quinotrierixin has been researched along with Multiple-Myeloma* in 1 studies
1 review(s) available for quinotrierixin and Multiple-Myeloma
| Article | Year |
|---|---|
Screening and identification of inhibitors of endoplasmic reticulum stress-induced activation of the IRE1α-XBP1 branch.
Endoplasmic reticulum (ER) stress and the subsequent adaptive cellular response, termed the unfolded protein response (UPR), have been implicated in several diseases, including cancer. In this review, I present a brief introduction to ER stress and the UPR and then summarize the importance of the IRE1α-XBP1 branch as a target for anticancer drug discovery. In addition, I introduce our approach to the identification of inhibitors against the IRE1α-XBP1 branch from microbial cultures. As a result of our screening, toyocamycin has been identified and toyocamycin showed anticancer activity against multiple myeloma. Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Drug Evaluation, Preclinical; Endoplasmic Reticulum Stress; Endoribonucleases; Humans; Lactams, Macrocyclic; Multiple Myeloma; Protein Serine-Threonine Kinases; Rifabutin; Toyocamycin; Unfolded Protein Response; X-Box Binding Protein 1 | 2019 |