Page last updated: 2024-10-20

quinolinic acid and Depression

quinolinic acid has been researched along with Depression in 28 studies

Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.

Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.

Research Excerpts

ExcerptRelevanceReference
" A series of metabolites of the pathway are neurologically active, among which kynerunic acid (KYNA) and quinolinic acid (QUIN) are molecules of great interest in recent studies on the mechanisms of inflammation-induced depression."9.12Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease. ( Bao, CH; Chen, LM; Huang, Y; Liang, SH; Liu, HR; Wang, D; Wu, HG; Wu, LY; Wu, Y, 2021)
"Abnormalities of the kynurenine (KYN) pathway may be implicated in the pathophysiology of depression."8.98Kynurenine pathway in depression: A systematic review and meta-analysis. ( Graff-Guerrero, A; Iwata, Y; Kubo, K; Mimura, M; Miyazaki, T; Moriguchi, S; Nakajima, S; Noda, Y; Ogyu, K; Omura, Y; Plitman, E; Tarumi, R; Tsugawa, S; Uchida, H; Wada, M, 2018)
"The aim of this paper is to elucidate the role of oxidative and nitrosative stress as well as the tryptophan catabolites pathway in the development of depression and the mechanism of action of antidepressant drugs, based on the available literature."8.95Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders. ( Czarny, P; Galecki, P; Sliwinski, T; Wigner, P, 2017)
"Here, we found the gut microbiota from healthy adolescent volunteers, first diagnosis patients of adolescent depression, and sertraline interveners after first diagnosis displayed significant difference, the relative abundance of Faecalibacterium, Roseburia, Collinsella, Blautia, Phascolarctobacterium, Lachnospiraceae-unclassified decreased in adolescent depressive patients, while restored after sertraline treatment."8.31Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in human and mice. ( Fan, Y; Gao, R; Liu, W; Wang, J; Wang, S; Wu, L; Xu, H; Xu, L; Yao, H; Yu, J; Yu, Z; Zhang, J; Zhang, L; Zhou, M, 2023)
"Kynurenine pathway, a neuroimmunological pathway plays a substantial role in depression."8.12Kynurenine monooxygenase inhibition and associated reduced quinolinic acid reverses depression-like behaviour by upregulating Nrf2/ARE pathway in mouse model of depression: In-vivo and In-silico studies. ( Bansal, Y; Bishnoi, M; Dhingra, N; Dhingra, R; Khare, P; Kondepudi, KK; Kuhad, A; Singh, R; Sodhi, RK, 2022)
"The results from this study suggest that alterations in the kynurenine pathway of tryptophan metabolism are associated with the presence of depression in the context of HIV infection."8.02Alterations in the Kynurenine Pathway of Tryptophan Metabolism Are Associated With Depression in People Living With HIV. ( Drivsholm, N; Faurholt-Jepsen, M; Gelpi, M; Kirkegaard-Klitbo, DM; Knudsen, AD; Midttun, Ø; Nielsen, SD; Trøseid, M; Ueland, PM, 2021)
"These data support the hypothesis that altered kynurenine metabolism may molecularly link sleep disturbance and depression."7.85Sleep disturbance and kynurenine metabolism in depression. ( Cho, HJ; Dantzer, R; Drevets, WC; Irwin, MR; Savitz, J; Teague, TK, 2017)
"Immunotherapy with the cytokine interferon-alpha (IFN-α) can induce symptoms of depression, and it is likely that the tryptophan-kynurenine pathway may be involved in this regard."7.81Interferon-alpha treatment induces depression-like behaviour accompanied by elevated hippocampal quinolinic acid levels in rats. ( Budac, DP; Elfving, B; Eskelund, A; Fischer, CW; Liebenberg, N; Tillmann, S; Wegener, G, 2015)
"The present study was to investigate the role of the quinolinic acid (QUIN) and its relationship with N-methyl-D-aspartic acid (NMDA) receptor and metabotropic glutamate receptor 1 (mGluR1) in depression induced by chronic unpredictable mild stress (CUMS) in hippocampus."7.79[Hippocampus quinolinic acid modulates glutamate and NMDAR/mGluR1 in chronic unpredictable mild stress-induced depression]. ( An, SC; Chen, HB; Li, F; Wu, S, 2013)
"Inflammation has an important physiological influence on mood and behavior."6.90Kynurenine metabolism and inflammation-induced depressed mood: A human experimental study. ( Cho, JH; Eisenberger, NI; Faull, K; Hwang, L; Irwin, MR; Kruse, JL; Olmstead, R, 2019)
"Considerable data relate major depressive disorder (MDD) with aberrant immune system functioning."5.72Peripheral and central kynurenine pathway abnormalities in major depression. ( Asratian, A; Boda, S; Dantzer, R; Erhardt, S; Hamilton, JP; Heilig, M; Holm, L; Kämpe, R; Paul, ER; Samuelsson, M; Schwieler, L; Trepci, A; Yngve, A, 2022)
"During IFN-α treatment Hamilton Depression Rating Scale scores rise significantly."5.42Quinolinic Acid Responses during Interferon-α-Induced Depressive Symptomatology in Patients with Chronic Hepatitis C Infection - A Novel Aspect for Depression and Inflammatory Hypothesis. ( Amouzadeh-Ghadikolai, O; Baranyi, A; Breitenecker, RJ; Meinitzer, A; Rothenhäusler, HB; Stauber, R, 2015)
" A series of metabolites of the pathway are neurologically active, among which kynerunic acid (KYNA) and quinolinic acid (QUIN) are molecules of great interest in recent studies on the mechanisms of inflammation-induced depression."5.12Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease. ( Bao, CH; Chen, LM; Huang, Y; Liang, SH; Liu, HR; Wang, D; Wu, HG; Wu, LY; Wu, Y, 2021)
"Abnormalities of the kynurenine (KYN) pathway may be implicated in the pathophysiology of depression."4.98Kynurenine pathway in depression: A systematic review and meta-analysis. ( Graff-Guerrero, A; Iwata, Y; Kubo, K; Mimura, M; Miyazaki, T; Moriguchi, S; Nakajima, S; Noda, Y; Ogyu, K; Omura, Y; Plitman, E; Tarumi, R; Tsugawa, S; Uchida, H; Wada, M, 2018)
"The aim of this paper is to elucidate the role of oxidative and nitrosative stress as well as the tryptophan catabolites pathway in the development of depression and the mechanism of action of antidepressant drugs, based on the available literature."4.95Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders. ( Czarny, P; Galecki, P; Sliwinski, T; Wigner, P, 2017)
"Here, we found the gut microbiota from healthy adolescent volunteers, first diagnosis patients of adolescent depression, and sertraline interveners after first diagnosis displayed significant difference, the relative abundance of Faecalibacterium, Roseburia, Collinsella, Blautia, Phascolarctobacterium, Lachnospiraceae-unclassified decreased in adolescent depressive patients, while restored after sertraline treatment."4.31Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in human and mice. ( Fan, Y; Gao, R; Liu, W; Wang, J; Wang, S; Wu, L; Xu, H; Xu, L; Yao, H; Yu, J; Yu, Z; Zhang, J; Zhang, L; Zhou, M, 2023)
"Kynurenine pathway, a neuroimmunological pathway plays a substantial role in depression."4.12Kynurenine monooxygenase inhibition and associated reduced quinolinic acid reverses depression-like behaviour by upregulating Nrf2/ARE pathway in mouse model of depression: In-vivo and In-silico studies. ( Bansal, Y; Bishnoi, M; Dhingra, N; Dhingra, R; Khare, P; Kondepudi, KK; Kuhad, A; Singh, R; Sodhi, RK, 2022)
"The results from this study suggest that alterations in the kynurenine pathway of tryptophan metabolism are associated with the presence of depression in the context of HIV infection."4.02Alterations in the Kynurenine Pathway of Tryptophan Metabolism Are Associated With Depression in People Living With HIV. ( Drivsholm, N; Faurholt-Jepsen, M; Gelpi, M; Kirkegaard-Klitbo, DM; Knudsen, AD; Midttun, Ø; Nielsen, SD; Trøseid, M; Ueland, PM, 2021)
" Evidence suggests that the kynurenine (KYN) pathway may be implicated in the pathophysiology of depression, but few studies have explored the association between the KYN pathway and cognitive impairment in MDD."3.91Cross-sectional relationship between kynurenine pathway metabolites and cognitive function in major depressive disorder. ( Chen, L; Li, H; Liu, W; Ning, Y; Wang, C; Zhan, Y; Zheng, W; Zhou, Y, 2019)
" These behavioral effects are associated with i/ a reversal of anxiety and reduced self-care, ii/ a decrease in parenchymal cytokine production, iii/ a modulation of the microglial reactivity and iv/ a decrease in microglial quinolinic acid production that is correlated with plasmatic peripheral production."3.91Microglial production of quinolinic acid as a target and a biomarker of the antidepressant effect of ketamine. ( Abdel-Ahad, P; Blatzer, M; Callebert, J; Chrétien, F; Danckaert, A; de Maricourt, P; De Medeiros, GF; Gaillard, R; Jouvion, G; Langeron, O; Launay, JM; Maignan, A; Petit, AC; Sharshar, T; Van Steenwinckel, J; Verdonk, F; Vinckier, F, 2019)
" Depression is hypothesized to be causally associated with an imbalance in the kynurenine pathway, with an increased metabolism down the 3-hydroxykynurenine (3HK) branch of the pathway leading to increased levels of the neurotoxic metabolite, quinolinic acid (QA), which is a putative N-methyl-d-aspartate (NMDA) receptor agonist."3.85Serum kynurenic acid is reduced in affective psychosis. ( Bliss, SA; Dantzer, R; Drevets, WC; Ford, BN; McMillin, JR; Morris, HM; Savitz, JB; Suzuki, H; Teague, TK; Wurfel, BE, 2017)
"These data support the hypothesis that altered kynurenine metabolism may molecularly link sleep disturbance and depression."3.85Sleep disturbance and kynurenine metabolism in depression. ( Cho, HJ; Dantzer, R; Drevets, WC; Irwin, MR; Savitz, J; Teague, TK, 2017)
"Immunotherapy with the cytokine interferon-alpha (IFN-α) can induce symptoms of depression, and it is likely that the tryptophan-kynurenine pathway may be involved in this regard."3.81Interferon-alpha treatment induces depression-like behaviour accompanied by elevated hippocampal quinolinic acid levels in rats. ( Budac, DP; Elfving, B; Eskelund, A; Fischer, CW; Liebenberg, N; Tillmann, S; Wegener, G, 2015)
"The present study was to investigate the role of the quinolinic acid (QUIN) and its relationship with N-methyl-D-aspartic acid (NMDA) receptor and metabotropic glutamate receptor 1 (mGluR1) in depression induced by chronic unpredictable mild stress (CUMS) in hippocampus."3.79[Hippocampus quinolinic acid modulates glutamate and NMDAR/mGluR1 in chronic unpredictable mild stress-induced depression]. ( An, SC; Chen, HB; Li, F; Wu, S, 2013)
"Inflammation has an important physiological influence on mood and behavior."2.90Kynurenine metabolism and inflammation-induced depressed mood: A human experimental study. ( Cho, JH; Eisenberger, NI; Faull, K; Hwang, L; Irwin, MR; Kruse, JL; Olmstead, R, 2019)
"Considerable data relate major depressive disorder (MDD) with aberrant immune system functioning."1.72Peripheral and central kynurenine pathway abnormalities in major depression. ( Asratian, A; Boda, S; Dantzer, R; Erhardt, S; Hamilton, JP; Heilig, M; Holm, L; Kämpe, R; Paul, ER; Samuelsson, M; Schwieler, L; Trepci, A; Yngve, A, 2022)
"During IFN-α treatment Hamilton Depression Rating Scale scores rise significantly."1.42Quinolinic Acid Responses during Interferon-α-Induced Depressive Symptomatology in Patients with Chronic Hepatitis C Infection - A Novel Aspect for Depression and Inflammatory Hypothesis. ( Amouzadeh-Ghadikolai, O; Baranyi, A; Breitenecker, RJ; Meinitzer, A; Rothenhäusler, HB; Stauber, R, 2015)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's19 (67.86)24.3611
2020's9 (32.14)2.80

Authors

AuthorsStudies
Paul, ER1
Schwieler, L1
Erhardt, S1
Boda, S1
Trepci, A1
Kämpe, R1
Asratian, A1
Holm, L1
Yngve, A1
Dantzer, R4
Heilig, M1
Hamilton, JP1
Samuelsson, M1
Kumar Arora, M1
Ratra, A1
Asdaq, SMB1
Alshamrani, AA1
Alsalman, AJ1
Kamal, M1
Tomar, R1
Sahoo, J1
Ashok, J1
Imran, M1
Bansal, Y1
Singh, R1
Sodhi, RK1
Khare, P1
Dhingra, R1
Dhingra, N1
Bishnoi, M1
Kondepudi, KK1
Kuhad, A1
de Arruda, CM1
Doneda, DL1
de Oliveira, VV1
da Silva, RAL1
de Matos, YAV1
Fernandes, IL1
Rohden, CAH1
Viola, GG1
Rios-Santos, F1
de Lima, E1
da Silva Buss, Z1
Vandresen-Filho, S1
Zhou, M1
Fan, Y1
Xu, L1
Yu, Z1
Wang, S1
Xu, H1
Zhang, J1
Zhang, L1
Liu, W2
Wu, L1
Yu, J1
Yao, H1
Wang, J2
Gao, R1
Ou, W1
Chen, Y1
Ju, Y1
Ma, M1
Qin, Y1
Bi, Y1
Liao, M1
Liu, B1
Liu, J1
Zhang, Y1
Li, L1
Drivsholm, N1
Knudsen, AD1
Faurholt-Jepsen, M1
Midttun, Ø1
Trøseid, M1
Kirkegaard-Klitbo, DM1
Ueland, PM1
Nielsen, SD1
Gelpi, M1
Chen, LM1
Bao, CH1
Wu, Y1
Liang, SH1
Wang, D1
Wu, LY1
Huang, Y1
Liu, HR1
Wu, HG1
Savitz, J2
Ford, BN2
Yeh, HW1
Akeman, E1
Cosgrove, K1
Clausen, AN1
Martell, C1
Kirlic, N1
Santiago, J1
Teague, TK3
Irwin, MR3
Paulus, MP1
Aupperle, RL1
Wurfel, BE1
Drevets, WC2
Bliss, SA1
McMillin, JR1
Suzuki, H1
Morris, HM1
Savitz, JB1
Cho, HJ1
Wigner, P1
Czarny, P1
Galecki, P1
Sliwinski, T1
Li, X1
He, S1
Hu, L1
Guo, J1
Huang, X1
Hu, J1
Qi, Y1
Chen, B1
Shang, D1
Wen, Y1
Duan, KM1
Ma, JH1
Wang, SY1
Huang, Z1
Zhou, Y2
Yu, H1
Ogyu, K1
Kubo, K1
Noda, Y1
Iwata, Y1
Tsugawa, S1
Omura, Y1
Wada, M1
Tarumi, R1
Plitman, E1
Moriguchi, S1
Miyazaki, T1
Uchida, H1
Graff-Guerrero, A1
Mimura, M1
Nakajima, S1
Elmer, GI1
Palacorolla, H1
Mayo, CL1
Brown, PL1
Jhou, TC1
Brady, D1
Shepard, PD1
Ramírez, LA1
Pérez-Padilla, EA1
García-Oscos, F1
Salgado, H1
Atzori, M1
Pineda, JC1
Zheng, W1
Wang, C1
Zhan, Y1
Li, H1
Chen, L1
Ning, Y1
Verdonk, F1
Petit, AC1
Abdel-Ahad, P1
Vinckier, F1
Jouvion, G1
de Maricourt, P1
De Medeiros, GF1
Danckaert, A1
Van Steenwinckel, J1
Blatzer, M1
Maignan, A1
Langeron, O1
Sharshar, T1
Callebert, J1
Launay, JM1
Chrétien, F1
Gaillard, R1
Kruse, JL1
Cho, JH1
Olmstead, R1
Hwang, L1
Faull, K1
Eisenberger, NI1
Chen, HB1
Li, F1
Wu, S1
An, SC1
Busse, M1
Busse, S1
Myint, AM1
Gos, T1
Dobrowolny, H1
Müller, UJ1
Bogerts, B1
Bernstein, HG1
Steiner, J1
Fischer, CW1
Eskelund, A1
Budac, DP1
Tillmann, S1
Liebenberg, N1
Elfving, B1
Wegener, G1
Baranyi, A1
Meinitzer, A1
Breitenecker, RJ1
Amouzadeh-Ghadikolai, O1
Stauber, R1
Rothenhäusler, HB1
Buras, A1
Waszkiewicz, N1
Szulc, A1
Birner, A1
Platzer, M1
Bengesser, SA1
Dalkner, N1
Fellendorf, FT1
Queissner, R1
Pilz, R1
Rauch, P1
Maget, A1
Hamm, C1
Herzog-Eberhard, S1
Mangge, H1
Fuchs, D1
Moll, N1
Zelzer, S1
Schütze, G1
Schwarz, M1
Reininghaus, B1
Kapfhammer, HP1
Reininghaus, EZ1
Raison, CL1
Kelley, KW1
Lawson, MA1
Woolwine, BJ1
Vogt, G1
Spivey, JR1
Saito, K1
Miller, AH1
Möller, M1
Du Preez, JL1
Harvey, BH1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Prediction of the Therapeutic Response in Depression Based on an Early Neuro-computational Modeling Assessment of Motivation[NCT05866575]136 participants (Anticipated)Interventional2023-06-01Not yet recruiting
Kynurenine Pathway Metabolites as Novel Translational Biological Markers of Irritable Bowel Syndrome: Relationship to Gastrointestinal Function, Cognition and Co-morbid Depression[NCT01304355]85 participants (Anticipated)Observational2011-01-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for quinolinic acid and Depression

ArticleYear
The kynurenine pathway in major depressive disorder under different disease states: A systematic review and meta-analysis.
    Journal of affective disorders, 2023, 10-15, Volume: 339

    Topics: Biomarkers; Depression; Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Quinolinic A

2023
Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease.
    Journal of neuroinflammation, 2021, Jun-14, Volume: 18, Issue:1

    Topics: Animals; Brain-Gut Axis; Depression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Inf

2021
Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders.
    Psychiatria Danubina, 2017, Volume: 29, Issue:4

    Topics: Antidepressive Agents; Antioxidants; Biomarkers; Depression; Depressive Disorder; Disease Progressio

2017
The role of tryptophan metabolism in postpartum depression.
    Metabolic brain disease, 2018, Volume: 33, Issue:3

    Topics: Depression; Depression, Postpartum; Depressive Disorder, Major; Female; Humans; Kynurenine; Quinolin

2018
Kynurenine pathway in depression: A systematic review and meta-analysis.
    Neuroscience and biobehavioral reviews, 2018, Volume: 90

    Topics: Brain; Depression; Depressive Disorder; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid

2018
A new theory of depression based on the serotonin/kynurenine relationship and the hypothalamicpituitary- adrenal axis
    Biomedica : revista del Instituto Nacional de Salud, 2018, 09-01, Volume: 38, Issue:3

    Topics: Animals; Bacterial Infections; Brain; Cytokines; Depression; Humans; Hypothalamo-Hypophyseal System;

2018
[Depression and inflammation in rheumatic diseases].
    Postepy higieny i medycyny doswiadczalnej (Online), 2016, Mar-04, Volume: 70

    Topics: Cytokines; Depression; Humans; Hypothalamo-Hypophyseal System; Indoleamine-Pyrrole 2,3,-Dioxygenase;

2016

Trials

1 trial available for quinolinic acid and Depression

ArticleYear
Kynurenine metabolism and inflammation-induced depressed mood: A human experimental study.
    Psychoneuroendocrinology, 2019, Volume: 109

    Topics: Adult; Affect; Cytokines; Depression; Endotoxins; Female; Humans; Inflammation; Interleukin-6; Kynur

2019

Other Studies

20 other studies available for quinolinic acid and Depression

ArticleYear
Peripheral and central kynurenine pathway abnormalities in major depression.
    Brain, behavior, and immunity, 2022, Volume: 101

    Topics: Depression; Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid

2022
Plumbagin Alleviates Intracerebroventricular-Quinolinic Acid Induced Depression-like Behavior and Memory Deficits in Wistar Rats.
    Molecules (Basel, Switzerland), 2022, Mar-11, Volume: 27, Issue:6

    Topics: Animals; Behavior, Animal; Depression; Male; Memory Disorders; Naphthoquinones; Oxidative Stress; Qu

2022
Kynurenine monooxygenase inhibition and associated reduced quinolinic acid reverses depression-like behaviour by upregulating Nrf2/ARE pathway in mouse model of depression: In-vivo and In-silico studies.
    Neuropharmacology, 2022, 09-01, Volume: 215

    Topics: Animals; Antioxidants; Depression; Depressive Disorder, Major; Disease Models, Animal; Humans; Kelch

2022
Involvement of kynurenine pathway and N-methyl-d-aspartate receptors in the antidepressant-like effect of vilazodone in the tail suspension test in mice.
    Pharmacology, biochemistry, and behavior, 2022, Volume: 218

    Topics: Animals; Antidepressive Agents; Depression; Hindlimb Suspension; Ketamine; Kynurenine; Mice; Quinoli

2022
Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in human and mice.
    Microbiome, 2023, 06-30, Volume: 11, Issue:1

    Topics: Adolescent; Animals; Coleoptera; Depression; Gastrointestinal Microbiome; Humans; Kynurenine; Metabo

2023
Alterations in the Kynurenine Pathway of Tryptophan Metabolism Are Associated With Depression in People Living With HIV.
    Journal of acquired immune deficiency syndromes (1999), 2021, 06-01, Volume: 87, Issue:2

    Topics: Antidepressive Agents; Comorbidity; Depression; Female; HIV Infections; Humans; Kynurenine; Male; Mi

2021
Behavioral activation therapy for depression is associated with a reduction in the concentration of circulating quinolinic acid - Erratum.
    Psychological medicine, 2022, Volume: 52, Issue:13

    Topics: Depression; Humans; Oxidative Stress; Quinolinic Acid

2022
Serum kynurenic acid is reduced in affective psychosis.
    Translational psychiatry, 2017, 05-02, Volume: 7, Issue:5

    Topics: Adult; Affective Disorders, Psychotic; Bipolar Disorder; Corpus Striatum; Cytokines; Depression; Dep

2017
Sleep disturbance and kynurenine metabolism in depression.
    Journal of psychosomatic research, 2017, Volume: 99

    Topics: Adult; Depression; Female; Humans; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Sleep Wake Dis

2017
Regulation of the kynurenine metabolism pathway by Xiaoyao San and the underlying effect in the hippocampus of the depressed rat.
    Journal of ethnopharmacology, 2018, Mar-25, Volume: 214

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cyclic AMP Resp

2018
The rostromedial tegmental nucleus modulates the development of stress-induced helpless behavior.
    Behavioural brain research, 2019, 02-01, Volume: 359

    Topics: Animals; Depression; Disease Models, Animal; Electric Stimulation; Electroshock; Habenula; Helplessn

2019
Cross-sectional relationship between kynurenine pathway metabolites and cognitive function in major depressive disorder.
    Psychoneuroendocrinology, 2019, Volume: 101

    Topics: Adult; Chromatography, Liquid; Cognition; Cross-Sectional Studies; Depression; Depressive Disorder,

2019
Microglial production of quinolinic acid as a target and a biomarker of the antidepressant effect of ketamine.
    Brain, behavior, and immunity, 2019, Volume: 81

    Topics: Animals; Antidepressive Agents; Anxiety; Anxiety Disorders; Biomarkers, Pharmacological; Depression;

2019
[Hippocampus quinolinic acid modulates glutamate and NMDAR/mGluR1 in chronic unpredictable mild stress-induced depression].
    Sheng li xue bao : [Acta physiologica Sinica], 2013, Dec-25, Volume: 65, Issue:6

    Topics: Animals; Behavior, Animal; Depression; Dizocilpine Maleate; Glutamic Acid; Hippocampus; Quinolinic A

2013
Decreased quinolinic acid in the hippocampus of depressive patients: evidence for local anti-inflammatory and neuroprotective responses?
    European archives of psychiatry and clinical neuroscience, 2015, Volume: 265, Issue:4

    Topics: Adult; Antidepressive Agents; Case-Control Studies; Depression; Female; Hippocampus; Humans; Magneti

2015
Interferon-alpha treatment induces depression-like behaviour accompanied by elevated hippocampal quinolinic acid levels in rats.
    Behavioural brain research, 2015, Oct-15, Volume: 293

    Topics: Animals; Antidepressive Agents; Chromatography, Liquid; Depression; Dose-Response Relationship, Drug

2015
Quinolinic Acid Responses during Interferon-α-Induced Depressive Symptomatology in Patients with Chronic Hepatitis C Infection - A Novel Aspect for Depression and Inflammatory Hypothesis.
    PloS one, 2015, Volume: 10, Issue:9

    Topics: Adult; Antiviral Agents; Depression; Female; Hepatitis C, Chronic; Humans; Interferon-alpha; Kynuren

2015
Increased breakdown of kynurenine towards its neurotoxic branch in bipolar disorder.
    PloS one, 2017, Volume: 12, Issue:2

    Topics: Adult; Bipolar Disorder; Brain; Case-Control Studies; Cognition; Depression; Female; Humans; Inflamm

2017
CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression.
    Molecular psychiatry, 2010, Volume: 15, Issue:4

    Topics: Adult; Antiviral Agents; Chemokine CCL2; Chromatography, High Pressure Liquid; Cytokines; Depression

2010
Development and validation of a single analytical method for the determination of tryptophan, and its kynurenine metabolites in rat plasma.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012, Jun-01, Volume: 898

    Topics: 3-Hydroxyanthranilic Acid; Animals; Charcoal; Chromatography, High Pressure Liquid; Depression; Kynu

2012