quinolinic acid has been researched along with Brain Injuries in 30 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Quinolinic acid was measured by mass spectrometry." | 2.69 | Quinolinic acid is increased in CSF and associated with mortality after traumatic brain injury in humans. ( Bell, MJ; Blight, AR; Clark, RS; DeKosky, ST; Heyes, MP; Kochanek, PM; Marion, DW; Sinz, EH; Wisniewski, SR, 1998) |
| "Levetiracetam (LVT) is a relatively novel antiepileptic drug (AED) known to act through binding with the synaptic vesicular 2A (SV2A) protein, thus modulating the presynaptic neurotransmitter release." | 1.48 | The Antiepileptic Drug Levetiracetam Protects Against Quinolinic Acid-Induced Toxicity in the Rat Striatum. ( Aguilera, G; Colín-González, AL; Dircio-Bautista, M; Galván-Arzate, S; García, E; Maya-López, M; Santamaría, A; Túnez, I; Villeda-Hernández, J, 2018) |
| "Lesions of the ventromedial prefrontal cortex induced impulsive deficits, and repeated milnacipran ameliorated the impulsive deficit both during the dosing period and after the cessation of the drug." | 1.40 | Milnacipran remediates impulsive deficits in rats with lesions of the ventromedial prefrontal cortex. ( Izumi, T; Ohmura, Y; Tsutsui-Kimura, I; Yoshida, T; Yoshioka, M, 2014) |
| "Quinolinic acid is an agonist at glutamate receptors sensitive to N-methyl-D-aspartate (NMDA)." | 1.34 | Interleukin-1beta but not tumor necrosis factor-alpha potentiates neuronal damage by quinolinic acid: protection by an adenosine A2A receptor antagonist. ( Behan, WM; Stone, TW, 2007) |
| "At later time points, a dense astrogliosis with proliferating astrocytes developed in the dorsal and medial striatum." | 1.31 | Time course of glial proliferation and glial apoptosis following excitotoxic CNS injury. ( Block, F; Dihné, M; Korr, H; Töpper, R, 2001) |
| "Quinolinic acid concentration was measured by gas chromatography/mass spectroscopy in 69 samples (4." | 1.30 | Quinolinic acid in the cerebrospinal fluid of children after traumatic brain injury. ( Adelson, PD; Bell, MJ; Blight, AR; Clark, RS; Heyes, MP; Kochanek, PM; Marion, DW; Sinz, EH; Wisniewski, SR, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (23.33) | 18.2507 |
| 2000's | 16 (53.33) | 29.6817 |
| 2010's | 7 (23.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dircio-Bautista, M | 1 |
| Colín-González, AL | 1 |
| Aguilera, G | 1 |
| Maya-López, M | 1 |
| Villeda-Hernández, J | 1 |
| Galván-Arzate, S | 1 |
| García, E | 1 |
| Túnez, I | 1 |
| Santamaría, A | 1 |
| Retailleau, A | 1 |
| Dejean, C | 1 |
| Fourneaux, B | 1 |
| Leinekugel, X | 1 |
| Boraud, T | 1 |
| Tremblay, M | 1 |
| Cocker, PJ | 1 |
| Hosking, JG | 1 |
| Zeeb, FD | 1 |
| Rogers, RD | 1 |
| Winstanley, CA | 1 |
| Tsutsui-Kimura, I | 1 |
| Yoshida, T | 1 |
| Ohmura, Y | 1 |
| Izumi, T | 1 |
| Yoshioka, M | 1 |
| Yan, EB | 1 |
| Frugier, T | 1 |
| Lim, CK | 1 |
| Heng, B | 1 |
| Sundaram, G | 1 |
| Tan, M | 1 |
| Rosenfeld, JV | 1 |
| Walker, DW | 1 |
| Guillemin, GJ | 2 |
| Morganti-Kossmann, MC | 1 |
| Lee, DE | 1 |
| Yue, X | 1 |
| Ibrahim, WG | 1 |
| Lentz, MR | 1 |
| Peterson, KL | 1 |
| Jagoda, EM | 1 |
| Kassiou, M | 1 |
| Maric, D | 1 |
| Reid, WC | 1 |
| Hammoud, DA | 1 |
| Maggiolini, E | 1 |
| Viaro, R | 1 |
| Franchi, G | 1 |
| Chung, RS | 1 |
| Leung, YK | 1 |
| Butler, CW | 1 |
| Chen, Y | 1 |
| Eaton, ED | 1 |
| Pankhurst, MW | 1 |
| West, AK | 1 |
| Morimoto, Y | 1 |
| Zhang, Q | 1 |
| Adachi, K | 1 |
| Hanbury, R | 1 |
| Chen, EY | 1 |
| Wuu, J | 1 |
| Kordower, JH | 1 |
| Fusco, FR | 1 |
| Zuccato, C | 1 |
| Tartari, M | 1 |
| Martorana, A | 1 |
| De March, Z | 1 |
| Giampà, C | 1 |
| Cattaneo, E | 1 |
| Bernardi, G | 1 |
| Hussain, N | 1 |
| Flumerfelt, BA | 1 |
| Rajakumar, N | 1 |
| Berger, RP | 1 |
| Heyes, MP | 3 |
| Wisniewski, SR | 3 |
| Adelson, PD | 2 |
| Thomas, N | 1 |
| Kochanek, PM | 3 |
| Collin, T | 1 |
| Arvidsson, A | 1 |
| Kokaia, Z | 1 |
| Lindvall, O | 1 |
| Curry, DJ | 1 |
| Wright, DA | 1 |
| Lee, RC | 1 |
| Kang, UJ | 1 |
| Frim, DM | 1 |
| Döbrössy, MD | 1 |
| Dunnett, SB | 1 |
| Acheson, A | 1 |
| Farrar, AM | 1 |
| Patak, M | 1 |
| Hausknecht, KA | 1 |
| Kieres, AK | 1 |
| Choi, S | 1 |
| de Wit, H | 1 |
| Richards, JB | 1 |
| Stone, TW | 1 |
| Behan, WM | 1 |
| Whishaw, IQ | 1 |
| Zeeb, F | 1 |
| Erickson, C | 1 |
| McDonald, RJ | 2 |
| Henry, RA | 1 |
| Hughes, SM | 1 |
| Connor, B | 2 |
| King, AL | 1 |
| Foong, N | 1 |
| Rizos, Z | 1 |
| Hong, NS | 1 |
| Kells, AP | 1 |
| Matyja, E | 1 |
| Kida, E | 1 |
| Orlando, LR | 1 |
| Luthi-Carter, R | 1 |
| Standaert, DG | 1 |
| Coyle, JT | 1 |
| Penney, JB | 1 |
| Young, AB | 1 |
| Sinz, EH | 2 |
| Bell, MJ | 2 |
| Clark, RS | 2 |
| DeKosky, ST | 1 |
| Blight, AR | 2 |
| Marion, DW | 2 |
| Hossain, MA | 1 |
| Fielding, KE | 1 |
| Trescher, WH | 1 |
| Ho, T | 1 |
| Wilson, MA | 1 |
| Laterra, J | 1 |
| Hanley, DF | 1 |
| Vizuete, ML | 1 |
| Venero, JL | 1 |
| Vargas, C | 1 |
| Ilundáin, AA | 1 |
| Echevarría, M | 1 |
| Machado, A | 1 |
| Cano, J | 1 |
| Dihné, M | 1 |
| Block, F | 1 |
| Korr, H | 1 |
| Töpper, R | 1 |
1 trial available for quinolinic acid and Brain Injuries
| Article | Year |
|---|---|
Quinolinic acid is increased in CSF and associated with mortality after traumatic brain injury in humans.
Topics: Adolescent; Adult; Aged; Brain Injuries; Humans; Hypothermia, Induced; Kinetics; Middle Aged; Progno | 1998 |
29 other studies available for quinolinic acid and Brain Injuries
| Article | Year |
|---|---|
The Antiepileptic Drug Levetiracetam Protects Against Quinolinic Acid-Induced Toxicity in the Rat Striatum.
Topics: Animals; Anticonvulsants; Brain Injuries; Corpus Striatum; Levetiracetam; Male; Neostriatum; Neuropr | 2018 |
Why am I lost without dopamine? Effects of 6-OHDA lesion on the encoding of reward and decision process in CA3.
Topics: Action Potentials; Adrenergic Agents; Animals; Brain Injuries; CA3 Region, Hippocampal; Decision Mak | 2013 |
Dissociable effects of basolateral amygdala lesions on decision making biases in rats when loss or gain is emphasized.
Topics: Analysis of Variance; Animals; Basolateral Nuclear Complex; Bias; Brain Injuries; Conditioning, Oper | 2014 |
Milnacipran remediates impulsive deficits in rats with lesions of the ventromedial prefrontal cortex.
Topics: Administration, Oral; Animals; Behavior, Animal; Brain Injuries; Brain-Derived Neurotrophic Factor; | 2014 |
Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans.
Topics: Adolescent; Adult; Aged; Biomarkers; Brain; Brain Injuries; Case-Control Studies; Female; Glasgow Ou | 2015 |
Lack of neuroinflammation in the HIV-1 transgenic rat: an [(18)F]-DPA714 PET imaging study.
Topics: Analysis of Variance; Animals; Body Weight; Brain Injuries; Brain Mapping; Cytokines; Encephalitis; | 2015 |
Suppression of activity in the forelimb motor cortex temporarily enlarges forelimb representation in the homotopic cortex in adult rats.
Topics: Action Potentials; Anesthetics, Local; Animals; Brain Injuries; Brain Mapping; Denervation; Dominanc | 2008 |
Metallothionein treatment attenuates microglial activation and expression of neurotoxic quinolinic acid following traumatic brain injury.
Topics: Analysis of Variance; Animals; Brain Injuries; Cell Count; Cells, Cultured; Cerebral Cortex; Culture | 2009 |
Effects of memantine, an N-methyl-D-aspartate receptor antagonist, on fatigue and neuronal brain damage in a rat model of combined (physical and mental) fatigue.
Topics: Animals; Brain Injuries; Fatigue; Male; Memantine; Models, Animal; Neuroprotective Agents; Pyramidal | 2012 |
Knockout of p75NTR does not alter the viability of striatal neurons following a metabolic or excitotoxic injury.
Topics: Animals; Astrocytes; Brain Injuries; Cell Death; Cell Survival; Energy Metabolism; Gliosis; Immunohi | 2003 |
Co-localization of brain-derived neurotrophic factor (BDNF) and wild-type huntingtin in normal and quinolinic acid-lesioned rat brain.
Topics: Animals; Blotting, Western; Brain Injuries; Brain-Derived Neurotrophic Factor; Calcium-Binding Prote | 2003 |
Glutamatergic regulation of long-term grafts of fetal lateral ganglionic eminence in a rat model of Huntington's disease.
Topics: Animals; Brain Injuries; Brain Tissue Transplantation; Corpus Striatum; Disease Models, Animal; Dizo | 2004 |
Assessment of the macrophage marker quinolinic acid in cerebrospinal fluid after pediatric traumatic brain injury: insight into the timing and severity of injury in child abuse.
Topics: Adolescent; Analysis of Variance; Brain Injuries; Child; Child Abuse; Child, Preschool; Humans; Infa | 2004 |
Quantitative analysis of the generation of different striatal neuronal subtypes in the adult brain following excitotoxic injury.
Topics: Analysis of Variance; Animals; Brain Injuries; Bromodeoxyuridine; Cell Count; Cell Proliferation; Ch | 2005 |
Surfactant poloxamer 188-related decreases in inflammation and tissue damage after experimental brain injury in rats.
Topics: Animals; Brain Injuries; Inflammation; Macrophages; Oxidative Stress; Poloxamer; Quinolinic Acid; Ra | 2004 |
The effects of lateralized training on spontaneous forelimb preference, lesion deficits, and graft-mediated functional recovery after unilateral striatal lesions in rats.
Topics: Animals; Behavior, Animal; Brain Injuries; Brain Tissue Transplantation; Corpus Striatum; Disease Mo | 2006 |
Nucleus accumbens lesions decrease sensitivity to rapid changes in the delay to reinforcement.
Topics: Animals; Behavior, Animal; Body Weight; Brain Injuries; Conditioning, Operant; Immunohistochemistry; | 2006 |
Interleukin-1beta but not tumor necrosis factor-alpha potentiates neuronal damage by quinolinic acid: protection by an adenosine A2A receptor antagonist.
Topics: Adenosine A2 Receptor Antagonists; Animals; Brain Injuries; Brain Ischemia; Cytoprotection; Drug Syn | 2007 |
Neurotoxic lesions of the caudate-putamen on a reaching for food task in the rat: acute sensorimotor neglect and chronic qualitative motor impairment follow lateral lesions and improved success follows medial lesions.
Topics: Animals; Behavior, Animal; Brain Injuries; Cell Death; Conditioning, Operant; Feeding Behavior; Func | 2007 |
AAV-mediated delivery of BDNF augments neurogenesis in the normal and quinolinic acid-lesioned adult rat brain.
Topics: Analysis of Variance; Animals; Brain Injuries; Brain-Derived Neurotrophic Factor; Bromodeoxyuridine; | 2007 |
Neurotoxic lesions of the medial prefrontal cortex or medial striatum impair multiple-location place learning in the water task: evidence for neural structures with complementary roles in behavioural flexibility.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Injuries; Corpus Striatum; Learning Disabilit | 2008 |
AAV-mediated expression of Bcl-xL or XIAP fails to induce neuronal resistance against quinolinic acid-induced striatal lesioning.
Topics: Animals; bcl-X Protein; Behavior, Animal; Brain Injuries; Corpus Striatum; Dependovirus; Dopamine an | 2008 |
Verapamil reduces quinolinic acid-induced neuronal damage in rat hippocampus in vitro.
Topics: Animals; Brain Injuries; Dendritic Cells; Hippocampus; In Vitro Techniques; Microscopy, Electron; Ne | 1993 |
N-acetylaspartylglutamate (NAAG) protects against rat striatal quinolinic acid lesions in vivo.
Topics: Animals; Brain Injuries; Corpus Striatum; Dipeptides; Injections; Male; Neuropeptides; Quinolinic Ac | 1997 |
Human FGF-1 gene delivery protects against quinolinate-induced striatal and hippocampal injury in neonatal rats.
Topics: Animals; Animals, Newborn; Blotting, Northern; Brain Injuries; Cells, Cultured; Corpus Striatum; End | 1998 |
Multiple mechanisms of excitotoxicity.
Topics: Brain Injuries; Child; Excitatory Amino Acid Antagonists; Humans; Quinolinic Acid | 1999 |
Quinolinic acid in the cerebrospinal fluid of children after traumatic brain injury.
Topics: Accidents, Traffic; Adolescent; Brain Injuries; Child; Child Abuse; Child, Preschool; Gas Chromatogr | 1999 |
Differential upregulation of aquaporin-4 mRNA expression in reactive astrocytes after brain injury: potential role in brain edema.
Topics: Animals; Aquaporin 4; Aquaporins; Astrocytes; Axotomy; Blood-Brain Barrier; Brain Edema; Brain Injur | 1999 |
Time course of glial proliferation and glial apoptosis following excitotoxic CNS injury.
Topics: Animals; Apoptosis; Astrocytes; Brain Injuries; Cell Count; Cell Division; Glial Fibrillary Acidic P | 2001 |