quinone has been researched along with Neoplasms in 30 studies
benzoquinone : The simplest members of the class of benzoquinones, consisting of cyclohexadiene which is substituted by two oxo groups.
1,4-benzoquinone : The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene.
quinone : Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included).
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Excerpt | Relevance | Reference |
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"This review uses the National Cancer Institute (NCI) COMPARE program to establish an extensive list of heterocyclic iminoquinones and quinones with similarities in differential growth inhibition patterns across the 60-cell line panel of the NCI Developmental Therapeutics Program (DTP)." | 3.01 | Heterocyclic Iminoquinones and Quinones from the National Cancer Institute (NCI, USA) COMPARE Analysis. ( Aldabbagh, F; Carty, MP; Faizi, M; Haji, N; Koutentis, PA, 2023) |
"Targeted anticancer effects of Q/A redox-pairs and their tolerance to normal cells and tissues are attributed to: (i) downregulation of quinone prenylation in cancer, leading to increased mitochondrial production of semiquinone and, consequently, superoxide; (ii) specific and accelerated redox-cycling of unprenylated quinones and ascorbate mainly in the impaired cancerous mitochondria due to their redox imbalance; and (iii) downregulation of tNOX." | 1.91 | Redox-Cycling "Mitocans" as Effective New Developments in Anticancer Therapy. ( Aoki, I; Bakalova, R; Higashi, T; Lazarova, D; Nikolova, B; Semkova, S; Shibata, S; Sumiyoshi, A; Vlaykova, T; Zhelev, Z, 2023) |
"Colorectal cancer (CRC), breast cancer, and chronic myeloid leukemia (CML) are life-threatening malignancies worldwide." | 1.72 | Studies on 1,4-Quinone Derivatives Exhibiting Anti-Leukemic Activity along with Anti-Colorectal and Anti-Breast Cancer Effects. ( Bayrak, N; Ciftci, H; Fujita, M; Kaya, N; Otsuka, M; Sever, B; Tateishi, H; TuYuN, AF; Yıldırım, H; Yıldız, M, 2022) |
"Given the putative role of PHGDH in cancer, development of inhibitors is required to explore its function." | 1.46 | α-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH). ( Cantley, LC; Corbet, C; Dutu, A; Feron, O; Frédérick, R; Mullarky, E; Ravez, S; Robin, AD; Spillier, Q, 2017) |
"Benzene is a widely recognized human carcinogen, the effect of which is attributed to the production of reactive oxygen species (ROS) from its metabolites." | 1.32 | Dysregulation of apoptosis by benzene metabolites and their relationships with carcinogenesis. ( Goto, R; Ibuki, Y, 2004) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 16 (53.33) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 5 (16.67) | 29.6817 |
2010's | 4 (13.33) | 24.3611 |
2020's | 5 (16.67) | 2.80 |
Authors | Studies |
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Diamandis, P | 1 |
Wildenhain, J | 1 |
Clarke, ID | 1 |
Sacher, AG | 1 |
Graham, J | 1 |
Bellows, DS | 1 |
Ling, EK | 1 |
Ward, RJ | 1 |
Jamieson, LG | 1 |
Tyers, M | 1 |
Dirks, PB | 1 |
Ravez, S | 1 |
Corbet, C | 1 |
Spillier, Q | 1 |
Dutu, A | 1 |
Robin, AD | 1 |
Mullarky, E | 1 |
Cantley, LC | 1 |
Feron, O | 1 |
Frédérick, R | 1 |
Luo, Y | 1 |
Wang, W | 1 |
Zeng, Y | 1 |
Wang, S | 1 |
Guo, X | 1 |
Hu, R | 1 |
Yang, G | 1 |
Ciftci, H | 1 |
Sever, B | 1 |
Kaya, N | 1 |
Bayrak, N | 1 |
Yıldız, M | 1 |
Yıldırım, H | 1 |
Tateishi, H | 1 |
Otsuka, M | 1 |
Fujita, M | 1 |
TuYuN, AF | 1 |
Bakalova, R | 1 |
Lazarova, D | 1 |
Sumiyoshi, A | 1 |
Shibata, S | 1 |
Zhelev, Z | 1 |
Nikolova, B | 1 |
Semkova, S | 1 |
Vlaykova, T | 1 |
Aoki, I | 1 |
Higashi, T | 1 |
Haji, N | 1 |
Faizi, M | 1 |
Koutentis, PA | 1 |
Carty, MP | 1 |
Aldabbagh, F | 1 |
Baird, L | 1 |
Suzuki, T | 1 |
Takahashi, Y | 1 |
Hishinuma, E | 1 |
Saigusa, D | 1 |
Yamamoto, M | 1 |
Polyakov, N | 1 |
Leshina, T | 1 |
Fedenok, L | 1 |
Slepneva, I | 1 |
Kirilyuk, I | 1 |
Furso, J | 1 |
Olchawa, M | 1 |
Sarna, T | 1 |
Elas, M | 1 |
Bilkis, I | 1 |
Weiner, L | 1 |
Kelly, RA | 1 |
Leedale, J | 1 |
Calleja, D | 1 |
Enoch, SJ | 1 |
Harrell, A | 1 |
Chadwick, AE | 1 |
Webb, S | 1 |
Douglas, M | 1 |
Lim, AR | 1 |
Porter, JR | 1 |
West, K | 1 |
Pink, MM | 1 |
Ge, J | 1 |
Wylie, AA | 1 |
Tibbits, TT | 1 |
Biggs, K | 1 |
Curtis, M | 1 |
Palombella, VJ | 1 |
Adams, J | 1 |
Fritz, CC | 1 |
Normant, E | 1 |
Xiao, Q | 1 |
Liu, Y | 1 |
Qiu, Y | 1 |
Yao, Z | 1 |
Zhou, G | 1 |
Yao, ZJ | 1 |
Jiang, S | 1 |
DI PIETRO, S | 1 |
SCHWERMER, B | 1 |
SCHREIBER, HW | 1 |
HASHIZUME, T | 1 |
TAKIZAWA, E | 1 |
RAVINA, A | 2 |
PESTEL, M | 1 |
JANBON, M | 1 |
BERTRAND, L | 1 |
BERTRAND, A | 1 |
FLANDRE, O | 1 |
ELOY, P | 1 |
DOMAGK, G | 1 |
RISSE, HJ | 1 |
TIEDEMANN, H | 1 |
OBRECHT, P | 1 |
FUSENIG, N | 1 |
LUCER, C | 1 |
SZLAZAK, W | 1 |
HOELZEL, F | 1 |
MAASS, H | 1 |
BOCK, H | 1 |
SUGISHITA, M | 2 |
TAKIZAWA, N | 1 |
OTA, M | 1 |
Ibuki, Y | 1 |
Goto, R | 1 |
MAYER, RL | 1 |
Schimmer, AD | 1 |
Dalili, S | 1 |
Batey, RA | 1 |
Riedl, SJ | 1 |
Das Sarma, M | 1 |
Ghosh, R | 1 |
Patra, A | 1 |
Hazra, B | 1 |
Mathew, AE | 1 |
Zee-Cheng, RK | 1 |
Cheng, CC | 1 |
KALAMANSON, AE | 1 |
LIPCHINA, LP | 1 |
CHETVERIKOV, AG | 1 |
3 reviews available for quinone and Neoplasms
Article | Year |
---|---|
Heterocyclic Iminoquinones and Quinones from the National Cancer Institute (NCI, USA) COMPARE Analysis.
Topics: Antineoplastic Agents; Indolequinones; NAD(P)H Dehydrogenase (Quinone); National Cancer Institute (U | 2023 |
Redox-Active Quinone Chelators: Properties, Mechanisms of Action, Cell Delivery, and Cell Toxicity.
Topics: Antibiotics, Antineoplastic; Benzoquinones; Electron Spin Resonance Spectroscopy; Humans; Neoplasms; | 2018 |
Targeting XIAP for the treatment of malignancy.
Topics: Apoptosis; Benzoquinones; Caspase Inhibitors; Clobetasol; Humans; Neoplasms; Oligonucleotides, Antis | 2006 |
27 other studies available for quinone and Neoplasms
Article | Year |
---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
α-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH).
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Evaluation, Preclinical; Enzyme In | 2017 |
A bioluminescent probe for NQO1 overexpressing cancer cell imaging
Topics: Benzoquinones; Humans; NAD(P)H Dehydrogenase (Quinone); Neoplasms; Quinones | 2022 |
Studies on 1,4-Quinone Derivatives Exhibiting Anti-Leukemic Activity along with Anti-Colorectal and Anti-Breast Cancer Effects.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug | 2022 |
Redox-Cycling "Mitocans" as Effective New Developments in Anticancer Therapy.
Topics: Adenosine Triphosphate; Animals; Ascorbic Acid; Mice; Neoplasms; Oxidation-Reduction; Quinones; Supe | 2023 |
Geldanamycin-Derived HSP90 Inhibitors Are Synthetic Lethal with NRF2.
Topics: Animals; Antineoplastic Agents; Benzoquinones; Cell Death; Cell Line, Tumor; Cell Proliferation; Dru | 2020 |
Modelling changes in glutathione homeostasis as a function of quinone redox metabolism.
Topics: Animals; Benzoquinones; Glutathione; Humans; Models, Biological; Neoplasms; Oxidation-Reduction | 2019 |
The antiproliferative activity of the heat shock protein 90 inhibitor IPI-504 is not dependent on NAD(P)H:quinone oxidoreductase 1 activity in vivo.
Topics: Animals; Benzoquinones; Cell Line, Tumor; Cell Proliferation; HCT116 Cells; HSP90 Heat-Shock Protein | 2009 |
Design, synthesis of symmetrical bivalent mimetics of annonaceous acetogenins and their cytotoxicities.
Topics: Acetogenins; Antineoplastic Agents; Benzoquinones; Cell Line, Tumor; Cell Proliferation; Cell Surviv | 2011 |
[Clinical experiences with ethyleneimino-quinone (E 39) in chemotherapy of various neoplasms].
Topics: Antineoplastic Agents; Benzoquinones; Neoplasms; Quinones | 1957 |
[Cytostatic treatment of malignant tumors with alcoxyethyleneimino-benzoquinone; Bayer E 39].
Topics: Antineoplastic Agents; Benzoquinones; Humans; Neoplasms | 1958 |
[Electron-microscopic observation on the levulose-sarcoma and the quinone-cancer in mice].
Topics: Animals; Benzoquinones; Electrons; Fructose; Mice; Microscopy; Microscopy, Electron; Neoplasms; Sarc | 1957 |
[Cytotoxic drugs and malignant tumors; action of triethylene melamine, of diethylene-dipropryloxy-benzoquinone and of thiophosphoramide].
Topics: Antineoplastic Agents; Benzoquinones; Neoplasms; Thiotepa; Triethylenemelamine | 1958 |
[Attempted treatment of advanced cancer with a derivative of the ethylene-imine-quinone group (E 39 or 6870 RP)].
Topics: Antineoplastic Agents; Benzoquinones; Ethylenes; Humans; Imines; Neoplasms; Quinones | 1958 |
[Current status of anti-cancer chemotherapy. IV. Diethylene-imine-dipropyloxy-benzoquinone and its derivatives].
Topics: Antineoplastic Agents; Benzoquinones; Imines; Neoplasms; Quinones | 1961 |
[Previous experiences with ethyleneiminobenzo-quinone in the treatment of malignant tumors in experiments and in clinical medicine].
Topics: Antineoplastic Agents; Benzoquinones; Humans; Neoplasms; Quinones | 1962 |
[The redox cycle of phenanthrene-quinone in ascites tumor cells and in a simplified model].
Topics: Ascites; Benzoquinones; Neoplasms; Neoplasms, Experimental; Oxidation-Reduction; Phenanthrenes | 1962 |
[ON THE EFFECT OF 2,3,5-TRIS(ETHYLENEIMINO)-P-BENZOQUINONE (TRENIMON) ON THE METABOLISM OF JENSEN SARCOMA].
Topics: Animals; Antineoplastic Agents; Benzoquinones; Carbohydrate Metabolism; Metabolism; NAD; Neoplasms; | 1965 |
[SUCCESSFUL RESULT OF THE USE OF CYTOSTATIC DRUGS OF THE ETHYLENEIMINO-BENZOQUINONE GROUP IN THE TREATMENT OF CANCER OF THE UTERINE CERVIX].
Topics: Antineoplastic Agents; Benzoquinones; Cytostatic Agents; Female; Humans; Neoplasms; Quinones; Uterin | 1965 |
[THE EFFECTS OF 2,3,5-TRIS-ETHYLENIMINO-1,4-BENZOQUINONE ON OXYGEN-CONSUMING REACTIONS IN YOSHIDA ASCITES SARCOMA CELLS].
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Ascites; Benzoquinones; Metabolism; NAD; Neo | 1964 |
Experimental studies on the skin- and lung-cancer, produced by the nonreduced quinone.
Topics: Benzoquinones; Humans; Lung Neoplasms; Neoplasms; Quinones; Skin | 1950 |
Transplantation of skin cancer in mice produced by quinones.
Topics: Animals; Benzoquinones; Mice; Neoplasms; Quinones; Skin; Skin Neoplasms | 1950 |
Dysregulation of apoptosis by benzene metabolites and their relationships with carcinogenesis.
Topics: Acetylcysteine; Animals; Apoptosis; Benzene; Benzoquinones; Caspase 3; Caspases; Cell Division; Enzy | 2004 |
Compounds of quinone structure as allergens and cancerogenic agents.
Topics: Allergens; Anaphylaxis; Benzoquinones; Coloring Agents; Humans; Hypersensitivity; Immune System Dise | 1950 |
Synthesis of novel aminoquinonoid analogues of diospyrin and evaluation of their inhibitory activity against murine and human cancer cells.
Topics: Animals; Antineoplastic Agents; Benzoquinones; Carcinoma, Ehrlich Tumor; Cell Line, Tumor; Cell Prol | 2008 |
Amino-substituted p-benzoquinones.
Topics: Adenocarcinoma; Animals; Benzoquinones; Chemical Phenomena; Chemistry; Colonic Neoplasms; Drug Evalu | 1986 |
[Electronic paramagnetic resonance reaction method in the study on the inter-activity between tumor and normal cells of semiquinone ion-radicals appearing from inhibitors of free radical processes].
Topics: Benzoquinones; Biochemical Phenomena; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; N | 1961 |