quinolinic acid has been researched along with Glioblastoma in 3 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There has been considerable scientific effort dedicated to understanding the biologic consequence and therapeutic implications of aberrant tryptophan metabolism in brain tumors and neurodegenerative diseases." | 4.31 | Quinolinate promotes macrophage-induced immune tolerance in glioblastoma through the NMDAR/PPARĪ³ signaling axis. ( Buelow, KL; Chinnaiyan, P; Kant, S; Kesarwani, P; Miller, CR; Prabhu, A; Zhao, Y, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Kesarwani, P | 1 |
| Kant, S | 1 |
| Zhao, Y | 1 |
| Prabhu, A | 1 |
| Buelow, KL | 1 |
| Miller, CR | 1 |
| Chinnaiyan, P | 1 |
| Di Serio, C | 1 |
| Cozzi, A | 1 |
| Angeli, I | 1 |
| Doria, L | 1 |
| Micucci, I | 1 |
| Pellerito, S | 1 |
| Mirone, P | 1 |
| Masotti, G | 1 |
| Moroni, F | 1 |
| Tarantini, F | 1 |
| Moffett, JR | 1 |
| Els, T | 1 |
| Espey, MG | 1 |
| Walter, SA | 1 |
| Streit, WJ | 1 |
| Namboodiri, MA | 1 |
3 other studies available for quinolinic acid and Glioblastoma
| Article | Year |
|---|---|
Quinolinate promotes macrophage-induced immune tolerance in glioblastoma through the NMDAR/PPARĪ³ signaling axis.
Topics: Animals; Biological Products; Brain Neoplasms; Glioblastoma; Immune Tolerance; Macrophages; Mice; Ne | 2023 |
Kynurenic acid inhibits the release of the neurotrophic fibroblast growth factor (FGF)-1 and enhances proliferation of glia cells, in vitro.
Topics: Animals; Cell Proliferation; Cells, Cultured; Culture Media, Conditioned; Endothelial Cells; Excitat | 2005 |
Quinolinate immunoreactivity in experimental rat brain tumors is present in macrophages but not in astrocytes.
Topics: Animals; Antibody Specificity; Astrocytes; Biomarkers; Brain Neoplasms; Corpus Striatum; Female; Gli | 1997 |