quinolinic acid has been researched along with Poliomyelitis in 4 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
Poliomyelitis: An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Spinal cord slices from poliovirus-inoculated macaques in vitro also converted [13C6]L-tryptophan to [13C6]quinolinic acid." | 1.28 | Poliovirus induces indoleamine-2,3-dioxygenase and quinolinic acid synthesis in macaque brain. ( Heyes, MP; Jacobowitz, D; Markey, SP; Saito, K; Takikawa, O; Vickers, JH, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Campagnola, G | 1 |
| Gong, P | 1 |
| Peersen, OB | 1 |
| Heyes, MP | 3 |
| Saito, K | 2 |
| Major, EO | 1 |
| Milstien, S | 1 |
| Markey, SP | 2 |
| Vickers, JH | 2 |
| Jacobowitz, D | 1 |
| Takikawa, O | 1 |
1 review available for quinolinic acid and Poliomyelitis
| Article | Year |
|---|---|
Quinolinic acid and inflammation.
Topics: Acquired Immunodeficiency Syndrome; Animals; Biomarkers; Brain Ischemia; Disease Models, Animal; HIV | 1993 |
3 other studies available for quinolinic acid and Poliomyelitis
| Article | Year |
|---|---|
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
Topics: Allosteric Regulation; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors; F | 2011 |
A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.
Topics: 3-Hydroxyanthranilic Acid; Animals; Biopterins; Brain; Encephalitis; Fetus; Indoleamine-Pyrrole 2,3, | 1993 |
Poliovirus induces indoleamine-2,3-dioxygenase and quinolinic acid synthesis in macaque brain.
Topics: Animals; Brain; Enzyme Induction; Immunohistochemistry; Interferon-gamma; Macaca; Poliomyelitis; Pol | 1992 |