quinolinic acid has been researched along with Encephalopathy, Toxic in 32 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cryptotanshinone (CTS), a major constituent from the roots of Salvia miltiorrhiza (Danshen), is widely used in the treatment of coronary heart disease, stroke and less commonly Alzheimer's disease." | 7.74 | Transport of cryptotanshinone, a major active triterpenoid in Salvia miltiorrhiza Bunge widely used in the treatment of stroke and Alzheimer's disease, across the blood-brain barrier. ( Cao, J; Chan, E; Chen, X; Chowbay, B; Duan, W; Li, CG; Liang, J; Lin, SG; Wen, JY; Yu, XY; Zhou, SF; Zhou, ZW, 2007) |
| " Quinolinic acid (QA)-induced seizures are used to average NMDA receptors-evoked neurotoxicity in animal models." | 7.72 | NMDA preconditioning protects against seizures and hippocampal neurotoxicity induced by quinolinic acid in mice. ( Boeck, CR; Ganzella, M; Lottermann, A; Vendite, D, 2004) |
| " Specially, chemical preconditioning models using N-methyl-d-aspartate (NMDA) pre-treatment, which has demonstrated to lead to neuroprotection against seizures and damage to neuronal tissue induced by quinolinic acid (QA)." | 4.87 | Cell signaling in NMDA preconditioning and neuroprotection in convulsions induced by quinolinic acid. ( Muller, Gdo A; Severino, PC; Tasca, CI; Vandresen-Filho, S, 2011) |
| "Aloysia gratissima aqueous extract (AE) was investigated as a putative protective agent against quinolinic acid (QA)-induced seizures in mice and hippocampal cell damage." | 3.80 | Aloysia gratissima prevents cellular damage induced by glutamatergic excitotoxicity. ( Bertoldo, DB; Dal-Cim, T; Maraschin, M; Martins, WC; Tasca, CI; Vandresen-Filho, S; Zeni, AL, 2014) |
| "Cryptotanshinone (CTS), a major constituent from the roots of Salvia miltiorrhiza (Danshen), is widely used in the treatment of coronary heart disease, stroke and less commonly Alzheimer's disease." | 3.74 | Transport of cryptotanshinone, a major active triterpenoid in Salvia miltiorrhiza Bunge widely used in the treatment of stroke and Alzheimer's disease, across the blood-brain barrier. ( Cao, J; Chan, E; Chen, X; Chowbay, B; Duan, W; Li, CG; Liang, J; Lin, SG; Wen, JY; Yu, XY; Zhou, SF; Zhou, ZW, 2007) |
| " Quinolinic acid (QA)-induced seizures are used to average NMDA receptors-evoked neurotoxicity in animal models." | 3.72 | NMDA preconditioning protects against seizures and hippocampal neurotoxicity induced by quinolinic acid in mice. ( Boeck, CR; Ganzella, M; Lottermann, A; Vendite, D, 2004) |
| " However, their toxic properties have yet to be explored in the nematode Caenorhabditis elegans (C." | 1.48 | Comparison of the Toxic Effects of Quinolinic Acid and 3-Nitropropionic Acid in C. elegans: Involvement of the SKN-1 Pathway. ( Aguilera-González, MF; Aschner, M; Avila, DS; Colonnello, A; de Lima, ME; García-Contreras, R; Kotlar, I; Ortíz-Plata, A; Santamaría, A; Soares, FAA, 2018) |
| "Ferulic acid (FA) is a phenolic compound possessing antioxidant and cytoprotective properties." | 1.48 | Comparing the Effects of Ferulic Acid and Sugarcane Aqueous Extract in In Vitro and In Vivo Neurotoxic Models. ( Aschner, M; Colonnello, A; de Lima, ME; García-Contreras, R; Kotlar, I; Ortíz-Plata, A; Santamaría, A; Soares, FAA, 2018) |
| "Treatment with rosiglitazone (5, 10 mg/kg) and VPA (100, 200 mg/kg) for 21 days significantly attenuated these behavioral, biochemical, and cellular alterations as compared to control (QA 200 nmol) group." | 1.40 | Rosiglitazone synergizes the neuroprotective effects of valproic acid against quinolinic acid-induced neurotoxicity in rats: targeting PPARγ and HDAC pathways. ( Chaudhary, T; Kumar, A; Mishra, J, 2014) |
| "Quinolinic acid is an endogenous excitotoxin that causes neurotoxicity in diverse areas of the brain and produces motor dysfunction." | 1.36 | Protective effect of rofecoxib and nimesulide against intra-striatal quinolinic acid-induced behavioral, oxidative stress and mitochondrial dysfunctions in rats. ( Kalonia, H; Kumar, A; Kumar, P; Nehru, B, 2010) |
| "Quinolinic acid has been reported to induce excitotoxicity by stimulating the N-methyl-D-aspartate receptor, causing calcium overload which in turn leads to the neurodegeneration." | 1.36 | Protective effect of montelukast against quinolinic acid/malonic acid induced neurotoxicity: possible behavioral, biochemical, mitochondrial and tumor necrosis factor-α level alterations in rats. ( Kalonia, H; Kumar, A; Kumar, P; Nehru, B, 2010) |
| " After sham-lesioned rats reached a stable baseline, a between-sessions heroin dose-response function was established." | 1.31 | The effects of excitotoxic lesions of the nucleus accumbens core or shell regions on intravenous heroin self-administration in rats. ( Alderson, HL; Everitt, BJ; Parkinson, JA; Robbins, TW, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (34.38) | 29.6817 |
| 2010's | 21 (65.63) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kotlar, I | 2 |
| Colonnello, A | 2 |
| Aguilera-González, MF | 1 |
| Avila, DS | 1 |
| de Lima, ME | 2 |
| García-Contreras, R | 2 |
| Ortíz-Plata, A | 3 |
| Soares, FAA | 2 |
| Aschner, M | 2 |
| Santamaría, A | 5 |
| Koo, YS | 1 |
| Kim, H | 1 |
| Park, JH | 1 |
| Kim, MJ | 1 |
| Shin, YI | 1 |
| Choi, BT | 1 |
| Lee, SY | 1 |
| Shin, HK | 1 |
| Liu, P | 1 |
| Li, Y | 1 |
| Qi, X | 1 |
| Xu, J | 1 |
| Liu, D | 1 |
| Ji, X | 1 |
| Chi, T | 1 |
| Liu, H | 1 |
| Zou, L | 1 |
| Petkau, TL | 1 |
| Zhu, S | 1 |
| Lu, G | 1 |
| Fernando, S | 1 |
| Cynader, M | 1 |
| Leavitt, BR | 1 |
| Mishra, J | 2 |
| Chaudhary, T | 1 |
| Kumar, A | 7 |
| Zeni, AL | 1 |
| Vandresen-Filho, S | 2 |
| Dal-Cim, T | 1 |
| Martins, WC | 1 |
| Bertoldo, DB | 1 |
| Maraschin, M | 1 |
| Tasca, CI | 2 |
| García-Lara, L | 1 |
| Pérez-Severiano, F | 2 |
| González-Esquivel, D | 1 |
| Elizondo, G | 1 |
| Segovia, J | 1 |
| Meier, TB | 1 |
| Drevets, WC | 1 |
| Wurfel, BE | 1 |
| Ford, BN | 1 |
| Morris, HM | 1 |
| Victor, TA | 1 |
| Bodurka, J | 1 |
| Teague, TK | 1 |
| Dantzer, R | 1 |
| Savitz, J | 1 |
| Saliba, SW | 1 |
| Vieira, EL | 1 |
| Santos, RP | 1 |
| Candelario-Jalil, E | 1 |
| Fiebich, BL | 1 |
| Vieira, LB | 1 |
| Teixeira, AL | 1 |
| de Oliveira, AC | 1 |
| Kalonia, H | 5 |
| Kumar, P | 5 |
| Nehru, B | 2 |
| Severino, PC | 1 |
| Muller, Gdo A | 1 |
| Guillemin, GJ | 2 |
| Carmona-Ramírez, I | 1 |
| Tobón-Velasco, JC | 1 |
| Orozco-Ibarra, M | 1 |
| González-Herrera, IG | 1 |
| Pedraza-Chaverrí, J | 2 |
| Maldonado, PD | 2 |
| Blundell, P | 1 |
| Symonds, M | 1 |
| Hall, G | 1 |
| Killcross, S | 1 |
| Bailey, GK | 1 |
| Salvatierra-Sánchez, R | 1 |
| Vázquez-Román, B | 1 |
| Santiago-López, D | 1 |
| Villeda-Hernández, J | 2 |
| Galván-Arzate, S | 2 |
| Jiménez-Capdeville, ME | 1 |
| Ali, SF | 1 |
| Cerstiaens, A | 1 |
| Huybrechts, J | 1 |
| Kotanen, S | 1 |
| Lebeau, I | 1 |
| Meylaers, K | 1 |
| De Loof, A | 1 |
| Schoofs, L | 1 |
| Popoli, P | 1 |
| Pintor, A | 1 |
| Tebano, MT | 1 |
| Frank, C | 1 |
| Pepponi, R | 1 |
| Nazzicone, V | 1 |
| Grieco, R | 1 |
| Pèzzola, A | 1 |
| Reggio, R | 1 |
| Minghetti, L | 1 |
| De Berardinis, MA | 1 |
| Martire, A | 1 |
| Potenza, RL | 1 |
| Domenici, MR | 1 |
| Massotti, M | 1 |
| Boeck, CR | 1 |
| Ganzella, M | 1 |
| Lottermann, A | 1 |
| Vendite, D | 1 |
| Rodríguez-Pérez, M | 1 |
| Medina-Campos, ON | 1 |
| Sánchez-García, A | 1 |
| Aguilera, P | 1 |
| Maharaj, H | 1 |
| Maharaj, DS | 1 |
| Daya, S | 2 |
| Müller, AC | 1 |
| Dairam, A | 1 |
| Limson, JL | 1 |
| Yu, XY | 1 |
| Lin, SG | 1 |
| Chen, X | 1 |
| Zhou, ZW | 1 |
| Liang, J | 1 |
| Duan, W | 1 |
| Chowbay, B | 1 |
| Wen, JY | 1 |
| Chan, E | 1 |
| Cao, J | 1 |
| Li, CG | 1 |
| Zhou, SF | 1 |
| Song, J | 1 |
| Lee, ST | 1 |
| Kang, W | 1 |
| Park, JE | 1 |
| Chu, K | 1 |
| Lee, SE | 1 |
| Hwang, T | 1 |
| Chung, H | 1 |
| Kim, M | 1 |
| Hutcheson, DM | 1 |
| Parkinson, JA | 2 |
| Robbins, TW | 2 |
| Everitt, BJ | 2 |
| Alderson, HL | 1 |
2 reviews available for quinolinic acid and Encephalopathy, Toxic
| Article | Year |
|---|---|
Cell signaling in NMDA preconditioning and neuroprotection in convulsions induced by quinolinic acid.
Topics: Animals; Brain; Brain Chemistry; Cerebrovascular Circulation; Excitatory Amino Acid Agonists; Glutam | 2011 |
Quinolinic acid, the inescapable neurotoxin.
Topics: Animals; Humans; Neurotoxicity Syndromes; Neurotoxins; Quinolinic Acid | 2012 |
30 other studies available for quinolinic acid and Encephalopathy, Toxic
| Article | Year |
|---|---|
Comparison of the Toxic Effects of Quinolinic Acid and 3-Nitropropionic Acid in C. elegans: Involvement of the SKN-1 Pathway.
Topics: Animals; Antihypertensive Agents; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Corpus St | 2018 |
Comparing the Effects of Ferulic Acid and Sugarcane Aqueous Extract in In Vitro and In Vivo Neurotoxic Models.
Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Birth Rate; Caenorhabditis elegans; Ca | 2018 |
Indoleamine 2,3-Dioxygenase-Dependent Neurotoxic Kynurenine Metabolism Contributes to Poststroke Depression Induced in Mice by Ischemic Stroke along with Spatial Restraint Stress.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Animals; Brain Ischemia; Depressive Disorder; Indoleamine-Pyr | 2018 |
Protein kinase C is involved in the neuroprotective effect of berberine against intrastriatal injection of quinolinic acid-induced biochemical alteration in mice.
Topics: Animals; Berberine; Cognitive Dysfunction; Disease Models, Animal; Glutamic Acid; Glycogen Synthase | 2019 |
Sensitivity to neurotoxic stress is not increased in progranulin-deficient mice.
Topics: Animals; Fluoresceins; Granulins; Intercellular Signaling Peptides and Proteins; Kainic Acid; Mice; | 2013 |
Rosiglitazone synergizes the neuroprotective effects of valproic acid against quinolinic acid-induced neurotoxicity in rats: targeting PPARγ and HDAC pathways.
Topics: Animals; Body Weight; Brain; Disease Models, Animal; Drug Synergism; Histone Deacetylase Inhibitors; | 2014 |
Aloysia gratissima prevents cellular damage induced by glutamatergic excitotoxicity.
Topics: Animals; Biological Transport; Cell Death; Cell Survival; Coumaric Acids; Excitatory Amino Acid Agon | 2014 |
Improvement of mitochondrial NAD(+)/FAD(+)-linked state-3 respiration by caffeine attenuates quinolinic acid induced motor impairment in rats: implications in Huntington's disease.
Topics: Animals; Antioxidants; Caffeine; Cell Respiration; Corpus Striatum; Disease Models, Animal; Dose-Res | 2014 |
Absence of aryl hydrocarbon receptors increases endogenous kynurenic acid levels and protects mouse brain against excitotoxic insult and oxidative stress.
Topics: Acetyltransferases; Animals; Basic Helix-Loop-Helix Transcription Factors; Brain; Disease Models, An | 2015 |
Relationship between neurotoxic kynurenine metabolites and reductions in right medial prefrontal cortical thickness in major depressive disorder.
Topics: Adult; Brain; C-Reactive Protein; Case-Control Studies; Cerebral Cortex; Depressive Disorder, Major; | 2016 |
Neuroprotective effects of intrastriatal injection of rapamycin in a mouse model of excitotoxicity induced by quinolinic acid.
Topics: Animals; Body Weight; Corpus Striatum; Cytokines; Disease Models, Animal; Dose-Response Relationship | 2017 |
Protective effect of rofecoxib and nimesulide against intra-striatal quinolinic acid-induced behavioral, oxidative stress and mitochondrial dysfunctions in rats.
Topics: Animals; Ataxia; Body Weight; Cell Survival; Corpus Striatum; Cyclooxygenase 2 Inhibitors; Lactones; | 2010 |
Pioglitazone ameliorates behavioral, biochemical and cellular alterations in quinolinic acid induced neurotoxicity: possible role of peroxisome proliferator activated receptor-Upsilon (PPARUpsilon) in Huntington's disease.
Topics: Animals; Antioxidants; Benzhydryl Compounds; Body Weight; Corpus Striatum; Disease Models, Animal; E | 2010 |
Comparative neuroprotective profile of statins in quinolinic acid induced neurotoxicity in rats.
Topics: Analysis of Variance; Animals; Atorvastatin; Behavior, Animal; Body Weight; Corpus Striatum; Fatty A | 2011 |
Protective effect of montelukast against quinolinic acid/malonic acid induced neurotoxicity: possible behavioral, biochemical, mitochondrial and tumor necrosis factor-α level alterations in rats.
Topics: Acetates; Analysis of Variance; Animals; Behavior, Animal; Body Weight; Brain; Brain Chemistry; Cata | 2010 |
Licofelone attenuates quinolinic acid induced Huntington like symptoms: possible behavioral, biochemical and cellular alterations.
Topics: Animals; Behavior, Animal; Biochemical Phenomena; Corpus Striatum; Cyclooxygenase 2 Inhibitors; Dise | 2011 |
Quinolinic acid: neurotoxicity.
Topics: Animals; Humans; Neurotoxicity Syndromes; Quinolinic Acid | 2012 |
RETRACTED: Curcumin restores Nrf2 levels and prevents quinolinic acid-induced neurotoxicity.
Topics: Animals; Corpus Striatum; Curcumin; Glutathione Peroxidase; Male; Neurodegenerative Diseases; Neurot | 2013 |
Within-event learning in rats with lesions of the basolateral amygdala.
Topics: Amygdala; Animals; Avoidance Learning; Conditioning, Operant; Learning; Male; Neurotoxicity Syndrome | 2013 |
Protective effects of the antioxidant selenium on quinolinic acid-induced neurotoxicity in rats: in vitro and in vivo studies.
Topics: Animals; Antioxidants; Behavior, Animal; Body Weight; Brain Chemistry; Corpus Striatum; gamma-Aminob | 2003 |
Neurotoxic and neurobehavioral effects of kynurenines in adult insects.
Topics: Animals; Apoptosis; Behavior, Animal; Cell Survival; Cells, Cultured; Diptera; Dose-Response Relatio | 2003 |
Neuroprotective effects of the mGlu5R antagonist MPEP towards quinolinic acid-induced striatal toxicity: involvement of pre- and post-synaptic mechanisms and lack of direct NMDA blocking activity.
Topics: Animals; Body Weight; Calcium; Cells, Cultured; Electroencephalography; Excitatory Amino Acid Antago | 2004 |
NMDA preconditioning protects against seizures and hippocampal neurotoxicity induced by quinolinic acid in mice.
Topics: Animals; Apoptosis; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Ago | 2004 |
S-Allylcysteine, a garlic-derived antioxidant, ameliorates quinolinic acid-induced neurotoxicity and oxidative damage in rats.
Topics: Animals; Antioxidants; Behavior, Animal; Blotting, Western; Body Weight; Cysteine; Garlic; Glutathio | 2004 |
Acetylsalicylic acid and acetaminophen protect against oxidative neurotoxicity.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflam | 2006 |
Mechanisms by which acyclovir reduces the oxidative neurotoxicity and biosynthesis of quinolinic acid.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Acyclovir; Animals; Antimetabolites; Electrochemistry; Indole | 2007 |
Transport of cryptotanshinone, a major active triterpenoid in Salvia miltiorrhiza Bunge widely used in the treatment of stroke and Alzheimer's disease, across the blood-brain barrier.
Topics: Alzheimer Disease; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Tran | 2007 |
Human embryonic stem cell-derived neural precursor transplants attenuate apomorphine-induced rotational behavior in rats with unilateral quinolinic acid lesions.
Topics: Animals; Apomorphine; Cell Differentiation; Cell Line; Dopamine Agonists; Embryonic Stem Cells; Hunt | 2007 |
The effects of nucleus accumbens core and shell lesions on intravenous heroin self-administration and the acquisition of drug-seeking behaviour under a second-order schedule of heroin reinforcement.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Excitatory Amino | 2001 |
The effects of excitotoxic lesions of the nucleus accumbens core or shell regions on intravenous heroin self-administration in rats.
Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; He | 2001 |