Page last updated: 2024-11-02

quinone and Neoplasms

quinone has been researched along with Neoplasms in 30 studies

benzoquinone : The simplest members of the class of benzoquinones, consisting of cyclohexadiene which is substituted by two oxo groups.
1,4-benzoquinone : The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene.
quinone : Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included).

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
"This review uses the National Cancer Institute (NCI) COMPARE program to establish an extensive list of heterocyclic iminoquinones and quinones with similarities in differential growth inhibition patterns across the 60-cell line panel of the NCI Developmental Therapeutics Program (DTP)."3.01Heterocyclic Iminoquinones and Quinones from the National Cancer Institute (NCI, USA) COMPARE Analysis. ( Aldabbagh, F; Carty, MP; Faizi, M; Haji, N; Koutentis, PA, 2023)
"Targeted anticancer effects of Q/A redox-pairs and their tolerance to normal cells and tissues are attributed to: (i) downregulation of quinone prenylation in cancer, leading to increased mitochondrial production of semiquinone and, consequently, superoxide; (ii) specific and accelerated redox-cycling of unprenylated quinones and ascorbate mainly in the impaired cancerous mitochondria due to their redox imbalance; and (iii) downregulation of tNOX."1.91Redox-Cycling "Mitocans" as Effective New Developments in Anticancer Therapy. ( Aoki, I; Bakalova, R; Higashi, T; Lazarova, D; Nikolova, B; Semkova, S; Shibata, S; Sumiyoshi, A; Vlaykova, T; Zhelev, Z, 2023)
"Colorectal cancer (CRC), breast cancer, and chronic myeloid leukemia (CML) are life-threatening malignancies worldwide."1.72Studies on 1,4-Quinone Derivatives Exhibiting Anti-Leukemic Activity along with Anti-Colorectal and Anti-Breast Cancer Effects. ( Bayrak, N; Ciftci, H; Fujita, M; Kaya, N; Otsuka, M; Sever, B; Tateishi, H; TuYuN, AF; Yıldırım, H; Yıldız, M, 2022)
"Given the putative role of PHGDH in cancer, development of inhibitors is required to explore its function."1.46α-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH). ( Cantley, LC; Corbet, C; Dutu, A; Feron, O; Frédérick, R; Mullarky, E; Ravez, S; Robin, AD; Spillier, Q, 2017)
"Benzene is a widely recognized human carcinogen, the effect of which is attributed to the production of reactive oxygen species (ROS) from its metabolites."1.32Dysregulation of apoptosis by benzene metabolites and their relationships with carcinogenesis. ( Goto, R; Ibuki, Y, 2004)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-199016 (53.33)18.7374
1990's0 (0.00)18.2507
2000's5 (16.67)29.6817
2010's4 (13.33)24.3611
2020's5 (16.67)2.80

Authors

AuthorsStudies
Diamandis, P1
Wildenhain, J1
Clarke, ID1
Sacher, AG1
Graham, J1
Bellows, DS1
Ling, EK1
Ward, RJ1
Jamieson, LG1
Tyers, M1
Dirks, PB1
Ravez, S1
Corbet, C1
Spillier, Q1
Dutu, A1
Robin, AD1
Mullarky, E1
Cantley, LC1
Feron, O1
Frédérick, R1
Luo, Y1
Wang, W1
Zeng, Y1
Wang, S1
Guo, X1
Hu, R1
Yang, G1
Ciftci, H1
Sever, B1
Kaya, N1
Bayrak, N1
Yıldız, M1
Yıldırım, H1
Tateishi, H1
Otsuka, M1
Fujita, M1
TuYuN, AF1
Bakalova, R1
Lazarova, D1
Sumiyoshi, A1
Shibata, S1
Zhelev, Z1
Nikolova, B1
Semkova, S1
Vlaykova, T1
Aoki, I1
Higashi, T1
Haji, N1
Faizi, M1
Koutentis, PA1
Carty, MP1
Aldabbagh, F1
Baird, L1
Suzuki, T1
Takahashi, Y1
Hishinuma, E1
Saigusa, D1
Yamamoto, M1
Polyakov, N1
Leshina, T1
Fedenok, L1
Slepneva, I1
Kirilyuk, I1
Furso, J1
Olchawa, M1
Sarna, T1
Elas, M1
Bilkis, I1
Weiner, L1
Kelly, RA1
Leedale, J1
Calleja, D1
Enoch, SJ1
Harrell, A1
Chadwick, AE1
Webb, S1
Douglas, M1
Lim, AR1
Porter, JR1
West, K1
Pink, MM1
Ge, J1
Wylie, AA1
Tibbits, TT1
Biggs, K1
Curtis, M1
Palombella, VJ1
Adams, J1
Fritz, CC1
Normant, E1
Xiao, Q1
Liu, Y1
Qiu, Y1
Yao, Z1
Zhou, G1
Yao, ZJ1
Jiang, S1
DI PIETRO, S1
SCHWERMER, B1
SCHREIBER, HW1
HASHIZUME, T1
TAKIZAWA, E1
RAVINA, A2
PESTEL, M1
JANBON, M1
BERTRAND, L1
BERTRAND, A1
FLANDRE, O1
ELOY, P1
DOMAGK, G1
RISSE, HJ1
TIEDEMANN, H1
OBRECHT, P1
FUSENIG, N1
LUCER, C1
SZLAZAK, W1
HOELZEL, F1
MAASS, H1
BOCK, H1
SUGISHITA, M2
TAKIZAWA, N1
OTA, M1
Ibuki, Y1
Goto, R1
MAYER, RL1
Schimmer, AD1
Dalili, S1
Batey, RA1
Riedl, SJ1
Das Sarma, M1
Ghosh, R1
Patra, A1
Hazra, B1
Mathew, AE1
Zee-Cheng, RK1
Cheng, CC1
KALAMANSON, AE1
LIPCHINA, LP1
CHETVERIKOV, AG1

Reviews

3 reviews available for quinone and Neoplasms

ArticleYear
Heterocyclic Iminoquinones and Quinones from the National Cancer Institute (NCI, USA) COMPARE Analysis.
    Molecules (Basel, Switzerland), 2023, Jul-04, Volume: 28, Issue:13

    Topics: Antineoplastic Agents; Indolequinones; NAD(P)H Dehydrogenase (Quinone); National Cancer Institute (U

2023
Redox-Active Quinone Chelators: Properties, Mechanisms of Action, Cell Delivery, and Cell Toxicity.
    Antioxidants & redox signaling, 2018, 05-20, Volume: 28, Issue:15

    Topics: Antibiotics, Antineoplastic; Benzoquinones; Electron Spin Resonance Spectroscopy; Humans; Neoplasms;

2018
Targeting XIAP for the treatment of malignancy.
    Cell death and differentiation, 2006, Volume: 13, Issue:2

    Topics: Apoptosis; Benzoquinones; Caspase Inhibitors; Clobetasol; Humans; Neoplasms; Oligonucleotides, Antis

2006

Other Studies

27 other studies available for quinone and Neoplasms

ArticleYear
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic

2007
α-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH).
    Journal of medicinal chemistry, 2017, 02-23, Volume: 60, Issue:4

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Evaluation, Preclinical; Enzyme In

2017
A bioluminescent probe for NQO1 overexpressing cancer cell imaging
    The Analyst, 2022, Nov-21, Volume: 147, Issue:23

    Topics: Benzoquinones; Humans; NAD(P)H Dehydrogenase (Quinone); Neoplasms; Quinones

2022
Studies on 1,4-Quinone Derivatives Exhibiting Anti-Leukemic Activity along with Anti-Colorectal and Anti-Breast Cancer Effects.
    Molecules (Basel, Switzerland), 2022, Dec-22, Volume: 28, Issue:1

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug

2022
Redox-Cycling "Mitocans" as Effective New Developments in Anticancer Therapy.
    International journal of molecular sciences, 2023, May-08, Volume: 24, Issue:9

    Topics: Adenosine Triphosphate; Animals; Ascorbic Acid; Mice; Neoplasms; Oxidation-Reduction; Quinones; Supe

2023
Geldanamycin-Derived HSP90 Inhibitors Are Synthetic Lethal with NRF2.
    Molecular and cellular biology, 2020, 10-26, Volume: 40, Issue:22

    Topics: Animals; Antineoplastic Agents; Benzoquinones; Cell Death; Cell Line, Tumor; Cell Proliferation; Dru

2020
Modelling changes in glutathione homeostasis as a function of quinone redox metabolism.
    Scientific reports, 2019, 04-19, Volume: 9, Issue:1

    Topics: Animals; Benzoquinones; Glutathione; Humans; Models, Biological; Neoplasms; Oxidation-Reduction

2019
The antiproliferative activity of the heat shock protein 90 inhibitor IPI-504 is not dependent on NAD(P)H:quinone oxidoreductase 1 activity in vivo.
    Molecular cancer therapeutics, 2009, Volume: 8, Issue:12

    Topics: Animals; Benzoquinones; Cell Line, Tumor; Cell Proliferation; HCT116 Cells; HSP90 Heat-Shock Protein

2009
Design, synthesis of symmetrical bivalent mimetics of annonaceous acetogenins and their cytotoxicities.
    Bioorganic & medicinal chemistry letters, 2011, Jun-15, Volume: 21, Issue:12

    Topics: Acetogenins; Antineoplastic Agents; Benzoquinones; Cell Line, Tumor; Cell Proliferation; Cell Surviv

2011
[Clinical experiences with ethyleneimino-quinone (E 39) in chemotherapy of various neoplasms].
    La Riforma medica, 1957, Jun-01, Volume: 71, Issue:22

    Topics: Antineoplastic Agents; Benzoquinones; Neoplasms; Quinones

1957
[Cytostatic treatment of malignant tumors with alcoxyethyleneimino-benzoquinone; Bayer E 39].
    Deutsche medizinische Wochenschrift (1946), 1958, Feb-28, Volume: 83, Issue:9

    Topics: Antineoplastic Agents; Benzoquinones; Humans; Neoplasms

1958
[Electron-microscopic observation on the levulose-sarcoma and the quinone-cancer in mice].
    Gan, 1957, Volume: 48, Issue:4

    Topics: Animals; Benzoquinones; Electrons; Fructose; Mice; Microscopy; Microscopy, Electron; Neoplasms; Sarc

1957
[Cytotoxic drugs and malignant tumors; action of triethylene melamine, of diethylene-dipropryloxy-benzoquinone and of thiophosphoramide].
    La Presse medicale, 1958, Mar-01, Volume: 66, Issue:17

    Topics: Antineoplastic Agents; Benzoquinones; Neoplasms; Thiotepa; Triethylenemelamine

1958
[Attempted treatment of advanced cancer with a derivative of the ethylene-imine-quinone group (E 39 or 6870 RP)].
    Montpellier medical, 1958, Volume: 53, Issue:6

    Topics: Antineoplastic Agents; Benzoquinones; Ethylenes; Humans; Imines; Neoplasms; Quinones

1958
[Current status of anti-cancer chemotherapy. IV. Diethylene-imine-dipropyloxy-benzoquinone and its derivatives].
    La Presse medicale, 1961, Jun-17, Volume: 69

    Topics: Antineoplastic Agents; Benzoquinones; Imines; Neoplasms; Quinones

1961
[Previous experiences with ethyleneiminobenzo-quinone in the treatment of malignant tumors in experiments and in clinical medicine].
    Archives internationales de pharmacodynamie et de therapie, 1962, Dec-01, Volume: 140

    Topics: Antineoplastic Agents; Benzoquinones; Humans; Neoplasms; Quinones

1962
[The redox cycle of phenanthrene-quinone in ascites tumor cells and in a simplified model].
    Zeitschrift fur Naturforschung. Teil B, Chemie, Biochemie, Biophysik, Biologie und verwandte Gebiete, 1962, Volume: 17B

    Topics: Ascites; Benzoquinones; Neoplasms; Neoplasms, Experimental; Oxidation-Reduction; Phenanthrenes

1962
[ON THE EFFECT OF 2,3,5-TRIS(ETHYLENEIMINO)-P-BENZOQUINONE (TRENIMON) ON THE METABOLISM OF JENSEN SARCOMA].
    Zeitschrift fur Krebsforschung, 1965, Feb-03, Volume: 66

    Topics: Animals; Antineoplastic Agents; Benzoquinones; Carbohydrate Metabolism; Metabolism; NAD; Neoplasms;

1965
[SUCCESSFUL RESULT OF THE USE OF CYTOSTATIC DRUGS OF THE ETHYLENEIMINO-BENZOQUINONE GROUP IN THE TREATMENT OF CANCER OF THE UTERINE CERVIX].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1965, Jan-11, Volume: 20

    Topics: Antineoplastic Agents; Benzoquinones; Cytostatic Agents; Female; Humans; Neoplasms; Quinones; Uterin

1965
[THE EFFECTS OF 2,3,5-TRIS-ETHYLENIMINO-1,4-BENZOQUINONE ON OXYGEN-CONSUMING REACTIONS IN YOSHIDA ASCITES SARCOMA CELLS].
    Arzneimittel-Forschung, 1964, Volume: 14

    Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Ascites; Benzoquinones; Metabolism; NAD; Neo

1964
Experimental studies on the skin- and lung-cancer, produced by the nonreduced quinone.
    Gan, 1950, Volume: 41, Issue:2-4

    Topics: Benzoquinones; Humans; Lung Neoplasms; Neoplasms; Quinones; Skin

1950
Transplantation of skin cancer in mice produced by quinones.
    Gan, 1950, Volume: 41, Issue:2-4

    Topics: Animals; Benzoquinones; Mice; Neoplasms; Quinones; Skin; Skin Neoplasms

1950
Dysregulation of apoptosis by benzene metabolites and their relationships with carcinogenesis.
    Biochimica et biophysica acta, 2004, Sep-06, Volume: 1690, Issue:1

    Topics: Acetylcysteine; Animals; Apoptosis; Benzene; Benzoquinones; Caspase 3; Caspases; Cell Division; Enzy

2004
Compounds of quinone structure as allergens and cancerogenic agents.
    Experientia, 1950, Jul-07, Volume: 6, Issue:7

    Topics: Allergens; Anaphylaxis; Benzoquinones; Coloring Agents; Humans; Hypersensitivity; Immune System Dise

1950
Synthesis of novel aminoquinonoid analogues of diospyrin and evaluation of their inhibitory activity against murine and human cancer cells.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:9

    Topics: Animals; Antineoplastic Agents; Benzoquinones; Carcinoma, Ehrlich Tumor; Cell Line, Tumor; Cell Prol

2008
Amino-substituted p-benzoquinones.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:9

    Topics: Adenocarcinoma; Animals; Benzoquinones; Chemical Phenomena; Chemistry; Colonic Neoplasms; Drug Evalu

1986
[Electronic paramagnetic resonance reaction method in the study on the inter-activity between tumor and normal cells of semiquinone ion-radicals appearing from inhibitors of free radical processes].
    Biofizika, 1961, Volume: 6(4)

    Topics: Benzoquinones; Biochemical Phenomena; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; N

1961