quinolinic acid has been researched along with Innate Inflammatory Response in 58 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
| Excerpt | Relevance | Reference |
|---|---|---|
| " A series of metabolites of the pathway are neurologically active, among which kynerunic acid (KYNA) and quinolinic acid (QUIN) are molecules of great interest in recent studies on the mechanisms of inflammation-induced depression." | 9.12 | Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease. ( Bao, CH; Chen, LM; Huang, Y; Liang, SH; Liu, HR; Wang, D; Wu, HG; Wu, LY; Wu, Y, 2021) |
| "The aim of this paper is to elucidate the role of oxidative and nitrosative stress as well as the tryptophan catabolites pathway in the development of depression and the mechanism of action of antidepressant drugs, based on the available literature." | 8.95 | Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders. ( Czarny, P; Galecki, P; Sliwinski, T; Wigner, P, 2017) |
| "BACKGROUNDThe kynurenine pathway (KP) has been identified as a potential mediator linking acute illness to cognitive dysfunction by generating neuroactive metabolites in response to inflammation." | 8.31 | Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients. ( Fang, EF; Figved, W; Frihagen, F; Giil, LM; Godø, A; Halaas, NB; Hassel, B; Henjum, K; Idland, AV; Knapskog, AB; McCann, A; Myrstad, M; Neerland, BE; Pollmann, CT; Quist-Paulsen, E; Raeder, J; Selbæk, G; Ueland, PM; Watne, LO; Zetterberg, H, 2023) |
| "There were statistically significant increases of CSF neopterin, kynurenine, quinolinic acid and kynurenine/tryptophan ratio (KYN/TRP) in the inflammation group compared to all control groups (all p < 0." | 8.31 | CSF neopterin, quinolinic acid and kynurenine/tryptophan ratio are biomarkers of active neuroinflammation. ( Andrews, PI; Antony, J; Ardern-Holmes, S; Bandodkar, S; Chung, J; Dale, RC; Farrar, MA; Gill, D; Guillemin, GJ; Guller, A; Gupta, S; Han, VX; Heng, B; Jones, HF; Kandula, T; Keating, BA; Kothur, K; Menezes, MP; Mohammad, S; Patel, S; Pillai, SC; Sampaio, H; Tantsis, E; Troedson, C; Webster, R; Yan, J, 2023) |
| "Our results suggest that periodontal inflammation plays a role in local and systemic tryptophan-kynurenine metabolism." | 8.12 | Influence of periodontal inflammation on tryptophan-kynurenine metabolism: a cross-sectional study. ( Akdoğan, N; Altıngöz, SM; Balcı, N; Günhan, M; Kurgan, Ş; Önder, C; Serdar, MA, 2022) |
| " We investigated associations between abdominal adipose tissue, alterations in kynurenine pathway of tryptophan metabolism, and systemic inflammation in people with HIV (PWH)." | 7.96 | Abdominal Adipose Tissue Is Associated With Alterations in Tryptophan-Kynurenine Metabolism and Markers of Systemic Inflammation in People With Human Immunodeficiency Virus. ( Gelpi, M; Lebech, AM; Lundgren, J; Midttun, Ø; Mocroft, A; Nielsen, SD; Trøseid, M; Ueland, PM; Ullum, H, 2020) |
| "Chronic stress or inflammation increases tryptophan metabolism along the kynurenine pathway (KP), and the generation of neuroactive kynurenine metabolites contributes to subsequent depressive-like behaviors." | 7.88 | Kynurenine pathway metabolic balance influences microglia activity: Targeting kynurenine monooxygenase to dampen neuroinflammation. ( Delgado, J; Garrison, AM; O'Connor, JC; Parrott, JM; Redus, L; Tuñon, A, 2018) |
| "Inflammatory proteins are thought to be causally involved in the generation of aggression, possibly due to direct effects of cytokines in the central nervous system and/or by generation of inflammatory metabolites along the tryptophan-kynurenine (TRP/KYN) pathway, including KYN and its active metabolites kynurenic acid (KA), quinolinic acid (QA), and picolinic acid (PA)." | 7.83 | Tryptophan, kynurenine, and kynurenine metabolites: Relationship to lifetime aggression and inflammatory markers in human subjects. ( Brundin, L; Christensen, K; Coccaro, EF; Coussons-Read, M; Erhardt, S; Fanning, JR; Fuchs, D; Goiny, M; Lee, R, 2016) |
| " Time-dependent changes in accumulation of (11)C-ketoprofen methyl ester during the neuroinflammatory process were evaluated by PET in rats with hemispheric neuroinflammation induced by intrastriatal injection of lipopolysaccharide or quinolinic acid." | 7.77 | In vivo expression of cyclooxygenase-1 in activated microglia and macrophages during neuroinflammation visualized by PET with 11C-ketoprofen methyl ester. ( Doi, H; Inoue, O; Matsumura, K; Onoe, H; Shukuri, M; Suzuki, M; Takashima, T; Takashima-Hirano, M; Tokuda, K; Watanabe, Y, 2011) |
| " The kynurenine pathway (KP), activated during neuroinflammation, is emerging as a possible contributory factor in ALS." | 7.76 | The kynurenine pathway and inflammation in amyotrophic lateral sclerosis. ( Brew, BJ; Chen, Y; Coggan, S; Cullen, KM; Garner, B; Grant, R; Guillemin, GJ; Meininger, V; Stankovic, R, 2010) |
| " Striatal injection of quinolinic acid (QUIN) resulted in marked inflammation characterized by microgliosis, astrogliosis and enhanced expressions of pro-inflammatory enzymes inducible nitric oxide synthase and cyclooxygenase-2." | 7.73 | Combined minocycline plus pyruvate treatment enhances effects of each agent to inhibit inflammation, oxidative damage, and neuronal loss in an excitotoxic animal model of Huntington's disease. ( Choi, HB; McLarnon, JG; Ryu, JK, 2006) |
| "Inflammation has an important physiological influence on mood and behavior." | 6.90 | Kynurenine metabolism and inflammation-induced depressed mood: A human experimental study. ( Cho, JH; Eisenberger, NI; Faull, K; Hwang, L; Irwin, MR; Kruse, JL; Olmstead, R, 2019) |
| "The pathomechanism of Alzheimer's disease (AD) certainly involves mitochondrial disturbances, glutamate excitotoxicity, and neuroinflammation." | 6.58 | Alzheimer's Disease: Recent Concepts on the Relation of Mitochondrial Disturbances, Excitotoxicity, Neuroinflammation, and Kynurenines. ( Klivényi, P; Szalárdy, L; Vécsei, L; Veres, G; Zádori, D, 2018) |
| "The kynurenine pathway (KP) is a major route of L-tryptophan catabolism leading to production of several neurobiologically active molecules." | 6.43 | Implications for the kynurenine pathway and quinolinic acid in amyotrophic lateral sclerosis. ( Brew, BJ; Guillemin, GJ; Meininger, V, 2005) |
| "Low-grade inflammation is common in obesity, but the mechanism between inflammation and cognitive impairment in obesity is unclear." | 5.91 | Butyrate ameliorates quinolinic acid-induced cognitive decline in obesity models. ( Fang, X; Ge, X; Geng, D; Guan, L; Hu, M; Huang, XF; Liu, S; Pan, W; Tang, R; Wang, L; Xie, Y; Yu, Y; Zhang, J; Zheng, K; Zheng, M; Zheng, P; Zhou, L; Zhou, M, 2023) |
| "Primary deficit schizophrenia is accompanied by an activated TRYCAT pathway as compared to controls and nondeficit schizophrenia." | 5.48 | Deficit, but Not Nondeficit, Schizophrenia Is Characterized by Mucosa-Associated Activation of the Tryptophan Catabolite (TRYCAT) Pathway with Highly Specific Increases in IgA Responses Directed to Picolinic, Xanthurenic, and Quinolinic Acid. ( Anderson, G; Carvalho, AF; Geffard, M; Kanchanatawan, B; Maes, M; Ormstad, H; Ruxrungtham, K; Sirivichayakul, S, 2018) |
| "Maternal inflammation has been linked to neurodevelopmental and neuropsychiatric disorders such as cerebral palsy, schizophrenia, and autism." | 5.46 | Maternal Inflammation Results in Altered Tryptophan Metabolism in Rabbit Placenta and Fetal Brain. ( Chugani, DC; Drewes, JL; Graham, DR; Kannan, S; Lesniak, WG; Nance, E; Rangaramanujam, K; Singh, S; Williams, M; Zhang, Z, 2017) |
| " A series of metabolites of the pathway are neurologically active, among which kynerunic acid (KYNA) and quinolinic acid (QUIN) are molecules of great interest in recent studies on the mechanisms of inflammation-induced depression." | 5.12 | Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease. ( Bao, CH; Chen, LM; Huang, Y; Liang, SH; Liu, HR; Wang, D; Wu, HG; Wu, LY; Wu, Y, 2021) |
| "The aim of this paper is to elucidate the role of oxidative and nitrosative stress as well as the tryptophan catabolites pathway in the development of depression and the mechanism of action of antidepressant drugs, based on the available literature." | 4.95 | Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders. ( Czarny, P; Galecki, P; Sliwinski, T; Wigner, P, 2017) |
| "BACKGROUNDThe kynurenine pathway (KP) has been identified as a potential mediator linking acute illness to cognitive dysfunction by generating neuroactive metabolites in response to inflammation." | 4.31 | Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients. ( Fang, EF; Figved, W; Frihagen, F; Giil, LM; Godø, A; Halaas, NB; Hassel, B; Henjum, K; Idland, AV; Knapskog, AB; McCann, A; Myrstad, M; Neerland, BE; Pollmann, CT; Quist-Paulsen, E; Raeder, J; Selbæk, G; Ueland, PM; Watne, LO; Zetterberg, H, 2023) |
| "There were statistically significant increases of CSF neopterin, kynurenine, quinolinic acid and kynurenine/tryptophan ratio (KYN/TRP) in the inflammation group compared to all control groups (all p < 0." | 4.31 | CSF neopterin, quinolinic acid and kynurenine/tryptophan ratio are biomarkers of active neuroinflammation. ( Andrews, PI; Antony, J; Ardern-Holmes, S; Bandodkar, S; Chung, J; Dale, RC; Farrar, MA; Gill, D; Guillemin, GJ; Guller, A; Gupta, S; Han, VX; Heng, B; Jones, HF; Kandula, T; Keating, BA; Kothur, K; Menezes, MP; Mohammad, S; Patel, S; Pillai, SC; Sampaio, H; Tantsis, E; Troedson, C; Webster, R; Yan, J, 2023) |
| "Our results suggest that periodontal inflammation plays a role in local and systemic tryptophan-kynurenine metabolism." | 4.12 | Influence of periodontal inflammation on tryptophan-kynurenine metabolism: a cross-sectional study. ( Akdoğan, N; Altıngöz, SM; Balcı, N; Günhan, M; Kurgan, Ş; Önder, C; Serdar, MA, 2022) |
| " We investigated associations between abdominal adipose tissue, alterations in kynurenine pathway of tryptophan metabolism, and systemic inflammation in people with HIV (PWH)." | 3.96 | Abdominal Adipose Tissue Is Associated With Alterations in Tryptophan-Kynurenine Metabolism and Markers of Systemic Inflammation in People With Human Immunodeficiency Virus. ( Gelpi, M; Lebech, AM; Lundgren, J; Midttun, Ø; Mocroft, A; Nielsen, SD; Trøseid, M; Ueland, PM; Ullum, H, 2020) |
| " Evidence has suggested that the activation of indoleamine-2,3-dioxygenase (IDO), the rate-limiting enzyme in the kynurenine pathway (KP), plays a crucial role in inflammation-related diseases." | 3.96 | Involvement of Indoleamine-2,3-Dioxygenase and Kynurenine Pathway in Experimental Autoimmune Encephalomyelitis in Mice. ( Boeira, SP; Cattelan Souza, L; Giacomeli, R; Jesse, CR; Prigol, M; Silva, MRP; Zarzecki, MS, 2020) |
| " These behavioral effects are associated with i/ a reversal of anxiety and reduced self-care, ii/ a decrease in parenchymal cytokine production, iii/ a modulation of the microglial reactivity and iv/ a decrease in microglial quinolinic acid production that is correlated with plasmatic peripheral production." | 3.91 | Microglial production of quinolinic acid as a target and a biomarker of the antidepressant effect of ketamine. ( Abdel-Ahad, P; Blatzer, M; Callebert, J; Chrétien, F; Danckaert, A; de Maricourt, P; De Medeiros, GF; Gaillard, R; Jouvion, G; Langeron, O; Launay, JM; Maignan, A; Petit, AC; Sharshar, T; Van Steenwinckel, J; Verdonk, F; Vinckier, F, 2019) |
| "Chronic stress or inflammation increases tryptophan metabolism along the kynurenine pathway (KP), and the generation of neuroactive kynurenine metabolites contributes to subsequent depressive-like behaviors." | 3.88 | Kynurenine pathway metabolic balance influences microglia activity: Targeting kynurenine monooxygenase to dampen neuroinflammation. ( Delgado, J; Garrison, AM; O'Connor, JC; Parrott, JM; Redus, L; Tuñon, A, 2018) |
| "A subgroup of individuals with mood and psychotic disorders shows evidence of inflammation that leads to activation of the kynurenine pathway and the increased production of neuroactive kynurenine metabolites." | 3.85 | Serum kynurenic acid is reduced in affective psychosis. ( Bliss, SA; Dantzer, R; Drevets, WC; Ford, BN; McMillin, JR; Morris, HM; Savitz, JB; Suzuki, H; Teague, TK; Wurfel, BE, 2017) |
| "Inflammatory proteins are thought to be causally involved in the generation of aggression, possibly due to direct effects of cytokines in the central nervous system and/or by generation of inflammatory metabolites along the tryptophan-kynurenine (TRP/KYN) pathway, including KYN and its active metabolites kynurenic acid (KA), quinolinic acid (QA), and picolinic acid (PA)." | 3.83 | Tryptophan, kynurenine, and kynurenine metabolites: Relationship to lifetime aggression and inflammatory markers in human subjects. ( Brundin, L; Christensen, K; Coccaro, EF; Coussons-Read, M; Erhardt, S; Fanning, JR; Fuchs, D; Goiny, M; Lee, R, 2016) |
| " Time-dependent changes in accumulation of (11)C-ketoprofen methyl ester during the neuroinflammatory process were evaluated by PET in rats with hemispheric neuroinflammation induced by intrastriatal injection of lipopolysaccharide or quinolinic acid." | 3.77 | In vivo expression of cyclooxygenase-1 in activated microglia and macrophages during neuroinflammation visualized by PET with 11C-ketoprofen methyl ester. ( Doi, H; Inoue, O; Matsumura, K; Onoe, H; Shukuri, M; Suzuki, M; Takashima, T; Takashima-Hirano, M; Tokuda, K; Watanabe, Y, 2011) |
| " The kynurenine pathway (KP), activated during neuroinflammation, is emerging as a possible contributory factor in ALS." | 3.76 | The kynurenine pathway and inflammation in amyotrophic lateral sclerosis. ( Brew, BJ; Chen, Y; Coggan, S; Cullen, KM; Garner, B; Grant, R; Guillemin, GJ; Meininger, V; Stankovic, R, 2010) |
| "Increased oxidative stress (SOX), inflammation and accelerated atherosclerosis have been reported in end-stage renal disease (ESRD), but their associations with kynurenine pathway activation remain unknown." | 3.75 | Kynurenine, quinolinic acid--the new factors linked to carotid atherosclerosis in patients with end-stage renal disease. ( Brzosko, S; Mysliwiec, M; Pawlak, D; Pawlak, K, 2009) |
| " Striatal injection of quinolinic acid (QUIN) resulted in marked inflammation characterized by microgliosis, astrogliosis and enhanced expressions of pro-inflammatory enzymes inducible nitric oxide synthase and cyclooxygenase-2." | 3.73 | Combined minocycline plus pyruvate treatment enhances effects of each agent to inhibit inflammation, oxidative damage, and neuronal loss in an excitotoxic animal model of Huntington's disease. ( Choi, HB; McLarnon, JG; Ryu, JK, 2006) |
| "Inflammation has an important physiological influence on mood and behavior." | 2.90 | Kynurenine metabolism and inflammation-induced depressed mood: A human experimental study. ( Cho, JH; Eisenberger, NI; Faull, K; Hwang, L; Irwin, MR; Kruse, JL; Olmstead, R, 2019) |
| "The pathomechanism of Alzheimer's disease (AD) certainly involves mitochondrial disturbances, glutamate excitotoxicity, and neuroinflammation." | 2.58 | Alzheimer's Disease: Recent Concepts on the Relation of Mitochondrial Disturbances, Excitotoxicity, Neuroinflammation, and Kynurenines. ( Klivényi, P; Szalárdy, L; Vécsei, L; Veres, G; Zádori, D, 2018) |
| "The kynurenine pathway (KP) is a major route of L-tryptophan catabolism leading to production of several neurobiologically active molecules." | 2.43 | Implications for the kynurenine pathway and quinolinic acid in amyotrophic lateral sclerosis. ( Brew, BJ; Guillemin, GJ; Meininger, V, 2005) |
| "Low-grade inflammation is common in obesity, but the mechanism between inflammation and cognitive impairment in obesity is unclear." | 1.91 | Butyrate ameliorates quinolinic acid-induced cognitive decline in obesity models. ( Fang, X; Ge, X; Geng, D; Guan, L; Hu, M; Huang, XF; Liu, S; Pan, W; Tang, R; Wang, L; Xie, Y; Yu, Y; Zhang, J; Zheng, K; Zheng, M; Zheng, P; Zhou, L; Zhou, M, 2023) |
| "Primary deficit schizophrenia is accompanied by an activated TRYCAT pathway as compared to controls and nondeficit schizophrenia." | 1.48 | Deficit, but Not Nondeficit, Schizophrenia Is Characterized by Mucosa-Associated Activation of the Tryptophan Catabolite (TRYCAT) Pathway with Highly Specific Increases in IgA Responses Directed to Picolinic, Xanthurenic, and Quinolinic Acid. ( Anderson, G; Carvalho, AF; Geffard, M; Kanchanatawan, B; Maes, M; Ormstad, H; Ruxrungtham, K; Sirivichayakul, S, 2018) |
| "As chronic inflammation is known to precipitate increased apoptosis of neurons and astrocytes, this could be a contributing factor to brain dysfunction." | 1.46 | Major Depression as a Neuroprogressive Prelude to Dementia: What Is the Evidence? ( Leonard, BE, 2017) |
| "Maternal inflammation has been linked to neurodevelopmental and neuropsychiatric disorders such as cerebral palsy, schizophrenia, and autism." | 1.46 | Maternal Inflammation Results in Altered Tryptophan Metabolism in Rabbit Placenta and Fetal Brain. ( Chugani, DC; Drewes, JL; Graham, DR; Kannan, S; Lesniak, WG; Nance, E; Rangaramanujam, K; Singh, S; Williams, M; Zhang, Z, 2017) |
| "Quinolinic acid was increased and kynurenic acid decreased over time in suicidal patients versus healthy controls." | 1.42 | A role for inflammatory metabolites as modulators of the glutamate N-methyl-D-aspartate receptor in depression and suicidality. ( Bay-Richter, C; Brundin, L; Erhardt, S; Guillemin, GJ; Lim, CK; Linderholm, KR; Samuelsson, M; Träskman-Bendz, L, 2015) |
| " In the H2O2/FeCl3/ascorbic acid variant of the deoxyribose degradation assay, the dose-response curve was U-shaped." | 1.39 | Quinolinic acid: neurotoxin or oxidative stress modulator? ( Chobot, V; Hadacek, F; Kubicova, L, 2013) |
| "Quinolinic acid (300 nmol) was administered intrastriatally into the striatum to induce Huntington's disease-like alteration." | 1.37 | Suppressing inflammatory cascade by cyclo-oxygenase inhibitors attenuates quinolinic acid induced Huntington's disease-like alterations in rats. ( Kalonia, H; Kumar, A, 2011) |
| "At this time, marked microgliosis (OX-42 marker) and astrogliosis (GFAP marker) were evident in QUIN-injected striatum." | 1.34 | Depletion of neutrophils reduces neuronal degeneration and inflammatory responses induced by quinolinic acid in vivo. ( McLarnon, JG; Ryu, JK; Tran, KC, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (5.17) | 18.2507 |
| 2000's | 10 (17.24) | 29.6817 |
| 2010's | 33 (56.90) | 24.3611 |
| 2020's | 12 (20.69) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Leclercq, S | 1 |
| Schwarz, M | 3 |
| Delzenne, NM | 1 |
| Stärkel, P | 1 |
| de Timary, P | 1 |
| Kurgan, Ş | 1 |
| Önder, C | 1 |
| Balcı, N | 1 |
| Akdoğan, N | 1 |
| Altıngöz, SM | 1 |
| Serdar, MA | 1 |
| Günhan, M | 1 |
| Watne, LO | 3 |
| Pollmann, CT | 3 |
| Neerland, BE | 3 |
| Quist-Paulsen, E | 3 |
| Halaas, NB | 3 |
| Idland, AV | 3 |
| Hassel, B | 3 |
| Henjum, K | 3 |
| Knapskog, AB | 3 |
| Frihagen, F | 3 |
| Raeder, J | 3 |
| Godø, A | 3 |
| Ueland, PM | 4 |
| McCann, A | 3 |
| Figved, W | 3 |
| Selbæk, G | 3 |
| Zetterberg, H | 3 |
| Fang, EF | 3 |
| Myrstad, M | 3 |
| Giil, LM | 3 |
| Ge, X | 1 |
| Zheng, M | 1 |
| Hu, M | 1 |
| Fang, X | 1 |
| Geng, D | 1 |
| Liu, S | 1 |
| Wang, L | 1 |
| Zhang, J | 1 |
| Guan, L | 1 |
| Zheng, P | 1 |
| Xie, Y | 1 |
| Pan, W | 1 |
| Zhou, M | 1 |
| Zhou, L | 1 |
| Tang, R | 1 |
| Zheng, K | 1 |
| Yu, Y | 1 |
| Huang, XF | 1 |
| Yan, J | 1 |
| Kothur, K | 1 |
| Mohammad, S | 1 |
| Chung, J | 1 |
| Patel, S | 1 |
| Jones, HF | 1 |
| Keating, BA | 1 |
| Han, VX | 1 |
| Webster, R | 1 |
| Ardern-Holmes, S | 1 |
| Antony, J | 1 |
| Menezes, MP | 1 |
| Tantsis, E | 1 |
| Gill, D | 1 |
| Gupta, S | 1 |
| Kandula, T | 1 |
| Sampaio, H | 1 |
| Farrar, MA | 1 |
| Troedson, C | 1 |
| Andrews, PI | 1 |
| Pillai, SC | 1 |
| Heng, B | 1 |
| Guillemin, GJ | 7 |
| Guller, A | 1 |
| Bandodkar, S | 1 |
| Dale, RC | 1 |
| Gelpi, M | 1 |
| Trøseid, M | 1 |
| Mocroft, A | 1 |
| Lebech, AM | 1 |
| Ullum, H | 1 |
| Midttun, Ø | 1 |
| Lundgren, J | 1 |
| Nielsen, SD | 1 |
| Moffett, JR | 2 |
| Arun, P | 1 |
| Puthillathu, N | 1 |
| Vengilote, R | 1 |
| Ives, JA | 1 |
| Badawy, AA | 2 |
| Namboodiri, AM | 1 |
| Zarzecki, MS | 1 |
| Cattelan Souza, L | 1 |
| Giacomeli, R | 1 |
| Silva, MRP | 1 |
| Prigol, M | 1 |
| Boeira, SP | 1 |
| Jesse, CR | 1 |
| Jiang, Y | 1 |
| Huang, Z | 1 |
| Mi, L | 1 |
| Zhou, Y | 1 |
| Saroj, P | 1 |
| Bansal, Y | 1 |
| Singh, R | 1 |
| Akhtar, A | 1 |
| Sodhi, RK | 1 |
| Bishnoi, M | 1 |
| Sah, SP | 1 |
| Kuhad, A | 1 |
| Chen, LM | 1 |
| Bao, CH | 1 |
| Wu, Y | 1 |
| Liang, SH | 1 |
| Wang, D | 1 |
| Wu, LY | 1 |
| Huang, Y | 1 |
| Liu, HR | 1 |
| Wu, HG | 1 |
| Meier, TB | 1 |
| Savitz, J | 1 |
| Verheyen, N | 1 |
| Meinitzer, A | 1 |
| Grübler, MR | 1 |
| Ablasser, K | 1 |
| Kolesnik, E | 1 |
| Fahrleitner-Pammer, A | 1 |
| Belyavskiy, E | 1 |
| Trummer, C | 1 |
| Schwetz, V | 1 |
| Pieske-Kraigher, E | 1 |
| Voelkl, J | 1 |
| Alesutan, I | 1 |
| Catena, C | 1 |
| Sechi, LA | 1 |
| Brussee, H | 1 |
| Lewinski, DV | 1 |
| März, W | 1 |
| Pieske, B | 1 |
| Pilz, S | 1 |
| Tomaschitz, A | 1 |
| Wurfel, BE | 1 |
| Drevets, WC | 1 |
| Bliss, SA | 1 |
| McMillin, JR | 1 |
| Suzuki, H | 1 |
| Ford, BN | 1 |
| Morris, HM | 1 |
| Teague, TK | 1 |
| Dantzer, R | 2 |
| Savitz, JB | 1 |
| Williams, M | 1 |
| Zhang, Z | 1 |
| Nance, E | 1 |
| Drewes, JL | 1 |
| Lesniak, WG | 1 |
| Singh, S | 1 |
| Chugani, DC | 1 |
| Rangaramanujam, K | 1 |
| Graham, DR | 1 |
| Kannan, S | 1 |
| Leonard, BE | 1 |
| Thirtamara-Rajamani, K | 1 |
| Li, P | 1 |
| Escobar Galvis, ML | 1 |
| Labrie, V | 1 |
| Brundin, P | 3 |
| Brundin, L | 4 |
| Wigner, P | 1 |
| Czarny, P | 1 |
| Galecki, P | 1 |
| Sliwinski, T | 1 |
| Amaral, AU | 1 |
| Seminotti, B | 1 |
| da Silva, JC | 1 |
| de Oliveira, FH | 1 |
| Ribeiro, RT | 1 |
| Vargas, CR | 1 |
| Leipnitz, G | 1 |
| Santamaría, A | 2 |
| Souza, DO | 1 |
| Wajner, M | 1 |
| Bahrami, Z | 1 |
| Firouzi, M | 1 |
| Hashemi-Monfared, A | 1 |
| Zahednasab, H | 1 |
| Harirchian, MH | 1 |
| Zádori, D | 1 |
| Veres, G | 1 |
| Szalárdy, L | 1 |
| Klivényi, P | 1 |
| Vécsei, L | 1 |
| Garrison, AM | 1 |
| Parrott, JM | 1 |
| Tuñon, A | 1 |
| Delgado, J | 1 |
| Redus, L | 1 |
| O'Connor, JC | 1 |
| Ramírez, LA | 1 |
| Pérez-Padilla, EA | 1 |
| García-Oscos, F | 1 |
| Salgado, H | 1 |
| Atzori, M | 1 |
| Pineda, JC | 1 |
| Verdonk, F | 1 |
| Petit, AC | 1 |
| Abdel-Ahad, P | 1 |
| Vinckier, F | 1 |
| Jouvion, G | 1 |
| de Maricourt, P | 1 |
| De Medeiros, GF | 1 |
| Danckaert, A | 1 |
| Van Steenwinckel, J | 1 |
| Blatzer, M | 1 |
| Maignan, A | 1 |
| Langeron, O | 1 |
| Sharshar, T | 1 |
| Callebert, J | 1 |
| Launay, JM | 1 |
| Chrétien, F | 1 |
| Gaillard, R | 1 |
| Kruse, JL | 1 |
| Cho, JH | 1 |
| Olmstead, R | 1 |
| Hwang, L | 1 |
| Faull, K | 1 |
| Eisenberger, NI | 1 |
| Irwin, MR | 1 |
| Lugo-Huitrón, R | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prediction of the Therapeutic Response in Depression Based on an Early Neuro-computational Modeling Assessment of Motivation[NCT05866575] | 136 participants (Anticipated) | Interventional | 2023-06-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
14 reviews available for quinolinic acid and Innate Inflammatory Response
| Article | Year |
|---|---|
Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease.
Topics: Animals; Brain-Gut Axis; Depression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Inf | 2021 |
The Kynurenine Pathway in Traumatic Brain Injury: Implications for Psychiatric Outcomes.
Topics: Brain Injuries, Traumatic; Humans; Inflammation; Kynurenine; Quinolinic Acid; Receptors, N-Methyl-D- | 2022 |
Is the Enzyme ACMSD a Novel Therapeutic Target in Parkinson's Disease?
Topics: Animals; Brain; Carboxy-Lyases; Humans; Inflammation; Mutation; Parkinson Disease; Quinolinic Acid | 2017 |
Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders.
Topics: Antidepressive Agents; Antioxidants; Biomarkers; Depression; Depressive Disorder; Disease Progressio | 2017 |
Alzheimer's Disease: Recent Concepts on the Relation of Mitochondrial Disturbances, Excitotoxicity, Neuroinflammation, and Kynurenines.
Topics: Alzheimer Disease; Animals; Central Nervous System; Disease Models, Animal; Energy Metabolism; Gluta | 2018 |
A new theory of depression based on the serotonin/kynurenine relationship and the hypothalamicpituitary- adrenal axis
Topics: Animals; Bacterial Infections; Brain; Cytokines; Depression; Humans; Hypothalamo-Hypophyseal System; | 2018 |
Quinolinic acid: an endogenous neurotoxin with multiple targets.
Topics: Animals; Energy Metabolism; Humans; Inflammation; Neurodegenerative Diseases; Neurotoxins; Oxidative | 2013 |
Is there a role for glutamate-mediated excitotoxicity in inflammation-induced depression?
Topics: Animals; Blood-Brain Barrier; Depressive Disorder; Glutamic Acid; Humans; Indoleamine-Pyrrole 2,3,-D | 2014 |
[Depression and inflammation in rheumatic diseases].
Topics: Cytokines; Depression; Humans; Hypothalamo-Hypophyseal System; Indoleamine-Pyrrole 2,3,-Dioxygenase; | 2016 |
The crossroads of neuroinflammation in infectious diseases: endothelial cells and astrocytes.
Topics: Astrocytes; Communicable Diseases; Endothelial Cells; Humans; Inflammation; Kynurenine; Neurons; Qui | 2012 |
The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations.
Topics: Aging; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Enzyme Inhibitors; Humans; Hunting | 2012 |
Implications for the kynurenine pathway and quinolinic acid in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Humans; Inflammation; Kynurenine; Models, Neurological; Moto | 2005 |
Integrative hypothesis for Huntington's disease: a brief review of experimental evidence.
Topics: Animals; Calcium; Cell Death; Disease Models, Animal; Energy Metabolism; Excitatory Amino Acids; Hum | 2007 |
Quinolinic acid and inflammation.
Topics: Acquired Immunodeficiency Syndrome; Animals; Biomarkers; Brain Ischemia; Disease Models, Animal; HIV | 1993 |
2 trials available for quinolinic acid and Innate Inflammatory Response
| Article | Year |
|---|---|
Low-grade inflammation and tryptophan-kynurenine pathway activation are associated with adverse cardiac remodeling in primary hyperparathyroidism: the EPATH trial.
Topics: Aged; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Echocardiography; Female; Humans; Hyp | 2017 |
Kynurenine metabolism and inflammation-induced depressed mood: A human experimental study.
Topics: Adult; Affect; Cytokines; Depression; Endotoxins; Female; Humans; Inflammation; Interleukin-6; Kynur | 2019 |
42 other studies available for quinolinic acid and Innate Inflammatory Response
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Alterations of kynurenine pathway in alcohol use disorder and abstinence: a link with gut microbiota, peripheral inflammation and psychological symptoms.
Topics: Alcoholism; Gastrointestinal Microbiome; Humans; Inflammation; Kynurenic Acid; Kynurenine; Quinolini | 2021 |
Influence of periodontal inflammation on tryptophan-kynurenine metabolism: a cross-sectional study.
Topics: Cross-Sectional Studies; Humans; Inflammation; Interleukin-6; Kynurenic Acid; Kynurenine; Quinolinic | 2022 |
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients.
Topics: Acute Disease; Delirium; Hip Fractures; Humans; Inflammation; Kynurenine; Quinolinic Acid | 2023 |
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients.
Topics: Acute Disease; Delirium; Hip Fractures; Humans; Inflammation; Kynurenine; Quinolinic Acid | 2023 |
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients.
Topics: Acute Disease; Delirium; Hip Fractures; Humans; Inflammation; Kynurenine; Quinolinic Acid | 2023 |
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients.
Topics: Acute Disease; Delirium; Hip Fractures; Humans; Inflammation; Kynurenine; Quinolinic Acid | 2023 |
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients.
Topics: Acute Disease; Delirium; Hip Fractures; Humans; Inflammation; Kynurenine; Quinolinic Acid | 2023 |
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients.
Topics: Acute Disease; Delirium; Hip Fractures; Humans; Inflammation; Kynurenine; Quinolinic Acid | 2023 |
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients.
Topics: Acute Disease; Delirium; Hip Fractures; Humans; Inflammation; Kynurenine; Quinolinic Acid | 2023 |
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients.
Topics: Acute Disease; Delirium; Hip Fractures; Humans; Inflammation; Kynurenine; Quinolinic Acid | 2023 |
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients.
Topics: Acute Disease; Delirium; Hip Fractures; Humans; Inflammation; Kynurenine; Quinolinic Acid | 2023 |
Butyrate ameliorates quinolinic acid-induced cognitive decline in obesity models.
Topics: Animals; Brain-Derived Neurotrophic Factor; Butyrates; Cognitive Dysfunction; Humans; Inflammation; | 2023 |
CSF neopterin, quinolinic acid and kynurenine/tryptophan ratio are biomarkers of active neuroinflammation.
Topics: Adolescent; Biomarkers; Child; Child, Preschool; Humans; Infant; Inflammation; Kynurenine; Leukocyto | 2023 |
Abdominal Adipose Tissue Is Associated With Alterations in Tryptophan-Kynurenine Metabolism and Markers of Systemic Inflammation in People With Human Immunodeficiency Virus.
Topics: Abdominal Fat; Aged; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Female; HIV; HIV Infec | 2020 |
Quinolinate as a Marker for Kynurenine Metabolite Formation and the Unresolved Question of NAD
Topics: Animals; Biomarkers; Cell Movement; Gerbillinae; Hippocampus; HSP90 Heat-Shock Proteins; Immunity; I | 2020 |
Involvement of Indoleamine-2,3-Dioxygenase and Kynurenine Pathway in Experimental Autoimmune Encephalomyelitis in Mice.
Topics: Animals; Body Weight; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Fem | 2020 |
The potential role of inflammation reaction in COVID-19 related posttraumatic stress disorder.
Topics: Astrocytes; Brain; COVID-19; Cytokines; Glucocorticoids; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenas | 2020 |
Neuroprotective effects of roflumilast against quinolinic acid-induced rat model of Huntington's disease through inhibition of NF-κB mediated neuroinflammatory markers and activation of cAMP/CREB/BDNF signaling pathway.
Topics: Aminopyridines; Animals; Benzamides; Brain-Derived Neurotrophic Factor; Cyclic AMP; Cyclic AMP Respo | 2021 |
Serum kynurenic acid is reduced in affective psychosis.
Topics: Adult; Affective Disorders, Psychotic; Bipolar Disorder; Corpus Striatum; Cytokines; Depression; Dep | 2017 |
Maternal Inflammation Results in Altered Tryptophan Metabolism in Rabbit Placenta and Fetal Brain.
Topics: Animals; Brain; Female; Indoles; Inflammation; Placenta; Pregnancy; Quinolinic Acid; Rabbits; Seroto | 2017 |
Major Depression as a Neuroprogressive Prelude to Dementia: What Is the Evidence?
Topics: Brain; Cytokines; Dementia; Depressive Disorder, Major; Humans; Inflammation; Kynurenine; Oxidative | 2017 |
Induction of Neuroinflammatory Response and Histopathological Alterations Caused by Quinolinic Acid Administration in the Striatum of Glutaryl-CoA Dehydrogenase Deficient Mice.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Brain Diseases, Metabolic; CD3 Complex; Corpus Striat | 2018 |
The effect of minocycline on indolamine 2, 3 dioxygenase expression and the levels of kynurenic acid and quinolinic acid in LPS-activated primary rat microglia.
Topics: Animals; Brain; Cell Survival; Cells, Cultured; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; | 2018 |
Kynurenine pathway metabolic balance influences microglia activity: Targeting kynurenine monooxygenase to dampen neuroinflammation.
Topics: Animals; Brain; Cell Line; Homeostasis; Hypothalamo-Hypophyseal System; Inflammation; Interleukin-1b | 2018 |
Hypothesis kynurenic and quinolinic acids: The main players of the kynurenine pathway and opponents in inflammatory disease.
Topics: Animals; Anti-Inflammatory Agents; Humans; Immunosuppressive Agents; Inflammation; Kynurenic Acid; K | 2018 |
Microglial production of quinolinic acid as a target and a biomarker of the antidepressant effect of ketamine.
Topics: Animals; Antidepressive Agents; Anxiety; Anxiety Disorders; Biomarkers, Pharmacological; Depression; | 2019 |
Quinolinic acid: neurotoxin or oxidative stress modulator?
Topics: Hormesis; Humans; Hydrogen Peroxide; Inflammation; Iron; Kynurenine; Neurotoxins; Oxidative Stress; | 2013 |
A role for inflammatory metabolites as modulators of the glutamate N-methyl-D-aspartate receptor in depression and suicidality.
Topics: Adult; Cytokines; Depressive Disorder; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Mal | 2015 |
The kynurenine pathway activities in a sub-Saharan HIV/AIDS population.
Topics: Acquired Immunodeficiency Syndrome; Adult; Africa South of the Sahara; Antiretroviral Therapy, Highl | 2015 |
Central kynurenine pathway shift with age in women.
Topics: Adult; Aged; Aged, 80 and over; Aging; Brain; Female; Humans; Inflammation; Kynurenic Acid; Kynureni | 2016 |
Repeated LPS Injection Induces Distinct Changes in the Kynurenine Pathway in Mice.
Topics: Animals; Brain; Immune System; Inflammation; Kynurenic Acid; Kynurenine; Lipopolysaccharides; Male; | 2016 |
Tryptophan, kynurenine, and kynurenine metabolites: Relationship to lifetime aggression and inflammatory markers in human subjects.
Topics: Adult; Aggression; Biomarkers; C-Reactive Protein; Female; Humans; Inflammation; Interleukin-6; Kynu | 2016 |
An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation.
Topics: Adolescent; Adult; Aged; Alleles; Carboxy-Lyases; Case-Control Studies; Child; Female; Humans; Infla | 2016 |
Deficit, but Not Nondeficit, Schizophrenia Is Characterized by Mucosa-Associated Activation of the Tryptophan Catabolite (TRYCAT) Pathway with Highly Specific Increases in IgA Responses Directed to Picolinic, Xanthurenic, and Quinolinic Acid.
Topics: Adult; Cross-Sectional Studies; Female; Humans; Immunoglobulin A; Inflammation; Male; Middle Aged; P | 2018 |
Increased breakdown of kynurenine towards its neurotoxic branch in bipolar disorder.
Topics: Adult; Bipolar Disorder; Brain; Case-Control Studies; Cognition; Depression; Female; Humans; Inflamm | 2017 |
Kynurenine, quinolinic acid--the new factors linked to carotid atherosclerosis in patients with end-stage renal disease.
Topics: Adult; Age Factors; Biomarkers; C-Reactive Protein; Carotid Artery Diseases; Cross-Sectional Studies | 2009 |
Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms.
Topics: 5-Hydroxytryptophan; Adult; Aged; C-Reactive Protein; Case-Control Studies; Creatinine; Female; Huma | 2009 |
The kynurenine pathway and inflammation in amyotrophic lateral sclerosis.
Topics: Adult; Amyotrophic Lateral Sclerosis; Brain; Female; HLA-DR Antigens; Humans; Indoleamine-Pyrrole 2, | 2010 |
Suppressing inflammatory cascade by cyclo-oxygenase inhibitors attenuates quinolinic acid induced Huntington's disease-like alterations in rats.
Topics: Animals; Brain; Caspase 3; Celecoxib; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; H | 2011 |
In vivo expression of cyclooxygenase-1 in activated microglia and macrophages during neuroinflammation visualized by PET with 11C-ketoprofen methyl ester.
Topics: Animals; Brain; Cyclooxygenase 1; Cyclooxygenase 2; Gene Expression Regulation, Enzymologic; Inflamm | 2011 |
Targeting the kynurenine pathway as a potential strategy to prevent and treat Alzheimer's disease.
Topics: Alzheimer Disease; Humans; Inflammation; Kynurenic Acid; Models, Biological; Quinolinic Acid; Recept | 2011 |
Effects of systemic and central nervous system localized inflammation on the contributions of metabolic precursors to the L-kynurenine and quinolinic acid pools in brain.
Topics: Animals; Body Fluid Compartments; Brain; Corpus Striatum; Encephalitis; Female; Gerbillinae; Inflamm | 2002 |
Association between inflammation and nigral neuronal damage following striatal excitotoxic lesion.
Topics: Animals; Brain Diseases; Cell Count; Chondroitin Sulfate Proteoglycans; Corpus Striatum; Dizocilpine | 2004 |
Surfactant poloxamer 188-related decreases in inflammation and tissue damage after experimental brain injury in rats.
Topics: Animals; Brain Injuries; Inflammation; Macrophages; Oxidative Stress; Poloxamer; Quinolinic Acid; Ra | 2004 |
Combined minocycline plus pyruvate treatment enhances effects of each agent to inhibit inflammation, oxidative damage, and neuronal loss in an excitotoxic animal model of Huntington's disease.
Topics: Analysis of Variance; Animals; Blotting, Western; Cell Death; Cyclooxygenase 2; Disease Models, Anim | 2006 |
Depletion of neutrophils reduces neuronal degeneration and inflammatory responses induced by quinolinic acid in vivo.
Topics: Animals; Apomorphine; Blood-Brain Barrier; Cell Survival; Gliosis; Immunohistochemistry; Inflammatio | 2007 |
The immune effects of TRYCATs (tryptophan catabolites along the IDO pathway): relevance for depression - and other conditions characterized by tryptophan depletion induced by inflammation.
Topics: Adult; Anti-Inflammatory Agents; Cytokines; Depressive Disorder; Female; Gene Expression Regulation; | 2007 |
Quinolinate immunoreactivity in experimental rat brain tumors is present in macrophages but not in astrocytes.
Topics: Animals; Antibody Specificity; Astrocytes; Biomarkers; Brain Neoplasms; Corpus Striatum; Female; Gli | 1997 |
Quinolinic acid-induced inflammation in the striatum does not impair the survival of neural allografts in the rat.
Topics: Animals; Astrocytes; Corpus Striatum; Embryo, Mammalian; Female; Graft Survival; Immunohistochemistr | 1998 |