quinolinic acid has been researched along with Central Nervous System Diseases in 7 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
Central Nervous System Diseases: Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Quinolinic acid is an agonist at the population of glutamate receptors which are sensitive to N-methyl-D-aspartate (NMDA), and kynurenic acid is an antagonist at several glutamate receptors." | 6.42 | Tryptophan metabolites and brain disorders. ( Clark, CJ; Darlington, LG; Forrest, CM; Mackay, GM; Stone, TW, 2003) |
| "Quinolinic acid (QUIN) is a neurotoxic metabolite of the kynurenine pathway that accumulates within the central nervous system following immune activation." | 5.29 | Quinolinic acid in tumors, hemorrhage and bacterial infections of the central nervous system in children. ( Heyes, MP; Milstien, S; Saito, K; Schiff, SJ, 1995) |
| "Quinolinic acid is an agonist at the population of glutamate receptors which are sensitive to N-methyl-D-aspartate (NMDA), and kynurenic acid is an antagonist at several glutamate receptors." | 2.42 | Tryptophan metabolites and brain disorders. ( Clark, CJ; Darlington, LG; Forrest, CM; Mackay, GM; Stone, TW, 2003) |
| "In patients with no apparent CNS disease, CSF PIC levels were 10-fold higher in samples taken between 20:00 and 16:00 h compared with those collected between 04:00 and 12:00 h." | 1.35 | Age and circadian influences on picolinic acid concentrations in human cerebrospinal fluid. ( Bilgin, A; Coggan, SE; Grant, RS; Smythe, GA, 2009) |
| "Quinolinic acid (QUIN) is a neurotoxic metabolite of the kynurenine pathway that accumulates within the central nervous system following immune activation." | 1.29 | Quinolinic acid in tumors, hemorrhage and bacterial infections of the central nervous system in children. ( Heyes, MP; Milstien, S; Saito, K; Schiff, SJ, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Costantino, G | 1 |
| Coggan, SE | 1 |
| Smythe, GA | 1 |
| Bilgin, A | 1 |
| Grant, RS | 1 |
| Kandanearatchi, A | 1 |
| Brew, BJ | 1 |
| Stone, TW | 2 |
| Mackay, GM | 1 |
| Forrest, CM | 1 |
| Clark, CJ | 1 |
| Darlington, LG | 1 |
| Heyes, MP | 2 |
| Saito, K | 1 |
| Milstien, S | 1 |
| Schiff, SJ | 1 |
| Lane, JH | 1 |
| Sasseville, VG | 1 |
| Smith, MO | 1 |
| Vogel, P | 1 |
| Pauley, DR | 1 |
| Lackner, AA | 1 |
3 reviews available for quinolinic acid and Central Nervous System Diseases
| Article | Year |
|---|---|
The kynurenine pathway and quinolinic acid: pivotal roles in HIV associated neurocognitive disorders.
Topics: Central Nervous System Diseases; Cognition Disorders; HIV; HIV Infections; Humans; Kynurenine; Quino | 2012 |
Tryptophan metabolites and brain disorders.
Topics: AIDS Dementia Complex; Brain Diseases; Central Nervous System Diseases; Humans; Huntington Disease; | 2003 |
Kynurenines in the CNS: from endogenous obscurity to therapeutic importance.
Topics: Animals; Central Nervous System; Central Nervous System Diseases; Humans; Kynurenine; Neurotoxins; Q | 2001 |
4 other studies available for quinolinic acid and Central Nervous System Diseases
| Article | Year |
|---|---|
Inhibitors of quinolinic acid synthesis: new weapons in the study of neuroinflammatory diseases.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Central Nervous System Diseases; Enzyme Inhibitors; Humans; K | 2014 |
Age and circadian influences on picolinic acid concentrations in human cerebrospinal fluid.
Topics: Aging; Analysis of Variance; C-Reactive Protein; Case-Control Studies; Central Nervous System Diseas | 2009 |
Quinolinic acid in tumors, hemorrhage and bacterial infections of the central nervous system in children.
Topics: Adolescent; Adult; Bacterial Infections; Biomarkers; Biopterins; Central Nervous System Diseases; Ce | 1995 |
Neuroinvasion by simian immunodeficiency virus coincides with increased numbers of perivascular macrophages/microglia and intrathecal immune activation.
Topics: Animals; Brain; Capillaries; Central Nervous System Diseases; Cerebrovascular Circulation; DNA, Vira | 1996 |