quinolinic acid has been researched along with Nerve Degeneration in 125 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The influence of embryonic mesencephalic, striatal and mesencephalic/striatal co-grafts on amphetamine- and apomorphine-induced rotation behaviour was assessed in a rat model of multiple system atrophy/striatonigral degeneration type using dopamine D1 ([3H]SCH23390) and D2 ([3H]spiperone) receptor and dopamine re-uptake ([3H]mazindol) autoradiography." | 7.70 | Autoradiographic study of striatal dopamine re-uptake sites and dopamine D1 and D2 receptors in a 6-hydroxydopamine and quinolinic acid double-lesion rat model of striatonigral degeneration (multiple system atrophy) and effects of embryonic ventral mesenc ( Granata, R; Jenner, P; Laboyrie, P; Poewe, W; Puschban, Z; Quinn, NP; Scherfler, C; Wenning, GK, 2000) |
| "Riluzole was administered prior to and consecutively for ten days following double lesion placement in the left-sided medial forebrain bundle and ipsilateral striatum." | 5.33 | Riluzole improves motor deficits and attenuates loss of striatal neurons in a sequential double lesion rat model of striatonigral degeneration (parkinson variant of multiple system atrophy). ( Diguet, E; Poewe, W; Puschban, Z; Sather, T; Scherfler, C; Stefanova, N; Tison, F; Wenning, GK, 2005) |
| "Kynurenic acid (KYNA) was tested as an antagonist of the neurotoxic and epileptogenic effects of the metabolically related brain constituent quinolinic acid (QUIN)." | 5.27 | Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid. ( Foster, AC; French, ED; Schwarcz, R; Vezzani, A, 1984) |
| "We assessed inbred, outbred and hybrid mouse strains for susceptibility to seizures and neurodegeneration induced by systemic administration of kainic acid (KA)." | 3.73 | Comparison of seizure phenotype and neurodegeneration induced by systemic kainic acid in inbred, outbred, and hybrid mouse strains. ( McLin, JP; Steward, O, 2006) |
| "The influence of embryonic mesencephalic, striatal and mesencephalic/striatal co-grafts on amphetamine- and apomorphine-induced rotation behaviour was assessed in a rat model of multiple system atrophy/striatonigral degeneration type using dopamine D1 ([3H]SCH23390) and D2 ([3H]spiperone) receptor and dopamine re-uptake ([3H]mazindol) autoradiography." | 3.70 | Autoradiographic study of striatal dopamine re-uptake sites and dopamine D1 and D2 receptors in a 6-hydroxydopamine and quinolinic acid double-lesion rat model of striatonigral degeneration (multiple system atrophy) and effects of embryonic ventral mesenc ( Granata, R; Jenner, P; Laboyrie, P; Poewe, W; Puschban, Z; Quinn, NP; Scherfler, C; Wenning, GK, 2000) |
| "Intrastriatal injections of quinolinic acid induce a pattern of neuronal degeneration similar to that seen in Huntington disease." | 3.69 | Intravenous administration of a transferrin receptor antibody-nerve growth factor conjugate prevents the degeneration of cholinergic striatal neurons in a model of Huntington disease. ( Bartus, RT; Bayer, R; Charles, V; Friden, PM; Kordower, JH; Putney, S; Walus, LR, 1994) |
| "In 1989, the Centers for Disease Control recognized the existence of an epidemic illness characterized by myalgia and eosinophilia in individuals taking preparations containing L-tryptophan." | 3.68 | Peripheral neuropathy associated with eosinophilia-myalgia syndrome. ( Bird, SJ; Culligan, NW; Edelsohn, L; Garcia, CA; Heiman-Patterson, TD; Heyes, MP; Parry, GJ; Shy, ME; Tatarian, GT; Varga, J, 1990) |
| "Huntington's disease is an inherited neurodegenerative disorder, characterized by loss of spiny neurons in the striatum and cortex, which usually happens in the third or fourth decades of life." | 1.35 | Microanatomical evidences for potential of mesenchymal stem cells in amelioration of striatal degeneration. ( Ali, M; Amin, EM; Maryam, MM; Morteza, BR; Reza, BA; Zeinab, N, 2008) |
| "However, in Huntington's disease there is a very early downregulation of CB(1) receptors in striatal neurons that, together with the undesirable psychoactive effects triggered by CB(1) receptor activation, foster the search for alternative pharmacological treatments." | 1.35 | Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity. ( Aguado, T; Azcoitia, I; Benito, C; Carrasco, C; Fernández-Ruiz, J; Galve-Roperh, I; Guzmán, M; Julien, B; Palazuelos, J; Pazos, MR; Resel, E; Romero, J; Sagredo, O, 2009) |
| "These changes preceded the onset of EEG seizures, which had a mean onset of 108 h after inoculation." | 1.35 | Glial activation precedes seizures and hippocampal neurodegeneration in measles virus-infected mice. ( Bertram, EH; Guidetti, P; Lehrmann, E; Löve, A; Schwarcz, R; Williamson, J, 2008) |
| "At this time, marked microgliosis (OX-42 marker) and astrogliosis (GFAP marker) were evident in QUIN-injected striatum." | 1.34 | Depletion of neutrophils reduces neuronal degeneration and inflammatory responses induced by quinolinic acid in vivo. ( McLarnon, JG; Ryu, JK; Tran, KC, 2007) |
| "Quinolinic acid is an agonist at glutamate receptors sensitive to N-methyl-D-aspartate (NMDA)." | 1.34 | Interleukin-1beta but not tumor necrosis factor-alpha potentiates neuronal damage by quinolinic acid: protection by an adenosine A2A receptor antagonist. ( Behan, WM; Stone, TW, 2007) |
| "Riluzole was administered prior to and consecutively for ten days following double lesion placement in the left-sided medial forebrain bundle and ipsilateral striatum." | 1.33 | Riluzole improves motor deficits and attenuates loss of striatal neurons in a sequential double lesion rat model of striatonigral degeneration (parkinson variant of multiple system atrophy). ( Diguet, E; Poewe, W; Puschban, Z; Sather, T; Scherfler, C; Stefanova, N; Tison, F; Wenning, GK, 2005) |
| "However, its potential in Huntington's disease (HD) models characterized by calpain-dependent degeneration and inflammation has not been investigated." | 1.33 | Minocycline in phenotypic models of Huntington's disease. ( Bantubungi, K; Blum, D; Brotchi, J; Brouillet, E; Chtarto, A; Déglon, N; Galas, MC; Greco, A; Jacquard, C; Levivier, M; Minghetti, L; Pintor, A; Popoli, P; Schiffmann, SN; Tai, K; Tenenbaum, L, 2005) |
| "Treatment with rolipram when started at 6 h after QA injection resulted in neuronal damage amounting to 60%; the result after starting at 24 h was not different from solvent (91%)." | 1.31 | Rolipram reduces excitotoxic neuronal damage. ( Block, F; Nolden-Koch, M; Schmidt, W; Schwarz, M, 2001) |
| " All three acids were neurotoxic in a dose-dependent manner; however, GA and 3GA were both more toxic than QUIN." | 1.31 | IGF-1 and bFGF reduce glutaric acid and 3-hydroxyglutaric acid toxicity in striatal cultures. ( Bjugstad, KB; Freed, CR; Goodman, S; Zawada, WM, 2001) |
| "Ebselen (EBS) is a seleno-organic compound with glutathione peroxidase-like activity which is neuroprotective in acute stroke ischemia." | 1.31 | Ebselen blocks the quinolinic acid-induced production of thiobarbituric acid reactive species but does not prevent the behavioral alterations produced by intra-striatal quinolinic acid administration in the rat. ( Mello, CF; Rocha, JB; Rossato, JI; Rubin, MA; Zeni, G, 2002) |
| "Apoptosis and necrosis are generally recognized as two distinct pathways of cell death, based on biochemical and morphological characteristics." | 1.30 | Non-NMDA and NMDA receptor-mediated excitotoxic neuronal deaths in adult brain are morphologically distinct: further evidence for an apoptosis-necrosis continuum. ( Martin, LJ; Portera-Cailliau, C; Price, DL, 1997) |
| "Taurine release was characterized in rat striatum that was excitotoxically lesioned compared to normal conditions." | 1.30 | Potassium-stimulated taurine release and nitric oxide synthase activity during quinolinic acid lesion of the rat striatum. ( Böckelmann, R; Reiser, M; Wolf, G, 1998) |
| "Using this animal model of Huntington's disease, we investigated the ability of the insulin-like growth factor-I (IGF-I) amino-terminal tripeptide glycine-proline-glutamate (GPE) to protect striatal neurons from degeneration." | 1.30 | The IGF-I amino-terminal tripeptide glycine-proline-glutamate (GPE) is neuroprotective to striatum in the quinolinic acid lesion animal model of Huntington's disease. ( Alexi, T; Clark, RG; Faull, RL; Gluckman, PD; Hughes, PE; van Roon-Mom, WM; Williams, CE, 1999) |
| " In contrast, neither QA up to 5 mM nor trans-ACPD had a significant toxic effect in either KCl group." | 1.30 | NMDA and non-NMDA receptor-mediated excitotoxicity are potentiated in cultured striatal neurons by prior chronic depolarization. ( Chen, Q; Reiner, A; Surmeier, DJ, 1999) |
| "CGP 37849 was a weaker neuroprotectant than MK-801 (ED50 0." | 1.29 | A comparative analysis of the neuroprotective properties of competitive and uncompetitive N-methyl-D-aspartate receptor antagonists in vivo: implications for the process of excitotoxic degeneration and its therapy. ( Fagg, GE; Massieu, L; McVey, M; Thedinga, KH, 1993) |
| "Rats treated with magnesium sulfate (subcutaneously injected, up to 600 mg/kg) were found to be protected from kainate neurotoxicity depending on the dose and time of application." | 1.28 | Magnesium sulphate subcutaneously injected protects against kainate-induced convulsions and neurodegeneration: in vivo study on the rat hippocampus. ( Abicht, K; Fischer, S; Hass, P; Keilhoff, G; Wolf, G, 1991) |
| "Adenosine A2 receptors were labeled and visualized by autoradiography in tissue sections of the human brain using the A2-selective agonist ligand [3H](2-p-(2-carboxyethyl)phenylamino)-5'-N-carboxamidoadenosine (CGS 21680)." | 1.28 | Adenosine A2 receptors: selective localization in the human basal ganglia and alterations with disease. ( Martinez-Mir, MI; Palacios, JM; Probst, A, 1991) |
| " The results presented demonstrate that this system can be used for the chronic administration of quinolinic acid with minimal non-specific damage." | 1.28 | A novel device for chronic intracranial drug delivery via microdialysis. ( Albin, RL; Bazzett, TJ; Becker, JB, 1991) |
| "Nimodipine was applied to the nutrient medium simultaneously with QUIN (both at 100 microM)." | 1.28 | Protective effect of nimodipine against quinolinic acid-induced damage of rat hippocampus in vitro. ( Kida, E; Matyja, E, 1991) |
| "Using the excitotoxic animal model of Huntington's disease, two experimental treatments were evaluated." | 1.28 | Neural grafts and pharmacological intervention in a model of Huntington's disease. ( Ford, LM; Giordano, M; Sanberg, PR; Shipley, MT, 1990) |
| "Kynurenic acid (KYNA) was tested as an antagonist of the neurotoxic and epileptogenic effects of the metabolically related brain constituent quinolinic acid (QUIN)." | 1.27 | Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid. ( Foster, AC; French, ED; Schwarcz, R; Vezzani, A, 1984) |
| " Dose-response curves to the two compounds appeared parallel but NMDA was 30-fold more potent than QUIN." | 1.27 | Quinolinate mimics neurotoxic actions of N-methyl-D-aspartate in rat cerebellar slices. ( Garthwaite, G; Garthwaite, J, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (8.80) | 18.7374 |
| 1990's | 64 (51.20) | 18.2507 |
| 2000's | 44 (35.20) | 29.6817 |
| 2010's | 6 (4.80) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lima, LCF | 1 |
| Saliba, SW | 2 |
| Andrade, JMO | 1 |
| Cunha, ML | 1 |
| Cassini-Vieira, P | 1 |
| Feltenberger, JD | 1 |
| Barcelos, LS | 1 |
| Guimarães, ALS | 1 |
| de-Paula, AMB | 1 |
| de Oliveira, ACP | 1 |
| Santos, SHS | 1 |
| Vieira, EL | 1 |
| Santos, RP | 1 |
| Candelario-Jalil, E | 1 |
| Fiebich, BL | 1 |
| Vieira, LB | 1 |
| Teixeira, AL | 1 |
| de Oliveira, AC | 1 |
| Figueiredo, C | 1 |
| Pais, TF | 1 |
| Gomes, JR | 1 |
| Chatterjee, S | 1 |
| Amin, EM | 1 |
| Reza, BA | 1 |
| Morteza, BR | 1 |
| Maryam, MM | 1 |
| Ali, M | 1 |
| Zeinab, N | 1 |
| Amori, L | 1 |
| Wu, HQ | 3 |
| Marinozzi, M | 1 |
| Pellicciari, R | 1 |
| Guidetti, P | 3 |
| Schwarcz, R | 10 |
| Graham, RK | 2 |
| Pouladi, MA | 1 |
| Joshi, P | 1 |
| Lu, G | 2 |
| Deng, Y | 2 |
| Wu, NP | 1 |
| Figueroa, BE | 1 |
| Metzler, M | 1 |
| André, VM | 1 |
| Slow, EJ | 2 |
| Raymond, L | 1 |
| Friedlander, R | 1 |
| Levine, MS | 1 |
| Leavitt, BR | 2 |
| Hayden, MR | 2 |
| Yamada, A | 1 |
| Yamamoto, K | 1 |
| Imamoto, N | 1 |
| Momosaki, S | 1 |
| Hosoi, R | 1 |
| Yamaguchi, M | 1 |
| Inoue, O | 1 |
| Palazuelos, J | 1 |
| Aguado, T | 1 |
| Pazos, MR | 1 |
| Julien, B | 1 |
| Carrasco, C | 1 |
| Resel, E | 1 |
| Sagredo, O | 1 |
| Benito, C | 1 |
| Romero, J | 1 |
| Azcoitia, I | 1 |
| Fernández-Ruiz, J | 1 |
| Guzmán, M | 1 |
| Galve-Roperh, I | 1 |
| Lee, ST | 1 |
| Chu, K | 1 |
| Jung, KH | 1 |
| Im, WS | 1 |
| Park, JE | 1 |
| Lim, HC | 1 |
| Won, CH | 1 |
| Shin, SH | 1 |
| Lee, SK | 1 |
| Kim, M | 1 |
| Roh, JK | 1 |
| Kincses, ZT | 1 |
| Toldi, J | 1 |
| Vécsei, L | 1 |
| Martin, LJ | 3 |
| Fjord-Larsen, L | 1 |
| Kusk, P | 1 |
| Emerich, DF | 4 |
| Thanos, C | 1 |
| Torp, M | 1 |
| Bintz, B | 1 |
| Tornøe, J | 1 |
| Johnsen, AH | 1 |
| Wahlberg, LU | 1 |
| Colín-González, AL | 1 |
| Orozco-Ibarra, M | 1 |
| Chánez-Cárdenas, ME | 1 |
| Rangel-López, E | 1 |
| Santamaría, A | 2 |
| Pedraza-Chaverri, J | 1 |
| Barrera-Oviedo, D | 1 |
| Maldonado, PD | 1 |
| Lisý, V | 1 |
| Stastný, F | 2 |
| Salzberg-Brenhouse, HC | 1 |
| Chen, EY | 2 |
| Baldwin, S | 1 |
| Hogeland, K | 1 |
| Ranelli, S | 1 |
| Lafreniere, D | 1 |
| Perdomo, B | 1 |
| Novak, L | 1 |
| Kladis, T | 1 |
| Fu, K | 1 |
| Basile, AS | 1 |
| Kordower, JH | 3 |
| Bartus, RT | 2 |
| Hanbury, R | 1 |
| Wuu, J | 1 |
| Katsuki, H | 1 |
| Akaike, A | 1 |
| Borlongan, CV | 2 |
| Skinner, SJ | 2 |
| Geaney, M | 2 |
| Vasconcellos, AV | 1 |
| Elliott, RB | 1 |
| Scherfler, C | 2 |
| Sather, T | 1 |
| Diguet, E | 1 |
| Stefanova, N | 1 |
| Puschban, Z | 2 |
| Tison, F | 1 |
| Poewe, W | 2 |
| Wenning, GK | 3 |
| Bantubungi, K | 1 |
| Jacquard, C | 1 |
| Greco, A | 1 |
| Pintor, A | 1 |
| Chtarto, A | 1 |
| Tai, K | 1 |
| Galas, MC | 1 |
| Tenenbaum, L | 1 |
| Déglon, N | 1 |
| Popoli, P | 2 |
| Minghetti, L | 1 |
| Brouillet, E | 1 |
| Brotchi, J | 1 |
| Levivier, M | 2 |
| Schiffmann, SN | 1 |
| Blum, D | 1 |
| Ryu, JK | 2 |
| Choi, HB | 1 |
| McLarnon, JG | 2 |
| Liang, ZQ | 1 |
| Wang, XX | 1 |
| Wang, Y | 2 |
| Chuang, DM | 1 |
| DiFiglia, M | 1 |
| Chase, TN | 3 |
| Qin, ZH | 2 |
| Roy, EJ | 1 |
| Takikawa, O | 1 |
| Kranz, DM | 1 |
| Brown, AR | 1 |
| Thomas, DL | 1 |
| Ganzella, M | 1 |
| Jardim, FM | 1 |
| Boeck, CR | 1 |
| Vendite, D | 1 |
| Haigh, B | 1 |
| Bissada, N | 1 |
| Pearson, J | 1 |
| Shehadeh, J | 1 |
| Bertram, L | 1 |
| Murphy, Z | 1 |
| Warby, SC | 1 |
| Doty, CN | 1 |
| Roy, S | 1 |
| Wellington, CL | 1 |
| Raymond, LA | 1 |
| Nicholson, DW | 1 |
| Dairam, A | 1 |
| Chetty, P | 1 |
| Daya, S | 2 |
| McLin, JP | 3 |
| Steward, O | 3 |
| Thompson, LM | 2 |
| DeMarch, Z | 1 |
| Giampà, C | 2 |
| Patassini, S | 2 |
| Martorana, A | 1 |
| Bernardi, G | 2 |
| Fusco, FR | 2 |
| Tran, KC | 1 |
| Masuo, Y | 1 |
| Ogura, A | 1 |
| Kobayashi, M | 1 |
| Masaki, T | 1 |
| Furuta, Y | 1 |
| Ono, T | 1 |
| Takamatsu, K | 1 |
| Stone, TW | 1 |
| Behan, WM | 1 |
| Poeggeler, B | 1 |
| Rassoulpour, A | 1 |
| Roberts, RC | 1 |
| Lusis, AJ | 1 |
| Davis, RC | 1 |
| Moresco, RM | 1 |
| Lavazza, T | 1 |
| Belloli, S | 1 |
| Lecchi, M | 1 |
| Pezzola, A | 1 |
| Todde, S | 1 |
| Matarrese, M | 1 |
| Carpinelli, A | 1 |
| Turolla, E | 1 |
| Zimarino, V | 1 |
| Malgaroli, A | 1 |
| Fazio, F | 1 |
| Silva-Adaya, D | 1 |
| Pérez-De La Cruz, V | 1 |
| Herrera-Mundo, MN | 1 |
| Mendoza-Macedo, K | 1 |
| Villeda-Hernández, J | 1 |
| Binienda, Z | 1 |
| Ali, SF | 1 |
| Lehrmann, E | 1 |
| Löve, A | 1 |
| Williamson, J | 1 |
| Bertram, EH | 1 |
| De March, Z | 1 |
| Zuccato, C | 1 |
| Bari, M | 1 |
| Gasperi, V | 1 |
| De Ceballos, ML | 1 |
| Maccarrone, M | 1 |
| Cattaneo, E | 1 |
| Thanos, CG | 1 |
| Kumar, U | 1 |
| Contestabile, A | 1 |
| Migani, P | 1 |
| Poli, A | 1 |
| Villani, L | 1 |
| Foster, AC | 5 |
| Vezzani, A | 3 |
| French, ED | 1 |
| Whetsell, WO | 1 |
| Chen, Q | 2 |
| Harris, C | 1 |
| Brown, CS | 1 |
| Howe, A | 1 |
| Surmeier, DJ | 2 |
| Reiner, A | 2 |
| Schmidt, W | 3 |
| Wolf, G | 7 |
| Calka, J | 1 |
| Schmidt, HH | 1 |
| Wiley, CA | 2 |
| Carlock, L | 1 |
| Walker, PD | 3 |
| Shan, Y | 2 |
| Gutridge, K | 1 |
| Massieu, L | 3 |
| Thedinga, KH | 2 |
| McVey, M | 1 |
| Fagg, GE | 2 |
| Töpper, R | 2 |
| Gehrmann, J | 1 |
| Banati, R | 1 |
| Schwarz, M | 3 |
| Block, F | 3 |
| Noth, J | 2 |
| Kreutzberg, GW | 1 |
| Matyja, E | 4 |
| Szmielew, A | 1 |
| Khaspekov, L | 2 |
| Victorov, I | 1 |
| Keilhoff, G | 4 |
| Wahl, F | 1 |
| Plotkine, M | 3 |
| Boulu, R | 1 |
| Obrenovitch, T | 1 |
| Symon, L | 1 |
| Uhler, TA | 1 |
| Frim, DM | 1 |
| Pakzaban, P | 1 |
| Isacson, O | 1 |
| Macaya, A | 1 |
| Munell, F | 1 |
| Gubits, RM | 1 |
| Burke, RE | 4 |
| Charles, V | 1 |
| Bayer, R | 1 |
| Putney, S | 1 |
| Walus, LR | 1 |
| Friden, PM | 1 |
| Fedele, E | 1 |
| Pascoe, M | 1 |
| Carlock, LR | 2 |
| Bazzett, TJ | 2 |
| Becker, JB | 2 |
| Kaatz, KW | 1 |
| Albin, RL | 2 |
| Iverfeldt, K | 1 |
| Walaas, SI | 1 |
| Greengard, P | 1 |
| Rocamora, N | 1 |
| Boddeke, HW | 1 |
| Mengod, G | 1 |
| Palacios, JM | 2 |
| Renkawek, K | 1 |
| Nakao, N | 1 |
| Grasbon-Frodl, EM | 1 |
| Widner, H | 1 |
| Brundin, P | 1 |
| Misztal, M | 1 |
| Skangiel-Kramska, J | 1 |
| Niewiadomska, G | 1 |
| Danysz, W | 1 |
| Granata, R | 2 |
| Laboyrie, PM | 1 |
| Quinn, NP | 2 |
| Jenner, P | 2 |
| Marsden, CD | 1 |
| Portera-Cailliau, C | 2 |
| Price, DL | 1 |
| Alexi, T | 2 |
| Venero, JL | 1 |
| Hefti, F | 1 |
| Joel, D | 1 |
| Ayalon, L | 1 |
| Tarrasch, R | 1 |
| Veenman, L | 1 |
| Feldon, J | 1 |
| Weiner, I | 1 |
| O'Neill, AB | 1 |
| Morgan, SJ | 1 |
| Brioni, JD | 1 |
| Böckelmann, R | 1 |
| Reiser, M | 1 |
| Tzschentke, TM | 1 |
| Schmidt, WJ | 1 |
| Watts, C | 1 |
| Dunnett, SB | 1 |
| Schiefer, J | 1 |
| Heinrich, PC | 1 |
| Lindenau, J | 1 |
| Noack, H | 1 |
| Asayama, K | 1 |
| Martel, J | 1 |
| Chopin, P | 1 |
| Colpaert, F | 1 |
| Marien, M | 1 |
| Nakai, M | 1 |
| Oo, TF | 3 |
| Henchcliffe, C | 1 |
| James, D | 1 |
| Ginsberg, SD | 1 |
| Hughes, PE | 1 |
| van Roon-Mom, WM | 1 |
| Faull, RL | 1 |
| Williams, CE | 1 |
| Clark, RG | 1 |
| Gluckman, PD | 1 |
| Kholodilov, NG | 1 |
| Neystat, M | 2 |
| Lo, SE | 1 |
| Larsen, KE | 1 |
| Sulzer, D | 1 |
| Laboyrie, P | 1 |
| Pérez-Navarro, E | 1 |
| Akerud, P | 1 |
| Marco, S | 1 |
| Canals, JM | 1 |
| Tolosa, E | 1 |
| Arenas, E | 1 |
| Alberch, J | 1 |
| Donaldson, D | 1 |
| Araujo, DM | 1 |
| Cherry, SR | 1 |
| Tatsukawa, KJ | 1 |
| Toyokuni, T | 1 |
| Kornblum, HI | 1 |
| Lee, SC | 1 |
| Lambat, Z | 1 |
| Conrad, N | 1 |
| Anoopkumar-Dukie, S | 1 |
| Walker, RB | 1 |
| Nolden-Koch, M | 1 |
| Rzhetskaya, M | 1 |
| Kholodilov, N | 1 |
| Yarygina, O | 1 |
| Wilson, A | 1 |
| El-Khodor, BF | 1 |
| Bjugstad, KB | 1 |
| Zawada, WM | 1 |
| Goodman, S | 1 |
| Freed, CR | 1 |
| Rossato, JI | 1 |
| Zeni, G | 1 |
| Mello, CF | 1 |
| Rubin, MA | 1 |
| Rocha, JB | 1 |
| Iacopino, A | 1 |
| Christakos, S | 1 |
| German, D | 1 |
| Sonsalla, PK | 1 |
| Altar, CA | 1 |
| Sauer, D | 2 |
| Allegrini, PR | 2 |
| Amacker, H | 1 |
| Davies, SW | 1 |
| Beardsall, K | 1 |
| Forloni, GL | 1 |
| Angeretti, N | 1 |
| Rizzi, M | 2 |
| Bakker, MH | 1 |
| Du, F | 1 |
| Susel, Z | 1 |
| Engber, TM | 1 |
| Kuo, S | 1 |
| Taylor, R | 2 |
| Fischer, S | 2 |
| Hass, P | 2 |
| Abicht, K | 1 |
| Martinez-Mir, MI | 1 |
| Probst, A | 1 |
| Bakhit, C | 1 |
| Armanini, M | 1 |
| Bennett, GL | 1 |
| Wong, WL | 1 |
| Hansen, SE | 1 |
| Buisson, A | 1 |
| Pateau, V | 1 |
| Boulu, RG | 2 |
| Finn, SF | 1 |
| Hyman, BT | 1 |
| Storey, E | 1 |
| Miller, JM | 1 |
| Beal, MF | 1 |
| Ignatowicz, E | 1 |
| Vezzani, AM | 1 |
| D'Incalci, M | 1 |
| Kida, E | 2 |
| Giordano, M | 1 |
| Ford, LM | 1 |
| Shipley, MT | 1 |
| Sanberg, PR | 1 |
| Miyamoto, M | 1 |
| Coyle, JT | 1 |
| Kozlovskiĭ, VL | 1 |
| Prakh'e, IV | 1 |
| Geĭnisman, NV | 1 |
| Lekieffre, D | 1 |
| Allix, M | 1 |
| Heiman-Patterson, TD | 1 |
| Bird, SJ | 1 |
| Parry, GJ | 1 |
| Varga, J | 1 |
| Shy, ME | 1 |
| Culligan, NW | 1 |
| Edelsohn, L | 1 |
| Tatarian, GT | 1 |
| Heyes, MP | 1 |
| Garcia, CA | 1 |
| Sugimoto, T | 1 |
| Mizuno, N | 1 |
| Ben-Ari, Y | 1 |
| Gill, R | 1 |
| Woodruff, GN | 1 |
| Garthwaite, G | 1 |
| Garthwaite, J | 1 |
| Sangalli, L | 1 |
| Speciale, C | 1 |
| Okuno, E | 1 |
4 reviews available for quinolinic acid and Nerve Degeneration
| Article | Year |
|---|---|
Kynurenines, neurodegeneration and Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Biosynthetic Pathways; Humans; Kynurenine; Molecular Struc | 2010 |
Recent advances in the use of selective neuron-destroying agents for neurobiological research.
Topics: Animals; Aziridines; Choline; Colchicine; Folic Acid; Glutamates; Glutamic Acid; Ibotenic Acid; Kain | 1984 |
Quantitative neuropathologic assessment of HIV-1 encephalitis.
Topics: AIDS Dementia Complex; Atrophy; Brain; Brain Chemistry; Cell Count; Encephalitis, Viral; Giant Cells | 1995 |
Quinolinic acid and kynurenic acid in the mammalian brain.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; AIDS Dementia Complex; Animals; Aspartic Acid; Biological Tra | 1991 |
121 other studies available for quinolinic acid and Nerve Degeneration
| Article | Year |
|---|---|
Neurodegeneration Alters Metabolic Profile and Sirt 1 Signaling in High-Fat-Induced Obese Mice.
Topics: Animals; Body Composition; Body Weight; Corpus Striatum; Diet, High-Fat; Male; Metabolic Networks an | 2017 |
Neuroprotective effects of intrastriatal injection of rapamycin in a mouse model of excitotoxicity induced by quinolinic acid.
Topics: Animals; Body Weight; Corpus Striatum; Cytokines; Disease Models, Animal; Dose-Response Relationship | 2017 |
Neuron-microglia crosstalk up-regulates neuronal FGF-2 expression which mediates neuroprotection against excitotoxicity via JNK1/2.
Topics: Animals; Brain Diseases; Calcium-Binding Proteins; Cathepsins; Cell Communication; Cell Death; Cells | 2008 |
Microanatomical evidences for potential of mesenchymal stem cells in amelioration of striatal degeneration.
Topics: Animals; Bone Marrow Transplantation; Cerebral Ventricles; Corpus Striatum; Disease Models, Animal; | 2008 |
Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum.
Topics: Adenosine; Animals; Animals, Newborn; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; D | 2009 |
Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease.
Topics: Animals; Brain; Brain Ischemia; Cells, Cultured; Dendritic Spines; Disease Models, Animal; Disease P | 2009 |
Lactate is an alternative energy fuel to glucose in neurons under anesthesia.
Topics: Anesthetics, General; Animals; Autoradiography; Brain; Brain Chemistry; Carbon Radioisotopes; Cell D | 2009 |
Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity.
Topics: Animals; Anti-Bacterial Agents; Biomarkers; Corpus Striatum; Humans; Huntingtin Protein; Huntington | 2009 |
Slowed progression in models of Huntington disease by adipose stem cell transplantation.
Topics: Adipocytes; Animals; Cell Line, Tumor; Cells, Cultured; Corpus Striatum; Culture Media, Conditioned; | 2009 |
An approach to experimental synaptic pathology using green fluorescent protein-transgenic mice and gene knockout mice to show mitochondrial permeability transition pore-driven excitotoxicity in interneurons and motoneurons.
Topics: Animals; Apoptosis; Cyclophilins; Female; Green Fluorescent Proteins; Interneurons; Kainic Acid; Mal | 2011 |
Increased encapsulated cell biodelivery of nerve growth factor in the brain by transposon-mediated gene transfer.
Topics: Alzheimer Disease; Animals; Brain; Capsules; Cell Line, Transformed; DNA Transposable Elements; Fema | 2012 |
Heme oxygenase-1 (HO-1) upregulation delays morphological and oxidative damage induced in an excitotoxic/pro-oxidant model in the rat striatum.
Topics: Animals; Corpus Striatum; Heme Oxygenase-1; Male; Metalloporphyrins; Nerve Degeneration; Neurons; Ne | 2013 |
Nitric oxide synthase inhibition and glutamate binding in quinolinate-lesioned rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Cell Membra | 2002 |
Inhibitors of cyclooxygenase-2, but not cyclooxygenase-1 provide structural and functional protection against quinolinic acid-induced neurodegeneration.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase | 2003 |
Knockout of p75NTR does not alter the viability of striatal neurons following a metabolic or excitotoxic injury.
Topics: Animals; Astrocytes; Brain Injuries; Cell Death; Cell Survival; Energy Metabolism; Gliosis; Immunohi | 2003 |
Excitotoxic degeneration of hypothalamic orexin neurons in slice culture.
Topics: Animals; Carrier Proteins; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Hypothalamic Hormones; | 2004 |
Neuroprotection by encapsulated choroid plexus in a rodent model of Huntington's disease.
Topics: Alginates; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Body Weight; Brain Tis | 2004 |
Riluzole improves motor deficits and attenuates loss of striatal neurons in a sequential double lesion rat model of striatonigral degeneration (parkinson variant of multiple system atrophy).
Topics: Animals; Biomarkers; Corpus Striatum; Denervation; Disease Models, Animal; Dopamine and cAMP-Regulat | 2005 |
Minocycline in phenotypic models of Huntington's disease.
Topics: Animals; Calpain; Caspases; Cell Death; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Do | 2005 |
Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Antineoplastic Agents; Carrier Proteins; Caspases; | 2005 |
Susceptibility of striatal neurons to excitotoxic injury correlates with basal levels of Bcl-2 and the induction of P53 and c-Myc immunoreactivity.
Topics: Adult; Aged, 80 and over; Animals; Calbindins; Choline O-Acetyltransferase; Corpus Striatum; Disease | 2005 |
Neuronal localization of indoleamine 2,3-dioxygenase in mice.
Topics: Animals; Encephalitis; Hippocampus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynureni | 2005 |
Time course of oxidative events in the hippocampus following intracerebroventricular infusion of quinolinic acid in mice.
Topics: AIDS Dementia Complex; Animals; Antioxidants; Cells, Cultured; Disease Models, Animal; Encephalitis; | 2006 |
Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.
Topics: Active Transport, Cell Nucleus; Animals; Brain; Caspase 6; Caspases; Cell Nucleus; Humans; Huntingti | 2006 |
Non-steroidal anti-inflammatory agents, tolmetin and sulindac, attenuate oxidative stress in rat brain homogenate and reduce quinolinic acid-induced neurodegeneration in rat hippocampal neurons.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Chemistry; Dizocilpine Maleate; Excitatory A | 2006 |
Comparison of seizure phenotype and neurodegeneration induced by systemic kainic acid in inbred, outbred, and hybrid mouse strains.
Topics: Animals; Cell Count; Dentate Gyrus; Drug Resistance; Excitatory Amino Acid Agonists; Fluoresceins; F | 2006 |
Differential susceptibility to striatal neurodegeneration induced by quinolinic acid and kainate in inbred, outbred and hybrid mouse strains.
Topics: Animals; Chimera; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Re | 2006 |
Beneficial effects of rolipram in a quinolinic acid model of striatal excitotoxicity.
Topics: Animals; Cell Survival; Corpus Striatum; Cyclic AMP Response Element-Binding Protein; Disease Models | 2007 |
Depletion of neutrophils reduces neuronal degeneration and inflammatory responses induced by quinolinic acid in vivo.
Topics: Animals; Apomorphine; Blood-Brain Barrier; Cell Survival; Gliosis; Immunohistochemistry; Inflammatio | 2007 |
Hippocalcin protects hippocampal neurons against excitotoxin damage by enhancing calcium extrusion.
Topics: Animals; Calcium; Cell Death; Cell Membrane; Cell Survival; Chlorocebus aethiops; COS Cells; Cytopro | 2007 |
Interleukin-1beta but not tumor necrosis factor-alpha potentiates neuronal damage by quinolinic acid: protection by an adenosine A2A receptor antagonist.
Topics: Adenosine A2 Receptor Antagonists; Animals; Brain Injuries; Brain Ischemia; Cytoprotection; Drug Syn | 2007 |
Dopamine receptor activation reveals a novel, kynurenate-sensitive component of striatal N-methyl-D-aspartate neurotoxicity.
Topics: Animals; Astrocytes; Cell Death; Corpus Striatum; Dopamine; Dopamine Agonists; Excitatory Amino Acid | 2007 |
Genes on distal chromosome 18 determine vulnerability to excitotoxic neurodegeneration following status epilepticus, but not striatal neurodegeneration induced by quinolinic acid.
Topics: Animals; Chromosomes, Mammalian; Corpus Striatum; Disease Susceptibility; Excitatory Amino Acid Agon | 2008 |
Quinolinic acid induced neurodegeneration in the striatum: a combined in vivo and in vitro analysis of receptor changes and microglia activation.
Topics: Animals; Carbon Radioisotopes; Corpus Striatum; Isoquinolines; Kinetics; Microglia; Nerve Degenerati | 2008 |
Excitotoxic damage, disrupted energy metabolism, and oxidative stress in the rat brain: antioxidant and neuroprotective effects of L-carnitine.
Topics: Animals; Antioxidants; Brain; Carnitine; Convulsants; Disease Models, Animal; Dose-Response Relation | 2008 |
Glial activation precedes seizures and hippocampal neurodegeneration in measles virus-infected mice.
Topics: Animals; Animals, Newborn; Astrocytes; Behavior, Animal; Cell Count; Coloring Agents; Cricetinae; Di | 2008 |
Cortical expression of brain derived neurotrophic factor and type-1 cannabinoid receptor after striatal excitotoxic lesions.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Communication; Cell Survival; Cerebral Cortex; Corp | 2008 |
Transplants of encapsulated rat choroid plexus cells exert neuroprotection in a rodent model of Huntington's disease.
Topics: Alginates; Animals; Capsules; Choroid Plexus; Corpus Striatum; Epithelial Cells; Glucuronic Acid; He | 2008 |
Somatostatin in medium-sized aspiny interneurons of striatum is responsible for their preservation in quinolinic acid and N-methyl-D-asparate-induced neurotoxicity.
Topics: Animals; Antibodies; Cell Survival; Cells, Cultured; Cytoprotection; Excitatory Amino Acid Antagonis | 2008 |
Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid.
Topics: Animals; Choline O-Acetyltransferase; Corpus Striatum; Hippocampus; Kynurenic Acid; Male; Nerve Dege | 1984 |
The organotypic tissue culture model of corticostriatal system used for examining amino acid neurotoxicity and its antagonism: studies on kainic acid, quinolinic acid and (-) 2-amino-7-phosphonoheptanoic acid.
Topics: 2-Amino-5-phosphonovalerate; Afferent Pathways; Amino Acids; Animals; Caudate Nucleus; Corpus Striat | 1983 |
Glutamate-mediated excitotoxic death of cultured striatal neurons is mediated by non-NMDA receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Basal Ganglia; Cell Death; Cells, | 1995 |
Evidence for bidirectional changes in nitric oxide synthase activity in the rat striatum after excitotoxically (quinolinic acid) induced degeneration.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Glutamate Decarboxylase; Immunohistochemistry; Male; | 1995 |
Transcription of the Huntington disease gene during the quinolinic acid excitotoxic cascade.
Topics: Animals; Blotting, Northern; Gene Expression; Huntington Disease; Male; Nerve Degeneration; Quinolin | 1995 |
A comparative analysis of the neuroprotective properties of competitive and uncompetitive N-methyl-D-aspartate receptor antagonists in vivo: implications for the process of excitotoxic degeneration and its therapy.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid | 1993 |
Rapid appearance of beta-amyloid precursor protein immunoreactivity in glial cells following excitotoxic brain injury.
Topics: Amyloid beta-Protein Precursor; Animals; Astrocytes; Brain Diseases; Corpus Striatum; Immunohistoche | 1995 |
Ultrastructural evaluation of neuronal damages induced by low doses of quinolinic acid in dissociated hippocampal culture.
Topics: Animals; Culture Techniques; Dendrites; Hippocampus; Mice; Nerve Degeneration; Pyramidal Cells; Quin | 1993 |
Comparison of double fluorescence staining and LDH-test for monitoring cell viability in vitro.
Topics: Animals; Biomarkers; Cell Survival; Cells, Cultured; Cerebral Cortex; Culture Media, Conditioned; Cy | 1993 |
Involvement of dopaminergic receptors in quinolinate-induced striatal lesions.
Topics: Animals; Corpus Striatum; Dopamine Agents; Dopamine Antagonists; Ergolines; Male; Necrosis; Nerve De | 1993 |
The effects of megadose methylprednisolone and U-78517F on toxicity mediated by glutamate receptors in the rat neostriatum.
Topics: Animals; Cell Survival; Chromans; Corpus Striatum; Dose-Response Relationship, Drug; Energy Metaboli | 1994 |
Apoptosis in substantia nigra following developmental striatal excitotoxic injury.
Topics: Animals; Apoptosis; Corpus Striatum; DNA; DNA Damage; Female; Immunoenzyme Techniques; Male; Microsc | 1994 |
Intravenous administration of a transferrin receptor antibody-nerve growth factor conjugate prevents the degeneration of cholinergic striatal neurons in a model of Huntington disease.
Topics: Animals; Antibodies, Monoclonal; Corpus Striatum; Huntington Disease; Male; Nerve Degeneration; Nerv | 1994 |
An evaluation of the role of extracellular amino acids in the delayed neurodegeneration induced by quinolinic acid in the rat striatum.
Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Corpus Striatum; Dialysis; Dizocilpine Maleate; Glu | 1993 |
Huntington's disease and low tryptophan diet.
Topics: Brain; Female; Humans; Huntington Disease; Models, Biological; Nerve Degeneration; Quinolinic Acid; | 1993 |
Timing the excitotoxic induction of heat shock protein 70 transcription.
Topics: Animals; Blotting, Northern; Corpus Striatum; Genes, fos; Glial Fibrillary Acidic Protein; Glutamate | 1993 |
Chronic intrastriatal dialytic administration of quinolinic acid produces selective neural degeneration.
Topics: Amphetamine; Animals; Atrophy; Corpus Striatum; Dialysis; Dose-Response Relationship, Drug; Electron | 1993 |
Altered processing of Alzheimer amyloid precursor protein in response to neuronal degeneration.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cerebral Cortex; Female; Functional | 1993 |
Neuronal death and neurotrophin gene expression: long-lasting stimulation of neurotrophin-3 messenger RNA in the degenerating CA1 and CA4 pyramidal cell layers.
Topics: Animals; Cell Death; Gene Expression; Hippocampus; In Situ Hybridization; Male; Nerve Degeneration; | 1993 |
Occurrence of lamellar bodies in the rat brain organotypic cultures in normal and pathological conditions.
Topics: Animals; Astrocytes; Brain; Hypoxia; In Vitro Techniques; Kainic Acid; Nerve Degeneration; Organelle | 1995 |
Antioxidant treatment protects striatal neurons against excitotoxic insults.
Topics: Animals; Antioxidants; Cell Death; Cell Survival; Cells, Cultured; Cyclic N-Oxides; Dopamine and cAM | 1996 |
Subchronic intraventricular infusion of quinolinic acid produces working memory impairment--a model of progressive excitotoxicity.
Topics: Alzheimer Disease; Animals; Cerebral Ventricles; Disease Models, Animal; Disease Progression; Drug A | 1996 |
Reversal of behavioural abnormalities by fetal allografts in a novel rat model of striatonigral degeneration.
Topics: Amphetamines; Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Fetal Tissue Transplantation; | 1996 |
Non-NMDA and NMDA receptor-mediated excitotoxic neuronal deaths in adult brain are morphologically distinct: further evidence for an apoptosis-necrosis continuum.
Topics: Animals; Apoptosis; Brain; Cell Death; Dizocilpine Maleate; Kainic Acid; Male; Necrosis; Nerve Degen | 1997 |
Protective effects of neurotrophin-4/5 and transforming growth factor-alpha on striatal neuronal phenotypic degeneration after excitotoxic lesioning with quinolinic acid.
Topics: Animals; Calcium-Binding Proteins; Cell Count; Choline O-Acetyltransferase; Female; Glutamate Decarb | 1997 |
NMDA receptor overstimulation triggers a prolonged wave of immediate early gene expression: relationship to excitotoxicity.
Topics: Animals; Calcium; Corpus Striatum; Dizocilpine Maleate; DNA-Binding Proteins; Early Growth Response | 1997 |
Quinolinic acid and neurodegeneration in AIDS.
Topics: AIDS Dementia Complex; Humans; Nerve Degeneration; Neurotoxins; Quinolinic Acid | 1995 |
Electrolytic lesion of globus pallidus ameliorates the behavioral and neurodegenerative effects of quinolinic acid lesion of the striatum: a potential novel treatment in a rat model of Huntington's disease.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Electrolysis; Globus Pallidus; Huntington Disease; | 1998 |
Histological and behavioral protection by (-)-nicotine against quinolinic acid-induced neurodegeneration in the hippocampus.
Topics: Animals; Brain Diseases; Cognition Disorders; Hippocampus; Male; Maze Learning; Memory Disorders; Ne | 1998 |
Potassium-stimulated taurine release and nitric oxide synthase activity during quinolinic acid lesion of the rat striatum.
Topics: Animals; Corpus Striatum; Cyclic GMP; Male; Microdialysis; Nerve Degeneration; Neurotoxins; NG-Nitro | 1998 |
The development of cocaine-induced behavioral sensitization is affected by discrete quinolinic acid lesions of the prelimbic medial prefrontal cortex.
Topics: Animals; Behavior, Animal; Cocaine; Dopamine Uptake Inhibitors; Exploratory Behavior; Locomotion; Ma | 1998 |
Effects of severity of host striatal damage on the morphological development of intrastriatal transplants in a rodent model of Huntington's disease: implications for timing of surgical intervention.
Topics: Acetylcholinesterase; Animals; Atrophy; Cell Count; Cell Survival; Cell Transplantation; Corpus Stri | 1998 |
Expression of interleukin 6 in the rat striatum following stereotaxic injection of quinolinic acid.
Topics: Animals; Astrocytes; Blotting, Northern; Corpus Striatum; Gene Expression; Glial Fibrillary Acidic P | 1998 |
Enhanced cellular glutathione peroxidase immunoreactivity in activated astrocytes and in microglia during excitotoxin induced neurodegeneration.
Topics: Animals; Astrocytes; Central Nervous System; Glutathione Peroxidase; Immunohistochemistry; Macrophag | 1998 |
Neuroprotective effects of the alpha2-adrenoceptor antagonists, (+)-efaroxan and (+/-)-idazoxan, against quinolinic acid-induced lesions of the rat striatum.
Topics: Adrenergic alpha-Antagonists; Animals; Apomorphine; Behavior, Animal; Benzofurans; Choline O-Acetylt | 1998 |
Free radical scavenger OPC-14117 attenuates quinolinic acid-induced NF-kappaB activation and apoptosis in rat striatum.
Topics: Animals; Apoptosis; Behavior, Animal; Corpus Striatum; DNA Fragmentation; DNA-Binding Proteins; Drug | 1999 |
Expression of c-fos, c-jun, and c-jun N-terminal kinase (JNK) in a developmental model of induced apoptotic death in neurons of the substantia nigra.
Topics: Animals; Apoptosis; Dopamine; Female; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mi | 1999 |
Fimbria-fornix transection and excitotoxicity produce similar neurodegeneration in the septum.
Topics: Animals; Denervation; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; | 1999 |
The IGF-I amino-terminal tripeptide glycine-proline-glutamate (GPE) is neuroprotective to striatum in the quinolinic acid lesion animal model of Huntington's disease.
Topics: Animals; Calbindin 2; Calbindins; Cell Count; Choline O-Acetyltransferase; Cholinergic Fibers; Corpu | 1999 |
NMDA and non-NMDA receptor-mediated excitotoxicity are potentiated in cultured striatal neurons by prior chronic depolarization.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepi | 1999 |
Increased expression of rat synuclein in the substantia nigra pars compacta identified by mRNA differential display in a model of developmental target injury.
Topics: alpha-Synuclein; Amino Acid Sequence; Animals; Apoptosis; Base Sequence; Blotting, Northern; Blottin | 1999 |
Autoradiographic study of striatal dopamine re-uptake sites and dopamine D1 and D2 receptors in a 6-hydroxydopamine and quinolinic acid double-lesion rat model of striatonigral degeneration (multiple system atrophy) and effects of embryonic ventral mesenc
Topics: Amphetamine; Animals; Apomorphine; Atrophy; Autoradiography; Behavior, Animal; Brain Tissue Transpla | 2000 |
Neurturin protects striatal projection neurons but not interneurons in a rat model of Huntington's disease.
Topics: Animals; Calbindins; Cell Count; Choline O-Acetyltransferase; Corpus Striatum; Disease Models, Anima | 2000 |
Metabolic changes after injection of quinolinic acid or 6-hydroxydopamine in the rat striatum: a time-course study using cytochrome oxidase and glycogene phosphorylase a histochemistry.
Topics: Animals; Autoradiography; Benzazepines; Biomarkers; Corpus Striatum; Disease Models, Animal; Dopamin | 2000 |
Deficits in striatal dopamine D(2) receptors and energy metabolism detected by in vivo microPET imaging in a rat model of Huntington's disease.
Topics: Animals; Autoradiography; Benzazepines; Cocaine; Corpus Striatum; Disease Models, Animal; Dopamine A | 2000 |
Excitotoxic injury stimulates pro-drug-induced 7-chlorokynurenate formation in the rat striatum in vivo.
Topics: Animals; Corpus Striatum; Injections, Intraperitoneal; Kynurenic Acid; Kynurenine; Male; Nerve Degen | 2001 |
An investigation into the neuroprotective properties of ibuprofen.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Dose-Response Relationship, Drug; Enzyme In | 2000 |
Rolipram reduces excitotoxic neuronal damage.
Topics: Animals; Antidepressive Agents; Cell Count; Dizocilpine Maleate; Drug Interactions; Excitatory Amino | 2001 |
Expression of cyclin-dependent kinase 5 and its activator p35 in models of induced apoptotic death in neurons of the substantia nigra in vivo.
Topics: Animals; Antibodies; Apoptosis; Axotomy; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Epitop | 2001 |
IGF-1 and bFGF reduce glutaric acid and 3-hydroxyglutaric acid toxicity in striatal cultures.
Topics: Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Antagonists; Fibroblast | 2001 |
Ebselen blocks the quinolinic acid-induced production of thiobarbituric acid reactive species but does not prevent the behavioral alterations produced by intra-striatal quinolinic acid administration in the rat.
Topics: Animals; Azoles; Behavior, Animal; Brain Ischemia; Drug Interactions; Grooming; Isoindoles; Lipid Pe | 2002 |
Calbindin-D28K-containing neurons in animal models of neurodegeneration: possible protection from excitotoxicity.
Topics: Animals; Basal Ganglia Diseases; Biogenic Amines; Calbindin 1; Calbindins; Calcium; Cell Survival; D | 1992 |
Evaluation of quinolinic acid induced excitotoxic neurodegeneration in rat striatum by quantitative magnetic resonance imaging in vivo.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Brain Edema; Choline O-Acetyltransferase; Corpus Striat | 1992 |
Application of magnetic resonance imaging to the measurement of neurodegeneration in rat brain: MRI data correlate strongly with histology and enzymatic analysis.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Cerebral Arteries; Choline O-Acetyltransferase; Clinica | 1992 |
Nerve growth factor selectively prevents excitotoxin induced degeneration of striatal cholinergic neurones.
Topics: Animals; Cell Death; Cholinergic Fibers; Corpus Striatum; Nerve Degeneration; Nerve Growth Factors; | 1992 |
Chronic infusion of quinolinic acid in rat striatum: effects on discrete neuronal populations.
Topics: Acetylcholinesterase; Animals; Atropine Derivatives; Cell Division; Corpus Striatum; Histocytochemis | 1992 |
An investigation of the mechanisms of delayed neurodegeneration caused by direct injection of quinolinate into the rat striatum in vivo.
Topics: Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Convulsants; Corpus Striatum; Dialysis; Diaz | 1991 |
Prolonged infusion of quinolinic acid into rat striatum as an excitotoxic model of neurodegenerative disease.
Topics: Animals; Choline O-Acetyltransferase; Convulsants; Corpus Striatum; Disease Models, Animal; Glutamat | 1991 |
A lot of "excitement' about neurodegeneration.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aging; Alzheimer Disease; Animals; Dizocilpine Maleate | 1991 |
Effects of MK-801, ketamine and alaptide on quinolinate models in the maturing hippocampus.
Topics: Animals; Cell Hypoxia; Dizocilpine Maleate; Hippocampus; Injections, Intraventricular; Ketamine; Mal | 1991 |
Magnesium sulphate subcutaneously injected protects against kainate-induced convulsions and neurodegeneration: in vivo study on the rat hippocampus.
Topics: Animals; Convulsants; Hippocampus; In Vitro Techniques; Injections, Subcutaneous; Kainic Acid; Magne | 1991 |
Adenosine A2 receptors: selective localization in the human basal ganglia and alterations with disease.
Topics: Adenosine; Aged; Aged, 80 and over; Animals; Basal Ganglia; Corpus Striatum; Female; Guinea Pigs; Hu | 1991 |
Increase in glia-derived nerve growth factor following destruction of hippocampal neurons.
Topics: Animals; Astrocytes; Cell Death; Choline O-Acetyltransferase; Glial Fibrillary Acidic Protein; Hippo | 1991 |
Nigrostriatal pathway modulates striatum vulnerability to quinolinic acid.
Topics: Animals; Corpus Striatum; Desipramine; Dopamine; Male; Nerve Degeneration; Neural Pathways; Oxidopam | 1991 |
Effects of aging on quinolinic acid lesions in rat striatum.
Topics: Aging; Animals; Biomarkers; Cerebral Cortex; Corpus Striatum; Disease Susceptibility; Hippocampus; M | 1991 |
A novel device for chronic intracranial drug delivery via microdialysis.
Topics: Animals; Atrophy; Brain; Convulsants; Corpus Striatum; Dialysis; Drug Delivery Systems; Infusion Pum | 1991 |
Nerve cell death induced in vivo by kainic acid and quinolinic acid does not involve apoptosis.
Topics: Animals; Calcium; Cell Death; DNA; Electrophoresis, Agar Gel; Gene Expression Regulation; Hippocampu | 1991 |
Protective effect of nimodipine against quinolinic acid-induced damage of rat hippocampus in vitro.
Topics: Animals; Hippocampus; Microscopy, Electron; Models, Neurological; Nerve Degeneration; Neurons; Nimod | 1991 |
Neural grafts and pharmacological intervention in a model of Huntington's disease.
Topics: Acetylcholinesterase; Amphetamine; Animals; Brain Tissue Transplantation; Catalepsy; Cerebral Cortex | 1990 |
Idebenone attenuates neuronal degeneration induced by intrastriatal injection of excitotoxins.
Topics: Animals; Apomorphine; Benzoquinones; Choline O-Acetyltransferase; Corpus Striatum; Glutamate Decarbo | 1990 |
[The neurodegenerative and convulsant action of quinolinic acid].
Topics: Animals; Convulsants; Dose-Response Relationship, Drug; Hippocampus; Injections, Intraventricular; M | 1990 |
Subcutaneously applied magnesium protects reliably against quinolinate-induced N-methyl-D-aspartate (NMDA)-mediated neurodegeneration and convulsions in rats: are there therapeutical implications.
Topics: Animals; Cerebral Ventricles; Hippocampus; Magnesium Sulfate; Male; Nerve Degeneration; Neurotoxins; | 1990 |
Kynurenic acid antagonizes hippocampal quinolinic acid neurotoxicity: behavioral and histological evaluation.
Topics: Animals; Exploratory Behavior; Hippocampus; Injections, Intraperitoneal; Kynurenic Acid; Male; Micro | 1990 |
Peripheral neuropathy associated with eosinophilia-myalgia syndrome.
Topics: Adult; Biopsy; Demyelinating Diseases; Drug Contamination; Eosinophilia; Female; Humans; Middle Aged | 1990 |
Quinolinic and kainic acids can enhance calcitonin gene-related peptide-like immunoreactivity in striatal neurons with substance P-like immunoreactivity.
Topics: Animals; Calcitonin Gene-Related Peptide; Cats; Caudate Nucleus; Corpus Striatum; Female; Kainic Aci | 1987 |
Seizures and brain damage: are excitatory amino acids involved?
Topics: Action Potentials; Amino Acids; Animals; Brain; Epilepsy; Glutamates; Glutamic Acid; Hippocampus; Ne | 1986 |
Neuroprotective effects of MK-801 in vivo: selectivity and evidence for delayed degeneration mediated by NMDA receptor activation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthesia; Animals; Aspartic Acid; Brain; | 1988 |
Quinolinate mimics neurotoxic actions of N-methyl-D-aspartate in rat cerebellar slices.
Topics: Animals; Aspartic Acid; Cerebellum; In Vitro Techniques; N-Methylaspartate; Nerve Degeneration; Pyri | 1987 |
ATP as a marker of excitotoxin-induced nerve cell death in vivo.
Topics: Adenosine Triphosphate; Animals; Cell Survival; Hippocampus; Kainic Acid; Male; Nerve Degeneration; | 1987 |
Increased quinolinic acid metabolism following neuronal degeneration in the rat hippocampus.
Topics: Animals; Hippocampus; Male; Nerve Degeneration; Oxidoreductases; Pentosyltransferases; Pyridines; Qu | 1987 |
The ultrastructure of rat hippocampal formation in organotypic tissue culture after exposure to quinolinic acid.
Topics: Animals; Culture Media; Hippocampus; Microscopy, Electron; Nerve Degeneration; Organ Culture Techniq | 1988 |
Involvement of excitatory amino acid receptors in the mechanisms underlying excitotoxic phenomena.
Topics: Action Potentials; Amino Acids, Dicarboxylic; Animals; Cell Survival; Dendrites; Epilepsy; Kynurenic | 1986 |