quinolinic acid has been researched along with Disease Exacerbation in 15 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this paper is to elucidate the role of oxidative and nitrosative stress as well as the tryptophan catabolites pathway in the development of depression and the mechanism of action of antidepressant drugs, based on the available literature." | 8.95 | Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders. ( Czarny, P; Galecki, P; Sliwinski, T; Wigner, P, 2017) |
| "The aim of this paper is to elucidate the role of oxidative and nitrosative stress as well as the tryptophan catabolites pathway in the development of depression and the mechanism of action of antidepressant drugs, based on the available literature." | 4.95 | Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders. ( Czarny, P; Galecki, P; Sliwinski, T; Wigner, P, 2017) |
| "Increased oxidative stress (SOX), inflammation and accelerated atherosclerosis have been reported in end-stage renal disease (ESRD), but their associations with kynurenine pathway activation remain unknown." | 3.75 | Kynurenine, quinolinic acid--the new factors linked to carotid atherosclerosis in patients with end-stage renal disease. ( Brzosko, S; Mysliwiec, M; Pawlak, D; Pawlak, K, 2009) |
| "These are astrocytosis, up-regulation of mRNA encoding the neuropeptide somatostatin (SRIF) and an increased expression of MHC Class II antigen." | 2.39 | Neuronal substrates for SIV encephalopathy. ( da Cunha, A; Eiden, LE; Rausch, DM, 1994) |
| "Disease progression was evaluated by virological assessment of blood and cerebral spinal fluid (CSF), CD4 T cell count in blood, and quinolinic acid levels in CSF (a surrogate marker of neuronal cell damage)." | 1.32 | HIV in central nervous system and behavioral development: an HIV-2287 macaque model of AIDS. ( Anderson, BD; Anderson, DM; Bielefeldt-Ohmann, H; Ho, RJ; Hu, SL; Kinman, LM; Leigh, J; Morton, WR; Worlein, JM, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 7 (46.67) | 29.6817 |
| 2010's | 6 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Robertson, DS | 1 |
| Wigner, P | 1 |
| Czarny, P | 1 |
| Galecki, P | 1 |
| Sliwinski, T | 1 |
| Botticelli, A | 1 |
| Cerbelli, B | 1 |
| Lionetto, L | 2 |
| Zizzari, I | 1 |
| Salati, M | 1 |
| Pisano, A | 1 |
| Federica, M | 1 |
| Simmaco, M | 2 |
| Nuti, M | 1 |
| Marchetti, P | 1 |
| Curto, M | 1 |
| Fazio, F | 1 |
| Corigliano, V | 1 |
| Comparelli, A | 1 |
| Ferracuti, S | 1 |
| Nicoletti, F | 1 |
| Baldessarini, RJ | 1 |
| van der Sluijs, KF | 1 |
| van de Pol, MA | 1 |
| Kulik, W | 1 |
| Dijkhuis, A | 1 |
| Smids, BS | 1 |
| van Eijk, HW | 1 |
| Karlas, JA | 1 |
| Molenkamp, R | 1 |
| Wolthers, KC | 1 |
| Johnston, SL | 1 |
| van der Zee, JS | 1 |
| Sterk, PJ | 1 |
| Lutter, R | 1 |
| Pawlak, K | 1 |
| Brzosko, S | 1 |
| Mysliwiec, M | 1 |
| Pawlak, D | 1 |
| Graham, RK | 1 |
| Pouladi, MA | 1 |
| Joshi, P | 1 |
| Lu, G | 1 |
| Deng, Y | 1 |
| Wu, NP | 1 |
| Figueroa, BE | 1 |
| Metzler, M | 1 |
| André, VM | 1 |
| Slow, EJ | 1 |
| Raymond, L | 1 |
| Friedlander, R | 1 |
| Levine, MS | 1 |
| Leavitt, BR | 1 |
| Hayden, MR | 1 |
| Xifró, X | 1 |
| Giralt, A | 1 |
| Saavedra, A | 1 |
| García-Martínez, JM | 1 |
| Díaz-Hernández, M | 1 |
| Lucas, JJ | 1 |
| Alberch, J | 1 |
| Pérez-Navarro, E | 1 |
| Lee, ST | 1 |
| Chu, K | 1 |
| Jung, KH | 1 |
| Im, WS | 1 |
| Park, JE | 1 |
| Lim, HC | 1 |
| Won, CH | 1 |
| Shin, SH | 1 |
| Lee, SK | 1 |
| Kim, M | 1 |
| Roh, JK | 1 |
| Nair, MP | 1 |
| Samikkannu, T | 1 |
| Medana, IM | 1 |
| Day, NP | 1 |
| Salahifar-Sabet, H | 1 |
| Stocker, R | 1 |
| Smythe, G | 1 |
| Bwanaisa, L | 1 |
| Njobvu, A | 1 |
| Kayira, K | 1 |
| Turner, GD | 1 |
| Taylor, TE | 1 |
| Hunt, NH | 1 |
| Kinman, LM | 1 |
| Worlein, JM | 1 |
| Leigh, J | 1 |
| Bielefeldt-Ohmann, H | 1 |
| Anderson, DM | 1 |
| Hu, SL | 1 |
| Morton, WR | 1 |
| Anderson, BD | 1 |
| Ho, RJ | 1 |
| Ramaswamy, S | 1 |
| McBride, JL | 1 |
| Kordower, JH | 1 |
| da Cunha, A | 1 |
| Eiden, LE | 1 |
| Rausch, DM | 1 |
| Misztal, M | 1 |
| Skangiel-Kramska, J | 1 |
| Niewiadomska, G | 1 |
| Danysz, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An MRI Ancillary Study of a Malaria Fever Randomized Controlled Trial (RCT)[NCT05746819] | 256 participants (Anticipated) | Observational | 2021-01-02 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for quinolinic acid and Disease Exacerbation
| Article | Year |
|---|---|
Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders.
Topics: Antidepressive Agents; Antioxidants; Biomarkers; Depression; Depressive Disorder; Disease Progressio | 2017 |
Differential regulation of neurotoxin in HIV clades: role of cocaine and methamphetamine.
Topics: Acquired Immunodeficiency Syndrome; AIDS Dementia Complex; Arachidonic Acid; Central Nervous System | 2012 |
Animal models of Huntington's disease.
Topics: Animals; Disease Models, Animal; Disease Progression; Genetic Vectors; Huntington Disease; Lentiviru | 2007 |
Neuronal substrates for SIV encephalopathy.
Topics: Animals; Astrocytes; Cognition Disorders; Disease Progression; Encephalitis, Viral; Gene Expression | 1994 |
1 trial available for quinolinic acid and Disease Exacerbation
| Article | Year |
|---|---|
Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria.
Topics: Adult; Child; Child, Preschool; Disease Progression; Humans; Kynurenine; Malaria, Cerebral; Malawi; | 2003 |
10 other studies available for quinolinic acid and Disease Exacerbation
| Article | Year |
|---|---|
Proposed biochemistry of Parkinson's and Alzheimer's diseases.
Topics: Aldehydes; Alzheimer Disease; Aspartic Acid; Betaine; Brain; Disease Progression; Humans; Kynurenine | 2017 |
Can IDO activity predict primary resistance to anti-PD-1 treatment in NSCLC?
Topics: Aged; Carcinoma, Non-Small-Cell Lung; Disease Progression; Drug Resistance, Neoplasm; Female; Humans | 2018 |
Serum xanthurenic acid levels: Reduced in subjects at ultra high risk for psychosis.
Topics: Adolescent; Adult; Disease Progression; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Ky | 2019 |
Systemic tryptophan and kynurenine catabolite levels relate to severity of rhinovirus-induced asthma exacerbation: a prospective study with a parallel-group design.
Topics: Adult; Asthma; Biomarkers; Breath Tests; Bronchoalveolar Lavage Fluid; Case-Control Studies; Cytokin | 2013 |
Kynurenine, quinolinic acid--the new factors linked to carotid atherosclerosis in patients with end-stage renal disease.
Topics: Adult; Age Factors; Biomarkers; C-Reactive Protein; Carotid Artery Diseases; Cross-Sectional Studies | 2009 |
Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease.
Topics: Animals; Brain; Brain Ischemia; Cells, Cultured; Dendritic Spines; Disease Models, Animal; Disease P | 2009 |
Reduced calcineurin protein levels and activity in exon-1 mouse models of Huntington's disease: role in excitotoxicity.
Topics: Adult; Aged; Animals; Brain; Brain-Derived Neurotrophic Factor; Calcineurin; Calcineurin Inhibitors; | 2009 |
Slowed progression in models of Huntington disease by adipose stem cell transplantation.
Topics: Adipocytes; Animals; Cell Line, Tumor; Cells, Cultured; Corpus Striatum; Culture Media, Conditioned; | 2009 |
HIV in central nervous system and behavioral development: an HIV-2287 macaque model of AIDS.
Topics: AIDS Dementia Complex; Analysis of Variance; Animals; Behavior, Animal; Cognition; Disease Progressi | 2004 |
Subchronic intraventricular infusion of quinolinic acid produces working memory impairment--a model of progressive excitotoxicity.
Topics: Alzheimer Disease; Animals; Cerebral Ventricles; Disease Models, Animal; Disease Progression; Drug A | 1996 |