quinone has been researched along with Idiopathic Parkinson Disease in 9 studies
benzoquinone : The simplest members of the class of benzoquinones, consisting of cyclohexadiene which is substituted by two oxo groups.
1,4-benzoquinone : The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene.
quinone : Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Parkinson's disease is a neurodegenerative disorder associated with progressive loss of dopaminergic cells in the substantia nigra." | 1.33 | Inhibition of vesicular monoamine transporter enhances vulnerability of dopaminergic cells: relevance to Parkinson's disease. ( Cho, Y; Choi, HJ; Hwang, O; Lee, SY, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Lü, MH | 1 |
| Wang, ZP | 1 |
| Xing, LZ | 1 |
| Zhang, W | 1 |
| Han, F | 1 |
| Huang, GL | 1 |
| Liu, W | 1 |
| Zhang, YX | 1 |
| Xu, J | 1 |
| Cui, J | 1 |
| Bagh, MB | 2 |
| Maiti, AK | 2 |
| Jana, S | 2 |
| Banerjee, K | 2 |
| Roy, A | 2 |
| Chakrabarti, S | 2 |
| Rekas, A | 1 |
| Knott, RB | 1 |
| Sokolova, A | 1 |
| Barnham, KJ | 1 |
| Perez, KA | 1 |
| Masters, CL | 1 |
| Drew, SC | 1 |
| Cappai, R | 1 |
| Curtain, CC | 1 |
| Pham, CL | 1 |
| Anderson, DG | 1 |
| Mariappan, SV | 1 |
| Buettner, GR | 1 |
| Doorn, JA | 1 |
| Zahid, M | 1 |
| Saeed, M | 1 |
| Yang, L | 1 |
| Beseler, C | 1 |
| Rogan, E | 1 |
| Cavalieri, EL | 1 |
| Asanuma, M | 2 |
| Miyazaki, I | 2 |
| Diaz-Corrales, FJ | 2 |
| Ogawa, N | 2 |
| Choi, HJ | 1 |
| Lee, SY | 1 |
| Cho, Y | 1 |
| Hwang, O | 1 |
| Das, A | 1 |
| Shimizu, M | 1 |
| Tanaka, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Placebo Controlled Trial of Intravenous N-Acetylcysteine for the Treatment of Acute Ischemic Stroke[NCT04918719] | Phase 2 | 118 participants (Anticipated) | Interventional | 2021-06-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for quinone and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Quinone formation as dopaminergic neuron-specific oxidative stress in the pathogenesis of sporadic Parkinson's disease and neurotoxin-induced parkinsonism.
Topics: Animals; Benzoquinones; Dopamine; Humans; Neurons; Neurotoxins; Oxidative Stress; Parkinson Disease; | 2004 |
8 other studies available for quinone and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Hybrids of polyphenolic/quinone acids, the potential preventive and therapeutic drugs for PD: Disaggregate α-Syn fibrils, inhibit inclusions, and repair damaged neurons in mice.
Topics: alpha-Synuclein; Animals; Benzoquinones; Horses; Lewy Bodies; Mice; Neurons; Parkinson Disease | 2023 |
Quinone and oxyradical scavenging properties of N-acetylcysteine prevent dopamine mediated inhibition of Na+, K+-ATPase and mitochondrial electron transport chain activity in rat brain: implications in the neuroprotective therapy of Parkinson's disease.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Benzoquinones; Brain; Disease Models, Animal; Dopam | 2008 |
The structure of dopamine induced alpha-synuclein oligomers.
Topics: alpha-Synuclein; Amyloid; Benzoquinones; Circular Dichroism; Cross-Linking Reagents; Dopamine; Elect | 2010 |
Oxidation of 3,4-dihydroxyphenylacetaldehyde, a toxic dopaminergic metabolite, to a semiquinone radical and an ortho-quinone.
Topics: 3,4-Dihydroxyphenylacetic Acid; Benzoquinones; Cyclooxygenase 2; Free Radicals; Humans; Oxidation-Re | 2011 |
Formation of dopamine quinone-DNA adducts and their potential role in the etiology of Parkinson's disease.
Topics: Acetylcysteine; Antioxidants; Benzoquinones; DNA Adducts; Dopamine; Humans; Hydrogen-Ion Concentrati | 2011 |
Inhibition of vesicular monoamine transporter enhances vulnerability of dopaminergic cells: relevance to Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcysteine; Animals; Benzoquinones; Biopterins; Cell Death; Cell | 2005 |
Dopamine but not 3,4-dihydroxy phenylacetic acid (DOPAC) inhibits brain respiratory chain activity by autoxidation and mitochondria catalyzed oxidation to quinone products: implications in Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzoquinones; Brain; Dopamine; Electron Transport; Electro | 2007 |
Pramipexole has ameliorating effects on levodopa-induced abnormal dopamine turnover in parkinsonian striatum and quenching effects on dopamine-semiquinone generated in vitro.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Antiparkinson Agents; Benzoquinones; | 2005 |