quinolinic acid has been researched along with Pregnancy in 36 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Several studies suggest a pathophysiologically relevant association between increased brain levels of the neuroinhibitory tryptophan metabolite kynurenic acid and cognitive dysfunctions in people with schizophrenia." | 7.88 | Maternal genotype determines kynurenic acid levels in the fetal brain: Implications for the pathophysiology of schizophrenia. ( Beggiato, S; Giorgini, F; Notarangelo, FM; Sathyasaikumar, KV; Schwarcz, R, 2018) |
| "Maternal inflammation has been linked to neurodevelopmental and neuropsychiatric disorders such as cerebral palsy, schizophrenia, and autism." | 5.46 | Maternal Inflammation Results in Altered Tryptophan Metabolism in Rabbit Placenta and Fetal Brain. ( Chugani, DC; Drewes, JL; Graham, DR; Kannan, S; Lesniak, WG; Nance, E; Rangaramanujam, K; Singh, S; Williams, M; Zhang, Z, 2017) |
| "Quinolinic acid was administered intraperitoneally in a dose of 30 or 60 mmol, once daily, throughout the entire gestation period." | 5.29 | Effect of quinolinic acid administered during pregnancy on the brain of offspring. ( Beskid, M, 1994) |
| "Quinolinic acid was administered intraperitoneally in a dose of 60 mmol, once daily, throughout the entire gestation period." | 5.29 | Toxic effect of quinolinic acid administered during pregnancy on the cerebral cortex of rat's offspring: an ultrastructural study. ( Beskid, M, 1994) |
| "Several studies suggest a pathophysiologically relevant association between increased brain levels of the neuroinhibitory tryptophan metabolite kynurenic acid and cognitive dysfunctions in people with schizophrenia." | 3.88 | Maternal genotype determines kynurenic acid levels in the fetal brain: Implications for the pathophysiology of schizophrenia. ( Beggiato, S; Giorgini, F; Notarangelo, FM; Sathyasaikumar, KV; Schwarcz, R, 2018) |
| "Quinolinic acid was positively associated with sSAT at birth." | 1.72 | The Kynurenine Pathway Metabolites in Cord Blood Positively Correlate With Early Childhood Adiposity. ( Cameron-Smith, D; Chong, MFF; Chong, YS; Eriksson, JG; Fortier, MV; Gluckman, PD; Godfrey, KM; Kothandaraman, N; Lee, YS; Michael, N; Sadananthan, SA; Tan, KH; Tan, KM; Tint, MT; Velan, SS; Yap, F, 2022) |
| "PDS was determined by an Edinburgh Postnatal Depression Scale (EPDS) score ≥ 13." | 1.56 | The role of kynurenine pathway and kynurenic aminotransferase alleles in postpartum depression following cesarean section in Chinese women. ( Duan, K; Hu, N; Huang, Z; Long, G; Ma, J; Quan, C; Wang, S; Yang, M; Yu, H; Zeng, G, 2020) |
| " However, their single actions cannot explain the extent of brain damage observed in this disorder, and the characterization of co-adjuvant involved in the early toxic processes evoked in AD is essential." | 1.48 | Synergistic Toxicity of the Neurometabolites Quinolinic Acid and Homocysteine in Cortical Neurons and Astrocytes: Implications in Alzheimer's Disease. ( Biasibetti-Brendler, H; Ferreira, F; Netto, CA; Pierozan, P; Schmitz, F; Wyse, ATS, 2018) |
| "PPD was diagnosed with an Edinburgh Postnatal Depression Scale (EPDS) score ≥13." | 1.48 | [Correlation between kynurenine metabolites and postpartum depression]. ( Duan, K; Quan, C; Tan, Y; Wang, S; Wen, S; Zhang, J, 2018) |
| "Maternal inflammation has been linked to neurodevelopmental and neuropsychiatric disorders such as cerebral palsy, schizophrenia, and autism." | 1.46 | Maternal Inflammation Results in Altered Tryptophan Metabolism in Rabbit Placenta and Fetal Brain. ( Chugani, DC; Drewes, JL; Graham, DR; Kannan, S; Lesniak, WG; Nance, E; Rangaramanujam, K; Singh, S; Williams, M; Zhang, Z, 2017) |
| "Quinolinic acid (QUIN) is an endogenous metabolite of the kynurenine pathway involved in several neurological disorders." | 1.42 | Quinolinic acid induces disrupts cytoskeletal homeostasis in striatal neurons. Protective role of astrocyte-neuron interaction. ( de Lima, BO; Ferreira, F; Pessoa-Pureur, R; Pierozan, P, 2015) |
| "Quinolinic acid (QUIN) is a glutamate agonist which markedly enhances the vulnerability of neural cells to excitotoxicity." | 1.40 | The phosphorylation status and cytoskeletal remodeling of striatal astrocytes treated with quinolinic acid. ( Bincoletto, C; de Castro Medaglia, N; Ferreira, F; Gonçalves Fernandes, C; Ortiz de Lima, B; Pessoa-Pureur, R; Pierozan, P; Soubhi Smaili, S; Totarelli Monteforte, P, 2014) |
| "Kynurenic acid is a tryptophan metabolite that is synthesized and released in the brain by astrocytes and acts as an antagonist of nicotinic acetylcholine receptors and N-methyl-d-aspartate glutamate receptors, both of which are critically involved in cognition as well as neural plasticity and brain development." | 1.39 | The effect of transient increases in kynurenic acid and quinolinic acid levels early in life on behavior in adulthood: Implications for schizophrenia. ( Bucci, DJ; Iaccarino, HF; Suckow, RF; Xie, S, 2013) |
| " In contrast, neither QA up to 5 mM nor trans-ACPD had a significant toxic effect in either KCl group." | 1.30 | NMDA and non-NMDA receptor-mediated excitotoxicity are potentiated in cultured striatal neurons by prior chronic depolarization. ( Chen, Q; Reiner, A; Surmeier, DJ, 1999) |
| "Quinolinic acid was administered intraperitoneally in a dose of 30 or 60 mmol, once daily, throughout the entire gestation period." | 1.29 | Effect of quinolinic acid administered during pregnancy on the brain of offspring. ( Beskid, M, 1994) |
| "Quinolinic acid was administered intraperitoneally in a dose of 60 mmol, once daily, throughout the entire gestation period." | 1.29 | Toxic effect of quinolinic acid administered during pregnancy on the cerebral cortex of rat's offspring: an ultrastructural study. ( Beskid, M, 1994) |
| " We observed that, while a decrease in total cell number produced by QUIN was not prevented by SP treatment, AChE-positive cells were rescued from the toxic damage." | 1.29 | Tachykinins protect cholinergic neurons from quinolinic acid excitotoxicity in striatal cultures. ( Alberch, J; Calvo, N; Pérez-Navarro, E; Reiriz, J, 1996) |
| "Using the excitotoxic animal model of Huntington's disease, two experimental treatments were evaluated." | 1.28 | Neural grafts and pharmacological intervention in a model of Huntington's disease. ( Ford, LM; Giordano, M; Sanberg, PR; Shipley, MT, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (30.56) | 18.2507 |
| 2000's | 10 (27.78) | 29.6817 |
| 2010's | 11 (30.56) | 24.3611 |
| 2020's | 4 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Tan, KM | 1 |
| Tint, MT | 1 |
| Kothandaraman, N | 1 |
| Michael, N | 1 |
| Sadananthan, SA | 1 |
| Velan, SS | 1 |
| Fortier, MV | 1 |
| Yap, F | 1 |
| Tan, KH | 1 |
| Gluckman, PD | 1 |
| Chong, YS | 1 |
| Chong, MFF | 1 |
| Lee, YS | 1 |
| Godfrey, KM | 1 |
| Eriksson, JG | 1 |
| Cameron-Smith, D | 1 |
| Quan, C | 2 |
| Wang, S | 2 |
| Duan, K | 2 |
| Ma, J | 1 |
| Yu, H | 1 |
| Yang, M | 1 |
| Hu, N | 1 |
| Long, G | 1 |
| Zeng, G | 1 |
| Huang, Z | 1 |
| Nassan, FL | 1 |
| Gunn, JA | 1 |
| Hill, MM | 1 |
| Williams, PL | 1 |
| Hauser, R | 1 |
| Notarangelo, FM | 2 |
| Schwarcz, R | 4 |
| Williams, M | 1 |
| Zhang, Z | 1 |
| Nance, E | 1 |
| Drewes, JL | 1 |
| Lesniak, WG | 1 |
| Singh, S | 1 |
| Chugani, DC | 1 |
| Rangaramanujam, K | 1 |
| Graham, DR | 1 |
| Kannan, S | 1 |
| Pierozan, P | 4 |
| Biasibetti-Brendler, H | 1 |
| Schmitz, F | 2 |
| Ferreira, F | 3 |
| Netto, CA | 1 |
| Wyse, ATS | 1 |
| Tan, Y | 1 |
| Wen, S | 1 |
| Zhang, J | 1 |
| Beggiato, S | 1 |
| Sathyasaikumar, KV | 1 |
| Giorgini, F | 1 |
| Kotlar, I | 1 |
| Rangel-López, E | 1 |
| Colonnello, A | 1 |
| Aguilera-Portillo, G | 1 |
| Serratos, IN | 1 |
| Galván-Arzate, S | 1 |
| Pedraza-Chaverri, J | 1 |
| Túnez, I | 1 |
| Wajner, M | 1 |
| Santamaría, A | 1 |
| Iaccarino, HF | 1 |
| Suckow, RF | 1 |
| Xie, S | 1 |
| Bucci, DJ | 1 |
| Ortiz de Lima, B | 1 |
| Gonçalves Fernandes, C | 1 |
| Totarelli Monteforte, P | 1 |
| de Castro Medaglia, N | 1 |
| Bincoletto, C | 1 |
| Soubhi Smaili, S | 1 |
| Pessoa-Pureur, R | 3 |
| Sano, M | 1 |
| Ferchaud-Roucher, V | 1 |
| Nael, C | 1 |
| Aguesse, A | 1 |
| Poupeau, G | 1 |
| Castellano, B | 1 |
| Darmaun, D | 1 |
| Zavitsanou, K | 1 |
| Lim, CK | 1 |
| Purves-Tyson, T | 1 |
| Karl, T | 1 |
| Kassiou, M | 1 |
| Banister, SD | 1 |
| Guillemin, GJ | 1 |
| Weickert, CS | 1 |
| de Lima, BO | 1 |
| Biasibetti, H | 1 |
| Ávila, H | 1 |
| Parisi, MM | 1 |
| Barbe-Tuana, F | 1 |
| Wyse, AT | 1 |
| Yu, P | 1 |
| Di Prospero, NA | 1 |
| Sapko, MT | 1 |
| Cai, T | 1 |
| Chen, A | 1 |
| Melendez-Ferro, M | 1 |
| Du, F | 1 |
| Whetsell, WO | 1 |
| Guidetti, P | 2 |
| Tagle, DA | 1 |
| Schweigert, ID | 1 |
| de Oliveira, DL | 1 |
| Scheibel, F | 1 |
| da Costa, F | 1 |
| Wofchuk, ST | 1 |
| Souza, DO | 1 |
| Perry, ML | 1 |
| Yan, E | 1 |
| Castillo-Meléndez, M | 1 |
| Smythe, G | 3 |
| Walker, D | 1 |
| Dairam, A | 1 |
| Müller, AC | 1 |
| Daya, S | 1 |
| Ceresoli-Borroni, G | 1 |
| Amori, L | 1 |
| Pellicciari, R | 1 |
| Chen, Q | 2 |
| Harris, C | 1 |
| Brown, CS | 1 |
| Howe, A | 1 |
| Surmeier, DJ | 2 |
| Reiner, A | 2 |
| Beskid, M | 3 |
| Nagra, RM | 1 |
| Heyes, MP | 1 |
| Wiley, CA | 1 |
| Jachimowicz, J | 1 |
| Taraszewska, A | 1 |
| DeLisi, LE | 1 |
| Calvo, N | 1 |
| Reiriz, J | 1 |
| Pérez-Navarro, E | 1 |
| Alberch, J | 1 |
| Oo, TF | 1 |
| Henchcliffe, C | 1 |
| James, D | 1 |
| Burke, RE | 1 |
| Guzman, R | 1 |
| Lövblad, KO | 1 |
| Meyer, M | 1 |
| Spenger, C | 1 |
| Schroth, G | 1 |
| Widmer, HR | 1 |
| Nicholls, T | 2 |
| Lacey, B | 1 |
| Nitsos, I | 2 |
| Walker, DW | 2 |
| Zanoli, P | 1 |
| Cannazza, G | 1 |
| Baraldi, M | 1 |
| Hurelbrink, CB | 1 |
| Armstrong, RJ | 1 |
| Dunnett, SB | 1 |
| Rosser, AE | 1 |
| Barker, RA | 1 |
| Giordano, M | 1 |
| Ford, LM | 1 |
| Shipley, MT | 1 |
| Sanberg, PR | 1 |
| Khaspekov, LG | 1 |
| Stastný, F | 1 |
| Viktorov, IV | 1 |
| Lisý, V | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Kynurenine Pathway Metabolites as Novel Translational Biological Markers of Irritable Bowel Syndrome: Relationship to Gastrointestinal Function, Cognition and Co-morbid Depression[NCT01304355] | 85 participants (Anticipated) | Observational | 2011-01-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for quinolinic acid and Pregnancy
| Article | Year |
|---|---|
Is there a viral or immune dysfunction etiology to schizophrenia? Re-evaluation a decade later.
Topics: Antibodies, Viral; Diarrhea Viruses, Bovine Viral; Female; Humans; Influenza, Human; Interleukin-2; | 1996 |
35 other studies available for quinolinic acid and Pregnancy
| Article | Year |
|---|---|
The Kynurenine Pathway Metabolites in Cord Blood Positively Correlate With Early Childhood Adiposity.
Topics: Adiposity; Adult; Birth Weight; Cesarean Section; Child; Child, Preschool; Female; Fetal Blood; Huma | 2022 |
The role of kynurenine pathway and kynurenic aminotransferase alleles in postpartum depression following cesarean section in Chinese women.
Topics: Adult; Alleles; Cesarean Section; Depression, Postpartum; Female; Genotype; Humans; Kynurenic Acid; | 2020 |
Association of urinary concentrations of phthalate metabolites with quinolinic acid among women: A potential link to neurological disorders.
Topics: Child; Female; Humans; Male; Massachusetts; Nervous System Diseases; Phthalic Acids; Pregnancy; Pros | 2020 |
A single prenatal lipopolysaccharide injection has acute, but not long-lasting, effects on cerebral kynurenine pathway metabolism in mice.
Topics: Animals; Female; Kynurenic Acid; Kynurenine; Lipopolysaccharides; Male; Mice; Placenta; Pregnancy; Q | 2021 |
Maternal Inflammation Results in Altered Tryptophan Metabolism in Rabbit Placenta and Fetal Brain.
Topics: Animals; Brain; Female; Indoles; Inflammation; Placenta; Pregnancy; Quinolinic Acid; Rabbits; Seroto | 2017 |
Synergistic Toxicity of the Neurometabolites Quinolinic Acid and Homocysteine in Cortical Neurons and Astrocytes: Implications in Alzheimer's Disease.
Topics: Analysis of Variance; Animals; Annexin A5; Astrocytes; Cells, Cultured; Cerebral Cortex; Coculture T | 2018 |
[Correlation between kynurenine metabolites and postpartum depression].
Topics: Biomarkers; Cesarean Section; China; Depression, Postpartum; Female; Humans; Incidence; Kynurenic Ac | 2018 |
Maternal genotype determines kynurenic acid levels in the fetal brain: Implications for the pathophysiology of schizophrenia.
Topics: Animals; Brain; Cognitive Dysfunction; Female; Genotype; Kynurenic Acid; Kynurenine; Kynurenine 3-Mo | 2018 |
Anandamide Reduces the Toxic Synergism Exerted by Quinolinic Acid and Glutaric Acid in Rat Brain Neuronal Cells.
Topics: Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Agonists; Carbamates; Cell Survival; Ce | 2019 |
The effect of transient increases in kynurenic acid and quinolinic acid levels early in life on behavior in adulthood: Implications for schizophrenia.
Topics: Analysis of Variance; Animals; Animals, Newborn; Attention; Behavior, Animal; Brain Chemistry; Cohor | 2013 |
The phosphorylation status and cytoskeletal remodeling of striatal astrocytes treated with quinolinic acid.
Topics: Actin Cytoskeleton; Animals; Apoptosis; Astrocytes; Blotting, Western; Calcium; Cell Proliferation; | 2014 |
Simultaneous detection of stable isotope-labeled and unlabeled L-tryptophan and of its main metabolites, L-kynurenine, serotonin and quinolinic acid, by gas chromatography/negative ion chemical ionization mass spectrometry.
Topics: Adult; Animals; Female; Gas Chromatography-Mass Spectrometry; Humans; Isotope Labeling; Kynurenine; | 2014 |
Effect of maternal immune activation on the kynurenine pathway in preadolescent rat offspring and on MK801-induced hyperlocomotion in adulthood: amelioration by COX-2 inhibition.
Topics: Animals; Brain; Celecoxib; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dizocilpine Maleate; | 2014 |
Quinolinic acid induces disrupts cytoskeletal homeostasis in striatal neurons. Protective role of astrocyte-neuron interaction.
Topics: Animals; Animals, Newborn; Astrocytes; Cell Communication; Cell Survival; Cells, Cultured; Chelating | 2015 |
Quinolinic acid neurotoxicity: Differential roles of astrocytes and microglia via FGF-2-mediated signaling in redox-linked cytoskeletal changes.
Topics: Animals; Astrocytes; Cell Communication; Coculture Techniques; Connexin 43; Corpus Striatum; Cytoske | 2016 |
Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice.
Topics: Animals; Behavior, Animal; Blood Chemical Analysis; Brain; Brain Chemistry; Female; Humans; Kidney; | 2004 |
Gestational and postnatal malnutrition affects sensitivity of young rats to picrotoxin and quinolinic acid and uptake of GABA by cortical and hippocampal slices.
Topics: Analysis of Variance; Animals; Animals, Newborn; Body Weight; Caseins; Cerebral Cortex; Dose-Respons | 2005 |
Quinolinic acid promotes albumin deposition in Purkinje cell, astrocytic activation and lipid peroxidation in fetal brain.
Topics: Albumins; Aldehydes; Analysis of Variance; Animals; Astrocytes; Blood Gas Analysis; Brain; Embryo, M | 2005 |
Non-steroidal anti-inflammatory agents, tolmetin and sulindac attenuate quinolinic acid (QA)-induced oxidative stress in primary hippocampal neurons and reduce QA-induced spatial reference memory deficits in male Wistar rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Cells, Cultured; Female; Glutathion | 2007 |
Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological implications.
Topics: Animals; Animals, Newborn; Brain Chemistry; Cyclopropanes; Deoxycholic Acid; Drug Administration Sch | 2007 |
Glutamate-mediated excitotoxic death of cultured striatal neurons is mediated by non-NMDA receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Basal Ganglia; Cell Death; Cells, | 1995 |
Effect of quinolinic acid administered during pregnancy on the brain of offspring.
Topics: Animals; Animals, Newborn; Brain; Cerebral Cortex; Corpus Striatum; Dose-Response Relationship, Drug | 1994 |
Toxic effect of quinolinic acid administered during pregnancy on the cerebral cortex of rat's offspring: an ultrastructural study.
Topics: Animals; Animals, Newborn; Astrocytes; Cell Nucleus; Cerebral Cortex; Cytoplasm; Dendrites; Female; | 1994 |
Viral load and its relationship to quinolinic acid, TNF alpha, and IL-6 levels in the CNS of retroviral infected mice.
Topics: Animals; Animals, Newborn; Brain; Brain Stem; Female; Interleukin-6; Leukemia Virus, Murine; Mice; M | 1994 |
The effect of quinolinic acid administered during pregnancy on the nigro-striatal complex of rat's offspring: ultrastructural investigation.
Topics: Animals; Corpus Striatum; Female; Injections, Intraperitoneal; Pregnancy; Prenatal Exposure Delayed | 1995 |
Tachykinins protect cholinergic neurons from quinolinic acid excitotoxicity in striatal cultures.
Topics: Animals; Cells, Cultured; Cholinergic Fibers; Corpus Striatum; Dose-Response Relationship, Drug; Fem | 1996 |
Expression of c-fos, c-jun, and c-jun N-terminal kinase (JNK) in a developmental model of induced apoptotic death in neurons of the substantia nigra.
Topics: Animals; Apoptosis; Dopamine; Female; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mi | 1999 |
NMDA and non-NMDA receptor-mediated excitotoxicity are potentiated in cultured striatal neurons by prior chronic depolarization.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepi | 1999 |
Imaging the rat brain on a 1.5 T clinical MR-scanner.
Topics: Animals; Artifacts; Blood-Brain Barrier; Brain; Brain Tissue Transplantation; Female; Huntington Dis | 2000 |
Regional changes in kynurenic acid, quinolinic acid, and glial fibrillary acidic protein concentrations in the fetal sheep brain after experimentally induced placental insufficiency.
Topics: Animals; Brain; Brain Chemistry; Embolism; Female; Femoral Artery; Gestational Age; Glial Fibrillary | 2001 |
Prenatal exposure to methyl mercury in rats: focus on changes in kynurenine pathway.
Topics: Animals; Aspartic Acid; Female; Fetus; Glutamic Acid; Hippocampus; Kynurenine; Mercury Poisoning, Ne | 2001 |
Kynurenine production and catabolism in fetal sheep with embolized or nonembolized placentas.
Topics: Animals; Disease Models, Animal; Embolism; Female; Fetal Blood; Fetal Diseases; Fetal Growth Retarda | 2001 |
Neural cells from primary human striatal xenografts migrate extensively in the adult rat CNS.
Topics: Animals; Brain Tissue Transplantation; Cell Differentiation; Cell Movement; Disease Models, Animal; | 2002 |
Neural grafts and pharmacological intervention in a model of Huntington's disease.
Topics: Acetylcholinesterase; Amphetamine; Animals; Brain Tissue Transplantation; Catalepsy; Cerebral Cortex | 1990 |
Cytotoxic effect of glutamate and its agonists on mouse hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Survival; Cells, Cultured; Dipeptides; Embryo, Mammalian; | 1990 |