quinolinic acid has been researched along with Depression in 28 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| " A series of metabolites of the pathway are neurologically active, among which kynerunic acid (KYNA) and quinolinic acid (QUIN) are molecules of great interest in recent studies on the mechanisms of inflammation-induced depression." | 9.12 | Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease. ( Bao, CH; Chen, LM; Huang, Y; Liang, SH; Liu, HR; Wang, D; Wu, HG; Wu, LY; Wu, Y, 2021) |
| "Abnormalities of the kynurenine (KYN) pathway may be implicated in the pathophysiology of depression." | 8.98 | Kynurenine pathway in depression: A systematic review and meta-analysis. ( Graff-Guerrero, A; Iwata, Y; Kubo, K; Mimura, M; Miyazaki, T; Moriguchi, S; Nakajima, S; Noda, Y; Ogyu, K; Omura, Y; Plitman, E; Tarumi, R; Tsugawa, S; Uchida, H; Wada, M, 2018) |
| "The aim of this paper is to elucidate the role of oxidative and nitrosative stress as well as the tryptophan catabolites pathway in the development of depression and the mechanism of action of antidepressant drugs, based on the available literature." | 8.95 | Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders. ( Czarny, P; Galecki, P; Sliwinski, T; Wigner, P, 2017) |
| "Here, we found the gut microbiota from healthy adolescent volunteers, first diagnosis patients of adolescent depression, and sertraline interveners after first diagnosis displayed significant difference, the relative abundance of Faecalibacterium, Roseburia, Collinsella, Blautia, Phascolarctobacterium, Lachnospiraceae-unclassified decreased in adolescent depressive patients, while restored after sertraline treatment." | 8.31 | Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in human and mice. ( Fan, Y; Gao, R; Liu, W; Wang, J; Wang, S; Wu, L; Xu, H; Xu, L; Yao, H; Yu, J; Yu, Z; Zhang, J; Zhang, L; Zhou, M, 2023) |
| "Kynurenine pathway, a neuroimmunological pathway plays a substantial role in depression." | 8.12 | Kynurenine monooxygenase inhibition and associated reduced quinolinic acid reverses depression-like behaviour by upregulating Nrf2/ARE pathway in mouse model of depression: In-vivo and In-silico studies. ( Bansal, Y; Bishnoi, M; Dhingra, N; Dhingra, R; Khare, P; Kondepudi, KK; Kuhad, A; Singh, R; Sodhi, RK, 2022) |
| "The results from this study suggest that alterations in the kynurenine pathway of tryptophan metabolism are associated with the presence of depression in the context of HIV infection." | 8.02 | Alterations in the Kynurenine Pathway of Tryptophan Metabolism Are Associated With Depression in People Living With HIV. ( Drivsholm, N; Faurholt-Jepsen, M; Gelpi, M; Kirkegaard-Klitbo, DM; Knudsen, AD; Midttun, Ø; Nielsen, SD; Trøseid, M; Ueland, PM, 2021) |
| "These data support the hypothesis that altered kynurenine metabolism may molecularly link sleep disturbance and depression." | 7.85 | Sleep disturbance and kynurenine metabolism in depression. ( Cho, HJ; Dantzer, R; Drevets, WC; Irwin, MR; Savitz, J; Teague, TK, 2017) |
| "Immunotherapy with the cytokine interferon-alpha (IFN-α) can induce symptoms of depression, and it is likely that the tryptophan-kynurenine pathway may be involved in this regard." | 7.81 | Interferon-alpha treatment induces depression-like behaviour accompanied by elevated hippocampal quinolinic acid levels in rats. ( Budac, DP; Elfving, B; Eskelund, A; Fischer, CW; Liebenberg, N; Tillmann, S; Wegener, G, 2015) |
| "The present study was to investigate the role of the quinolinic acid (QUIN) and its relationship with N-methyl-D-aspartic acid (NMDA) receptor and metabotropic glutamate receptor 1 (mGluR1) in depression induced by chronic unpredictable mild stress (CUMS) in hippocampus." | 7.79 | [Hippocampus quinolinic acid modulates glutamate and NMDAR/mGluR1 in chronic unpredictable mild stress-induced depression]. ( An, SC; Chen, HB; Li, F; Wu, S, 2013) |
| "Inflammation has an important physiological influence on mood and behavior." | 6.90 | Kynurenine metabolism and inflammation-induced depressed mood: A human experimental study. ( Cho, JH; Eisenberger, NI; Faull, K; Hwang, L; Irwin, MR; Kruse, JL; Olmstead, R, 2019) |
| "Considerable data relate major depressive disorder (MDD) with aberrant immune system functioning." | 5.72 | Peripheral and central kynurenine pathway abnormalities in major depression. ( Asratian, A; Boda, S; Dantzer, R; Erhardt, S; Hamilton, JP; Heilig, M; Holm, L; Kämpe, R; Paul, ER; Samuelsson, M; Schwieler, L; Trepci, A; Yngve, A, 2022) |
| "During IFN-α treatment Hamilton Depression Rating Scale scores rise significantly." | 5.42 | Quinolinic Acid Responses during Interferon-α-Induced Depressive Symptomatology in Patients with Chronic Hepatitis C Infection - A Novel Aspect for Depression and Inflammatory Hypothesis. ( Amouzadeh-Ghadikolai, O; Baranyi, A; Breitenecker, RJ; Meinitzer, A; Rothenhäusler, HB; Stauber, R, 2015) |
| " A series of metabolites of the pathway are neurologically active, among which kynerunic acid (KYNA) and quinolinic acid (QUIN) are molecules of great interest in recent studies on the mechanisms of inflammation-induced depression." | 5.12 | Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease. ( Bao, CH; Chen, LM; Huang, Y; Liang, SH; Liu, HR; Wang, D; Wu, HG; Wu, LY; Wu, Y, 2021) |
| "Abnormalities of the kynurenine (KYN) pathway may be implicated in the pathophysiology of depression." | 4.98 | Kynurenine pathway in depression: A systematic review and meta-analysis. ( Graff-Guerrero, A; Iwata, Y; Kubo, K; Mimura, M; Miyazaki, T; Moriguchi, S; Nakajima, S; Noda, Y; Ogyu, K; Omura, Y; Plitman, E; Tarumi, R; Tsugawa, S; Uchida, H; Wada, M, 2018) |
| "The aim of this paper is to elucidate the role of oxidative and nitrosative stress as well as the tryptophan catabolites pathway in the development of depression and the mechanism of action of antidepressant drugs, based on the available literature." | 4.95 | Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders. ( Czarny, P; Galecki, P; Sliwinski, T; Wigner, P, 2017) |
| "Here, we found the gut microbiota from healthy adolescent volunteers, first diagnosis patients of adolescent depression, and sertraline interveners after first diagnosis displayed significant difference, the relative abundance of Faecalibacterium, Roseburia, Collinsella, Blautia, Phascolarctobacterium, Lachnospiraceae-unclassified decreased in adolescent depressive patients, while restored after sertraline treatment." | 4.31 | Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in human and mice. ( Fan, Y; Gao, R; Liu, W; Wang, J; Wang, S; Wu, L; Xu, H; Xu, L; Yao, H; Yu, J; Yu, Z; Zhang, J; Zhang, L; Zhou, M, 2023) |
| "Kynurenine pathway, a neuroimmunological pathway plays a substantial role in depression." | 4.12 | Kynurenine monooxygenase inhibition and associated reduced quinolinic acid reverses depression-like behaviour by upregulating Nrf2/ARE pathway in mouse model of depression: In-vivo and In-silico studies. ( Bansal, Y; Bishnoi, M; Dhingra, N; Dhingra, R; Khare, P; Kondepudi, KK; Kuhad, A; Singh, R; Sodhi, RK, 2022) |
| "The results from this study suggest that alterations in the kynurenine pathway of tryptophan metabolism are associated with the presence of depression in the context of HIV infection." | 4.02 | Alterations in the Kynurenine Pathway of Tryptophan Metabolism Are Associated With Depression in People Living With HIV. ( Drivsholm, N; Faurholt-Jepsen, M; Gelpi, M; Kirkegaard-Klitbo, DM; Knudsen, AD; Midttun, Ø; Nielsen, SD; Trøseid, M; Ueland, PM, 2021) |
| " Evidence suggests that the kynurenine (KYN) pathway may be implicated in the pathophysiology of depression, but few studies have explored the association between the KYN pathway and cognitive impairment in MDD." | 3.91 | Cross-sectional relationship between kynurenine pathway metabolites and cognitive function in major depressive disorder. ( Chen, L; Li, H; Liu, W; Ning, Y; Wang, C; Zhan, Y; Zheng, W; Zhou, Y, 2019) |
| " These behavioral effects are associated with i/ a reversal of anxiety and reduced self-care, ii/ a decrease in parenchymal cytokine production, iii/ a modulation of the microglial reactivity and iv/ a decrease in microglial quinolinic acid production that is correlated with plasmatic peripheral production." | 3.91 | Microglial production of quinolinic acid as a target and a biomarker of the antidepressant effect of ketamine. ( Abdel-Ahad, P; Blatzer, M; Callebert, J; Chrétien, F; Danckaert, A; de Maricourt, P; De Medeiros, GF; Gaillard, R; Jouvion, G; Langeron, O; Launay, JM; Maignan, A; Petit, AC; Sharshar, T; Van Steenwinckel, J; Verdonk, F; Vinckier, F, 2019) |
| " Depression is hypothesized to be causally associated with an imbalance in the kynurenine pathway, with an increased metabolism down the 3-hydroxykynurenine (3HK) branch of the pathway leading to increased levels of the neurotoxic metabolite, quinolinic acid (QA), which is a putative N-methyl-d-aspartate (NMDA) receptor agonist." | 3.85 | Serum kynurenic acid is reduced in affective psychosis. ( Bliss, SA; Dantzer, R; Drevets, WC; Ford, BN; McMillin, JR; Morris, HM; Savitz, JB; Suzuki, H; Teague, TK; Wurfel, BE, 2017) |
| "These data support the hypothesis that altered kynurenine metabolism may molecularly link sleep disturbance and depression." | 3.85 | Sleep disturbance and kynurenine metabolism in depression. ( Cho, HJ; Dantzer, R; Drevets, WC; Irwin, MR; Savitz, J; Teague, TK, 2017) |
| "Immunotherapy with the cytokine interferon-alpha (IFN-α) can induce symptoms of depression, and it is likely that the tryptophan-kynurenine pathway may be involved in this regard." | 3.81 | Interferon-alpha treatment induces depression-like behaviour accompanied by elevated hippocampal quinolinic acid levels in rats. ( Budac, DP; Elfving, B; Eskelund, A; Fischer, CW; Liebenberg, N; Tillmann, S; Wegener, G, 2015) |
| "The present study was to investigate the role of the quinolinic acid (QUIN) and its relationship with N-methyl-D-aspartic acid (NMDA) receptor and metabotropic glutamate receptor 1 (mGluR1) in depression induced by chronic unpredictable mild stress (CUMS) in hippocampus." | 3.79 | [Hippocampus quinolinic acid modulates glutamate and NMDAR/mGluR1 in chronic unpredictable mild stress-induced depression]. ( An, SC; Chen, HB; Li, F; Wu, S, 2013) |
| "Inflammation has an important physiological influence on mood and behavior." | 2.90 | Kynurenine metabolism and inflammation-induced depressed mood: A human experimental study. ( Cho, JH; Eisenberger, NI; Faull, K; Hwang, L; Irwin, MR; Kruse, JL; Olmstead, R, 2019) |
| "Considerable data relate major depressive disorder (MDD) with aberrant immune system functioning." | 1.72 | Peripheral and central kynurenine pathway abnormalities in major depression. ( Asratian, A; Boda, S; Dantzer, R; Erhardt, S; Hamilton, JP; Heilig, M; Holm, L; Kämpe, R; Paul, ER; Samuelsson, M; Schwieler, L; Trepci, A; Yngve, A, 2022) |
| "During IFN-α treatment Hamilton Depression Rating Scale scores rise significantly." | 1.42 | Quinolinic Acid Responses during Interferon-α-Induced Depressive Symptomatology in Patients with Chronic Hepatitis C Infection - A Novel Aspect for Depression and Inflammatory Hypothesis. ( Amouzadeh-Ghadikolai, O; Baranyi, A; Breitenecker, RJ; Meinitzer, A; Rothenhäusler, HB; Stauber, R, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 19 (67.86) | 24.3611 |
| 2020's | 9 (32.14) | 2.80 |
| Authors | Studies |
|---|---|
| Paul, ER | 1 |
| Schwieler, L | 1 |
| Erhardt, S | 1 |
| Boda, S | 1 |
| Trepci, A | 1 |
| Kämpe, R | 1 |
| Asratian, A | 1 |
| Holm, L | 1 |
| Yngve, A | 1 |
| Dantzer, R | 4 |
| Heilig, M | 1 |
| Hamilton, JP | 1 |
| Samuelsson, M | 1 |
| Kumar Arora, M | 1 |
| Ratra, A | 1 |
| Asdaq, SMB | 1 |
| Alshamrani, AA | 1 |
| Alsalman, AJ | 1 |
| Kamal, M | 1 |
| Tomar, R | 1 |
| Sahoo, J | 1 |
| Ashok, J | 1 |
| Imran, M | 1 |
| Bansal, Y | 1 |
| Singh, R | 1 |
| Sodhi, RK | 1 |
| Khare, P | 1 |
| Dhingra, R | 1 |
| Dhingra, N | 1 |
| Bishnoi, M | 1 |
| Kondepudi, KK | 1 |
| Kuhad, A | 1 |
| de Arruda, CM | 1 |
| Doneda, DL | 1 |
| de Oliveira, VV | 1 |
| da Silva, RAL | 1 |
| de Matos, YAV | 1 |
| Fernandes, IL | 1 |
| Rohden, CAH | 1 |
| Viola, GG | 1 |
| Rios-Santos, F | 1 |
| de Lima, E | 1 |
| da Silva Buss, Z | 1 |
| Vandresen-Filho, S | 1 |
| Zhou, M | 1 |
| Fan, Y | 1 |
| Xu, L | 1 |
| Yu, Z | 1 |
| Wang, S | 1 |
| Xu, H | 1 |
| Zhang, J | 1 |
| Zhang, L | 1 |
| Liu, W | 2 |
| Wu, L | 1 |
| Yu, J | 1 |
| Yao, H | 1 |
| Wang, J | 2 |
| Gao, R | 1 |
| Ou, W | 1 |
| Chen, Y | 1 |
| Ju, Y | 1 |
| Ma, M | 1 |
| Qin, Y | 1 |
| Bi, Y | 1 |
| Liao, M | 1 |
| Liu, B | 1 |
| Liu, J | 1 |
| Zhang, Y | 1 |
| Li, L | 1 |
| Drivsholm, N | 1 |
| Knudsen, AD | 1 |
| Faurholt-Jepsen, M | 1 |
| Midttun, Ø | 1 |
| Trøseid, M | 1 |
| Kirkegaard-Klitbo, DM | 1 |
| Ueland, PM | 1 |
| Nielsen, SD | 1 |
| Gelpi, M | 1 |
| Chen, LM | 1 |
| Bao, CH | 1 |
| Wu, Y | 1 |
| Liang, SH | 1 |
| Wang, D | 1 |
| Wu, LY | 1 |
| Huang, Y | 1 |
| Liu, HR | 1 |
| Wu, HG | 1 |
| Savitz, J | 2 |
| Ford, BN | 2 |
| Yeh, HW | 1 |
| Akeman, E | 1 |
| Cosgrove, K | 1 |
| Clausen, AN | 1 |
| Martell, C | 1 |
| Kirlic, N | 1 |
| Santiago, J | 1 |
| Teague, TK | 3 |
| Irwin, MR | 3 |
| Paulus, MP | 1 |
| Aupperle, RL | 1 |
| Wurfel, BE | 1 |
| Drevets, WC | 2 |
| Bliss, SA | 1 |
| McMillin, JR | 1 |
| Suzuki, H | 1 |
| Morris, HM | 1 |
| Savitz, JB | 1 |
| Cho, HJ | 1 |
| Wigner, P | 1 |
| Czarny, P | 1 |
| Galecki, P | 1 |
| Sliwinski, T | 1 |
| Li, X | 1 |
| He, S | 1 |
| Hu, L | 1 |
| Guo, J | 1 |
| Huang, X | 1 |
| Hu, J | 1 |
| Qi, Y | 1 |
| Chen, B | 1 |
| Shang, D | 1 |
| Wen, Y | 1 |
| Duan, KM | 1 |
| Ma, JH | 1 |
| Wang, SY | 1 |
| Huang, Z | 1 |
| Zhou, Y | 2 |
| Yu, H | 1 |
| Ogyu, K | 1 |
| Kubo, K | 1 |
| Noda, Y | 1 |
| Iwata, Y | 1 |
| Tsugawa, S | 1 |
| Omura, Y | 1 |
| Wada, M | 1 |
| Tarumi, R | 1 |
| Plitman, E | 1 |
| Moriguchi, S | 1 |
| Miyazaki, T | 1 |
| Uchida, H | 1 |
| Graff-Guerrero, A | 1 |
| Mimura, M | 1 |
| Nakajima, S | 1 |
| Elmer, GI | 1 |
| Palacorolla, H | 1 |
| Mayo, CL | 1 |
| Brown, PL | 1 |
| Jhou, TC | 1 |
| Brady, D | 1 |
| Shepard, PD | 1 |
| Ramírez, LA | 1 |
| Pérez-Padilla, EA | 1 |
| García-Oscos, F | 1 |
| Salgado, H | 1 |
| Atzori, M | 1 |
| Pineda, JC | 1 |
| Zheng, W | 1 |
| Wang, C | 1 |
| Zhan, Y | 1 |
| Li, H | 1 |
| Chen, L | 1 |
| Ning, Y | 1 |
| Verdonk, F | 1 |
| Petit, AC | 1 |
| Abdel-Ahad, P | 1 |
| Vinckier, F | 1 |
| Jouvion, G | 1 |
| de Maricourt, P | 1 |
| De Medeiros, GF | 1 |
| Danckaert, A | 1 |
| Van Steenwinckel, J | 1 |
| Blatzer, M | 1 |
| Maignan, A | 1 |
| Langeron, O | 1 |
| Sharshar, T | 1 |
| Callebert, J | 1 |
| Launay, JM | 1 |
| Chrétien, F | 1 |
| Gaillard, R | 1 |
| Kruse, JL | 1 |
| Cho, JH | 1 |
| Olmstead, R | 1 |
| Hwang, L | 1 |
| Faull, K | 1 |
| Eisenberger, NI | 1 |
| Chen, HB | 1 |
| Li, F | 1 |
| Wu, S | 1 |
| An, SC | 1 |
| Busse, M | 1 |
| Busse, S | 1 |
| Myint, AM | 1 |
| Gos, T | 1 |
| Dobrowolny, H | 1 |
| Müller, UJ | 1 |
| Bogerts, B | 1 |
| Bernstein, HG | 1 |
| Steiner, J | 1 |
| Fischer, CW | 1 |
| Eskelund, A | 1 |
| Budac, DP | 1 |
| Tillmann, S | 1 |
| Liebenberg, N | 1 |
| Elfving, B | 1 |
| Wegener, G | 1 |
| Baranyi, A | 1 |
| Meinitzer, A | 1 |
| Breitenecker, RJ | 1 |
| Amouzadeh-Ghadikolai, O | 1 |
| Stauber, R | 1 |
| Rothenhäusler, HB | 1 |
| Buras, A | 1 |
| Waszkiewicz, N | 1 |
| Szulc, A | 1 |
| Birner, A | 1 |
| Platzer, M | 1 |
| Bengesser, SA | 1 |
| Dalkner, N | 1 |
| Fellendorf, FT | 1 |
| Queissner, R | 1 |
| Pilz, R | 1 |
| Rauch, P | 1 |
| Maget, A | 1 |
| Hamm, C | 1 |
| Herzog-Eberhard, S | 1 |
| Mangge, H | 1 |
| Fuchs, D | 1 |
| Moll, N | 1 |
| Zelzer, S | 1 |
| Schütze, G | 1 |
| Schwarz, M | 1 |
| Reininghaus, B | 1 |
| Kapfhammer, HP | 1 |
| Reininghaus, EZ | 1 |
| Raison, CL | 1 |
| Kelley, KW | 1 |
| Lawson, MA | 1 |
| Woolwine, BJ | 1 |
| Vogt, G | 1 |
| Spivey, JR | 1 |
| Saito, K | 1 |
| Miller, AH | 1 |
| Möller, M | 1 |
| Du Preez, JL | 1 |
| Harvey, BH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prediction of the Therapeutic Response in Depression Based on an Early Neuro-computational Modeling Assessment of Motivation[NCT05866575] | 136 participants (Anticipated) | Interventional | 2023-06-01 | Not yet recruiting | |||
| Kynurenine Pathway Metabolites as Novel Translational Biological Markers of Irritable Bowel Syndrome: Relationship to Gastrointestinal Function, Cognition and Co-morbid Depression[NCT01304355] | 85 participants (Anticipated) | Observational | 2011-01-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for quinolinic acid and Depression
| Article | Year |
|---|---|
The kynurenine pathway in major depressive disorder under different disease states: A systematic review and meta-analysis.
Topics: Biomarkers; Depression; Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Quinolinic A | 2023 |
Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease.
Topics: Animals; Brain-Gut Axis; Depression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Inf | 2021 |
Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders.
Topics: Antidepressive Agents; Antioxidants; Biomarkers; Depression; Depressive Disorder; Disease Progressio | 2017 |
The role of tryptophan metabolism in postpartum depression.
Topics: Depression; Depression, Postpartum; Depressive Disorder, Major; Female; Humans; Kynurenine; Quinolin | 2018 |
Kynurenine pathway in depression: A systematic review and meta-analysis.
Topics: Brain; Depression; Depressive Disorder; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid | 2018 |
A new theory of depression based on the serotonin/kynurenine relationship and the hypothalamicpituitary- adrenal axis
Topics: Animals; Bacterial Infections; Brain; Cytokines; Depression; Humans; Hypothalamo-Hypophyseal System; | 2018 |
[Depression and inflammation in rheumatic diseases].
Topics: Cytokines; Depression; Humans; Hypothalamo-Hypophyseal System; Indoleamine-Pyrrole 2,3,-Dioxygenase; | 2016 |
1 trial available for quinolinic acid and Depression
| Article | Year |
|---|---|
Kynurenine metabolism and inflammation-induced depressed mood: A human experimental study.
Topics: Adult; Affect; Cytokines; Depression; Endotoxins; Female; Humans; Inflammation; Interleukin-6; Kynur | 2019 |
20 other studies available for quinolinic acid and Depression
| Article | Year |
|---|---|
Peripheral and central kynurenine pathway abnormalities in major depression.
Topics: Depression; Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid | 2022 |
Plumbagin Alleviates Intracerebroventricular-Quinolinic Acid Induced Depression-like Behavior and Memory Deficits in Wistar Rats.
Topics: Animals; Behavior, Animal; Depression; Male; Memory Disorders; Naphthoquinones; Oxidative Stress; Qu | 2022 |
Kynurenine monooxygenase inhibition and associated reduced quinolinic acid reverses depression-like behaviour by upregulating Nrf2/ARE pathway in mouse model of depression: In-vivo and In-silico studies.
Topics: Animals; Antioxidants; Depression; Depressive Disorder, Major; Disease Models, Animal; Humans; Kelch | 2022 |
Involvement of kynurenine pathway and N-methyl-d-aspartate receptors in the antidepressant-like effect of vilazodone in the tail suspension test in mice.
Topics: Animals; Antidepressive Agents; Depression; Hindlimb Suspension; Ketamine; Kynurenine; Mice; Quinoli | 2022 |
Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in human and mice.
Topics: Adolescent; Animals; Coleoptera; Depression; Gastrointestinal Microbiome; Humans; Kynurenine; Metabo | 2023 |
Alterations in the Kynurenine Pathway of Tryptophan Metabolism Are Associated With Depression in People Living With HIV.
Topics: Antidepressive Agents; Comorbidity; Depression; Female; HIV Infections; Humans; Kynurenine; Male; Mi | 2021 |
Behavioral activation therapy for depression is associated with a reduction in the concentration of circulating quinolinic acid - Erratum.
Topics: Depression; Humans; Oxidative Stress; Quinolinic Acid | 2022 |
Serum kynurenic acid is reduced in affective psychosis.
Topics: Adult; Affective Disorders, Psychotic; Bipolar Disorder; Corpus Striatum; Cytokines; Depression; Dep | 2017 |
Sleep disturbance and kynurenine metabolism in depression.
Topics: Adult; Depression; Female; Humans; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Sleep Wake Dis | 2017 |
Regulation of the kynurenine metabolism pathway by Xiaoyao San and the underlying effect in the hippocampus of the depressed rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cyclic AMP Resp | 2018 |
The rostromedial tegmental nucleus modulates the development of stress-induced helpless behavior.
Topics: Animals; Depression; Disease Models, Animal; Electric Stimulation; Electroshock; Habenula; Helplessn | 2019 |
Cross-sectional relationship between kynurenine pathway metabolites and cognitive function in major depressive disorder.
Topics: Adult; Chromatography, Liquid; Cognition; Cross-Sectional Studies; Depression; Depressive Disorder, | 2019 |
Microglial production of quinolinic acid as a target and a biomarker of the antidepressant effect of ketamine.
Topics: Animals; Antidepressive Agents; Anxiety; Anxiety Disorders; Biomarkers, Pharmacological; Depression; | 2019 |
[Hippocampus quinolinic acid modulates glutamate and NMDAR/mGluR1 in chronic unpredictable mild stress-induced depression].
Topics: Animals; Behavior, Animal; Depression; Dizocilpine Maleate; Glutamic Acid; Hippocampus; Quinolinic A | 2013 |
Decreased quinolinic acid in the hippocampus of depressive patients: evidence for local anti-inflammatory and neuroprotective responses?
Topics: Adult; Antidepressive Agents; Case-Control Studies; Depression; Female; Hippocampus; Humans; Magneti | 2015 |
Interferon-alpha treatment induces depression-like behaviour accompanied by elevated hippocampal quinolinic acid levels in rats.
Topics: Animals; Antidepressive Agents; Chromatography, Liquid; Depression; Dose-Response Relationship, Drug | 2015 |
Quinolinic Acid Responses during Interferon-α-Induced Depressive Symptomatology in Patients with Chronic Hepatitis C Infection - A Novel Aspect for Depression and Inflammatory Hypothesis.
Topics: Adult; Antiviral Agents; Depression; Female; Hepatitis C, Chronic; Humans; Interferon-alpha; Kynuren | 2015 |
Increased breakdown of kynurenine towards its neurotoxic branch in bipolar disorder.
Topics: Adult; Bipolar Disorder; Brain; Case-Control Studies; Cognition; Depression; Female; Humans; Inflamm | 2017 |
CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression.
Topics: Adult; Antiviral Agents; Chemokine CCL2; Chromatography, High Pressure Liquid; Cytokines; Depression | 2010 |
Development and validation of a single analytical method for the determination of tryptophan, and its kynurenine metabolites in rat plasma.
Topics: 3-Hydroxyanthranilic Acid; Animals; Charcoal; Chromatography, High Pressure Liquid; Depression; Kynu | 2012 |