quinolinic acid has been researched along with Depression, Endogenous in 8 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Abnormalities of the kynurenine (KYN) pathway may be implicated in the pathophysiology of depression." | 8.98 | Kynurenine pathway in depression: A systematic review and meta-analysis. ( Graff-Guerrero, A; Iwata, Y; Kubo, K; Mimura, M; Miyazaki, T; Moriguchi, S; Nakajima, S; Noda, Y; Ogyu, K; Omura, Y; Plitman, E; Tarumi, R; Tsugawa, S; Uchida, H; Wada, M, 2018) |
| "The aim of this paper is to elucidate the role of oxidative and nitrosative stress as well as the tryptophan catabolites pathway in the development of depression and the mechanism of action of antidepressant drugs, based on the available literature." | 8.95 | Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders. ( Czarny, P; Galecki, P; Sliwinski, T; Wigner, P, 2017) |
| "Abnormalities of the kynurenine (KYN) pathway may be implicated in the pathophysiology of depression." | 4.98 | Kynurenine pathway in depression: A systematic review and meta-analysis. ( Graff-Guerrero, A; Iwata, Y; Kubo, K; Mimura, M; Miyazaki, T; Moriguchi, S; Nakajima, S; Noda, Y; Ogyu, K; Omura, Y; Plitman, E; Tarumi, R; Tsugawa, S; Uchida, H; Wada, M, 2018) |
| "The aim of this paper is to elucidate the role of oxidative and nitrosative stress as well as the tryptophan catabolites pathway in the development of depression and the mechanism of action of antidepressant drugs, based on the available literature." | 4.95 | Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders. ( Czarny, P; Galecki, P; Sliwinski, T; Wigner, P, 2017) |
| "Quinolinic acid was increased and kynurenic acid decreased over time in suicidal patients versus healthy controls." | 1.42 | A role for inflammatory metabolites as modulators of the glutamate N-methyl-D-aspartate receptor in depression and suicidality. ( Bay-Richter, C; Brundin, L; Erhardt, S; Guillemin, GJ; Lim, CK; Linderholm, KR; Samuelsson, M; Träskman-Bendz, L, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 6 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wigner, P | 1 |
| Czarny, P | 1 |
| Galecki, P | 1 |
| Sliwinski, T | 1 |
| Ogyu, K | 1 |
| Kubo, K | 1 |
| Noda, Y | 1 |
| Iwata, Y | 1 |
| Tsugawa, S | 1 |
| Omura, Y | 1 |
| Wada, M | 1 |
| Tarumi, R | 1 |
| Plitman, E | 1 |
| Moriguchi, S | 1 |
| Miyazaki, T | 1 |
| Uchida, H | 1 |
| Graff-Guerrero, A | 1 |
| Mimura, M | 1 |
| Nakajima, S | 1 |
| Koo, YS | 1 |
| Kim, H | 1 |
| Park, JH | 1 |
| Kim, MJ | 1 |
| Shin, YI | 1 |
| Choi, BT | 1 |
| Lee, SY | 1 |
| Shin, HK | 1 |
| Dantzer, R | 1 |
| Walker, AK | 1 |
| Bay-Richter, C | 1 |
| Linderholm, KR | 1 |
| Lim, CK | 1 |
| Samuelsson, M | 1 |
| Träskman-Bendz, L | 1 |
| Guillemin, GJ | 1 |
| Erhardt, S | 1 |
| Brundin, L | 1 |
| Eskelund, A | 1 |
| Budac, DP | 1 |
| Sanchez, C | 1 |
| Elfving, B | 1 |
| Wegener, G | 1 |
| Maes, M | 1 |
| Mihaylova, I | 1 |
| Ruyter, MD | 1 |
| Kubera, M | 1 |
| Bosmans, E | 1 |
| Martin, A | 1 |
| Heyes, MP | 1 |
| Salazar, AM | 1 |
| Kampen, DL | 1 |
| Williams, J | 1 |
| Law, WA | 1 |
| Coats, ME | 1 |
| Markey, SP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prediction of the Therapeutic Response in Depression Based on an Early Neuro-computational Modeling Assessment of Motivation[NCT05866575] | 136 participants (Anticipated) | Interventional | 2023-06-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for quinolinic acid and Depression, Endogenous
| Article | Year |
|---|---|
Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders.
Topics: Antidepressive Agents; Antioxidants; Biomarkers; Depression; Depressive Disorder; Disease Progressio | 2017 |
Kynurenine pathway in depression: A systematic review and meta-analysis.
Topics: Brain; Depression; Depressive Disorder; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid | 2018 |
Is there a role for glutamate-mediated excitotoxicity in inflammation-induced depression?
Topics: Animals; Blood-Brain Barrier; Depressive Disorder; Glutamic Acid; Humans; Indoleamine-Pyrrole 2,3,-D | 2014 |
5 other studies available for quinolinic acid and Depression, Endogenous
| Article | Year |
|---|---|
Indoleamine 2,3-Dioxygenase-Dependent Neurotoxic Kynurenine Metabolism Contributes to Poststroke Depression Induced in Mice by Ischemic Stroke along with Spatial Restraint Stress.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Animals; Brain Ischemia; Depressive Disorder; Indoleamine-Pyr | 2018 |
A role for inflammatory metabolites as modulators of the glutamate N-methyl-D-aspartate receptor in depression and suicidality.
Topics: Adult; Cytokines; Depressive Disorder; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Mal | 2015 |
Female Flinders Sensitive Line rats show estrous cycle-independent depression-like behavior and altered tryptophan metabolism.
Topics: 5-Hydroxytryptophan; Animals; Anxiety; Brain; Depressive Disorder; Disease Models, Animal; Estrous C | 2016 |
The immune effects of TRYCATs (tryptophan catabolites along the IDO pathway): relevance for depression - and other conditions characterized by tryptophan depletion induced by inflammation.
Topics: Adult; Anti-Inflammatory Agents; Cytokines; Depressive Disorder; Female; Gene Expression Regulation; | 2007 |
Progressive slowing of reaction time and increasing cerebrospinal fluid concentrations of quinolinic acid in HIV-infected individuals.
Topics: Adult; AIDS Dementia Complex; Anxiety Disorders; Depressive Disorder; Female; HIV Seropositivity; Hu | 1992 |