Page last updated: 2024-11-02

quinone and Leukemia

quinone has been researched along with Leukemia in 5 studies

benzoquinone : The simplest members of the class of benzoquinones, consisting of cyclohexadiene which is substituted by two oxo groups.
1,4-benzoquinone : The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene.
quinone : Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included).

Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Research Excerpts

ExcerptRelevanceReference
"Chronic exposure to benzene results in progressive decline of hematopoietic function and may lead to the onset of various disorders, including aplastic anemia, myelodysplastic syndrome, and leukemia."3.72Exposure of hematopoietic stem cells to benzene or 1,4-benzoquinone induces gender-specific gene expression. ( Abernethy, DJ; Faiola, B; Fuller, ES; Pluta, L; Recio, L; Rose, J; Wong, VA, 2004)
"Benzene is an established human and animal carcinogen."1.33Topoisomerase II inhibition by myeloperoxidase-activated hydroquinone: a potential mechanism underlying the genotoxic and carcinogenic effects of benzene. ( Eastmond, DA; Hasegawa, L; Mondrala, ST, 2005)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19902 (40.00)18.7374
1990's1 (20.00)18.2507
2000's2 (40.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
OLMER, J1
SOBESLAVSKY, C1
SOCHMAN, J1
MOTYCKA, K1
Faiola, B1
Fuller, ES1
Wong, VA1
Pluta, L1
Abernethy, DJ1
Rose, J1
Recio, L1
Eastmond, DA1
Mondrala, ST1
Hasegawa, L1
LĂ©vay, G1
Ross, D1
Bodell, WJ1

Other Studies

5 other studies available for quinone and Leukemia

ArticleYear
[First therapeutic trials with the ethylene-quinone E 39].
    Marseille medical, 1957, Volume: 94, Issue:7

    Topics: Antineoplastic Agents; Benzoquinones; Carcinoma, Squamous Cell; Disease; Ethylenes; Humans; Leukemia

1957
[Effect of certain benzoquinone-ethyleneimino derivatives on experiemental mouse leukemia].
    Neoplasma, 1959, Volume: 6

    Topics: Animals; Antineoplastic Agents; Benzoquinones; Leukemia; Leukemia, Experimental; Mice; Quinones

1959
Exposure of hematopoietic stem cells to benzene or 1,4-benzoquinone induces gender-specific gene expression.
    Stem cells (Dayton, Ohio), 2004, Volume: 22, Issue:5

    Topics: Animals; Apoptosis; Benzene; Benzoquinones; Carcinogens; Cell Cycle Proteins; Cell Transformation, N

2004
Topoisomerase II inhibition by myeloperoxidase-activated hydroquinone: a potential mechanism underlying the genotoxic and carcinogenic effects of benzene.
    Chemico-biological interactions, 2005, May-30, Volume: 153-154

    Topics: Benzene; Benzoquinones; Carcinogens; Dithiothreitol; DNA Topoisomerases, Type II; DNA, Kinetoplast;

2005
Peroxidase activation of hydroquinone results in the formation of DNA adducts in HL-60 cells, mouse bone marrow macrophages and human bone marrow.
    Carcinogenesis, 1993, Volume: 14, Issue:11

    Topics: Animals; Benzoquinones; Biotransformation; Bone Marrow; Cell Line; DNA; DNA, Neoplasm; Humans; Hydro

1993