Page last updated: 2024-10-20

quinolinic acid and Neuroblastoma

quinolinic acid has been researched along with Neuroblastoma in 5 studies

Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.

Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

Research Excerpts

ExcerptRelevanceReference
"Urolithin B and auraptene have been reported to exert potent antioxidant effects - however, little is known about the protective effects of these compounds against QA-induced neurotoxicity."5.91The Effects of Urolithin B and Auraptene on Quinolinic Acid-induced Toxicity in the SH-SY5Y Neuroblastoma Cell Line. ( Abbasinezhad-Moud, F; Afshari, AR; Azadi, N; Forouzanfar, F; Jalili-Nik, M; Mirzavi, F; Mohebbati, R; Rakhshandeh, H; Sanati, M; Soukhtanloo, M, 2023)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's1 (20.00)29.6817
2010's2 (40.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Abbasinezhad-Moud, F1
Mirzavi, F1
Rakhshandeh, H1
Mohebbati, R1
Forouzanfar, F1
Jalili-Nik, M1
Azadi, N1
Sanati, M1
Afshari, AR1
Soukhtanloo, M1
Gao, SM1
Wang, L1
Shi, YX1
Ju, CX1
Zhang, F1
Li, FX1
Wszelaki, N1
Melzig, MF1
Moffett, JR1
Els, T1
Espey, MG1
Walter, SA1
Streit, WJ1
Namboodiri, MA1
Oo, TF1
Siman, R1
Burke, RE1

Other Studies

5 other studies available for quinolinic acid and Neuroblastoma

ArticleYear
The Effects of Urolithin B and Auraptene on Quinolinic Acid-induced Toxicity in the SH-SY5Y Neuroblastoma Cell Line.
    Alternatives to laboratory animals : ATLA, 2023, Volume: 51, Issue:1

    Topics: Antioxidants; Apoptosis; Cell Line, Tumor; Cell Survival; Humans; Neuroblastoma; Oxidative Stress; Q

2023
[Protective effects of total epimedium flavonoids against QA-induced toxicity in SH-SY5Y cells].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2013, Volume: 36, Issue:12

    Topics: Antioxidants; Apoptosis; Calcium; Cell Line, Tumor; Cell Survival; Epimedium; Flavonoids; Flow Cytom

2013
Research on an in vitro cell system for testing the neurotoxicity of kynurenine pathway metabolites.
    Die Pharmazie, 2011, Volume: 66, Issue:11

    Topics: Brain Neoplasms; Cell Differentiation; Cell Line, Tumor; Cell Survival; Coloring Agents; Fluorescent

2011
Quinolinate immunoreactivity in experimental rat brain tumors is present in macrophages but not in astrocytes.
    Experimental neurology, 1997, Volume: 144, Issue:2

    Topics: Animals; Antibody Specificity; Astrocytes; Biomarkers; Brain Neoplasms; Corpus Striatum; Female; Gli

1997
Distinct nuclear and cytoplasmic localization of caspase cleavage products in two models of induced apoptotic death in dopamine neurons of the substantia nigra.
    Experimental neurology, 2002, Volume: 175, Issue:1

    Topics: Actins; Animals; Antibody Specificity; Apoptosis; Caspases; Cell Compartmentation; Cell Nucleus; Cyt

2002