Page last updated: 2024-11-02

quinone and Aging

quinone has been researched along with Aging in 8 studies

benzoquinone : The simplest members of the class of benzoquinones, consisting of cyclohexadiene which is substituted by two oxo groups.
1,4-benzoquinone : The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene.
quinone : Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included).

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"We report that α-tocotrienol quinone (ATQ3) is a metabolite of α-tocotrienol, and that ATQ3 is a potent cellular protectant against oxidative stress and aging."7.77α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. ( Amagata, A; Barnes, A; Enns, GM; Hinman, A; Jankowski, O; Kheifets, V; Komatsuzaki, R; Lee, E; Miller, G; Mollard, P; Murase, K; Sadun, AA; Shrader, WD; Thoolen, M; Wesson, K, 2011)
"We report that α-tocotrienol quinone (ATQ3) is a metabolite of α-tocotrienol, and that ATQ3 is a potent cellular protectant against oxidative stress and aging."3.77α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. ( Amagata, A; Barnes, A; Enns, GM; Hinman, A; Jankowski, O; Kheifets, V; Komatsuzaki, R; Lee, E; Miller, G; Mollard, P; Murase, K; Sadun, AA; Shrader, WD; Thoolen, M; Wesson, K, 2011)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (37.50)18.2507
2000's1 (12.50)29.6817
2010's3 (37.50)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Doroshow, JH1
Farooq, U1
Pan, Y1
Disasa, D1
Qi, J1
Wang, Y1
Oxer, D1
Hekimi, S1
Shrader, WD1
Amagata, A1
Barnes, A1
Enns, GM1
Hinman, A1
Jankowski, O1
Kheifets, V1
Komatsuzaki, R1
Lee, E1
Mollard, P1
Murase, K1
Sadun, AA1
Thoolen, M1
Wesson, K1
Miller, G1
Jin, S1
Sato, N1
Atherton, NM1
Hendry, GA1
Möbius, K1
Rohrer, M1
Törring, JT1
Stevens, JC1
Wallace, KB1
Eells, JT1
Madeira, VM1
Cortopassi, G1
Jones, DP1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Therapeutic Trial of EPI -743 In Patients With Disorders of Energy Utilization or Oxidation-Reduction[NCT01642056]Phase 1/Phase 220 participants (Actual)Interventional2012-09-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Newcastle Paediatric Mitochondrial Disease Scale (NPMDS) Part I-III, 14 Months

"NPMDS is a semi-quantitative clinical rating scale that evaluates the progression of mitochondrial disease in pediatric patients.~The NPMDS scale provides an assessment of the progression of mitochondrial disease. Scores from Parts I-III are added to get a value between 0 and 130, with higher scores representing more severe disease." (NCT01642056)
Timeframe: 14 months

InterventionUnits on a scale (Mean)
EPI-743, Then Placebo26
Placebo, Then EPI-74315.8

Newcastle Paediatric Mitochondrial Disease Scale (NPMDS) Part I-III, 6 Months

"NPMDS is a semi-quantitative clinical rating scale that evaluates the progression of mitochondrial disease in pediatric patients.~The NPMDS scale provides an assessment of the progression of mitochondrial disease. Scores from Parts I-III are added to get a value between 0 and 130, with higher scores representing more severe disease." (NCT01642056)
Timeframe: 6 months

InterventionUnits on a scale (Mean)
EPI-743, Then Placebo27.1
Placebo, Then EPI-74320.2

Newcastle Paediatric Mitochondrial Disease Scale (NPMDS) Part I-III, Baseline

"NPMDS is a semi-quantitative clinical rating scale that evaluates the progression of mitochondrial disease in pediatric patients.~The NPMDS scale provides an assessment of the progression of mitochondrial disease. Scores from Parts I-III are added to get a value between 0 and 130, with higher scores representing more severe disease." (NCT01642056)
Timeframe: Baseline - Day 0

InterventionUnits on a scale (Mean)
EPI-743, Then Placebo23.9
Placebo, Then EPI-74320.4

Newcastle Paediatric Mitochondrial Disease Scale (NPMDS) Part I-III, Post Washout

"NPMDS is a semi-quantitative clinical rating scale that evaluates the progression of mitochondrial disease in pediatric patients.~The NPMDS scale provides an assessment of the progression of mitochondrial disease. Scores from Parts I-III are added to get a value between 0 and 130, with higher scores representing more severe disease." (NCT01642056)
Timeframe: 8 month - Post washout

InterventionUnits on a scale (Mean)
EPI-743, Then Placebo27.1
Placebo, Then EPI-74318.3

Other Studies

8 other studies available for quinone and Aging

ArticleYear
Effect of Anticancer Quinones on Reactive Oxygen Production by Adult Rat Heart Myocytes.
    Oxidative medicine and cellular longevity, 2020, Volume: 2020

    Topics: Aging; Animals; Antineoplastic Agents; Benzoquinones; Cell Respiration; Cyanides; Doxorubicin; Free

2020
Novel Anti-Aging Benzoquinone Derivatives from
    Molecules (Basel, Switzerland), 2019, Apr-11, Volume: 24, Issue:7

    Topics: Aging; Benzoquinones; Boraginaceae; Humans; Longevity; Medicine, Ayurvedic; Molecular Structure; Pla

2019
Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis.
    Nature communications, 2015, Mar-06, Volume: 6

    Topics: Aging; Analysis of Variance; Animals; Benzoquinones; Gene Silencing; Immunoblotting; Integrases; Lon

2015
α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging.
    Bioorganic & medicinal chemistry letters, 2011, Jun-15, Volume: 21, Issue:12

    Topics: Aging; Animals; Antioxidants; Benzoquinones; Cells, Cultured; Dogs; Dose-Response Relationship, Drug

2011
Benzoquinone, the substance essential for antibacterial activity in aqueous extracts from succulent young shoots of the pear Pyrus spp.
    Phytochemistry, 2003, Volume: 62, Issue:1

    Topics: Aging; Anti-Bacterial Agents; Benzoquinones; Chromatography, High Pressure Liquid; Hydroquinones; Ma

2003
A free radical ubiquitously associated with senescence in plants: evidence for a quinone.
    Free radical research communications, 1993, Volume: 19, Issue:5

    Topics: Aging; Benzoquinones; Electron Spin Resonance Spectroscopy; Free Radicals; Plants; Time Factors

1993
Detection of tastes in mixture with other tastes: issues of masking and aging.
    Chemical senses, 1996, Volume: 21, Issue:2

    Topics: Adolescent; Adult; Aged; Aging; Benzoquinones; Humans; Perceptual Masking; Sodium Chloride; Sucrose;

1996
Mitochondria-mediated cell injury. Symposium overview.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1997, Volume: 38, Issue:1

    Topics: Aging; Apoptosis; Benzoquinones; Calcium; Cell Cycle; Energy Metabolism; Formates; Herbicides; Homeo

1997