quinone has been researched along with Neoplasms in 30 studies
benzoquinone : The simplest members of the class of benzoquinones, consisting of cyclohexadiene which is substituted by two oxo groups.
1,4-benzoquinone : The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene.
quinone : Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included).
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This review uses the National Cancer Institute (NCI) COMPARE program to establish an extensive list of heterocyclic iminoquinones and quinones with similarities in differential growth inhibition patterns across the 60-cell line panel of the NCI Developmental Therapeutics Program (DTP)." | 3.01 | Heterocyclic Iminoquinones and Quinones from the National Cancer Institute (NCI, USA) COMPARE Analysis. ( Aldabbagh, F; Carty, MP; Faizi, M; Haji, N; Koutentis, PA, 2023) |
| "Targeted anticancer effects of Q/A redox-pairs and their tolerance to normal cells and tissues are attributed to: (i) downregulation of quinone prenylation in cancer, leading to increased mitochondrial production of semiquinone and, consequently, superoxide; (ii) specific and accelerated redox-cycling of unprenylated quinones and ascorbate mainly in the impaired cancerous mitochondria due to their redox imbalance; and (iii) downregulation of tNOX." | 1.91 | Redox-Cycling "Mitocans" as Effective New Developments in Anticancer Therapy. ( Aoki, I; Bakalova, R; Higashi, T; Lazarova, D; Nikolova, B; Semkova, S; Shibata, S; Sumiyoshi, A; Vlaykova, T; Zhelev, Z, 2023) |
| "Colorectal cancer (CRC), breast cancer, and chronic myeloid leukemia (CML) are life-threatening malignancies worldwide." | 1.72 | Studies on 1,4-Quinone Derivatives Exhibiting Anti-Leukemic Activity along with Anti-Colorectal and Anti-Breast Cancer Effects. ( Bayrak, N; Ciftci, H; Fujita, M; Kaya, N; Otsuka, M; Sever, B; Tateishi, H; TuYuN, AF; Yıldırım, H; Yıldız, M, 2022) |
| "Given the putative role of PHGDH in cancer, development of inhibitors is required to explore its function." | 1.46 | α-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH). ( Cantley, LC; Corbet, C; Dutu, A; Feron, O; Frédérick, R; Mullarky, E; Ravez, S; Robin, AD; Spillier, Q, 2017) |
| "Benzene is a widely recognized human carcinogen, the effect of which is attributed to the production of reactive oxygen species (ROS) from its metabolites." | 1.32 | Dysregulation of apoptosis by benzene metabolites and their relationships with carcinogenesis. ( Goto, R; Ibuki, Y, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (53.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (16.67) | 29.6817 |
| 2010's | 4 (13.33) | 24.3611 |
| 2020's | 5 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Ravez, S | 1 |
| Corbet, C | 1 |
| Spillier, Q | 1 |
| Dutu, A | 1 |
| Robin, AD | 1 |
| Mullarky, E | 1 |
| Cantley, LC | 1 |
| Feron, O | 1 |
| Frédérick, R | 1 |
| Luo, Y | 1 |
| Wang, W | 1 |
| Zeng, Y | 1 |
| Wang, S | 1 |
| Guo, X | 1 |
| Hu, R | 1 |
| Yang, G | 1 |
| Ciftci, H | 1 |
| Sever, B | 1 |
| Kaya, N | 1 |
| Bayrak, N | 1 |
| Yıldız, M | 1 |
| Yıldırım, H | 1 |
| Tateishi, H | 1 |
| Otsuka, M | 1 |
| Fujita, M | 1 |
| TuYuN, AF | 1 |
| Bakalova, R | 1 |
| Lazarova, D | 1 |
| Sumiyoshi, A | 1 |
| Shibata, S | 1 |
| Zhelev, Z | 1 |
| Nikolova, B | 1 |
| Semkova, S | 1 |
| Vlaykova, T | 1 |
| Aoki, I | 1 |
| Higashi, T | 1 |
| Haji, N | 1 |
| Faizi, M | 1 |
| Koutentis, PA | 1 |
| Carty, MP | 1 |
| Aldabbagh, F | 1 |
| Baird, L | 1 |
| Suzuki, T | 1 |
| Takahashi, Y | 1 |
| Hishinuma, E | 1 |
| Saigusa, D | 1 |
| Yamamoto, M | 1 |
| Polyakov, N | 1 |
| Leshina, T | 1 |
| Fedenok, L | 1 |
| Slepneva, I | 1 |
| Kirilyuk, I | 1 |
| Furso, J | 1 |
| Olchawa, M | 1 |
| Sarna, T | 1 |
| Elas, M | 1 |
| Bilkis, I | 1 |
| Weiner, L | 1 |
| Kelly, RA | 1 |
| Leedale, J | 1 |
| Calleja, D | 1 |
| Enoch, SJ | 1 |
| Harrell, A | 1 |
| Chadwick, AE | 1 |
| Webb, S | 1 |
| Douglas, M | 1 |
| Lim, AR | 1 |
| Porter, JR | 1 |
| West, K | 1 |
| Pink, MM | 1 |
| Ge, J | 1 |
| Wylie, AA | 1 |
| Tibbits, TT | 1 |
| Biggs, K | 1 |
| Curtis, M | 1 |
| Palombella, VJ | 1 |
| Adams, J | 1 |
| Fritz, CC | 1 |
| Normant, E | 1 |
| Xiao, Q | 1 |
| Liu, Y | 1 |
| Qiu, Y | 1 |
| Yao, Z | 1 |
| Zhou, G | 1 |
| Yao, ZJ | 1 |
| Jiang, S | 1 |
| DI PIETRO, S | 1 |
| SCHWERMER, B | 1 |
| SCHREIBER, HW | 1 |
| HASHIZUME, T | 1 |
| TAKIZAWA, E | 1 |
| RAVINA, A | 2 |
| PESTEL, M | 1 |
| JANBON, M | 1 |
| BERTRAND, L | 1 |
| BERTRAND, A | 1 |
| FLANDRE, O | 1 |
| ELOY, P | 1 |
| DOMAGK, G | 1 |
| RISSE, HJ | 1 |
| TIEDEMANN, H | 1 |
| OBRECHT, P | 1 |
| FUSENIG, N | 1 |
| LUCER, C | 1 |
| SZLAZAK, W | 1 |
| HOELZEL, F | 1 |
| MAASS, H | 1 |
| BOCK, H | 1 |
| SUGISHITA, M | 2 |
| TAKIZAWA, N | 1 |
| OTA, M | 1 |
| Ibuki, Y | 1 |
| Goto, R | 1 |
| MAYER, RL | 1 |
| Schimmer, AD | 1 |
| Dalili, S | 1 |
| Batey, RA | 1 |
| Riedl, SJ | 1 |
| Das Sarma, M | 1 |
| Ghosh, R | 1 |
| Patra, A | 1 |
| Hazra, B | 1 |
| Mathew, AE | 1 |
| Zee-Cheng, RK | 1 |
| Cheng, CC | 1 |
| KALAMANSON, AE | 1 |
| LIPCHINA, LP | 1 |
| CHETVERIKOV, AG | 1 |
3 reviews available for quinone and Neoplasms
| Article | Year |
|---|---|
Heterocyclic Iminoquinones and Quinones from the National Cancer Institute (NCI, USA) COMPARE Analysis.
Topics: Antineoplastic Agents; Indolequinones; NAD(P)H Dehydrogenase (Quinone); National Cancer Institute (U | 2023 |
Redox-Active Quinone Chelators: Properties, Mechanisms of Action, Cell Delivery, and Cell Toxicity.
Topics: Antibiotics, Antineoplastic; Benzoquinones; Electron Spin Resonance Spectroscopy; Humans; Neoplasms; | 2018 |
Targeting XIAP for the treatment of malignancy.
Topics: Apoptosis; Benzoquinones; Caspase Inhibitors; Clobetasol; Humans; Neoplasms; Oligonucleotides, Antis | 2006 |
27 other studies available for quinone and Neoplasms
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
α-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH).
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Evaluation, Preclinical; Enzyme In | 2017 |
A bioluminescent probe for NQO1 overexpressing cancer cell imaging
Topics: Benzoquinones; Humans; NAD(P)H Dehydrogenase (Quinone); Neoplasms; Quinones | 2022 |
Studies on 1,4-Quinone Derivatives Exhibiting Anti-Leukemic Activity along with Anti-Colorectal and Anti-Breast Cancer Effects.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug | 2022 |
Redox-Cycling "Mitocans" as Effective New Developments in Anticancer Therapy.
Topics: Adenosine Triphosphate; Animals; Ascorbic Acid; Mice; Neoplasms; Oxidation-Reduction; Quinones; Supe | 2023 |
Geldanamycin-Derived HSP90 Inhibitors Are Synthetic Lethal with NRF2.
Topics: Animals; Antineoplastic Agents; Benzoquinones; Cell Death; Cell Line, Tumor; Cell Proliferation; Dru | 2020 |
Modelling changes in glutathione homeostasis as a function of quinone redox metabolism.
Topics: Animals; Benzoquinones; Glutathione; Humans; Models, Biological; Neoplasms; Oxidation-Reduction | 2019 |
The antiproliferative activity of the heat shock protein 90 inhibitor IPI-504 is not dependent on NAD(P)H:quinone oxidoreductase 1 activity in vivo.
Topics: Animals; Benzoquinones; Cell Line, Tumor; Cell Proliferation; HCT116 Cells; HSP90 Heat-Shock Protein | 2009 |
Design, synthesis of symmetrical bivalent mimetics of annonaceous acetogenins and their cytotoxicities.
Topics: Acetogenins; Antineoplastic Agents; Benzoquinones; Cell Line, Tumor; Cell Proliferation; Cell Surviv | 2011 |
[Clinical experiences with ethyleneimino-quinone (E 39) in chemotherapy of various neoplasms].
Topics: Antineoplastic Agents; Benzoquinones; Neoplasms; Quinones | 1957 |
[Cytostatic treatment of malignant tumors with alcoxyethyleneimino-benzoquinone; Bayer E 39].
Topics: Antineoplastic Agents; Benzoquinones; Humans; Neoplasms | 1958 |
[Electron-microscopic observation on the levulose-sarcoma and the quinone-cancer in mice].
Topics: Animals; Benzoquinones; Electrons; Fructose; Mice; Microscopy; Microscopy, Electron; Neoplasms; Sarc | 1957 |
[Cytotoxic drugs and malignant tumors; action of triethylene melamine, of diethylene-dipropryloxy-benzoquinone and of thiophosphoramide].
Topics: Antineoplastic Agents; Benzoquinones; Neoplasms; Thiotepa; Triethylenemelamine | 1958 |
[Attempted treatment of advanced cancer with a derivative of the ethylene-imine-quinone group (E 39 or 6870 RP)].
Topics: Antineoplastic Agents; Benzoquinones; Ethylenes; Humans; Imines; Neoplasms; Quinones | 1958 |
[Current status of anti-cancer chemotherapy. IV. Diethylene-imine-dipropyloxy-benzoquinone and its derivatives].
Topics: Antineoplastic Agents; Benzoquinones; Imines; Neoplasms; Quinones | 1961 |
[Previous experiences with ethyleneiminobenzo-quinone in the treatment of malignant tumors in experiments and in clinical medicine].
Topics: Antineoplastic Agents; Benzoquinones; Humans; Neoplasms; Quinones | 1962 |
[The redox cycle of phenanthrene-quinone in ascites tumor cells and in a simplified model].
Topics: Ascites; Benzoquinones; Neoplasms; Neoplasms, Experimental; Oxidation-Reduction; Phenanthrenes | 1962 |
[ON THE EFFECT OF 2,3,5-TRIS(ETHYLENEIMINO)-P-BENZOQUINONE (TRENIMON) ON THE METABOLISM OF JENSEN SARCOMA].
Topics: Animals; Antineoplastic Agents; Benzoquinones; Carbohydrate Metabolism; Metabolism; NAD; Neoplasms; | 1965 |
[SUCCESSFUL RESULT OF THE USE OF CYTOSTATIC DRUGS OF THE ETHYLENEIMINO-BENZOQUINONE GROUP IN THE TREATMENT OF CANCER OF THE UTERINE CERVIX].
Topics: Antineoplastic Agents; Benzoquinones; Cytostatic Agents; Female; Humans; Neoplasms; Quinones; Uterin | 1965 |
[THE EFFECTS OF 2,3,5-TRIS-ETHYLENIMINO-1,4-BENZOQUINONE ON OXYGEN-CONSUMING REACTIONS IN YOSHIDA ASCITES SARCOMA CELLS].
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Ascites; Benzoquinones; Metabolism; NAD; Neo | 1964 |
Experimental studies on the skin- and lung-cancer, produced by the nonreduced quinone.
Topics: Benzoquinones; Humans; Lung Neoplasms; Neoplasms; Quinones; Skin | 1950 |
Transplantation of skin cancer in mice produced by quinones.
Topics: Animals; Benzoquinones; Mice; Neoplasms; Quinones; Skin; Skin Neoplasms | 1950 |
Dysregulation of apoptosis by benzene metabolites and their relationships with carcinogenesis.
Topics: Acetylcysteine; Animals; Apoptosis; Benzene; Benzoquinones; Caspase 3; Caspases; Cell Division; Enzy | 2004 |
Compounds of quinone structure as allergens and cancerogenic agents.
Topics: Allergens; Anaphylaxis; Benzoquinones; Coloring Agents; Humans; Hypersensitivity; Immune System Dise | 1950 |
Synthesis of novel aminoquinonoid analogues of diospyrin and evaluation of their inhibitory activity against murine and human cancer cells.
Topics: Animals; Antineoplastic Agents; Benzoquinones; Carcinoma, Ehrlich Tumor; Cell Line, Tumor; Cell Prol | 2008 |
Amino-substituted p-benzoquinones.
Topics: Adenocarcinoma; Animals; Benzoquinones; Chemical Phenomena; Chemistry; Colonic Neoplasms; Drug Evalu | 1986 |
[Electronic paramagnetic resonance reaction method in the study on the inter-activity between tumor and normal cells of semiquinone ion-radicals appearing from inhibitors of free radical processes].
Topics: Benzoquinones; Biochemical Phenomena; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; N | 1961 |