quinolinic acid has been researched along with Chronic Disease in 4 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Elevated brain concentrations of the neurotoxin and NMDA receptor agonist quinolinic acid (QUIN) have been demonstrated in portacaval-shunted (PCS) rats, a chronic hepatic encephalopathy (HE) model." | 7.69 | Brain quinolinic acid in chronic experimental hepatic encephalopathy: effects of an exogenous ammonium acetate challenge. ( Bengtsson, F; Bergqvist, PB; Bugge, M; Heyes, MP, 1995) |
| "Plasma quinolinic acid levels were significantly increased by stage I encephalopathy in patients with acute liver failure and by stages II and III in patients with chronic liver failure." | 7.69 | The relationship between plasma and brain quinolinic acid levels and the severity of hepatic encephalopathy. ( al-Mardini, H; Basile, AS; Harrison, P; Heyes, MP; Hughes, RD; Li, Y; Record, CO; Saito, K; Williams, R, 1995) |
| "Elevated brain concentrations of the neurotoxin and NMDA receptor agonist quinolinic acid (QUIN) have been demonstrated in portacaval-shunted (PCS) rats, a chronic hepatic encephalopathy (HE) model." | 3.69 | Brain quinolinic acid in chronic experimental hepatic encephalopathy: effects of an exogenous ammonium acetate challenge. ( Bengtsson, F; Bergqvist, PB; Bugge, M; Heyes, MP, 1995) |
| "Plasma quinolinic acid levels were significantly increased by stage I encephalopathy in patients with acute liver failure and by stages II and III in patients with chronic liver failure." | 3.69 | The relationship between plasma and brain quinolinic acid levels and the severity of hepatic encephalopathy. ( al-Mardini, H; Basile, AS; Harrison, P; Heyes, MP; Hughes, RD; Li, Y; Record, CO; Saito, K; Williams, R, 1995) |
| " This stimulation induces indoleamine 2,3-dioxygenase (IDO), an enzyme that reduces the tryptophan bioavailability to synthesize serotonin." | 1.51 | Chronic Mild Stress Alters Kynurenine Pathways Changing the Glutamate Neurotransmission in Frontal Cortex of Rats. ( Caso, JR; García-Bueno, B; Leza, JC; Madrigal, JLM; Martín-Hernández, D; Tendilla-Beltrán, H, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Joisten, N | 1 |
| Ruas, JL | 1 |
| Braidy, N | 1 |
| Guillemin, GJ | 1 |
| Zimmer, P | 1 |
| Martín-Hernández, D | 1 |
| Tendilla-Beltrán, H | 1 |
| Madrigal, JLM | 1 |
| García-Bueno, B | 1 |
| Leza, JC | 1 |
| Caso, JR | 1 |
| Bergqvist, PB | 1 |
| Heyes, MP | 2 |
| Bugge, M | 1 |
| Bengtsson, F | 1 |
| Basile, AS | 1 |
| Saito, K | 1 |
| al-Mardini, H | 1 |
| Record, CO | 1 |
| Hughes, RD | 1 |
| Harrison, P | 1 |
| Williams, R | 1 |
| Li, Y | 1 |
1 review available for quinolinic acid and Chronic Disease
| Article | Year |
|---|---|
The kynurenine pathway in chronic diseases: a compensatory mechanism or a driving force?
Topics: Chronic Disease; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan | 2021 |
3 other studies available for quinolinic acid and Chronic Disease
| Article | Year |
|---|---|
Chronic Mild Stress Alters Kynurenine Pathways Changing the Glutamate Neurotransmission in Frontal Cortex of Rats.
Topics: Animals; Antidepressive Agents; Chronic Disease; Cytokines; Frontal Lobe; Glutamate Plasma Membrane | 2019 |
Brain quinolinic acid in chronic experimental hepatic encephalopathy: effects of an exogenous ammonium acetate challenge.
Topics: Acetates; Animals; Brain; Chronic Disease; Hepatic Encephalopathy; Male; Quinolinic Acid; Rats; Rats | 1995 |
The relationship between plasma and brain quinolinic acid levels and the severity of hepatic encephalopathy.
Topics: Acute Disease; Adult; Brain; Chronic Disease; Female; Hepatic Encephalopathy; Humans; Liver Failure; | 1995 |