quinolinic acid has been researched along with Spinal Cord Injuries in 9 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Standardized spinal cord injuries were produced in anesthetized guinea pigs, using lateral compression of the spinal cord." | 1.40 | Effects of methylprednisolone and 4-chloro-3-hydroxyanthranilic acid in experimental spinal cord injury in the guinea pig appear to be mediated by different and potentially complementary mechanisms. ( Blight, AR; Gay, EA; Heyes, MP; Yates, JR, 2014) |
| "Quinolinic acid (QUIN) is an excitotoxic tryptophan metabolite that is produced by activated macrophages." | 1.29 | Quinolinic acid accumulation and functional deficits following experimental spinal cord injury. ( Blight, AR; Cohen, TI; Heyes, MP; Saito, K, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (66.67) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yates, JR | 2 |
| Gay, EA | 1 |
| Heyes, MP | 6 |
| Blight, AR | 5 |
| Cohen, TI | 1 |
| Saito, K | 2 |
| Popovich, PG | 1 |
| Reinhard, JF | 1 |
| Flanagan, EM | 1 |
| Stokes, BT | 1 |
| Leroy, EC | 1 |
| Fanardjian, VV | 1 |
| Papoyan, EV | 1 |
| Pogossian, VI | 1 |
| Gevorkyan, OV | 1 |
| Jeffery, ND | 1 |
| Fitzgerald, M | 1 |
1 review available for quinolinic acid and Spinal Cord Injuries
| Article | Year |
|---|---|
The kynurenine pathway and neurologic disease. Therapeutic strategies.
Topics: 3-Hydroxyanthranilic Acid; Animals; Gerbillinae; Guinea Pigs; Humans; Kynurenine; Macrophage Activat | 1996 |
8 other studies available for quinolinic acid and Spinal Cord Injuries
| Article | Year |
|---|---|
Effects of methylprednisolone and 4-chloro-3-hydroxyanthranilic acid in experimental spinal cord injury in the guinea pig appear to be mediated by different and potentially complementary mechanisms.
Topics: 3-Hydroxyanthranilic Acid; Animals; Behavior, Animal; Disease Models, Animal; Evoked Potentials, Som | 2014 |
4-chloro-3-hydroxyanthranilate reduces local quinolinic acid synthesis, improves functional recovery, and preserves white matter after spinal cord injury.
Topics: 3-Hydroxyanthranilic Acid; Algorithms; Animals; Behavior, Animal; Blood-Brain Barrier; Female; Guine | 2006 |
Quinolinic acid accumulation and functional deficits following experimental spinal cord injury.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; 3-Hydroxyanthranilic Acid; Animals; Dioxygenases; Evoked Pote | 1995 |
Elevation of the neurotoxin quinolinic acid occurs following spinal cord trauma.
Topics: Animals; Blood-Brain Barrier; Female; Immunohistochemistry; Macrophages; Microglia; Quinolinic Acid; | 1994 |
Increased levels of the excitotoxin quinolinic acid in spinal cord following contusion injury.
Topics: Animals; Female; Guinea Pigs; Kynurenine; Macrophages; Neurotoxins; Quinolinic Acid; Reference Value | 1993 |
Quinolinic acid accumulation in injured spinal cord: time course, distribution, and species differences between rat and guinea pig.
Topics: Animals; Disease Models, Animal; Female; Guinea Pigs; Quinolinic Acid; Rats; Rats, Sprague-Dawley; S | 1997 |
Comparison of the effects of electrolytic and chemical destruction of the red nucleus on the compensatory capacity of rats with rubrospinal tract lesions.
Topics: Animals; Brain; Conditioning, Psychological; Electrolysis; Male; Motor Activity; Neural Pathways; Ne | 1999 |
Effects of red nucleus ablation and exogenous neurotrophin-3 on corticospinal axon terminal distribution in the adult rat.
Topics: Animals; Biotin; Denervation; Dextrans; Fluorescent Dyes; Male; Nerve Regeneration; Neuronal Plastic | 2001 |