quinone has been researched along with Acute Promyelocytic Leukemia in 5 studies
benzoquinone : The simplest members of the class of benzoquinones, consisting of cyclohexadiene which is substituted by two oxo groups.
1,4-benzoquinone : The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene.
quinone : Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Benzene is a well known environmental carcinogen which causes myeloid leukemia." | 1.35 | Generation of phosphorylated histone H2AX by benzene metabolites. ( Ibuki, Y; Ishihama, M; Toyooka, T, 2008) |
| " Comparison of the slopes of the dose-response curves showed that hydroquinone was 7-9 times more effective than 1,2,4,-benzenetriol and catechol at inducing DNA adducts." | 1.28 | Potentiation of DNA adduct formation in HL-60 cells by combinations of benzene metabolites. ( Bodell, WJ; Lévay, G, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ishihama, M | 1 |
| Toyooka, T | 1 |
| Ibuki, Y | 1 |
| Lévay, G | 3 |
| Ross, D | 1 |
| Bodell, WJ | 3 |
| Oliveira, NL | 1 |
| Kalf, GF | 1 |
| Pongracz, K | 1 |
5 other studies available for quinone and Acute Promyelocytic Leukemia
| Article | Year |
|---|---|
Generation of phosphorylated histone H2AX by benzene metabolites.
Topics: Benzene; Benzoquinones; Cell Survival; DNA Breaks, Double-Stranded; Dose-Response Relationship, Drug | 2008 |
Peroxidase activation of hydroquinone results in the formation of DNA adducts in HL-60 cells, mouse bone marrow macrophages and human bone marrow.
Topics: Animals; Benzoquinones; Biotransformation; Bone Marrow; Cell Line; DNA; DNA, Neoplasm; Humans; Hydro | 1993 |
Potentiation of DNA adduct formation in HL-60 cells by combinations of benzene metabolites.
Topics: Autoradiography; Benzene; Benzoquinones; Catechols; Cell Line; Cell Survival; DNA, Neoplasm; Humans; | 1992 |
Induced differentiation of HL-60 promyelocytic leukemia cells to monocyte/macrophages is inhibited by hydroquinone, a hematotoxic metabolite of benzene.
Topics: Benzene Derivatives; Benzoquinones; Calcitriol; Cell Differentiation; Dose-Response Relationship, Dr | 1992 |
Detection of DNA adducts in HL-60 cells treated with hydroquinone and p-benzoquinone by 32P-postlabeling.
Topics: Benzoquinones; Cell Survival; DNA; Humans; Hydroquinones; Leukemia, Promyelocytic, Acute; Phosphorus | 1991 |