quinolinic acid has been researched along with Gaucher Disease in 1 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
Gaucher Disease: An autosomal recessive disorder caused by a deficiency of acid beta-glucosidase (GLUCOSYLCERAMIDASE) leading to intralysosomal accumulation of glycosylceramide mainly in cells of the MONONUCLEAR PHAGOCYTE SYSTEM. The characteristic Gaucher cells, glycosphingolipid-filled HISTIOCYTES, displace normal cells in BONE MARROW and visceral organs causing skeletal deterioration, hepatosplenomegaly, and organ dysfunction. There are several subtypes based on the presence and severity of neurological involvement.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Enzyme dosage ranged from 120 to 480 U/kg of body weight/month." | 2.68 | Prospective study of neurological responses to treatment with macrophage-targeted glucocerebrosidase in patients with type 3 Gaucher's disease. ( Aerts, JM; Barton, NW; Brady, RO; Dambrosia, JM; DeGraba, T; Heyes, MP; Oliver, K; Parker, CC; Patterson, MC; Schiffmann, R; Tedeschi, G; Zirzow, GC, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schiffmann, R | 1 |
| Heyes, MP | 1 |
| Aerts, JM | 1 |
| Dambrosia, JM | 1 |
| Patterson, MC | 1 |
| DeGraba, T | 1 |
| Parker, CC | 1 |
| Zirzow, GC | 1 |
| Oliver, K | 1 |
| Tedeschi, G | 1 |
| Brady, RO | 1 |
| Barton, NW | 1 |
1 trial available for quinolinic acid and Gaucher Disease
| Article | Year |
|---|---|
Prospective study of neurological responses to treatment with macrophage-targeted glucocerebrosidase in patients with type 3 Gaucher's disease.
Topics: Antibodies; Biomarkers; Child; Child, Preschool; Electroencephalography; Evoked Potentials, Auditory | 1997 |