quinolinic acid has been researched along with Uremia in 6 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Increased oxidative stress (SOX), inflammation and accelerated atherosclerosis have been reported in end-stage renal disease (ESRD), but their associations with kynurenine pathway activation remain unknown." | 3.75 | Kynurenine, quinolinic acid--the new factors linked to carotid atherosclerosis in patients with end-stage renal disease. ( Brzosko, S; Mysliwiec, M; Pawlak, D; Pawlak, K, 2009) |
| "Quinolinic acid was first identified in uremic serum by use of gas chromatography/mass spectrometry." | 1.28 | Accumulation of quinolinic acid in uremic serum and its removal by hemodialysis. ( Emoto, Y; Hashimoto, N; Maeda, K; Miyazaki, T; Niwa, T; Takeda, N; Tatematsu, A; Yoshizumi, H, 1991) |
| " It is concluded that some of the protein binding inhibitors have toxic effects on cell function of various tissues and play a role in pathophysiology of uremia." | 1.28 | [Study on the uremic protein binding inhibitors as uremic toxin: toxic effect on erythroid colony formation, lymphocyte blast formation and renal function]. ( Kawashima, Y, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pawlak, K | 2 |
| Brzosko, S | 1 |
| Mysliwiec, M | 2 |
| Pawlak, D | 2 |
| Schefold, JC | 1 |
| Zeden, JP | 1 |
| Fotopoulou, C | 1 |
| von Haehling, S | 1 |
| Pschowski, R | 1 |
| Hasper, D | 1 |
| Volk, HD | 1 |
| Schuett, C | 1 |
| Reinke, P | 1 |
| Malyszko, J | 1 |
| Buczko, W | 1 |
| Niwa, T | 1 |
| Yoshizumi, H | 1 |
| Emoto, Y | 1 |
| Miyazaki, T | 1 |
| Hashimoto, N | 1 |
| Takeda, N | 1 |
| Tatematsu, A | 1 |
| Maeda, K | 1 |
| Kawashima, Y | 2 |
| Sanaka, T | 1 |
| Sugino, N | 1 |
| Takahashi, M | 1 |
| Mizoguchi, H | 1 |
6 other studies available for quinolinic acid and Uremia
| Article | Year |
|---|---|
Kynurenine, quinolinic acid--the new factors linked to carotid atherosclerosis in patients with end-stage renal disease.
Topics: Adult; Age Factors; Biomarkers; C-Reactive Protein; Carotid Artery Diseases; Cross-Sectional Studies | 2009 |
Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms.
Topics: 5-Hydroxytryptophan; Adult; Aged; C-Reactive Protein; Case-Control Studies; Creatinine; Female; Huma | 2009 |
Accumulation of toxic products degradation of kynurenine in hemodialyzed patients.
Topics: Female; Humans; Kidney; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Quinoli | 2001 |
Accumulation of quinolinic acid in uremic serum and its removal by hemodialysis.
Topics: Adult; Aged; Convulsants; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Middle Aged; Q | 1991 |
[Study on the uremic protein binding inhibitors as uremic toxin: toxic effect on erythroid colony formation, lymphocyte blast formation and renal function].
Topics: Animals; Cell Division; Cells, Cultured; Erythroid Precursor Cells; Hippurates; In Vitro Techniques; | 1989 |
Suppressive effect of quinolinic acid and hippuric acid on bone marrow erythroid growth and lymphocyte blast formation in uremia.
Topics: Anemia; Erythropoiesis; Hippurates; Humans; In Vitro Techniques; Lymphocyte Activation; Protein Bind | 1987 |