quinolinic acid has been researched along with HIV Coinfection in 16 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The results from this study suggest that alterations in the kynurenine pathway of tryptophan metabolism are associated with the presence of depression in the context of HIV infection." | 8.02 | Alterations in the Kynurenine Pathway of Tryptophan Metabolism Are Associated With Depression in People Living With HIV. ( Drivsholm, N; Faurholt-Jepsen, M; Gelpi, M; Kirkegaard-Klitbo, DM; Knudsen, AD; Midttun, Ø; Nielsen, SD; Trøseid, M; Ueland, PM, 2021) |
| " We investigated associations between abdominal adipose tissue, alterations in kynurenine pathway of tryptophan metabolism, and systemic inflammation in people with HIV (PWH)." | 7.96 | Abdominal Adipose Tissue Is Associated With Alterations in Tryptophan-Kynurenine Metabolism and Markers of Systemic Inflammation in People With Human Immunodeficiency Virus. ( Gelpi, M; Lebech, AM; Lundgren, J; Midttun, Ø; Mocroft, A; Nielsen, SD; Trøseid, M; Ueland, PM; Ullum, H, 2020) |
| "The results from this study suggest that alterations in the kynurenine pathway of tryptophan metabolism are associated with the presence of depression in the context of HIV infection." | 4.02 | Alterations in the Kynurenine Pathway of Tryptophan Metabolism Are Associated With Depression in People Living With HIV. ( Drivsholm, N; Faurholt-Jepsen, M; Gelpi, M; Kirkegaard-Klitbo, DM; Knudsen, AD; Midttun, Ø; Nielsen, SD; Trøseid, M; Ueland, PM, 2021) |
| " We investigated associations between abdominal adipose tissue, alterations in kynurenine pathway of tryptophan metabolism, and systemic inflammation in people with HIV (PWH)." | 3.96 | Abdominal Adipose Tissue Is Associated With Alterations in Tryptophan-Kynurenine Metabolism and Markers of Systemic Inflammation in People With Human Immunodeficiency Virus. ( Gelpi, M; Lebech, AM; Lundgren, J; Midttun, Ø; Mocroft, A; Nielsen, SD; Trøseid, M; Ueland, PM; Ullum, H, 2020) |
| "Quinolinic acid (QUIN) is a product of tryptophan metabolism that can act as an endogenous brain excitotoxin when released by activated macrophages." | 1.32 | CSF quinolinic acid levels are determined by local HIV infection: cross-sectional analysis and modelling of dynamics following antiretroviral therapy. ( Heyes, M; Nilsson, A; Price, RW; Valle, M; Verotta, D, 2004) |
| "Quinolinic acid (QUIN) is an endogenous N-methyl-D-aspartate receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction." | 1.28 | Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. ( Crowley, JS; Davis, LE; Demitrack, MA; Der, M; Dilling, LA; Elia, J; Heyes, MP; Kruesi, MJ; Lackner, A; Saito, K, 1992) |
| "Quinolinic acid is an "excitotoxic" metabolite and an agonist of N-methyl-D-aspartate receptors." | 1.28 | Quinolinic acid in cerebrospinal fluid and serum in HIV-1 infection: relationship to clinical and neurological status. ( Brew, BJ; Heyes, MP; Keilp, J; Martin, A; Mouradian, MM; Price, RW; Sadler, AE; Salazar, AM; Sidtis, JJ; Yergey, JA, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (56.25) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Gelpi, M | 2 |
| Ueland, PM | 2 |
| Trøseid, M | 2 |
| Mocroft, A | 1 |
| Lebech, AM | 1 |
| Ullum, H | 1 |
| Midttun, Ø | 2 |
| Lundgren, J | 1 |
| Nielsen, SD | 2 |
| Drivsholm, N | 1 |
| Knudsen, AD | 1 |
| Faurholt-Jepsen, M | 1 |
| Kirkegaard-Klitbo, DM | 1 |
| Bipath, P | 1 |
| Levay, PF | 1 |
| Viljoen, M | 1 |
| Kandanearatchi, A | 1 |
| Brew, BJ | 3 |
| Valle, M | 1 |
| Price, RW | 2 |
| Nilsson, A | 1 |
| Heyes, M | 1 |
| Verotta, D | 1 |
| Lipton, SA | 1 |
| Yeh, M | 1 |
| Dreyer, EB | 1 |
| Milstien, S | 1 |
| Sakai, N | 1 |
| Krieger, C | 1 |
| Vickers, JH | 1 |
| Saito, K | 2 |
| Heyes, MP | 6 |
| Birdsall, HH | 1 |
| Ozluoglu, LN | 1 |
| Lew, HL | 1 |
| Trial, J | 1 |
| Brown, DP | 1 |
| Wofford, MJ | 1 |
| Jerger, JF | 1 |
| Rossen, RD | 1 |
| Yoshioka, M | 1 |
| Bradley, WG | 1 |
| Shapshak, P | 1 |
| Nagano, I | 1 |
| Stewart, RV | 1 |
| Xin, KQ | 1 |
| Srivastava, AK | 1 |
| Nakamura, S | 1 |
| Fuchs, D | 1 |
| Gisslén, M | 1 |
| Larsson, M | 1 |
| Norkrans, G | 1 |
| Hagberg, L | 1 |
| Wachter, H | 1 |
| Look, MP | 1 |
| Altfeld, M | 1 |
| Kreuzer, KA | 1 |
| Riezler, R | 1 |
| Stabler, SP | 1 |
| Allen, RH | 1 |
| Sauerbruch, T | 1 |
| Rockstroh, JK | 1 |
| Ellis, RJ | 1 |
| Ryan, L | 1 |
| Childers, ME | 1 |
| Grant, I | 1 |
| Wolfson, T | 1 |
| Archibald, S | 1 |
| Jernigan, TL | 1 |
| Crowley, JS | 1 |
| Davis, LE | 1 |
| Demitrack, MA | 1 |
| Der, M | 1 |
| Dilling, LA | 1 |
| Elia, J | 1 |
| Kruesi, MJ | 1 |
| Lackner, A | 1 |
| Martin, A | 1 |
| Salazar, AM | 1 |
| Sidtis, JJ | 1 |
| Yergey, JA | 1 |
| Mouradian, MM | 1 |
| Sadler, AE | 1 |
| Keilp, J | 1 |
5 reviews available for quinolinic acid and HIV Coinfection
| Article | Year |
|---|---|
The kynurenine pathway and quinolinic acid: pivotal roles in HIV associated neurocognitive disorders.
Topics: Central Nervous System Diseases; Cognition Disorders; HIV; HIV Infections; Humans; Kynurenine; Quino | 2012 |
Update on current models of HIV-related neuronal injury: platelet-activating factor, arachidonic acid and nitric oxide.
Topics: AIDS Dementia Complex; Arachidonic Acid; Cytokines; HIV Envelope Protein gp120; HIV Infections; Huma | 1994 |
Metabolism and neuropathologic significance of quinolinic acid and kynurenic acid.
Topics: Animals; Disease Models, Animal; HIV Infections; HIV-1; Humans; Kynurenic Acid; Neuritis; Neuroimmun | 1993 |
Quinolinic acid and inflammation.
Topics: Acquired Immunodeficiency Syndrome; Animals; Biomarkers; Brain Ischemia; Disease Models, Animal; HIV | 1993 |
Role of immune activation and cytokine expression in HIV-1-associated neurologic diseases.
Topics: AIDS Dementia Complex; Apoptosis; Cell Adhesion; Cytokines; Endothelium, Vascular; Glutamic Acid; HI | 1995 |
2 trials available for quinolinic acid and HIV Coinfection
| Article | Year |
|---|---|
Parallel decrease in neurotoxin quinolinic acid and soluble tumor necrosis factor receptor p75 in serum during highly active antiretroviral therapy of HIV type 1 disease.
Topics: Adult; Aged; Aged, 80 and over; Anti-HIV Agents; Antigens, CD; Drug Therapy, Combination; Female; HI | 2000 |
Elevated cerebrospinal fluid quinolinic acid levels are associated with region-specific cerebral volume loss in HIV infection.
Topics: Adult; Atrophy; beta 2-Microglobulin; Biomarkers; Brain; Cohort Studies; Corpus Striatum; Cross-Sect | 2001 |
9 other studies available for quinolinic acid and HIV Coinfection
| Article | Year |
|---|---|
Abdominal Adipose Tissue Is Associated With Alterations in Tryptophan-Kynurenine Metabolism and Markers of Systemic Inflammation in People With Human Immunodeficiency Virus.
Topics: Abdominal Fat; Aged; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Female; HIV; HIV Infec | 2020 |
Alterations in the Kynurenine Pathway of Tryptophan Metabolism Are Associated With Depression in People Living With HIV.
Topics: Antidepressive Agents; Comorbidity; Depression; Female; HIV Infections; Humans; Kynurenine; Male; Mi | 2021 |
The kynurenine pathway activities in a sub-Saharan HIV/AIDS population.
Topics: Acquired Immunodeficiency Syndrome; Adult; Africa South of the Sahara; Antiretroviral Therapy, Highl | 2015 |
CSF quinolinic acid levels are determined by local HIV infection: cross-sectional analysis and modelling of dynamics following antiretroviral therapy.
Topics: Adult; AIDS Dementia Complex; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Biomarkers; Cr | 2004 |
Cerebrospinal fluid nitrite/nitrate levels in neurologic diseases.
Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Biopterins; HIV Infections; Humans; Hunti | 1994 |
Auditory P300 abnormalities and leukocyte activation in HIV infection.
Topics: Acoustic Stimulation; Adult; Audiometry, Pure-Tone; Electroencephalography; Evoked Potentials, Audit | 1994 |
Increase of tryptophan in serum and in cerebrospinal fluid of patients with HIV infection during zidovudine therapy.
Topics: Anti-HIV Agents; Biopterins; Chromatography, High Pressure Liquid; HIV Infections; HIV Seropositivit | 1996 |
Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease.
Topics: Aged; Animals; Brain Diseases; Encephalitis; Female; HIV Infections; Humans; Kynurenic Acid; Kynuren | 1992 |
Quinolinic acid in cerebrospinal fluid and serum in HIV-1 infection: relationship to clinical and neurological status.
Topics: AIDS Dementia Complex; Convulsants; HIV Infections; HIV-1; Humans; Neurotoxins; Quinolinic Acid; Qui | 1991 |