quinolinic acid has been researched along with Kidney Failure, Chronic in 8 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Quinolinic acid (QA) is a potent endogenous excitotoxin; elevation of its concentration in an organism has been implicated in the pathogenesis of various disorders." | 5.32 | Contribution of quinolinic acid in the development of anemia in renal insufficiency. ( Buczko, W; Koda, M; Pawlak, D; Pawlak, S; Wolczynski, S, 2003) |
| "Increased oxidative stress (SOX), inflammation and accelerated atherosclerosis have been reported in end-stage renal disease (ESRD), but their associations with kynurenine pathway activation remain unknown." | 3.75 | Kynurenine, quinolinic acid--the new factors linked to carotid atherosclerosis in patients with end-stage renal disease. ( Brzosko, S; Mysliwiec, M; Pawlak, D; Pawlak, K, 2009) |
| "Quinolinic acid (QA) is a potent endogenous excitotoxin; elevation of its concentration in an organism has been implicated in the pathogenesis of various disorders." | 1.32 | Contribution of quinolinic acid in the development of anemia in renal insufficiency. ( Buczko, W; Koda, M; Pawlak, D; Pawlak, S; Wolczynski, S, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (87.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pawlak, K | 2 |
| Brzosko, S | 1 |
| Mysliwiec, M | 2 |
| Pawlak, D | 6 |
| Schefold, JC | 1 |
| Zeden, JP | 1 |
| Fotopoulou, C | 1 |
| von Haehling, S | 1 |
| Pschowski, R | 1 |
| Hasper, D | 1 |
| Volk, HD | 1 |
| Schuett, C | 1 |
| Reinke, P | 1 |
| Myśliwiec, P | 3 |
| Myśliwiec, H | 1 |
| Dadan, J | 1 |
| Buczko, W | 5 |
| Koda, M | 1 |
| Pawlak, S | 1 |
| Wolczynski, S | 1 |
| Tankiewicz, A | 2 |
| Koide, K | 1 |
| Toyama, J | 1 |
| Inoue, N | 1 |
| Koshikawa, S | 1 |
| Akizawa, T | 1 |
| Takahashi, K | 1 |
| Hidaka, S | 1 |
| Yamane, Y | 1 |
| Shinoda, K | 1 |
| Nakao, M | 1 |
8 other studies available for quinolinic acid and Kidney Failure, Chronic
| Article | Year |
|---|---|
Kynurenine, quinolinic acid--the new factors linked to carotid atherosclerosis in patients with end-stage renal disease.
Topics: Adult; Age Factors; Biomarkers; C-Reactive Protein; Carotid Artery Diseases; Cross-Sectional Studies | 2009 |
Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms.
Topics: 5-Hydroxytryptophan; Adult; Aged; C-Reactive Protein; Case-Control Studies; Creatinine; Female; Huma | 2009 |
[Tryptophan and its metabolites in renal allograft recipients].
Topics: Adult; Aged; Creatinine; Female; Humans; Kidney Failure, Chronic; Kidney Transplantation; Kynurenine | 2009 |
Contribution of quinolinic acid in the development of anemia in renal insufficiency.
Topics: Anemia; Animals; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Survival; Cobalt; Disease Models, Ani | 2003 |
Kynurenine and its metabolites in the rat with experimental renal insufficiency.
Topics: Animals; Drinking; Eating; Kidney Failure, Chronic; Kynurenine; Male; Quinolinic Acid; Rats; Rats, W | 2001 |
Tryptophan metabolism via the kynurenine pathway in experimental chronic renal failure.
Topics: Animals; Chromatography, High Pressure Liquid; Creatinine; Kidney; Kidney Failure, Chronic; Kynureni | 2002 |
Endogenous neurotoxine-quinolinic acid is increased in renal allograft recipients.
Topics: Adult; Aged; Female; Humans; Kidney Failure, Chronic; Kidney Transplantation; Male; Middle Aged; Neu | 2002 |
[Uremic peak 2a in high performance liquid chromatography--acidic components and their membrane permeability].
Topics: Cell Membrane Permeability; Chromatography, High Pressure Liquid; Glutamine; Humans; Kidney Failure, | 1986 |