Page last updated: 2024-10-20

quinolinic acid and Epilepsy

quinolinic acid has been researched along with Epilepsy in 16 studies

Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.

Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Research Excerpts

ExcerptRelevanceReference
"There was a statistically significant decrease of CSF kynurenic acid in patients with epileptic spasms compared to OND (p<0."8.12Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids. ( Antony, J; Ardern-Holmes, S; Bandodkar, S; Dale, RC; Gill, D; Guillemin, GJ; Guller, A; Gupta, S; Han, VX; Heng, B; Innes, EA; Jones, HF; Kothur, K; Menezes, MP; Mohammad, S; Patel, S; Pires, AS; Tantsis, E; Troedson, C; Tsang, E; Webster, R; Wienholt, L; Yan, J, 2022)
"p."5.31Guanosine and GMP prevent seizures induced by quinolinic acid in mice. ( da Silveira Perla, A; de Faria Maraschin, J; Lara, DR; Onofre Souza, D; Schmidt, AP, 2000)
"There was a statistically significant decrease of CSF kynurenic acid in patients with epileptic spasms compared to OND (p<0."4.12Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids. ( Antony, J; Ardern-Holmes, S; Bandodkar, S; Dale, RC; Gill, D; Guillemin, GJ; Guller, A; Gupta, S; Han, VX; Heng, B; Innes, EA; Jones, HF; Kothur, K; Menezes, MP; Mohammad, S; Patel, S; Pires, AS; Tantsis, E; Troedson, C; Tsang, E; Webster, R; Wienholt, L; Yan, J, 2022)
"We had shown that production of quinolinic acid is high in the brain of epilepsy-prone El mice and that this is due to an increase in the activity of 3-hydroxyanthranilate 3,4-dioxygenase (3-HAO, EC 1."3.69Increase in the level of mRNA for 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice. ( Asai, H; Kitoh, J; Mori, H; Nakagawa, Y; Nakano, K, 1995)
" Several crucial questions remain to be addressed before a case can be made for a 'quinolinic acid hypothesis' of temporal lobe epilepsy."3.67Quinolinic acid: a pathogen in seizure disorders? ( French, ED; Köhler, C; Okuno, E; Schwarcz, R; Speciale, C, 1986)
"Quinolinic acid was not detected in the brain of patients who received antiepileptic drugs other than carbamazepine prior to surgery or in brain endothelial cultures obtained from a control patient."1.38A pro-convulsive carbamazepine metabolite: quinolinic acid in drug resistant epileptic human brain. ( Alexopoulos, AV; Ghosh, C; Gonzalez-Martinez, J; Hossain, M; Janigro, D; Marchi, N; Rasmussen, P; Yang, H, 2012)
"Quinolinic acid (QA) has been used as a model for experimental overstimulation of the glutamatergic system."1.32Quinolinic acid promotes seizures and decreases glutamate uptake in young rats: reversal by orally administered guanosine. ( de Oliveira, DL; Frizzo, ME; Horn, JF; Moriguchi, E; Rodrigues, JM; Souza, DO; Wofchuk, S, 2004)
"p."1.31Guanosine and GMP prevent seizures induced by quinolinic acid in mice. ( da Silveira Perla, A; de Faria Maraschin, J; Lara, DR; Onofre Souza, D; Schmidt, AP, 2000)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19905 (31.25)18.7374
1990's3 (18.75)18.2507
2000's6 (37.50)29.6817
2010's1 (6.25)24.3611
2020's1 (6.25)2.80

Authors

AuthorsStudies
Yan, J1
Kothur, K1
Innes, EA1
Han, VX1
Jones, HF1
Patel, S1
Tsang, E1
Webster, R1
Gupta, S1
Troedson, C1
Menezes, MP1
Antony, J1
Ardern-Holmes, S1
Tantsis, E1
Mohammad, S1
Wienholt, L1
Pires, AS1
Heng, B1
Guillemin, GJ1
Guller, A1
Gill, D1
Bandodkar, S1
Dale, RC1
Ghosh, C1
Marchi, N1
Hossain, M1
Rasmussen, P1
Alexopoulos, AV1
Gonzalez-Martinez, J1
Yang, H1
Janigro, D1
Juhász, C1
Chugani, DC1
Padhye, UN1
Muzik, O1
Shah, A1
Asano, E1
Mangner, TJ1
Chakraborty, PK1
Sood, S1
Chugani, HT1
de Oliveira, DL1
Horn, JF1
Rodrigues, JM1
Frizzo, ME2
Moriguchi, E1
Souza, DO2
Wofchuk, S1
Rho, JM1
Nakano, K2
Takahashi, S1
Mizobuchi, M1
Kuroda, T1
Masuda, K1
Kitoh, J2
Nakagawa, Y1
Asai, H1
Mori, H1
Schmidt, AP2
Lara, DR2
de Faria Maraschin, J1
da Silveira Perla, A1
Onofre Souza, D1
Stone, TW2
Burgos, JS1
Ramírez, G1
Manfridi, A1
Forloni, GL1
Vezzani, A2
Fodritto, F1
De Simoni, MG1
Ben-Ari, Y1
Schwarcz, R2
Connick, JH1
Winn, P1
Hastings, MH1
English, M1
Guiso, G1
Caccia, S1
Stasi, MA1
Salmona, M1
Romano, M1
Garattini, S1
Foster, AC1
Speciale, C1
Okuno, E1
French, ED1
Köhler, C1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Prednisolone vs. Vigabatrin in the First-line Treatment of Infantile Spasms[NCT02299115]Phase 30 participants (Actual)Interventional2017-09-05Withdrawn (stopped due to Most centres are now using oral steroids as 1st line treatment so question of efficacy is no longer of high interest.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for quinolinic acid and Epilepsy

ArticleYear
Basic science behind the catastrophic epilepsies.
    Epilepsia, 2004, Volume: 45 Suppl 5

    Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Corticotropin-Releasing Hormone; Epilepsies

2004
Kynurenic acid antagonists and kynurenine pathway inhibitors.
    Expert opinion on investigational drugs, 2001, Volume: 10, Issue:4

    Topics: Brain Ischemia; Epilepsy; Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; Neu

2001
Endogenous excitotoxic agents.
    Ciba Foundation symposium, 1987, Volume: 126

    Topics: Animals; Aspartic Acid; Cell Survival; Central Nervous System; Dementia; Epilepsy; Glutamates; Gluta

1987

Other Studies

13 other studies available for quinolinic acid and Epilepsy

ArticleYear
Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids.
    EBioMedicine, 2022, Volume: 84

    Topics: 3-Hydroxyanthranilic Acid; Adrenal Cortex Hormones; Animals; Biomarkers; Chromatography, Liquid; Epi

2022
A pro-convulsive carbamazepine metabolite: quinolinic acid in drug resistant epileptic human brain.
    Neurobiology of disease, 2012, Volume: 46, Issue:3

    Topics: Adult; Anticonvulsants; Biotransformation; Brain Chemistry; Carbamazepine; Child; Chromatography, Hi

2012
Evaluation with alpha-[11C]methyl-L-tryptophan positron emission tomography for reoperation after failed epilepsy surgery.
    Epilepsia, 2004, Volume: 45, Issue:2

    Topics: Adolescent; Adult; Age Factors; Carbon Radioisotopes; Child; Child, Preschool; Electroencephalograph

2004
Quinolinic acid promotes seizures and decreases glutamate uptake in young rats: reversal by orally administered guanosine.
    Brain research, 2004, Aug-20, Volume: 1018, Issue:1

    Topics: Administration, Oral; Aging; Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Anim

2004
High levels of quinolinic acid in brain of epilepsy-prone E1 mice.
    Brain research, 1993, Aug-13, Volume: 619, Issue:1-2

    Topics: Aging; Amino Acids; Animals; Cerebral Cortex; Epilepsy; Escherichia coli; Lipopolysaccharides; Methi

1993
Increase in the level of mRNA for 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice.
    Bioscience, biotechnology, and biochemistry, 1995, Volume: 59, Issue:11

    Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Animals; Brain; Dioxygenases; Epilepsy; Genetic Predispositio

1995
Guanosine and GMP prevent seizures induced by quinolinic acid in mice.
    Brain research, 2000, May-02, Volume: 864, Issue:1

    Topics: Animals; Anticonvulsants; Central Nervous System; Dose-Response Relationship, Drug; Drug Interaction

2000
Effect of orally administered guanosine on seizures and death induced by glutamatergic agents.
    Brain research, 2001, Sep-07, Volume: 912, Issue:2

    Topics: Animals; Brain; Caffeine; Death; Dizocilpine Maleate; Dose-Response Relationship, Drug; Elapid Venom

2001
Functional and histological consequences of quinolinic and kainic acid-induced seizures on hippocampal somatostatin neurons.
    Neuroscience, 1991, Volume: 41, Issue:1

    Topics: Animals; Cell Survival; Cysteamine; Electroencephalography; Epilepsy; Hippocampus; Kainic Acid; Male

1991
Seizures and brain damage: are excitatory amino acids involved?
    Advances in experimental medicine and biology, 1986, Volume: 203

    Topics: Action Potentials; Amino Acids; Animals; Brain; Epilepsy; Glutamates; Glutamic Acid; Hippocampus; Ne

1986
Effect of aspartame on seizures in various models of experimental epilepsy.
    Toxicology and applied pharmacology, 1988, Volume: 96, Issue:3

    Topics: Animals; Aspartame; Brain Chemistry; Dipeptides; Electroshock; Epilepsy; Male; Pentylenetetrazole; P

1988
Involvement of excitatory amino acid receptors in the mechanisms underlying excitotoxic phenomena.
    Advances in experimental medicine and biology, 1986, Volume: 203

    Topics: Action Potentials; Amino Acids, Dicarboxylic; Animals; Cell Survival; Dendrites; Epilepsy; Kynurenic

1986
Quinolinic acid: a pathogen in seizure disorders?
    Advances in experimental medicine and biology, 1986, Volume: 203

    Topics: Afferent Pathways; Animals; Brain; Brain Mapping; Cholinergic Fibers; Convulsants; Epilepsy; Kainic

1986