quinolinic acid has been researched along with Nervous System Diseases in 30 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
Nervous System Diseases: Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There were statistically significant increases of CSF neopterin, kynurenine, quinolinic acid and kynurenine/tryptophan ratio (KYN/TRP) in the inflammation group compared to all control groups (all p < 0." | 8.31 | CSF neopterin, quinolinic acid and kynurenine/tryptophan ratio are biomarkers of active neuroinflammation. ( Andrews, PI; Antony, J; Ardern-Holmes, S; Bandodkar, S; Chung, J; Dale, RC; Farrar, MA; Gill, D; Guillemin, GJ; Guller, A; Gupta, S; Han, VX; Heng, B; Jones, HF; Kandula, T; Keating, BA; Kothur, K; Menezes, MP; Mohammad, S; Patel, S; Pillai, SC; Sampaio, H; Tantsis, E; Troedson, C; Webster, R; Yan, J, 2023) |
| "Kynurenine is a metabolite of the tryptophan-nicotine-amide-adenine-dinucleotide pathway." | 6.38 | [Kynurenine and its metabolites in nervous system diseases]. ( Schwab, F; Vécsei, L, 1992) |
| "There were statistically significant increases of CSF neopterin, kynurenine, quinolinic acid and kynurenine/tryptophan ratio (KYN/TRP) in the inflammation group compared to all control groups (all p < 0." | 4.31 | CSF neopterin, quinolinic acid and kynurenine/tryptophan ratio are biomarkers of active neuroinflammation. ( Andrews, PI; Antony, J; Ardern-Holmes, S; Bandodkar, S; Chung, J; Dale, RC; Farrar, MA; Gill, D; Guillemin, GJ; Guller, A; Gupta, S; Han, VX; Heng, B; Jones, HF; Kandula, T; Keating, BA; Kothur, K; Menezes, MP; Mohammad, S; Patel, S; Pillai, SC; Sampaio, H; Tantsis, E; Troedson, C; Webster, R; Yan, J, 2023) |
| "Quinolinic acid is an agonist at the N-methyl-D-aspartate sensitive subtype of glutamate receptors in the brain, while kynurenic acid is an antagonist and, thus, a potential neuroprotectant." | 2.41 | Endogenous neurotoxins from tryptophan. ( Stone, TW, 2001) |
| "Kynurenine is a metabolite of the tryptophan-nicotine-amide-adenine-dinucleotide pathway." | 2.38 | [Kynurenine and its metabolites in nervous system diseases]. ( Schwab, F; Vécsei, L, 1992) |
| "Quinolinic acid (QUIN) is an endogenous N-methyl-D-aspartate receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction." | 1.28 | Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. ( Crowley, JS; Davis, LE; Demitrack, MA; Der, M; Dilling, LA; Elia, J; Heyes, MP; Kruesi, MJ; Lackner, A; Saito, K, 1992) |
| "In patients with encephalopathy, serum QUIN was elevated with corresponding increments in CSF QUIN." | 1.28 | Neuroactive kynurenines in Lyme borreliosis. ( Halperin, JJ; Heyes, MP, 1992) |
| "Tonic-clonic seizures were induced by 225-450 mg/kg Quin." | 1.28 | Studies on the potential neurotoxic and convulsant effects of increased blood levels of quinolinic acid in rats with altered blood-brain barrier permeability. ( Castiglioni, M; Samanin, R; Stasi, MA; Vezzani, A; Weckermann, B; Wu, HQ, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (10.00) | 18.7374 |
| 1990's | 20 (66.67) | 18.2507 |
| 2000's | 1 (3.33) | 29.6817 |
| 2010's | 3 (10.00) | 24.3611 |
| 2020's | 3 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pires, AS | 1 |
| Sundaram, G | 1 |
| Heng, B | 2 |
| Krishnamurthy, S | 1 |
| Brew, BJ | 2 |
| Guillemin, GJ | 2 |
| Yan, J | 1 |
| Kothur, K | 1 |
| Mohammad, S | 1 |
| Chung, J | 1 |
| Patel, S | 1 |
| Jones, HF | 1 |
| Keating, BA | 1 |
| Han, VX | 1 |
| Webster, R | 1 |
| Ardern-Holmes, S | 1 |
| Antony, J | 1 |
| Menezes, MP | 1 |
| Tantsis, E | 1 |
| Gill, D | 1 |
| Gupta, S | 1 |
| Kandula, T | 1 |
| Sampaio, H | 1 |
| Farrar, MA | 1 |
| Troedson, C | 1 |
| Andrews, PI | 1 |
| Pillai, SC | 1 |
| Guller, A | 1 |
| Bandodkar, S | 1 |
| Dale, RC | 1 |
| Nassan, FL | 2 |
| Gunn, JA | 2 |
| Hill, MM | 2 |
| Williams, PL | 1 |
| Hauser, R | 2 |
| Coull, BA | 1 |
| Colín-González, AL | 1 |
| Aguilera, G | 1 |
| Santamaría, A | 2 |
| Shemesh, N | 1 |
| Sadan, O | 1 |
| Melamed, E | 1 |
| Offen, D | 1 |
| Cohen, Y | 1 |
| Schwarcz, R | 1 |
| Foster, AC | 1 |
| French, ED | 1 |
| Whetsell, WO | 1 |
| Köhler, C | 1 |
| Fendt, M | 1 |
| Koch, M | 1 |
| Schnitzler, HU | 1 |
| Reinhard, JF | 1 |
| Erickson, JB | 1 |
| Flanagan, EM | 1 |
| Rausch, DM | 1 |
| Heyes, M | 1 |
| Eiden, LE | 1 |
| Altagracia, M | 1 |
| Kravzov, J | 1 |
| Ríos, C | 1 |
| Ordaz, H | 1 |
| Gonzalez, L | 1 |
| Nagra, RM | 1 |
| Heyes, MP | 8 |
| Wiley, CA | 1 |
| Milstien, S | 1 |
| Sakai, N | 1 |
| Krieger, C | 1 |
| Vickers, JH | 1 |
| Saito, K | 2 |
| Birdsall, HH | 1 |
| Ozluoglu, LN | 1 |
| Lew, HL | 1 |
| Trial, J | 1 |
| Brown, DP | 1 |
| Wofford, MJ | 1 |
| Jerger, JF | 1 |
| Rossen, RD | 1 |
| Stone, TW | 1 |
| Freese, A | 1 |
| Finklestein, SP | 1 |
| DiFiglia, M | 1 |
| Fuchs, D | 1 |
| Weiss, G | 1 |
| Werner-Felmayer, G | 1 |
| Reibnegger, G | 1 |
| Wachter, H | 1 |
| Vécsei, L | 1 |
| Schwab, F | 1 |
| Crowley, JS | 1 |
| Davis, LE | 1 |
| Demitrack, MA | 1 |
| Der, M | 1 |
| Dilling, LA | 1 |
| Elia, J | 1 |
| Kruesi, MJ | 1 |
| Lackner, A | 1 |
| Halperin, JJ | 1 |
| Susel, Z | 2 |
| Engber, TM | 2 |
| Kuo, S | 1 |
| Chase, TN | 2 |
| Markey, SP | 1 |
| Boni, RL | 1 |
| Yergey, JA | 1 |
| Yamada, K | 2 |
| Nabeshima, T | 2 |
| Kameyama, T | 2 |
| Boegman, RJ | 1 |
| Jhamandas, K | 1 |
| Beninger, RJ | 1 |
| Fuji, K | 1 |
| Vezzani, A | 1 |
| Stasi, MA | 1 |
| Wu, HQ | 1 |
| Castiglioni, M | 1 |
| Weckermann, B | 1 |
| Samanin, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of 3-month Probiotic Mix Supplementation (L. Helveticus R-0052, B. Longum R-0175) on Gut Microbiota and Metabolome, Endocannabinoid and Immune Systems Activation, Along With Symptoms of Fatigue in Professional Dancers[NCT05567653] | 60 participants (Anticipated) | Interventional | 2022-09-21 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for quinolinic acid and Nervous System Diseases
| Article | Year |
|---|---|
Recent advances in clinical trials targeting the kynurenine pathway.
Topics: Humans; Kynurenine; Male; Nervous System Diseases; Quinolinic Acid; Tryptophan | 2022 |
Cannabinoids: Glutamatergic Transmission and Kynurenines.
Topics: Animals; Brain; Cannabinoids; Humans; Kynurenine; Nervous System Diseases; Quinolinic Acid | 2016 |
Quinolinic acid in neurological disease: opportunities for novel drug discovery.
Topics: Animals; Humans; Nervous System Diseases; Quinolinic Acid | 1994 |
Quinolinic acid and inflammation.
Topics: Acquired Immunodeficiency Syndrome; Animals; Biomarkers; Brain Ischemia; Disease Models, Animal; HIV | 1993 |
The kynurenine pathway and neurologic disease. Therapeutic strategies.
Topics: 3-Hydroxyanthranilic Acid; Animals; Gerbillinae; Guinea Pigs; Humans; Kynurenine; Macrophage Activat | 1996 |
Endogenous neurotoxins from tryptophan.
Topics: Animals; Humans; Kynurenine; Nervous System Diseases; Neurotoxins; Quinolinic Acid; Tryptophan | 2001 |
[Kynurenine and its metabolites in nervous system diseases].
Topics: Humans; Kynurenic Acid; Kynurenine; Nervous System Diseases; Quinolinic Acid; Quinolinic Acids | 1992 |
Mass spectrometric determinations of tryptophan and its metabolites.
Topics: Animals; Body Fluids; Gas Chromatography-Mass Spectrometry; Humans; Mass Spectrometry; Melatonin; Mo | 1991 |
22 other studies available for quinolinic acid and Nervous System Diseases
| Article | Year |
|---|---|
CSF neopterin, quinolinic acid and kynurenine/tryptophan ratio are biomarkers of active neuroinflammation.
Topics: Adolescent; Biomarkers; Child; Child, Preschool; Humans; Infant; Inflammation; Kynurenine; Leukocyto | 2023 |
Association of urinary concentrations of phthalate metabolites with quinolinic acid among women: A potential link to neurological disorders.
Topics: Child; Female; Humans; Male; Massachusetts; Nervous System Diseases; Phthalic Acids; Pregnancy; Pros | 2020 |
High phthalate exposure increased urinary concentrations of quinolinic acid, implicated in the pathogenesis of neurological disorders: Is this a potential missing link?
Topics: Animals; Cross-Sectional Studies; Humans; Male; Nervous System Diseases; Phthalic Acids; Pilot Proje | 2019 |
Longitudinal MRI and MRSI characterization of the quinolinic acid rat model for excitotoxicity: peculiar apparent diffusion coefficients and recovery of N-acetyl aspartate levels.
Topics: Animals; Aspartic Acid; Behavior, Animal; Brain; Diffusion Magnetic Resonance Imaging; Disease Model | 2010 |
Excitotoxic models for neurodegenerative disorders.
Topics: Amino Acids; Animals; Axons; Dendrites; Epilepsy, Temporal Lobe; Hippocampus; Humans; Ibotenic Acid; | 1984 |
Sensorimotor gating deficit after lesions of the superior colliculus.
Topics: Acoustic Stimulation; Animals; Electroshock; Male; Nervous System Diseases; Neurotoxins; Quinolinic | 1994 |
Effects of chronic zidovudine administration on CNS function and virus burden after perinatal SIV infection in rhesus monkeys.
Topics: Animals; Animals, Newborn; Antigens, Viral; Cognition; Macaca mulatta; Motor Activity; Nervous Syste | 1994 |
Dapsone administration prevents quinolinate-induced neurotoxicity in rats.
Topics: Animals; Apomorphine; Dapsone; Injections; Male; Neostriatum; Nervous System Diseases; Quinolinic Ac | 1994 |
Viral load and its relationship to quinolinic acid, TNF alpha, and IL-6 levels in the CNS of retroviral infected mice.
Topics: Animals; Animals, Newborn; Brain; Brain Stem; Female; Interleukin-6; Leukemia Virus, Murine; Mice; M | 1994 |
Cerebrospinal fluid nitrite/nitrate levels in neurologic diseases.
Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Biopterins; HIV Infections; Humans; Hunti | 1994 |
Auditory P300 abnormalities and leukocyte activation in HIV infection.
Topics: Acoustic Stimulation; Adult; Audiometry, Pure-Tone; Electroencephalography; Evoked Potentials, Audit | 1994 |
Basic fibroblast growth factor protects striatal neurons in vitro from NMDA-receptor mediated excitotoxicity.
Topics: Animals; Cell Death; Corpus Striatum; Fibroblast Growth Factor 2; Glutamates; Glutamic Acid; Kainic | 1992 |
Immune activation and neuronal injury in AIDS.
Topics: Acquired Immunodeficiency Syndrome; HIV-1; Humans; Interferon-gamma; Nervous System Diseases; Neuron | 1992 |
Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease.
Topics: Aged; Animals; Brain Diseases; Encephalitis; Female; HIV Infections; Humans; Kynurenic Acid; Kynuren | 1992 |
Quinolinic acid in culture media used for in vitro neurotoxicology studies.
Topics: Animals; Cattle; Chickens; Culture Media; Goats; Horses; Humans; Mice; Nervous System Diseases; Quin | 1992 |
Neuroactive kynurenines in Lyme borreliosis.
Topics: Brain Diseases; Humans; Kynurenine; Lyme Disease; Lymphokines; Multiple Sclerosis; Nervous System Di | 1992 |
Prolonged infusion of quinolinic acid into rat striatum as an excitotoxic model of neurodegenerative disease.
Topics: Animals; Choline O-Acetyltransferase; Convulsants; Corpus Striatum; Disease Models, Animal; Glutamat | 1991 |
Impairment of active avoidance response in rats with continuous infusion of quinolinic acid into the lateral ventricle.
Topics: Animals; Avoidance Learning; Behavior, Animal; Convulsants; Disease Models, Animal; Injections, Intr | 1991 |
Neurotoxicity of tryptophan metabolites.
Topics: Animals; Cerebral Cortex; Choline O-Acetyltransferase; Kynurenic Acid; Male; NADP; Nervous System Di | 1990 |
Neurotoxicity induced by continuous infusion of quinolinic acid into the lateral ventricle in rats.
Topics: Animals; Brain; Cerebral Cortex; Choline O-Acetyltransferase; Corpus Striatum; Dizocilpine Maleate; | 1990 |
Behavioral evaluation of the anti-excitotoxic properties of MK-801: comparison with neurochemical measurements.
Topics: Animals; Anticonvulsants; Apomorphine; Choline O-Acetyltransferase; Corpus Striatum; Dibenzocyclohep | 1989 |
Studies on the potential neurotoxic and convulsant effects of increased blood levels of quinolinic acid in rats with altered blood-brain barrier permeability.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Blood-Brain Barrier; Cerebral Co | 1989 |