quinolinic acid has been researched along with Mitochondrial Diseases in 3 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
Mitochondrial Diseases: Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Quinolinic acid is an endogenous excitotoxin that causes neurotoxicity in diverse areas of the brain and produces motor dysfunction." | 1.36 | Protective effect of rofecoxib and nimesulide against intra-striatal quinolinic acid-induced behavioral, oxidative stress and mitochondrial dysfunctions in rats. ( Kalonia, H; Kumar, A; Kumar, P; Nehru, B, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Castellano-Gonzalez, G | 1 |
| Jacobs, KR | 1 |
| Don, E | 1 |
| Cole, NJ | 1 |
| Adams, S | 1 |
| Lim, CK | 1 |
| Lovejoy, DB | 1 |
| Guillemin, GJ | 1 |
| Zádori, D | 1 |
| Klivényi, P | 1 |
| Vámos, E | 1 |
| Fülöp, F | 1 |
| Toldi, J | 1 |
| Vécsei, L | 1 |
| Kalonia, H | 1 |
| Kumar, P | 1 |
| Kumar, A | 1 |
| Nehru, B | 1 |
1 review available for quinolinic acid and Mitochondrial Diseases
| Article | Year |
|---|---|
Kynurenines in chronic neurodegenerative disorders: future therapeutic strategies.
Topics: Animals; Brain; Glutamic Acid; Humans; Kynurenic Acid; Mitochondrial Diseases; NAD; Neurodegenerativ | 2009 |
2 other studies available for quinolinic acid and Mitochondrial Diseases
| Article | Year |
|---|---|
Kynurenine 3-Monooxygenase Activity in Human Primary Neurons and Effect on Cellular Bioenergetics Identifies New Neurotoxic Mechanisms.
Topics: Adenosine Triphosphate; Brain; Cell Survival; HEK293 Cells; Humans; Kynurenic Acid; Kynurenine; Kynu | 2019 |
Protective effect of rofecoxib and nimesulide against intra-striatal quinolinic acid-induced behavioral, oxidative stress and mitochondrial dysfunctions in rats.
Topics: Animals; Ataxia; Body Weight; Cell Survival; Corpus Striatum; Cyclooxygenase 2 Inhibitors; Lactones; | 2010 |