quinolinic acid has been researched along with Parkinson Disease in 21 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Boosting KYNA levels, through interference with the KP enzymes or through application of prodrugs/analogs with high bioavailability and potency, is a promising clinical approach." | 2.82 | Kynurenic acid in neurodegenerative disorders-unique neuroprotection or double-edged sword? ( Ostapiuk, A; Urbanska, EM, 2022) |
| "L-kynurenine is a central compound of this pathway since it can change to the neuroprotective agent kynurenic acid or to the neurotoxic agent quinolinic acid." | 2.43 | Kynurenines, Parkinson's disease and other neurodegenerative disorders: preclinical and clinical studies. ( Németh, H; Toldi, J; Vécsei, L, 2006) |
| "Adenosine A2 receptors were labeled and visualized by autoradiography in tissue sections of the human brain using the A2-selective agonist ligand [3H](2-p-(2-carboxyethyl)phenylamino)-5'-N-carboxamidoadenosine (CGS 21680)." | 1.28 | Adenosine A2 receptors: selective localization in the human basal ganglia and alterations with disease. ( Martinez-Mir, MI; Palacios, JM; Probst, A, 1991) |
| "These neurons degenerate in Alzheimer's disease, and there is a corresponding deficiency of cortical choline acetyltransferase activity." | 1.27 | Galanin-like immunoreactivity is unchanged in Alzheimer's disease and Parkinson's disease dementia cerebral cortex. ( Beal, MF; Chattha, GK; Clevens, RA; Gabriel, SM; MacGarvey, UM; Mazurek, MF, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.76) | 18.7374 |
| 1990's | 6 (28.57) | 18.2507 |
| 2000's | 7 (33.33) | 29.6817 |
| 2010's | 5 (23.81) | 24.3611 |
| 2020's | 2 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Ostapiuk, A | 1 |
| Urbanska, EM | 1 |
| Qin, W | 1 |
| Shi, Y | 1 |
| Chen, W | 1 |
| Jia, X | 1 |
| Asakawa, T | 1 |
| Thirtamara-Rajamani, K | 1 |
| Li, P | 1 |
| Escobar Galvis, ML | 1 |
| Labrie, V | 1 |
| Brundin, P | 2 |
| Brundin, L | 1 |
| Robertson, DS | 1 |
| Yoon, HH | 1 |
| Kim, YH | 1 |
| Shin, ES | 1 |
| Jeon, SR | 1 |
| Kaindlstorfer, C | 1 |
| García, J | 1 |
| Winkler, C | 1 |
| Wenning, GK | 1 |
| Nikkhah, G | 1 |
| Döbrössy, MD | 1 |
| Tan, L | 2 |
| Yu, JT | 1 |
| Olds, ME | 2 |
| Jacques, DB | 2 |
| Kpoyov, O | 1 |
| Kopyov, O | 1 |
| Németh, H | 1 |
| Toldi, J | 1 |
| Vécsei, L | 1 |
| Oo, TF | 2 |
| Henchcliffe, C | 1 |
| James, D | 1 |
| Burke, RE | 2 |
| Lonser, RR | 1 |
| Corthésy, ME | 1 |
| Morrison, PF | 1 |
| Gogate, N | 1 |
| Oldfield, EH | 1 |
| Kholodilov, NG | 1 |
| Neystat, M | 1 |
| Lo, SE | 1 |
| Larsen, KE | 1 |
| Sulzer, D | 1 |
| Emgård, M | 1 |
| Karlsson, J | 1 |
| Hansson, O | 1 |
| Levivier, M | 1 |
| Donaldson, D | 1 |
| Ravikumar, A | 1 |
| Deepadevi, KV | 1 |
| Arun, P | 1 |
| Manojkumar, V | 1 |
| Kurup, PA | 1 |
| Stone, TW | 1 |
| Wu, HQ | 1 |
| Rassoulpour, A | 1 |
| Schwarcz, R | 1 |
| Taylor, R | 1 |
| Martinez-Mir, MI | 1 |
| Probst, A | 1 |
| Palacios, JM | 1 |
| Beal, MF | 1 |
| Clevens, RA | 1 |
| Chattha, GK | 1 |
| MacGarvey, UM | 1 |
| Mazurek, MF | 1 |
| Gabriel, SM | 1 |
6 reviews available for quinolinic acid and Parkinson Disease
| Article | Year |
|---|---|
Kynurenic acid in neurodegenerative disorders-unique neuroprotection or double-edged sword?
Topics: Alzheimer Disease; Animals; Brain; Excitatory Amino Acid Antagonists; Humans; Huntington Disease; Ky | 2022 |
Can kynurenine pathway be considered as a next-generation therapeutic target for Parkinson's disease? An update information.
Topics: 3-Hydroxyanthranilic Acid; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Levodopa; Parki | 2022 |
Is the Enzyme ACMSD a Novel Therapeutic Target in Parkinson's Disease?
Topics: Animals; Brain; Carboxy-Lyases; Humans; Inflammation; Mutation; Parkinson Disease; Quinolinic Acid | 2017 |
The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations.
Topics: Aging; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Enzyme Inhibitors; Humans; Hunting | 2012 |
Kynurenines, Parkinson's disease and other neurodegenerative disorders: preclinical and clinical studies.
Topics: Animals; Humans; Kynurenine; Neurodegenerative Diseases; Parkinson Disease; Quinolinic Acid; Recepto | 2006 |
Kynurenic acid antagonists and kynurenine pathway inhibitors.
Topics: Brain Ischemia; Epilepsy; Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; Neu | 2001 |
15 other studies available for quinolinic acid and Parkinson Disease
| Article | Year |
|---|---|
Proposed biochemistry of Parkinson's and Alzheimer's diseases.
Topics: Aldehydes; Alzheimer Disease; Aspartic Acid; Betaine; Brain; Disease Progression; Humans; Kynurenine | 2017 |
A rat model of striatonigral degeneration generated by simultaneous injection of 6-hydroxydopamine into the medial forebrain bundle and quinolinic acid into the striatum.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Dopamine Plasma Mem | 2014 |
Behavioral and histological analysis of a partial double-lesion model of parkinson-variant multiple system atrophy.
Topics: Animals; Apomorphine; Cell Count; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Dopami | 2012 |
Behavioral/neurophysiological investigation of effects of combining a quinolinic acid entopeduncular lesion with a fetal mesencephalic tissue transplant in striatum of the 6-OHDA hemilesioned rat.
Topics: Amphetamine; Animals; Apomorphine; Brain Diseases; Brain Tissue Transplantation; Corpus Striatum; Do | 2003 |
Behavioral and anatomical effects of quinolinic acid in the striatum of the hemiparkinsonian rat.
Topics: Adrenergic Agents; Amphetamine; Animals; Behavior, Animal; Corpus Striatum; Disease Models, Animal; | 2005 |
Expression of c-fos, c-jun, and c-jun N-terminal kinase (JNK) in a developmental model of induced apoptotic death in neurons of the substantia nigra.
Topics: Animals; Apoptosis; Dopamine; Female; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mi | 1999 |
Convection-enhanced selective excitotoxic ablation of the neurons of the globus pallidus internus for treatment of parkinsonism in nonhuman primates.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Albumins; Animals; Antiparkinson Agents; Disease Model | 1999 |
Increased expression of rat synuclein in the substantia nigra pars compacta identified by mRNA differential display in a model of developmental target injury.
Topics: alpha-Synuclein; Amino Acid Sequence; Animals; Apoptosis; Base Sequence; Blotting, Northern; Blottin | 1999 |
Patterns of cell death and dopaminergic neuron survival in intrastriatal nigral grafts.
Topics: Animals; Apoptosis; Biomarkers; Brain Tissue Transplantation; Cell Survival; Corpus Striatum; Dopami | 1999 |
Metabolic changes after injection of quinolinic acid or 6-hydroxydopamine in the rat striatum: a time-course study using cytochrome oxidase and glycogene phosphorylase a histochemistry.
Topics: Animals; Autoradiography; Benzazepines; Biomarkers; Corpus Striatum; Disease Models, Animal; Dopamin | 2000 |
Tryptophan and tyrosine catabolic pattern in neuropsychiatric disorders.
Topics: Adult; Biogenic Monoamines; Brain Diseases; Brain Neoplasms; Digoxin; Epilepsy, Generalized; Erythro | 2000 |
Effect of systemic L-DOPA administration on extracellular kynurenate levels in the rat striatum.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Astrocytes; Dopamine; Dose-Response Relationship, | 2002 |
A lot of "excitement' about neurodegeneration.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aging; Alzheimer Disease; Animals; Dizocilpine Maleate | 1991 |
Adenosine A2 receptors: selective localization in the human basal ganglia and alterations with disease.
Topics: Adenosine; Aged; Aged, 80 and over; Animals; Basal Ganglia; Corpus Striatum; Female; Guinea Pigs; Hu | 1991 |
Galanin-like immunoreactivity is unchanged in Alzheimer's disease and Parkinson's disease dementia cerebral cortex.
Topics: Aged; Alzheimer Disease; Animals; Cerebral Cortex; Choline O-Acetyltransferase; Chromatography, High | 1988 |