quinolinic acid has been researched along with Cerebral Ischemia in 14 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Strokes are becoming less severe due to increased numbers of intensive care units and improved treatments." | 1.62 | Increased serum QUIN/KYNA is a reliable biomarker of post-stroke cognitive decline. ( Callebert, J; Chabriat, H; Cogo, A; Huberfeld, G; Kubis, N; Launay, JM; Maïer, B; Mangin, G; Mazighi, M, 2021) |
| "Quinolinic acid is an agonist at glutamate receptors sensitive to N-methyl-D-aspartate (NMDA)." | 1.34 | Interleukin-1beta but not tumor necrosis factor-alpha potentiates neuronal damage by quinolinic acid: protection by an adenosine A2A receptor antagonist. ( Behan, WM; Stone, TW, 2007) |
| "Ten minutes of global cerebral ischemia did not modify the interaction between KAIN and KYNA." | 1.33 | Kynurenic acid attenuates NMDA-induced pial arteriolar dilation in newborn pigs. ( Bari, F; Busija, DW; Domoki, F; Guidetti, P; Nagy, K; Schwarcz, R, 2006) |
| "Ebselen (EBS) is a seleno-organic compound with glutathione peroxidase-like activity which is neuroprotective in acute stroke ischemia." | 1.31 | Ebselen blocks the quinolinic acid-induced production of thiobarbituric acid reactive species but does not prevent the behavioral alterations produced by intra-striatal quinolinic acid administration in the rat. ( Mello, CF; Rocha, JB; Rossato, JI; Rubin, MA; Zeni, G, 2002) |
| "Quinolinic acid is an excitotoxic kynurenine pathway metabolite, the concentration of which increases in human brain during immune activation." | 1.30 | Species heterogeneity between gerbils and rats: quinolinate production by microglia and astrocytes and accumulations in response to ischemic brain injury and systemic immune activation. ( Beagles, KE; Chen, CY; Heyes, MP; Kawai, K; Li, J; Markey, SP; Nowak, TS; Proescholdt, MA; Proescholdt, MG; Saito, K; Zito, MA, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 4 (28.57) | 18.2507 |
| 2000's | 7 (50.00) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Cogo, A | 1 |
| Mangin, G | 1 |
| Maïer, B | 1 |
| Callebert, J | 1 |
| Mazighi, M | 1 |
| Chabriat, H | 1 |
| Launay, JM | 1 |
| Huberfeld, G | 1 |
| Kubis, N | 1 |
| Koo, YS | 1 |
| Kim, H | 1 |
| Park, JH | 1 |
| Kim, MJ | 1 |
| Shin, YI | 1 |
| Choi, BT | 1 |
| Lee, SY | 1 |
| Shin, HK | 1 |
| Graham, RK | 1 |
| Pouladi, MA | 1 |
| Joshi, P | 1 |
| Lu, G | 1 |
| Deng, Y | 1 |
| Wu, NP | 1 |
| Figueroa, BE | 1 |
| Metzler, M | 1 |
| André, VM | 1 |
| Slow, EJ | 1 |
| Raymond, L | 1 |
| Friedlander, R | 1 |
| Levine, MS | 1 |
| Leavitt, BR | 1 |
| Hayden, MR | 1 |
| Carpenedo, R | 1 |
| Meli, E | 1 |
| Peruginelli, F | 1 |
| Pellegrini-Giampietro, DE | 1 |
| Moroni, F | 1 |
| Bari, F | 1 |
| Nagy, K | 1 |
| Guidetti, P | 1 |
| Schwarcz, R | 1 |
| Busija, DW | 1 |
| Domoki, F | 1 |
| Stone, TW | 2 |
| Behan, WM | 1 |
| Heyes, MP | 3 |
| Saito, K | 1 |
| Chen, CY | 1 |
| Proescholdt, MG | 1 |
| Nowak, TS | 2 |
| Li, J | 1 |
| Beagles, KE | 1 |
| Proescholdt, MA | 1 |
| Zito, MA | 1 |
| Kawai, K | 1 |
| Markey, SP | 1 |
| Henrich-Noack, P | 1 |
| Flor, PJ | 1 |
| Sabelhaus, CF | 1 |
| Prass, K | 1 |
| Dirnagl, U | 1 |
| Gasparini, F | 1 |
| Sauter, A | 1 |
| Rudin, M | 1 |
| Reymann, KG | 1 |
| Rossato, JI | 1 |
| Zeni, G | 1 |
| Mello, CF | 1 |
| Rubin, MA | 1 |
| Rocha, JB | 1 |
| Burke, RE | 1 |
| Macaya, A | 1 |
| DeVivo, D | 1 |
| Kenyon, N | 1 |
| Janec, EM | 1 |
| Wieloch, T | 1 |
3 reviews available for quinolinic acid and Cerebral Ischemia
| Article | Year |
|---|---|
Quinolinic acid and inflammation.
Topics: Acquired Immunodeficiency Syndrome; Animals; Biomarkers; Brain Ischemia; Disease Models, Animal; HIV | 1993 |
Kynurenic acid antagonists and kynurenine pathway inhibitors.
Topics: Brain Ischemia; Epilepsy; Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; Neu | 2001 |
Neurochemical correlates to selective neuronal vulnerability.
Topics: Adenosine; Afferent Pathways; Animals; Aspartic Acid; Brain Diseases; Brain Ischemia; Calcium; Chlor | 1985 |
11 other studies available for quinolinic acid and Cerebral Ischemia
| Article | Year |
|---|---|
Increased serum QUIN/KYNA is a reliable biomarker of post-stroke cognitive decline.
Topics: Animals; Biomarkers; Brain; Brain Ischemia; Cognitive Dysfunction; Diabetes Mellitus, Experimental; | 2021 |
Indoleamine 2,3-Dioxygenase-Dependent Neurotoxic Kynurenine Metabolism Contributes to Poststroke Depression Induced in Mice by Ischemic Stroke along with Spatial Restraint Stress.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Animals; Brain Ischemia; Depressive Disorder; Indoleamine-Pyr | 2018 |
Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease.
Topics: Animals; Brain; Brain Ischemia; Cells, Cultured; Dendritic Spines; Disease Models, Animal; Disease P | 2009 |
Kynurenine 3-mono-oxygenase inhibitors attenuate post-ischemic neuronal death in organotypic hippocampal slice cultures.
Topics: Alanine; Animals; Brain Ischemia; Cell Death; Cell Hypoxia; Culture Media, Conditioned; Enzyme Inhib | 2002 |
Kynurenic acid attenuates NMDA-induced pial arteriolar dilation in newborn pigs.
Topics: Analysis of Variance; Animals; Animals, Newborn; Brain Ischemia; Cerebral Arteries; Disease Models, | 2006 |
Interleukin-1beta but not tumor necrosis factor-alpha potentiates neuronal damage by quinolinic acid: protection by an adenosine A2A receptor antagonist.
Topics: Adenosine A2 Receptor Antagonists; Animals; Brain Injuries; Brain Ischemia; Cytoprotection; Drug Syn | 2007 |
Species heterogeneity between gerbils and rats: quinolinate production by microglia and astrocytes and accumulations in response to ischemic brain injury and systemic immune activation.
Topics: Animals; Astrocytes; Brain Ischemia; Encephalitis; Gerbillinae; Immune System; Injections, Intraperi | 1997 |
Distinct influence of the group III metabotropic glutamate receptor agonist (R,S)-4-phosphonophenylglycine [(R,S)-PPG] on different forms of neuronal damage.
Topics: Action Potentials; Animals; Brain Diseases; Brain Ischemia; Cell Hypoxia; Corpus Striatum; Cytoprote | 2000 |
Ebselen blocks the quinolinic acid-induced production of thiobarbituric acid reactive species but does not prevent the behavioral alterations produced by intra-striatal quinolinic acid administration in the rat.
Topics: Animals; Azoles; Behavior, Animal; Brain Ischemia; Drug Interactions; Grooming; Isoindoles; Lipid Pe | 2002 |
Neonatal hypoxic-ischemic or excitotoxic striatal injury results in a decreased adult number of substantia nigra neurons.
Topics: Animals; Animals, Newborn; Brain Ischemia; Calbindins; Corpus Striatum; Dopamine; Hypoxia, Brain; Im | 1992 |
Delayed increases in regional brain quinolinic acid follow transient ischemia in the gerbil.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Dopamin | 1990 |