quinolinic acid has been researched along with Hepatic Encephalopathy in 13 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Elevated brain concentrations of the neurotoxin and NMDA receptor agonist quinolinic acid (QUIN) have been demonstrated in portacaval-shunted (PCS) rats, a chronic hepatic encephalopathy (HE) model." | 7.69 | Brain quinolinic acid in chronic experimental hepatic encephalopathy: effects of an exogenous ammonium acetate challenge. ( Bengtsson, F; Bergqvist, PB; Bugge, M; Heyes, MP, 1995) |
| "Quinolinic acid is an excitatory, neurotoxic tryptophan metabolite proposed to play a role in the pathogenesis of hepatic encephalopathy." | 7.69 | The relationship between plasma and brain quinolinic acid levels and the severity of hepatic encephalopathy in animal models of fulminant hepatic failure. ( Basile, AS; Heyes, MP; Li, Y; Saito, K, 1995) |
| "Plasma quinolinic acid levels were significantly increased by stage I encephalopathy in patients with acute liver failure and by stages II and III in patients with chronic liver failure." | 7.69 | The relationship between plasma and brain quinolinic acid levels and the severity of hepatic encephalopathy. ( al-Mardini, H; Basile, AS; Harrison, P; Heyes, MP; Hughes, RD; Li, Y; Record, CO; Saito, K; Williams, R, 1995) |
| "Increased brain quinolinic acid (QUIN) levels have been suggested to play a role in hepatic encephalopathy (HE)." | 7.69 | Brain extracellular quinolinic acid in chronic experimental hepatic encephalopathy as assessed by in vivo microdialysis: acute effects of L-tryptophan. ( Apelqvist, G; Bengtsson, F; Bergqvist, PB; Butterworth, RF; Heyes, MP, 1996) |
| "Quinolinic acid (QuinA) is a tryptophan metabolite produced by activated macrophages." | 5.39 | Increased serum levels of quinolinic acid indicate enhanced severity of hepatic dysfunction in patients with liver cirrhosis. ( Daniel, V; Elhadedy, H; Fusch, G; Iancu, M; Jung, G; Lahdou, I; Mehrabi, A; Opelz, G; Oweira, H; Sadeghi, M; Sandra-Petrescu, F; Schefold, JC; Schmidt, J; Terness, P, 2013) |
| "Several combined pathogenetic factors such as hyperammonemia, different brain tryptophan metabolic disturbances and serotonin physiological/pharmacological alterations not yet defined in all details, will often give rise to the clinical neuropsychiatric condition known as hepatic encephalopathy (HE)." | 4.80 | Brain tryptophan/serotonin perturbations in metabolic encephalopathy and the hazards involved in the use of psychoactive drugs. ( Bengtsson, F, 1999) |
| "Elevated brain concentrations of the neurotoxin and NMDA receptor agonist quinolinic acid (QUIN) have been demonstrated in portacaval-shunted (PCS) rats, a chronic hepatic encephalopathy (HE) model." | 3.69 | Brain quinolinic acid in chronic experimental hepatic encephalopathy: effects of an exogenous ammonium acetate challenge. ( Bengtsson, F; Bergqvist, PB; Bugge, M; Heyes, MP, 1995) |
| "Quinolinic acid is an excitatory, neurotoxic tryptophan metabolite proposed to play a role in the pathogenesis of hepatic encephalopathy." | 3.69 | The relationship between plasma and brain quinolinic acid levels and the severity of hepatic encephalopathy in animal models of fulminant hepatic failure. ( Basile, AS; Heyes, MP; Li, Y; Saito, K, 1995) |
| "Plasma quinolinic acid levels were significantly increased by stage I encephalopathy in patients with acute liver failure and by stages II and III in patients with chronic liver failure." | 3.69 | The relationship between plasma and brain quinolinic acid levels and the severity of hepatic encephalopathy. ( al-Mardini, H; Basile, AS; Harrison, P; Heyes, MP; Hughes, RD; Li, Y; Record, CO; Saito, K; Williams, R, 1995) |
| "Increased brain quinolinic acid (QUIN) levels have been suggested to play a role in hepatic encephalopathy (HE)." | 3.69 | Brain extracellular quinolinic acid in chronic experimental hepatic encephalopathy as assessed by in vivo microdialysis: acute effects of L-tryptophan. ( Apelqvist, G; Bengtsson, F; Bergqvist, PB; Butterworth, RF; Heyes, MP, 1996) |
| "Adenosine is an ubiquitous purine that can protect neurons by suppressing excitatory neurotransmitter release, reducing calcium fluxes and inhibiting NMDA receptors." | 2.44 | Tryptophan, adenosine, neurodegeneration and neuroprotection. ( Darlington, LG; Forrest, CM; Mackay, GM; Stone, TW; Stoy, N, 2007) |
| "Quinolinic acid (QuinA) is a tryptophan metabolite produced by activated macrophages." | 1.39 | Increased serum levels of quinolinic acid indicate enhanced severity of hepatic dysfunction in patients with liver cirrhosis. ( Daniel, V; Elhadedy, H; Fusch, G; Iancu, M; Jung, G; Lahdou, I; Mehrabi, A; Opelz, G; Oweira, H; Sadeghi, M; Sandra-Petrescu, F; Schefold, JC; Schmidt, J; Terness, P, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (23.08) | 18.7374 |
| 1990's | 7 (53.85) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lahdou, I | 1 |
| Sadeghi, M | 1 |
| Oweira, H | 1 |
| Fusch, G | 1 |
| Daniel, V | 1 |
| Mehrabi, A | 1 |
| Jung, G | 1 |
| Elhadedy, H | 1 |
| Schmidt, J | 1 |
| Sandra-Petrescu, F | 1 |
| Iancu, M | 1 |
| Opelz, G | 1 |
| Terness, P | 1 |
| Schefold, JC | 1 |
| Holt, DE | 1 |
| Washabau, RJ | 1 |
| Djali, S | 1 |
| Dayrell-Hart, B | 1 |
| Drobatz, KJ | 1 |
| Heyes, MP | 7 |
| Robinson, MB | 1 |
| Stone, TW | 1 |
| Forrest, CM | 1 |
| Mackay, GM | 1 |
| Stoy, N | 1 |
| Darlington, LG | 1 |
| Bergqvist, PB | 3 |
| Bugge, M | 1 |
| Bengtsson, F | 4 |
| Basile, AS | 2 |
| Saito, K | 3 |
| Li, Y | 2 |
| al-Mardini, H | 1 |
| Record, CO | 1 |
| Hughes, RD | 1 |
| Harrison, P | 1 |
| Williams, R | 1 |
| Apelqvist, G | 1 |
| Butterworth, RF | 1 |
| Seishima, M | 1 |
| Noma, A | 1 |
| Nagamura, Y | 1 |
| Quearry, BJ | 1 |
| Markey, SP | 1 |
| Moroni, F | 3 |
| Lombardi, G | 3 |
| Carlà, V | 3 |
| Pellegrini, D | 1 |
| Carassale, GL | 1 |
| Cortesini, C | 1 |
| Lal, S | 1 |
| Etienne, P | 1 |
| Nair, NP | 1 |
2 reviews available for quinolinic acid and Hepatic Encephalopathy
| Article | Year |
|---|---|
Tryptophan, adenosine, neurodegeneration and neuroprotection.
Topics: Adenosine; Animals; Hepatic Encephalopathy; Humans; Kynurenine; NAD; Neurodegenerative Diseases; Neu | 2007 |
Brain tryptophan/serotonin perturbations in metabolic encephalopathy and the hazards involved in the use of psychoactive drugs.
Topics: Animals; Brain; Hepatic Encephalopathy; Humans; Indoles; Psychotropic Drugs; Quinolinic Acid; Seroto | 1999 |
11 other studies available for quinolinic acid and Hepatic Encephalopathy
| Article | Year |
|---|---|
Increased serum levels of quinolinic acid indicate enhanced severity of hepatic dysfunction in patients with liver cirrhosis.
Topics: Adult; Biomarkers; C-Reactive Protein; End Stage Liver Disease; Hepatic Encephalopathy; Humans; Inte | 2013 |
Cerebrospinal fluid glutamine, tryptophan, and tryptophan metabolite concentrations in dogs with portosystemic shunts.
Topics: Alanine; Animals; Dietary Proteins; Dog Diseases; Dogs; Female; Glutamine; Hepatic Encephalopathy; H | 2002 |
Brain quinolinic acid in chronic experimental hepatic encephalopathy: effects of an exogenous ammonium acetate challenge.
Topics: Acetates; Animals; Brain; Chronic Disease; Hepatic Encephalopathy; Male; Quinolinic Acid; Rats; Rats | 1995 |
The relationship between plasma and brain quinolinic acid levels and the severity of hepatic encephalopathy in animal models of fulminant hepatic failure.
Topics: Animals; Brain; Galactosamine; Hepatic Encephalopathy; Male; Osmolar Concentration; Quinolinic Acid; | 1995 |
The relationship between plasma and brain quinolinic acid levels and the severity of hepatic encephalopathy.
Topics: Acute Disease; Adult; Brain; Chronic Disease; Female; Hepatic Encephalopathy; Humans; Liver Failure; | 1995 |
Brain extracellular quinolinic acid in chronic experimental hepatic encephalopathy as assessed by in vivo microdialysis: acute effects of L-tryptophan.
Topics: Animals; Brain; Disease Models, Animal; Hepatic Encephalopathy; Male; Microdialysis; Quinolinic Acid | 1996 |
Is quinolinic acid involved in the pathogenesis of hepatic encephalopathy?
Topics: Animals; Brain; Cerebral Cortex; Disease Models, Animal; Extracellular Space; Hepatic Encephalopathy | 1996 |
Kynurenine pathway metabolism in the galactosamine model of hepatic injury.
Topics: Animals; Brain; Female; Galactosamine; Gerbillinae; Hepatic Encephalopathy; Kynurenine; Lipopolysacc | 1996 |
Content of quinolinic acid and of other tryptophan metabolites increases in brain regions of rats used as experimental models of hepatic encephalopathy.
Topics: Acetates; Animals; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Disease Models, Animal; Hepatic E | 1986 |
Increase in the content of quinolinic acid in cerebrospinal fluid and frontal cortex of patients with hepatic failure.
Topics: Aged; Cerebral Cortex; Hepatic Encephalopathy; Humans; Hydroxyindoleacetic Acid; Middle Aged; Pyridi | 1986 |
The physiopathological role of quinolinic acid in the mammalian central nervous system.
Topics: Aging; Alzheimer Disease; Animals; Cerebral Cortex; Gas Chromatography-Mass Spectrometry; Hepatic En | 1988 |