quinolinic acid has been researched along with Epilepsy, Temporal Lobe in 6 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
Epilepsy, Temporal Lobe: A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the TEMPORAL LOBE, most commonly from its mesial aspect. A wide variety of psychic phenomena may be associated, including illusions, hallucinations, dyscognitive states, and affective experiences. The majority of complex partial seizures (see EPILEPSY, COMPLEX PARTIAL) originate from the temporal lobes. Temporal lobe seizures may be classified by etiology as cryptogenic, familial, or symptomatic. (From Adams et al., Principles of Neurology, 6th ed, p321).
| Excerpt | Relevance | Reference |
|---|---|---|
| "QUIN seizures showed particular sensitivity to carbamazepine (5 mg/kg) but were resistant to diphenylhydantoin unless a relatively high dose was used (100 mg/kg)." | 5.27 | Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments. ( Samanin, R; Tullii, M; Vezzani, A; Wu, HQ, 1986) |
| "Spontaneous recurrent seizures induced by pilocarpine were monitored behaviorally prior to and after PING or under control conditions." | 1.62 | Non-invasive, neurotoxic surgery reduces seizures in a rat model of temporal lobe epilepsy. ( Bertram, EH; Buckmaster, PS; Ghobadi, SN; Habte, FG; Hou, Q; Huang, A; Keunen, O; Lee, KS; Li, N; Narang, S; Qiu, L; Wang, J; Wintermark, M; Zhang, Y, 2021) |
| "Quinolinic acid was not detected in the brain of patients who received antiepileptic drugs other than carbamazepine prior to surgery or in brain endothelial cultures obtained from a control patient." | 1.38 | A pro-convulsive carbamazepine metabolite: quinolinic acid in drug resistant epileptic human brain. ( Alexopoulos, AV; Ghosh, C; Gonzalez-Martinez, J; Hossain, M; Janigro, D; Marchi, N; Rasmussen, P; Yang, H, 2012) |
| "QUIN seizures showed particular sensitivity to carbamazepine (5 mg/kg) but were resistant to diphenylhydantoin unless a relatively high dose was used (100 mg/kg)." | 1.27 | Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments. ( Samanin, R; Tullii, M; Vezzani, A; Wu, HQ, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, Y | 1 |
| Buckmaster, PS | 1 |
| Qiu, L | 1 |
| Wang, J | 1 |
| Keunen, O | 1 |
| Ghobadi, SN | 1 |
| Huang, A | 1 |
| Hou, Q | 1 |
| Li, N | 1 |
| Narang, S | 1 |
| Habte, FG | 1 |
| Bertram, EH | 1 |
| Lee, KS | 1 |
| Wintermark, M | 1 |
| Ghosh, C | 1 |
| Marchi, N | 1 |
| Hossain, M | 1 |
| Rasmussen, P | 1 |
| Alexopoulos, AV | 1 |
| Gonzalez-Martinez, J | 1 |
| Yang, H | 1 |
| Janigro, D | 1 |
| Schwarcz, R | 3 |
| Köhler, C | 2 |
| Foster, AC | 1 |
| French, ED | 1 |
| Whetsell, WO | 1 |
| Du, F | 1 |
| Vezzani, A | 1 |
| Wu, HQ | 1 |
| Tullii, M | 1 |
| Samanin, R | 1 |
1 review available for quinolinic acid and Epilepsy, Temporal Lobe
| Article | Year |
|---|---|
Quinolinic acid and kynurenic acid in the mammalian brain.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; AIDS Dementia Complex; Animals; Aspartic Acid; Biological Tra | 1991 |
5 other studies available for quinolinic acid and Epilepsy, Temporal Lobe
| Article | Year |
|---|---|
Non-invasive, neurotoxic surgery reduces seizures in a rat model of temporal lobe epilepsy.
Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Epilepsy, Temporal Lobe; Intraoperative Neurop | 2021 |
A pro-convulsive carbamazepine metabolite: quinolinic acid in drug resistant epileptic human brain.
Topics: Adult; Anticonvulsants; Biotransformation; Brain Chemistry; Carbamazepine; Child; Chromatography, Hi | 2012 |
Differential vulnerability of central neurons of the rat to quinolinic acid.
Topics: Animals; Brain; Corpus Striatum; Diencephalon; Epilepsy, Temporal Lobe; Hippocampus; Huntington Dise | 1983 |
Excitotoxic models for neurodegenerative disorders.
Topics: Amino Acids; Animals; Axons; Dendrites; Epilepsy, Temporal Lobe; Hippocampus; Humans; Ibotenic Acid; | 1984 |
Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Chlorpromazine; Diazepam; Disease Models, | 1986 |