Page last updated: 2024-11-02

quinone and Alkaptonuria

quinone has been researched along with Alkaptonuria in 3 studies

benzoquinone : The simplest members of the class of benzoquinones, consisting of cyclohexadiene which is substituted by two oxo groups.
1,4-benzoquinone : The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene.
quinone : Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included).

Alkaptonuria: An inborn error of amino acid metabolism resulting from a defect in the enzyme HOMOGENTISATE 1,2-DIOXYGENASE, an enzyme involved in the breakdown of PHENYLALANINE and TYROSINE. It is characterized by accumulation of HOMOGENTISIC ACID in the urine, OCHRONOSIS in various tissues, and ARTHRITIS.

Research Excerpts

ExcerptRelevanceReference
" Such a deficiency leads to the accumulation of homogentisic acid (HGA) and its oxidized/polymerized products in connective tissues, where melanin-like pigments accumulate (ochronosis)."7.77Redox-proteomics of the effects of homogentisic acid in an in vitro human serum model of alkaptonuric ochronosis. ( Bernardini, G; Bianchini, C; Braconi, D; Laschi, M; Millucci, L; Santucci, A; Spreafico, A, 2011)
" Such a deficiency leads to the accumulation of homogentisic acid (HGA) and its oxidized/polymerized products in connective tissues, where melanin-like pigments accumulate (ochronosis)."3.77Redox-proteomics of the effects of homogentisic acid in an in vitro human serum model of alkaptonuric ochronosis. ( Bernardini, G; Bianchini, C; Braconi, D; Laschi, M; Millucci, L; Santucci, A; Spreafico, A, 2011)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19901 (33.33)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Braconi, D1
Bianchini, C1
Bernardini, G1
Laschi, M1
Millucci, L1
Spreafico, A1
Santucci, A1
Lorenzini, S1
Mannoni, A1
Selvi, E1
Wolff, JA1
Barshop, B1
Nyhan, WL1
Leslie, J1
Seegmiller, JE1
Gruber, H1
Garst, M1
Winter, S1
Michals, K1
Matalon, R1

Other Studies

3 other studies available for quinone and Alkaptonuria

ArticleYear
Redox-proteomics of the effects of homogentisic acid in an in vitro human serum model of alkaptonuric ochronosis.
    Journal of inherited metabolic disease, 2011, Volume: 34, Issue:6

    Topics: Alkaptonuria; Benzoquinones; Glutathione Peroxidase; Glutathione Reductase; Homogentisic Acid; Human

2011
Alkaptonuria.
    The New England journal of medicine, 2003, 04-03, Volume: 348, Issue:14

    Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Alkaptonuria; Antioxidants; Ascorbic Acid; Benzoquinones; Cyclo

2003
Effects of ascorbic acid in alkaptonuria: alterations in benzoquinone acetic acid and an ontogenic effect in infancy.
    Pediatric research, 1989, Volume: 26, Issue:2

    Topics: Aged; Alkaptonuria; Ascorbic Acid; Benzoquinones; Homogentisic Acid; Humans; Infant; Male; Middle Ag

1989