quinone has been researched along with Aging in 8 studies
benzoquinone : The simplest members of the class of benzoquinones, consisting of cyclohexadiene which is substituted by two oxo groups.
1,4-benzoquinone : The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene.
quinone : Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included).
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report that α-tocotrienol quinone (ATQ3) is a metabolite of α-tocotrienol, and that ATQ3 is a potent cellular protectant against oxidative stress and aging." | 7.77 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. ( Amagata, A; Barnes, A; Enns, GM; Hinman, A; Jankowski, O; Kheifets, V; Komatsuzaki, R; Lee, E; Miller, G; Mollard, P; Murase, K; Sadun, AA; Shrader, WD; Thoolen, M; Wesson, K, 2011) |
| "We report that α-tocotrienol quinone (ATQ3) is a metabolite of α-tocotrienol, and that ATQ3 is a potent cellular protectant against oxidative stress and aging." | 3.77 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. ( Amagata, A; Barnes, A; Enns, GM; Hinman, A; Jankowski, O; Kheifets, V; Komatsuzaki, R; Lee, E; Miller, G; Mollard, P; Murase, K; Sadun, AA; Shrader, WD; Thoolen, M; Wesson, K, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Doroshow, JH | 1 |
| Farooq, U | 1 |
| Pan, Y | 1 |
| Disasa, D | 1 |
| Qi, J | 1 |
| Wang, Y | 1 |
| Oxer, D | 1 |
| Hekimi, S | 1 |
| Shrader, WD | 1 |
| Amagata, A | 1 |
| Barnes, A | 1 |
| Enns, GM | 1 |
| Hinman, A | 1 |
| Jankowski, O | 1 |
| Kheifets, V | 1 |
| Komatsuzaki, R | 1 |
| Lee, E | 1 |
| Mollard, P | 1 |
| Murase, K | 1 |
| Sadun, AA | 1 |
| Thoolen, M | 1 |
| Wesson, K | 1 |
| Miller, G | 1 |
| Jin, S | 1 |
| Sato, N | 1 |
| Atherton, NM | 1 |
| Hendry, GA | 1 |
| Möbius, K | 1 |
| Rohrer, M | 1 |
| Törring, JT | 1 |
| Stevens, JC | 1 |
| Wallace, KB | 1 |
| Eells, JT | 1 |
| Madeira, VM | 1 |
| Cortopassi, G | 1 |
| Jones, DP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Therapeutic Trial of EPI -743 In Patients With Disorders of Energy Utilization or Oxidation-Reduction[NCT01642056] | Phase 1/Phase 2 | 20 participants (Actual) | Interventional | 2012-09-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"NPMDS is a semi-quantitative clinical rating scale that evaluates the progression of mitochondrial disease in pediatric patients.~The NPMDS scale provides an assessment of the progression of mitochondrial disease. Scores from Parts I-III are added to get a value between 0 and 130, with higher scores representing more severe disease." (NCT01642056)
Timeframe: 14 months
| Intervention | Units on a scale (Mean) |
|---|---|
| EPI-743, Then Placebo | 26 |
| Placebo, Then EPI-743 | 15.8 |
"NPMDS is a semi-quantitative clinical rating scale that evaluates the progression of mitochondrial disease in pediatric patients.~The NPMDS scale provides an assessment of the progression of mitochondrial disease. Scores from Parts I-III are added to get a value between 0 and 130, with higher scores representing more severe disease." (NCT01642056)
Timeframe: 6 months
| Intervention | Units on a scale (Mean) |
|---|---|
| EPI-743, Then Placebo | 27.1 |
| Placebo, Then EPI-743 | 20.2 |
"NPMDS is a semi-quantitative clinical rating scale that evaluates the progression of mitochondrial disease in pediatric patients.~The NPMDS scale provides an assessment of the progression of mitochondrial disease. Scores from Parts I-III are added to get a value between 0 and 130, with higher scores representing more severe disease." (NCT01642056)
Timeframe: Baseline - Day 0
| Intervention | Units on a scale (Mean) |
|---|---|
| EPI-743, Then Placebo | 23.9 |
| Placebo, Then EPI-743 | 20.4 |
"NPMDS is a semi-quantitative clinical rating scale that evaluates the progression of mitochondrial disease in pediatric patients.~The NPMDS scale provides an assessment of the progression of mitochondrial disease. Scores from Parts I-III are added to get a value between 0 and 130, with higher scores representing more severe disease." (NCT01642056)
Timeframe: 8 month - Post washout
| Intervention | Units on a scale (Mean) |
|---|---|
| EPI-743, Then Placebo | 27.1 |
| Placebo, Then EPI-743 | 18.3 |
8 other studies available for quinone and Aging
| Article | Year |
|---|---|
Effect of Anticancer Quinones on Reactive Oxygen Production by Adult Rat Heart Myocytes.
Topics: Aging; Animals; Antineoplastic Agents; Benzoquinones; Cell Respiration; Cyanides; Doxorubicin; Free | 2020 |
Novel Anti-Aging Benzoquinone Derivatives from
Topics: Aging; Benzoquinones; Boraginaceae; Humans; Longevity; Medicine, Ayurvedic; Molecular Structure; Pla | 2019 |
Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis.
Topics: Aging; Analysis of Variance; Animals; Benzoquinones; Gene Silencing; Immunoblotting; Integrases; Lon | 2015 |
α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging.
Topics: Aging; Animals; Antioxidants; Benzoquinones; Cells, Cultured; Dogs; Dose-Response Relationship, Drug | 2011 |
Benzoquinone, the substance essential for antibacterial activity in aqueous extracts from succulent young shoots of the pear Pyrus spp.
Topics: Aging; Anti-Bacterial Agents; Benzoquinones; Chromatography, High Pressure Liquid; Hydroquinones; Ma | 2003 |
A free radical ubiquitously associated with senescence in plants: evidence for a quinone.
Topics: Aging; Benzoquinones; Electron Spin Resonance Spectroscopy; Free Radicals; Plants; Time Factors | 1993 |
Detection of tastes in mixture with other tastes: issues of masking and aging.
Topics: Adolescent; Adult; Aged; Aging; Benzoquinones; Humans; Perceptual Masking; Sodium Chloride; Sucrose; | 1996 |
Mitochondria-mediated cell injury. Symposium overview.
Topics: Aging; Apoptosis; Benzoquinones; Calcium; Cell Cycle; Energy Metabolism; Formates; Herbicides; Homeo | 1997 |