Female; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurons; Nitric Oxide; Nitroprusside; Oxadiazoles; Quinoxalines | 1997 |
Increased vascular responsiveness to alpha 2-adrenergic stimulation during NOS inhibition-induced hypertension.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Blood Pressure; Body Weight; Brimonidine Tartrate; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Male; Mesenteric Artery, Superior; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitroarginine; Norepinephrine; Phenylephrine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Systole; Vasoconstriction; Yohimbine | 1997 |
Effect of selective inhibition of soluble guanylyl cyclase on the K(Ca) channel activity in coronary artery smooth muscle.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine; Animals; Cattle; Coronary Vessels; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Iloprost; In Vitro Techniques; Kinetics; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Nitroso Compounds; Oxadiazoles; Patch-Clamp Techniques; Peptides; Potassium Channels; Quinoxalines; Scorpion Venoms; Vasodilation | 1998 |
Nitric oxide-sensitive guanylyl cyclase inhibits acetylcholine release and excitatory motor transmission in the guinea-pig ileum.
Topics: Acetylcholine; Animals; Depression, Chemical; Electric Stimulation; Enzyme Inhibitors; Female; Guanylate Cyclase; Guinea Pigs; Ileum; Indazoles; Male; Motor Neurons; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Quinoxalines; Synaptic Transmission | 1998 |
Localization of heme oxygenase-2 immunoreactivity to parasympathetic ganglia of human and guinea-pig airways.
Topics: Animals; Atropine; Carbon Monoxide; Cyclic GMP; Enzyme Inhibitors; Female; Ganglia, Parasympathetic; Ganglionic Blockers; Guanylate Cyclase; Guinea Pigs; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Membrane Proteins; Muscarinic Antagonists; Muscle Contraction; Oxadiazoles; Protoporphyrins; Quinoxalines; Receptors, Cholinergic; Respiratory Physiological Phenomena; Respiratory System; Synaptic Transmission; Trimethaphan; Vagus Nerve | 1998 |
Blockade of nitrergic neuroeffector transmission in guinea-pig colon by a selective inhibitor of soluble guanylyl cyclase.
Topics: Animals; Colon; Electrophysiology; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Oxadiazoles; Quinoxalines; Solubility; Synaptic Transmission | 1998 |
The expression of functional postsynaptic alpha2-adrenoceptors in the corpus cavernosum smooth muscle.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Calcium; Cyclic AMP; Male; Muscle Contraction; Muscle, Smooth; Oxymetazoline; Penis; Phenylephrine; Prazosin; Quinoxalines; Rabbits; Radioligand Assay; Receptors, Adrenergic, alpha-2; Second Messenger Systems; Synapses; Tritium; Yohimbine | 1998 |
Alpha-adrenoceptor subtypes of dog saphenous vein: another unusual property.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Calcium; Dogs; Female; Fluorescence; Fura-2; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Potassium Chloride; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha; Saphenous Vein; Signal Transduction; Yohimbine | 1998 |
AMPA and NMDA receptor-dependent spinal LTP after nociceptive tetanic stimulation.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Excitatory Amino Acid Antagonists; Female; Long-Term Potentiation; Muscle Contraction; Pain; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1998 |
Characteristics of adrenoceptors in the human radial artery: clinical implications.
Topics: Adrenergic Agonists; Adrenergic Antagonists; Animals; Brimonidine Tartrate; Coronary Artery Bypass; Coronary Vessels; Endothelium, Vascular; Humans; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Quinoxalines; Radial Artery; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Swine; Vasoconstriction | 1998 |
Nitrergic relaxation of the horse corpus cavernosum. Role of cGMP.
Topics: Adenosine Triphosphate; Animals; Calcium; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Horses; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; NADPH Dehydrogenase; Nerve Fibers; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Penis; Potassium Channels; Quinoxalines; Tetrodotoxin | 1998 |
Alpha2-adrenoceptor-mediated contractions of the porcine isolated ear artery: evidence for a cyclic AMP-dependent and a cyclic AMP-independent mechanism.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenergic alpha-Agonists; Angiotensin II; Animals; Arteries; Brimonidine Tartrate; Colforsin; Cyclic AMP; Ear; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Nitroprusside; Quinoxalines; Receptors, Adrenergic, alpha-2; Swine | 1998 |
Influence of a selective guanylate cyclase inhibitor, and of the contraction level, on nitrergic relaxations in the gastric fundus.
Topics: Animals; Chymotrypsin; Electric Stimulation; Enzyme Inhibitors; Gastric Fundus; Guanylate Cyclase; Muscle Contraction; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar | 1998 |
Nitric oxide-independent activation of soluble guanylyl cyclase contributes to endotoxin shock in rats.
Topics: Animals; Aorta; Blood Pressure; Charybdotoxin; Dexamethasone; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Escherichia coli; Guanidines; Guanylate Cyclase; Heart Rate; In Vitro Techniques; Lipopolysaccharides; Male; Methylene Blue; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Oxadiazoles; Quinoxalines; Rats; Rats, Inbred WKY; Shock, Septic; Tetraethylammonium | 1998 |
Role of endothelial carbon monoxide in attenuated vasoreactivity following chronic hypoxia.
Topics: Animals; Aorta, Thoracic; Arsenites; Carbon Monoxide; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Heme Oxygenase (Decyclizing); Hypoxia; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroarginine; Oxadiazoles; Penicillamine; Phenylephrine; Protoporphyrins; Quinoxalines; Rats; Rats, Sprague-Dawley; Reference Values; S-Nitroso-N-Acetylpenicillamine; Sodium Compounds | 1998 |
Rilmenidine reveals differences in the pharmacological characteristics of prejunctional alpha2-adrenoceptors in the guinea-pig, rat and pig.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Arteries; Brimonidine Tartrate; Clonidine; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Ileum; Male; Muscle Contraction; Oxazoles; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Rilmenidine; Species Specificity; Swine; Vas Deferens | 1998 |
New 1,4-dihydropyridines conjugated to furoxanyl moieties, endowed with both nitric oxide-like and calcium channel antagonist vasodilator activities.
Topics: Animals; Aorta, Thoracic; Binding, Competitive; Calcium Channel Blockers; Cerebral Cortex; Dihydropyridines; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nitric Oxide Donors; Oxadiazoles; Quinoxalines; Radioligand Assay; Rats; Rats, Wistar; Structure-Activity Relationship; Vasodilator Agents | 1998 |
Effects of the soluble guanylyl cyclase activator, YC-1, on vascular tone, cyclic GMP levels and phosphodiesterase activity.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indazoles; Isoenzymes; Kinetics; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Oxadiazoles; Phosphoric Diester Hydrolases; Quinoxalines; Rabbits; Vasodilator Agents | 1999 |
A study of NPY-mediated contractions of the porcine isolated ear artery.
Topics: Adenylyl Cyclases; Adrenergic alpha-Agonists; Angiotensin II; Animals; Brimonidine Tartrate; Colforsin; Cyclic AMP; Ear, External; In Vitro Techniques; Isometric Contraction; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Neuropeptide Y; Nitroprusside; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Neuropeptide Y; Regional Blood Flow; Swine; Vasoconstrictor Agents; Vasodilator Agents | 1999 |
Tonic inhibitory action by nitric oxide on spontaneous mechanical activity in rat proximal colon: involvement of cyclic GMP and apamin-sensitive K+ channels.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colon; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Phosphodiesterase Inhibitors; Potassium Channels; Purinones; Quinoxalines; Rats; Rats, Wistar | 1999 |
Importance of agonists in alpha-adrenoceptor classification and localisation of alpha1-adrenoceptors in human prostate.
Topics: Adrenergic alpha-Agonists; Animals; Binding, Competitive; Brimonidine Tartrate; Calcium; Carotid Artery, Common; Cells, Cultured; Fibroblasts; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Phenylephrine; Prazosin; Prostate; Quinoxalines; Rabbits; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Saphenous Vein | 1999 |
The neuromuscular transmission fade (Wedensky inhibition) induced by L-arginine in neuromuscular preparations from rats.
Topics: Animals; Arginine; Diaphragm; Electric Stimulation; Enzyme Inhibitors; Female; In Vitro Techniques; Male; Molsidomine; Muscle Contraction; Muscle, Skeletal; Neuromuscular Junction; Nitroarginine; Oxadiazoles; Phrenic Nerve; Quinoxalines; Rats; Rats, Wistar; Synaptic Transmission | 1999 |
Effects of some imidazolidine alpha2-adrenoceptor agonists in rat isolated atria.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Clonidine; Drug Interactions; Electric Stimulation; Female; Heart Atria; Heart Rate; Idazoxan; Imidazoles; In Vitro Techniques; Muscle Contraction; Norepinephrine; Pargyline; Prazosin; Quinoxalines; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Time Factors | 1999 |
Pranidipine enhances relaxation produced by endothelium-derived relaxing factor in carotid artery.
Topics: Acetylcholine; Animals; Calcium Channel Blockers; Carotid Arteries; Dihydropyridines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Membrane Potentials; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroarginine; Nitroprusside; Norepinephrine; Oxadiazoles; Potassium; Quinoxalines; Vasoconstrictor Agents; Vasodilator Agents | 1999 |
Effects of dietary L-arginine on the reactivity of canine coronary arteries.
Topics: Adrenergic alpha-Agonists; Animals; Arginine; Brimonidine Tartrate; Calcimycin; Coronary Vessels; Dietary Supplements; Dinoprost; Dogs; Endothelium, Vascular; Ionophores; Male; Muscle Contraction; Muscle, Smooth; Nitric Oxide; omega-N-Methylarginine; Quinoxalines; Tetraethylammonium | 1999 |
Effects of superoxide anion generators and thiol modulators on nitrergic transmission and relaxation to exogenous nitric oxide in the sheep urethra.
Topics: Animals; Ascorbate Oxidase; Benzoates; Ditiocarb; Electric Stimulation; Enzyme Inhibitors; Female; Guanylate Cyclase; Imidazoles; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Oxadiazoles; Quinoxalines; Sheep; Sulfhydryl Compounds; Superoxide Dismutase; Superoxides; Synaptic Transmission; Urethra | 2000 |
The mechanisms of alpha(2)-adrenoceptor agonist-induced contraction in longitudinal muscle of the porcine uterus.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcium; Calcium Channel Blockers; Clonidine; Colforsin; Cyclic AMP; Female; Fluorescent Dyes; Fura-2; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Myometrium; Pertussis Toxin; Quinoxalines; Swine; Uterus; Verapamil; Virulence Factors, Bordetella | 2000 |
Pharmacological characterization of neurogenic responses of the sheep isolated internal anal sphincter.
Topics: Anal Canal; Animals; Autonomic Nervous System; Calcium; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Muscle Contraction; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxadiazoles; Quinoxalines; Sheep | 2000 |
Role of cGMP as a mediator of nerve-induced motor functions of the opossum esophagus.
Topics: Animals; Atropine; Cyclic GMP; Enteric Nervous System; Enzyme Inhibitors; Esophagogastric Junction; Female; Gastrointestinal Motility; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Smooth; Nitric Oxide; Opossums; Oxadiazoles; Parasympatholytics; Quinoxalines; Vasoactive Intestinal Peptide | 2000 |
Modulation of nitrergic relaxant responses by peptides in the mouse gastric fundus.
Topics: Animals; Apamin; Carbachol; Cholinergic Agonists; Chymotrypsin; Electric Stimulation; Enzyme Inhibitors; Gastric Fundus; Guanylate Cyclase; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle Relaxation; Neuropeptides; Neurotransmitter Agents; Nitroarginine; Oxadiazoles; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Quinoxalines; Vasoactive Intestinal Peptide | 2001 |
Effect of NO donors on protein phosphorylation in intact vascular and nonvascular smooth muscles.
Topics: Animals; Aorta, Thoracic; Atrial Natriuretic Factor; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Myometrium; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Penicillamine; Phosphoproteins; Phosphorylation; Quinoxalines; Rats; S-Nitroso-N-Acetylpenicillamine; Vas Deferens | 2001 |
Role of spinal alpha1-adrenoceptor subtypes in the bladder reflex in anesthetized rats.
Topics: Anesthesia, General; Animals; Brain Stem; Efferent Pathways; Female; Injections, Spinal; Locus Coeruleus; Models, Neurological; Muscle Contraction; Piperazines; Pressure; Quinazolines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Reflex; Thymine; Urethane; Urinary Bladder | 2001 |
Effects of dietary L-arginine on structure and function of flow-restricted vein grafts.
Topics: Adrenergic alpha-Agonists; Amino Acids; Animals; Arginine; Blood Flow Velocity; Brimonidine Tartrate; Calcimycin; Constriction, Pathologic; Dietary Supplements; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; Femoral Artery; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Quinoxalines; Saphenous Vein; Vascular Patency | 2001 |
Alpha-adrenoceptor agonists produce Ca2+ oscillations in isolated rat aorta: role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Brimonidine Tartrate; Calcium Channel Blockers; Calcium Signaling; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indoles; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Protein Kinase C; Quinoxalines; Rats; Rats, Wistar; Verapamil | 2000 |
The influence of nitric oxide donors on the responses to nitrergic nerve stimulation in the mouse duodenum.
Topics: Animals; Dose-Response Relationship, Drug; Duodenum; Electric Stimulation; Enzyme Inhibitors; Ethylmaleimide; Female; Hemoglobins; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Nitroglycerin; Nitroprusside; Oxadiazoles; Quinoxalines; Thiazines | 2001 |
Neural regulation of in vitro giant contractions in the rat colon.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Antineoplastic Agents; Benzazepines; Calcium Channel Agonists; Calcium Channel Blockers; Colon; Cyclic GMP; Dopamine Antagonists; Enzyme Inhibitors; Hexamethonium; Imines; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nicotinic Antagonists; Nitric Oxide; Nitroarginine; omega-Conotoxins; Oxadiazoles; Peristalsis; Quinoxalines; Rats; Rats, Sprague-Dawley; Suramin; Tetrodotoxin | 2001 |
Disturbance of the prejunctional modulation of cholinergic neurotransmission during chronic granulomatous inflammation of the mouse ileum.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic Antagonists; Animals; Brimonidine Tartrate; Carbachol; Cholinergic Agents; Cholinergic Agonists; Cholinergic Antagonists; Chronic Disease; Dimethylphenylpiperazinium Iodide; Dose-Response Relationship, Drug; Electric Stimulation; Granuloma; Hexamethonium; Histamine; Histamine Agonists; Histamine Antagonists; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Neuromuscular Junction; Peroxidase; Quinoxalines; Receptors, Histamine; Schistosoma mansoni; Schistosomiasis mansoni; Synaptic Transmission; Tetrodotoxin | 2001 |
Role of alpha(2)-adrenoceptors in the sympathetic inhibition of motility reflexes of guinea-pig ileum.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Electric Stimulation; Female; Ganglionic Blockers; Gastrointestinal Motility; Guinea Pigs; Hexamethonium; Ileum; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth; Physical Stimulation; Quinoxalines; Receptors, Adrenergic, alpha-2; Reflex; Sympathetic Nervous System | 2001 |
Dual mechanism of action of nicorandil on rabbit corpus cavernosal smooth muscle tone.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Animals; Enzyme Activation; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nicorandil; Nitroprusside; Oxadiazoles; Penis; Phenylephrine; Potassium Channels; Quinoxalines; Rabbits; Vasodilator Agents | 2001 |
Actions of NO donors and endogenous nitrergic transmitter on the longitudinal muscle of rat ileum in vitro: mechanisms involved.
Topics: Animals; Apamin; Atropine; Calcium Channels; Charybdotoxin; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Ileum; Molsidomine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nifedipine; Nitric Oxide; Nitroprusside; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Tetrodotoxin | 2001 |
Characterization of vagal input to the rat esophageal muscle.
Topics: Animals; Atropine; Enteric Nervous System; Enzyme Inhibitors; Esophagus; Galanin; Gastrointestinal Agents; Hexamethonium; Hydrazines; Male; Motor Neurons; Muscle Contraction; Muscle, Skeletal; Muscle, Smooth; Nicotinic Antagonists; Nitric Oxide Donors; Nitroarginine; Nitrogen Oxides; Oxadiazoles; Parasympatholytics; Quinoxalines; Rats; Rats, Wistar; Serotonin; Tetrodotoxin; Tubocurarine; Vagus Nerve; Vasoactive Intestinal Peptide | 2001 |
The vasorelaxation of cerebral arteries by carbon monoxide.
Topics: Animals; Carbon Monoxide; Cerebral Arteries; Dinoprost; Dogs; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Muscle Contraction; Oxadiazoles; Potassium Channel Blockers; Potassium Chloride; Quinoxalines; Tetraethylammonium; Vasodilation | 2001 |
Mechanism of a nitric oxide donor NOR 1-induced relaxation in longitudinal muscle of rat proximal colon.
Topics: Animals; Calcium; Carbachol; Colon; Culture Techniques; Cyclic GMP; DNA-Binding Proteins; Dose-Response Relationship, Drug; Male; Models, Biological; Muscle Contraction; Muscle Relaxation; Muscle, Skeletal; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Thapsigargin; Thionucleotides | 2001 |
alpha(2)-adrenoceptor antagonist properties of OPC-28326, a novel selective peripheral vasodilator.
Topics: Adrenergic alpha-Antagonists; Aniline Compounds; Animals; Azepines; Binding, Competitive; Blood Pressure; Brimonidine Tartrate; Decerebrate State; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Muscle Contraction; Mydriasis; Piperidines; Quinoxalines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Vas Deferens; Vasodilator Agents; Yohimbine | 2001 |
Relaxation and modulation of cyclic AMP production in response to atrial natriuretic peptides in guinea pig tracheal smooth muscle.
Topics: Adenylyl Cyclases; Animals; Apamin; Atrial Natriuretic Factor; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Natriuretic Peptide, C-Type; Nitroprusside; Oxadiazoles; Peptide Fragments; Peptides; Phosphodiesterase Inhibitors; Potassium Channel Blockers; Quinoxalines; Rolipram; Trachea | 2001 |
Altered glutamate receptor function during recovery of bladder detrusor-external urethral sphincter coordination in a rat model of spinal cord injury.
Topics: Animals; Excitatory Amino Acid Antagonists; Female; Hindlimb; Injections, Spinal; Muscle Contraction; Muscle, Smooth; Piperazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Spinal Cord Injuries; Urethra; Urinary Bladder; Urodynamics | 2002 |
Lysophosphatidylcholine potentiates vascular contractile responses in rat aorta via activation of tyrosine kinase.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Brimonidine Tartrate; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Genistein; Lysophosphatidylcholines; Male; Muscle Contraction; Phosphorylation; Potassium; Protein-Tyrosine Kinases; Quinoxalines; Rats; Rats, Wistar; Vasoconstrictor Agents | 2002 |
SK&F 104078, a post-junctionally selective alpha 2-adrenoceptor antagonist in the human saphenous vein in vitro.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Aged; Benzazepines; Brimonidine Tartrate; Humans; In Vitro Techniques; Middle Aged; Muscle Contraction; Muscle, Smooth, Vascular; Neuromuscular Junction; Norepinephrine; Quinoxalines; Saphenous Vein | 1992 |
Antispasmodic activity of tert-aminoalkylderivatives of 3-benzyl-, 3-benzylaza- and 3-benzyldiazaquinoxalinones.
Topics: Acetylcholine; Animals; Benzyl Compounds; Female; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Quinoxalines | 1992 |
Postjunctional alpha-adrenoceptors in the rabbit isolated distal saphenous artery: indirect sensitivity to prazosin of responses to noradrenaline mediated via postjunctional alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Angiotensin II; Animals; Brimonidine Tartrate; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Prazosin; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha; Yohimbine | 1991 |
Additional evidence for functional subclassification of alpha-2 adrenoceptors based on a new selective antagonist, SK&F 104856.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Atrial Function; Benzazepines; Binding, Competitive; Brimonidine Tartrate; Dogs; Electric Stimulation; Female; Guinea Pigs; Heart Atria; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Quinoxalines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Serotonin; Synaptic Transmission; Tritium; Vas Deferens | 1991 |
Contraction-mediating alpha 2-adrenoceptors in the mouse vas deferens.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Dioxanes; Drug Interactions; Idazoxan; Male; Mice; Muscle Contraction; Neuropeptide Y; Phenylephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha; Suramin; Vas Deferens; Yohimbine | 1991 |
Imidazo[4,5-b]quinoxaline cyanines as neurokinin antagonists.
Topics: Animals; Chemical Phenomena; Chemistry; Guinea Pigs; Imidazoles; Muscle Contraction; Muscle, Smooth; Neurokinin A; Quinoxalines; Rats; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Structure-Activity Relationship | 1991 |
[Pharmacological studies of celiprolol: II. Alpha 2-Adrenoceptor blocking effects of a cardioselective beta-blocker, celiprolol].
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Arteries; Blood Pressure; Brimonidine Tartrate; Celiprolol; In Vitro Techniques; Male; Muscle Contraction; Propanolamines; Quinoxalines; Rats; Rats, Inbred Strains; Tail; Tetrodotoxin; Vas Deferens; Vasoconstriction; Yohimbine | 1990 |
Effects of pre-contraction with endothelin-1 on alpha 2-adrenoceptor- and (endothelium-dependent) neuropeptide Y-mediated contractions in the isolated vascular bed of the rat tail.
Topics: Animals; Blood Pressure; Brimonidine Tartrate; Cholic Acids; Endothelins; Endothelium, Vascular; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Neuropeptide Y; Phenylephrine; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Regional Blood Flow; Tail; Yohimbine | 1990 |
In vivo and in vitro studies of alpha 2-adrenoceptor responses in human vascular smooth muscle.
Topics: Adult; Animals; Arm; Brimonidine Tartrate; Dioxanes; Dioxins; Doxazosin; Epinephrine; Humans; Idazoxan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha; Regional Blood Flow; Vasomotor System | 1985 |
Contractile properties of human prostate adenomas and the development of infravesical obstruction.
Topics: Aged; Brimonidine Tartrate; Carbachol; Humans; Male; Muscle Contraction; Muscle, Smooth; Phenylephrine; Potassium Chloride; Prostatic Hyperplasia; Quinoxalines; Sensory Receptor Cells; Urinary Bladder Neck Obstruction | 1989 |
Regional variation of postjunctional alpha-adrenoceptor responses in the developing renal vascular bed of sheep.
Topics: Age Factors; Animals; Animals, Newborn; Brimonidine Tartrate; Fetus; Guanabenz; Isometric Contraction; Kidney; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Quinoxalines; Receptors, Adrenergic, alpha; Renal Artery; Renal Veins; Sheep; Vasoconstriction | 1989 |
Pertussis toxin inhibits endothelium-dependent relaxations to certain agonists in porcine coronary arteries.
Topics: Adenylate Cyclase Toxin; Animals; Brimonidine Tartrate; Coronary Vessels; Endothelium, Vascular; Male; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Oxyhemoglobins; Pertussis Toxin; Platelet Aggregation; Quinoxalines; Serotonin; Swine; Thrombin; Virulence Factors, Bordetella | 1989 |
A comparison of the actions of noradrenaline and UK-14,304 in the longitudinal smooth muscle of the rat isolated portal vein--no evidence for a population of post-junctional alpha 2-adrenoceptors.
Topics: Animals; Brimonidine Tartrate; Dioxanes; Idazoxan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Portal Vein; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1988 |
Effects of desipramine on stimulation-induced contractions of the vas deferens of rats pretreated either chronically with desipramine or acutely with idazoxan.
Topics: Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Desipramine; Dioxanes; Dioxins; Drug Interactions; Electric Stimulation; Idazoxan; Male; Muscle Contraction; Muscle, Smooth; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Time Factors; Vas Deferens | 1985 |
Studies on YM-12617: a selective and potent antagonist of postsynaptic alpha 1-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Blood Pressure; Brain; Brimonidine Tartrate; Clonidine; Dioxanes; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Muscle Contraction; Phenylephrine; Pulmonary Artery; Quinoxalines; Rabbits; Rats; Receptors, Adrenergic, alpha; Sulfonamides; Tritium; Vas Deferens | 1985 |
A difference in the affinity of some selective alpha 2-adrenoceptor antagonists when compared on isolated vasa deferentia of rat and rabbit.
Topics: Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Quinoxalines; Rabbits; Rats; Vas Deferens | 1985 |
Neural control of jejunal and ileal motility and transmural potential difference in the ferret.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Atropine; Brimonidine Tartrate; Dioxanes; Ferrets; Gastrointestinal Motility; Idazoxan; Ileum; In Vitro Techniques; Jejunum; Male; Membrane Potentials; Muscle Contraction; Quinoxalines | 1986 |
Evidence for a receptor mediated action of norepinephrine distinct from alpha- and beta-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Cystamine; Guinea Pigs; Histamine Antagonists; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Quinoxalines; Receptors, Adrenergic | 1986 |
Pharmacological characterization of the postsynaptic alpha-adrenoceptors in isolated canine mesenteric arteries and veins.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Brimonidine Tartrate; Dogs; Dopamine; Female; In Vitro Techniques; Male; Mesenteric Arteries; Mesenteric Veins; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha; Synapses; Yohimbine | 1987 |
Characterization of the alpha-adrenoceptors mediating positive inotropy of rat left atria by use of selective agonists and antagonists.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Brimonidine Tartrate; Dioxanes; Idazoxan; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Methoxamine; Muscle Contraction; Myocardial Contraction; Phenylephrine; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Stimulation, Chemical | 1987 |
The effects of some alpha-adrenoceptor antagonists on the responses of the canine saphenous vein to B-HT 933, UK-14304 and methoxamine.
Topics: Adrenergic alpha-Antagonists; Animals; Azepines; Brimonidine Tartrate; Dioxanes; Dogs; Idazoxan; In Vitro Techniques; Male; Methoxamine; Muscle Contraction; Muscle, Smooth, Vascular; Potassium Chloride; Quinoxalines; Saphenous Vein | 1987 |
Alpha 2-adrenoceptor-mediated responses to so-called selective alpha 1-adrenoceptor agonists after partial blockade of alpha 1-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Dogs; Drug Interactions; In Vitro Techniques; Methoxamine; Muscle Contraction; Muscle, Smooth, Vascular; Phenoxybenzamine; Phenylephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha; Verapamil; Yohimbine | 1987 |
Evidence that the population of postjunctional-adrenoceptors mediating contraction of smooth muscle in the rabbit isolated ear vein is predominantly alpha 2.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Brimonidine Tartrate; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Prazosin; Quinoxalines; Rabbits; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Veins; Yohimbine | 1988 |
Influence of the vascular endothelium on agonist-induced contractions and relaxations in rat aorta.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Antihypertensive Agents; Aorta, Thoracic; Brimonidine Tartrate; Cyclic GMP; Endothelium; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Prostaglandin Endoperoxides, Synthetic; Quinoxalines; Rats; Rats, Inbred Strains | 1986 |