Page last updated: 2024-11-02

quinone and Idiopathic Parkinson Disease

quinone has been researched along with Idiopathic Parkinson Disease in 9 studies

benzoquinone : The simplest members of the class of benzoquinones, consisting of cyclohexadiene which is substituted by two oxo groups.
1,4-benzoquinone : The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene.
quinone : Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included).

Research Excerpts

ExcerptRelevanceReference
"Parkinson's disease is a neurodegenerative disorder associated with progressive loss of dopaminergic cells in the substantia nigra."1.33Inhibition of vesicular monoamine transporter enhances vulnerability of dopaminergic cells: relevance to Parkinson's disease. ( Cho, Y; Choi, HJ; Hwang, O; Lee, SY, 2005)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (55.56)29.6817
2010's3 (33.33)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Lü, MH1
Wang, ZP1
Xing, LZ1
Zhang, W1
Han, F1
Huang, GL1
Liu, W1
Zhang, YX1
Xu, J1
Cui, J1
Bagh, MB2
Maiti, AK2
Jana, S2
Banerjee, K2
Roy, A2
Chakrabarti, S2
Rekas, A1
Knott, RB1
Sokolova, A1
Barnham, KJ1
Perez, KA1
Masters, CL1
Drew, SC1
Cappai, R1
Curtain, CC1
Pham, CL1
Anderson, DG1
Mariappan, SV1
Buettner, GR1
Doorn, JA1
Zahid, M1
Saeed, M1
Yang, L1
Beseler, C1
Rogan, E1
Cavalieri, EL1
Asanuma, M2
Miyazaki, I2
Diaz-Corrales, FJ2
Ogawa, N2
Choi, HJ1
Lee, SY1
Cho, Y1
Hwang, O1
Das, A1
Shimizu, M1
Tanaka, K1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized Placebo Controlled Trial of Intravenous N-Acetylcysteine for the Treatment of Acute Ischemic Stroke[NCT04918719]Phase 2118 participants (Anticipated)Interventional2021-06-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for quinone and Idiopathic Parkinson Disease

ArticleYear
Quinone formation as dopaminergic neuron-specific oxidative stress in the pathogenesis of sporadic Parkinson's disease and neurotoxin-induced parkinsonism.
    Acta medica Okayama, 2004, Volume: 58, Issue:5

    Topics: Animals; Benzoquinones; Dopamine; Humans; Neurons; Neurotoxins; Oxidative Stress; Parkinson Disease;

2004

Other Studies

8 other studies available for quinone and Idiopathic Parkinson Disease

ArticleYear
Hybrids of polyphenolic/quinone acids, the potential preventive and therapeutic drugs for PD: Disaggregate α-Syn fibrils, inhibit inclusions, and repair damaged neurons in mice.
    European journal of medicinal chemistry, 2023, Mar-05, Volume: 249

    Topics: alpha-Synuclein; Animals; Benzoquinones; Horses; Lewy Bodies; Mice; Neurons; Parkinson Disease

2023
Quinone and oxyradical scavenging properties of N-acetylcysteine prevent dopamine mediated inhibition of Na+, K+-ATPase and mitochondrial electron transport chain activity in rat brain: implications in the neuroprotective therapy of Parkinson's disease.
    Free radical research, 2008, Volume: 42, Issue:6

    Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Benzoquinones; Brain; Disease Models, Animal; Dopam

2008
The structure of dopamine induced alpha-synuclein oligomers.
    European biophysics journal : EBJ, 2010, Volume: 39, Issue:10

    Topics: alpha-Synuclein; Amyloid; Benzoquinones; Circular Dichroism; Cross-Linking Reagents; Dopamine; Elect

2010
Oxidation of 3,4-dihydroxyphenylacetaldehyde, a toxic dopaminergic metabolite, to a semiquinone radical and an ortho-quinone.
    The Journal of biological chemistry, 2011, Jul-29, Volume: 286, Issue:30

    Topics: 3,4-Dihydroxyphenylacetic Acid; Benzoquinones; Cyclooxygenase 2; Free Radicals; Humans; Oxidation-Re

2011
Formation of dopamine quinone-DNA adducts and their potential role in the etiology of Parkinson's disease.
    IUBMB life, 2011, Volume: 63, Issue:12

    Topics: Acetylcysteine; Antioxidants; Benzoquinones; DNA Adducts; Dopamine; Humans; Hydrogen-Ion Concentrati

2011
Inhibition of vesicular monoamine transporter enhances vulnerability of dopaminergic cells: relevance to Parkinson's disease.
    Neurochemistry international, 2005, Volume: 46, Issue:4

    Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcysteine; Animals; Benzoquinones; Biopterins; Cell Death; Cell

2005
Dopamine but not 3,4-dihydroxy phenylacetic acid (DOPAC) inhibits brain respiratory chain activity by autoxidation and mitochondria catalyzed oxidation to quinone products: implications in Parkinson's disease.
    Brain research, 2007, Mar-30, Volume: 1139

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzoquinones; Brain; Dopamine; Electron Transport; Electro

2007
Pramipexole has ameliorating effects on levodopa-induced abnormal dopamine turnover in parkinsonian striatum and quenching effects on dopamine-semiquinone generated in vitro.
    Neurological research, 2005, Volume: 27, Issue:5

    Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Antiparkinson Agents; Benzoquinones;

2005