quinone has been researched along with Idiopathic Parkinson Disease in 9 studies
benzoquinone : The simplest members of the class of benzoquinones, consisting of cyclohexadiene which is substituted by two oxo groups.
1,4-benzoquinone : The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene.
quinone : Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included).
Excerpt | Relevance | Reference |
---|---|---|
"Parkinson's disease is a neurodegenerative disorder associated with progressive loss of dopaminergic cells in the substantia nigra." | 1.33 | Inhibition of vesicular monoamine transporter enhances vulnerability of dopaminergic cells: relevance to Parkinson's disease. ( Cho, Y; Choi, HJ; Hwang, O; Lee, SY, 2005) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 5 (55.56) | 29.6817 |
2010's | 3 (33.33) | 24.3611 |
2020's | 1 (11.11) | 2.80 |
Authors | Studies |
---|---|
Lü, MH | 1 |
Wang, ZP | 1 |
Xing, LZ | 1 |
Zhang, W | 1 |
Han, F | 1 |
Huang, GL | 1 |
Liu, W | 1 |
Zhang, YX | 1 |
Xu, J | 1 |
Cui, J | 1 |
Bagh, MB | 2 |
Maiti, AK | 2 |
Jana, S | 2 |
Banerjee, K | 2 |
Roy, A | 2 |
Chakrabarti, S | 2 |
Rekas, A | 1 |
Knott, RB | 1 |
Sokolova, A | 1 |
Barnham, KJ | 1 |
Perez, KA | 1 |
Masters, CL | 1 |
Drew, SC | 1 |
Cappai, R | 1 |
Curtain, CC | 1 |
Pham, CL | 1 |
Anderson, DG | 1 |
Mariappan, SV | 1 |
Buettner, GR | 1 |
Doorn, JA | 1 |
Zahid, M | 1 |
Saeed, M | 1 |
Yang, L | 1 |
Beseler, C | 1 |
Rogan, E | 1 |
Cavalieri, EL | 1 |
Asanuma, M | 2 |
Miyazaki, I | 2 |
Diaz-Corrales, FJ | 2 |
Ogawa, N | 2 |
Choi, HJ | 1 |
Lee, SY | 1 |
Cho, Y | 1 |
Hwang, O | 1 |
Das, A | 1 |
Shimizu, M | 1 |
Tanaka, K | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Randomized Placebo Controlled Trial of Intravenous N-Acetylcysteine for the Treatment of Acute Ischemic Stroke[NCT04918719] | Phase 2 | 118 participants (Anticipated) | Interventional | 2021-06-01 | Not yet recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
1 review available for quinone and Idiopathic Parkinson Disease
Article | Year |
---|---|
Quinone formation as dopaminergic neuron-specific oxidative stress in the pathogenesis of sporadic Parkinson's disease and neurotoxin-induced parkinsonism.
Topics: Animals; Benzoquinones; Dopamine; Humans; Neurons; Neurotoxins; Oxidative Stress; Parkinson Disease; | 2004 |
8 other studies available for quinone and Idiopathic Parkinson Disease
Article | Year |
---|---|
Hybrids of polyphenolic/quinone acids, the potential preventive and therapeutic drugs for PD: Disaggregate α-Syn fibrils, inhibit inclusions, and repair damaged neurons in mice.
Topics: alpha-Synuclein; Animals; Benzoquinones; Horses; Lewy Bodies; Mice; Neurons; Parkinson Disease | 2023 |
Quinone and oxyradical scavenging properties of N-acetylcysteine prevent dopamine mediated inhibition of Na+, K+-ATPase and mitochondrial electron transport chain activity in rat brain: implications in the neuroprotective therapy of Parkinson's disease.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Benzoquinones; Brain; Disease Models, Animal; Dopam | 2008 |
The structure of dopamine induced alpha-synuclein oligomers.
Topics: alpha-Synuclein; Amyloid; Benzoquinones; Circular Dichroism; Cross-Linking Reagents; Dopamine; Elect | 2010 |
Oxidation of 3,4-dihydroxyphenylacetaldehyde, a toxic dopaminergic metabolite, to a semiquinone radical and an ortho-quinone.
Topics: 3,4-Dihydroxyphenylacetic Acid; Benzoquinones; Cyclooxygenase 2; Free Radicals; Humans; Oxidation-Re | 2011 |
Formation of dopamine quinone-DNA adducts and their potential role in the etiology of Parkinson's disease.
Topics: Acetylcysteine; Antioxidants; Benzoquinones; DNA Adducts; Dopamine; Humans; Hydrogen-Ion Concentrati | 2011 |
Inhibition of vesicular monoamine transporter enhances vulnerability of dopaminergic cells: relevance to Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcysteine; Animals; Benzoquinones; Biopterins; Cell Death; Cell | 2005 |
Dopamine but not 3,4-dihydroxy phenylacetic acid (DOPAC) inhibits brain respiratory chain activity by autoxidation and mitochondria catalyzed oxidation to quinone products: implications in Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzoquinones; Brain; Dopamine; Electron Transport; Electro | 2007 |
Pramipexole has ameliorating effects on levodopa-induced abnormal dopamine turnover in parkinsonian striatum and quenching effects on dopamine-semiquinone generated in vitro.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Antiparkinson Agents; Benzoquinones; | 2005 |