quinolinic acid has been researched along with Brain Inflammation in 19 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although some ITES syndromes have recognisable MRI neuroimaging phenotypes, there are otherwise few biomarkers of disease." | 5.91 | CSF neopterin and quinolinic acid are biomarkers of neuroinflammation and neurotoxicity in FIRES and other infection-triggered encephalopathy syndromes. ( Andrews, PI; Ardern-Holmes, S; Bandodkar, S; Calvert, S; Dale, RC; Gill, D; Gupta, S; Han, VX; Kandula, T; Kothur, K; Malone, S; Menezes, MP; Mohammad, S; Patel, S; Subramanian, G; Thomas, T; Troedson, C; Waak, M; Yan, J, 2023) |
| "Quinolinic acid (QUIN) is a well-known neuroactive metabolite of tryptophan degradation pathway or kynurenine pathway." | 5.48 | Effect of wedelolactone and gallic acid on quinolinic acid-induced neurotoxicity and impaired motor function: significance to sporadic amyotrophic lateral sclerosis. ( Goli, D; S, M; T, P, 2018) |
| "Although some ITES syndromes have recognisable MRI neuroimaging phenotypes, there are otherwise few biomarkers of disease." | 1.91 | CSF neopterin and quinolinic acid are biomarkers of neuroinflammation and neurotoxicity in FIRES and other infection-triggered encephalopathy syndromes. ( Andrews, PI; Ardern-Holmes, S; Bandodkar, S; Calvert, S; Dale, RC; Gill, D; Gupta, S; Han, VX; Kandula, T; Kothur, K; Malone, S; Menezes, MP; Mohammad, S; Patel, S; Subramanian, G; Thomas, T; Troedson, C; Waak, M; Yan, J, 2023) |
| "Quinolinic acid (QUIN) is a well-known neuroactive metabolite of tryptophan degradation pathway or kynurenine pathway." | 1.48 | Effect of wedelolactone and gallic acid on quinolinic acid-induced neurotoxicity and impaired motor function: significance to sporadic amyotrophic lateral sclerosis. ( Goli, D; S, M; T, P, 2018) |
| "However, its potential in Huntington's disease (HD) models characterized by calpain-dependent degeneration and inflammation has not been investigated." | 1.33 | Minocycline in phenotypic models of Huntington's disease. ( Bantubungi, K; Blum, D; Brotchi, J; Brouillet, E; Chtarto, A; Déglon, N; Galas, MC; Greco, A; Jacquard, C; Levivier, M; Minghetti, L; Pintor, A; Popoli, P; Schiffmann, SN; Tai, K; Tenenbaum, L, 2005) |
| "Quinolinic acid is an excitotoxic kynurenine pathway metabolite, the concentration of which increases in human brain during immune activation." | 1.30 | Species heterogeneity between gerbils and rats: quinolinate production by microglia and astrocytes and accumulations in response to ischemic brain injury and systemic immune activation. ( Beagles, KE; Chen, CY; Heyes, MP; Kawai, K; Li, J; Markey, SP; Nowak, TS; Proescholdt, MA; Proescholdt, MG; Saito, K; Zito, MA, 1997) |
| "Quinolinic acid is a neurotoxic tryptophan metabolite produced locally during immune activation." | 1.30 | Depletion of systemic macrophages by liposome-encapsulated clodronate attenuates increases in brain quinolinic acid during CNS-localized and systemic immune activation. ( Heyes, MP; Koennecke, LA; Proescholdt, MG; van Rooijen, N; Zito, MA, 1999) |
| "Quinolinic acid (QUIN) is an endogenous N-methyl-D-aspartate receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction." | 1.28 | Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. ( Crowley, JS; Davis, LE; Demitrack, MA; Der, M; Dilling, LA; Elia, J; Heyes, MP; Kruesi, MJ; Lackner, A; Saito, K, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (26.32) | 18.2507 |
| 2000's | 10 (52.63) | 29.6817 |
| 2010's | 3 (15.79) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Dale, RC | 1 |
| Thomas, T | 1 |
| Patel, S | 1 |
| Han, VX | 1 |
| Kothur, K | 1 |
| Troedson, C | 1 |
| Gupta, S | 1 |
| Gill, D | 1 |
| Malone, S | 1 |
| Waak, M | 1 |
| Calvert, S | 1 |
| Subramanian, G | 1 |
| Andrews, PI | 1 |
| Kandula, T | 1 |
| Menezes, MP | 1 |
| Ardern-Holmes, S | 1 |
| Mohammad, S | 1 |
| Bandodkar, S | 1 |
| Yan, J | 1 |
| S, M | 1 |
| T, P | 1 |
| Goli, D | 1 |
| Lee, DE | 1 |
| Yue, X | 1 |
| Ibrahim, WG | 1 |
| Lentz, MR | 1 |
| Peterson, KL | 1 |
| Jagoda, EM | 1 |
| Kassiou, M | 1 |
| Maric, D | 1 |
| Reid, WC | 1 |
| Hammoud, DA | 1 |
| Erhardt, S | 1 |
| Lim, CK | 1 |
| Linderholm, KR | 1 |
| Janelidze, S | 1 |
| Lindqvist, D | 1 |
| Samuelsson, M | 1 |
| Lundberg, K | 1 |
| Postolache, TT | 1 |
| Träskman-Bendz, L | 1 |
| Guillemin, GJ | 2 |
| Brundin, L | 1 |
| Kita, T | 1 |
| Morrison, PF | 1 |
| Heyes, MP | 5 |
| Markey, SP | 3 |
| Obrenovitch, TP | 2 |
| Urenjak, J | 1 |
| Smythe, G | 1 |
| Takikawa, O | 2 |
| Brew, BJ | 1 |
| Bantubungi, K | 1 |
| Jacquard, C | 1 |
| Greco, A | 1 |
| Pintor, A | 1 |
| Chtarto, A | 1 |
| Tai, K | 1 |
| Galas, MC | 1 |
| Tenenbaum, L | 1 |
| Déglon, N | 1 |
| Popoli, P | 1 |
| Minghetti, L | 1 |
| Brouillet, E | 1 |
| Brotchi, J | 1 |
| Levivier, M | 1 |
| Schiffmann, SN | 1 |
| Blum, D | 1 |
| Ryu, JK | 1 |
| Choi, HB | 1 |
| McLarnon, JG | 1 |
| Roy, EJ | 1 |
| Kranz, DM | 1 |
| Brown, AR | 1 |
| Thomas, DL | 1 |
| Walker, DG | 1 |
| Link, J | 1 |
| Lue, LF | 1 |
| Dalsing-Hernandez, JE | 1 |
| Boyes, BE | 1 |
| Ganzella, M | 1 |
| Jardim, FM | 1 |
| Boeck, CR | 1 |
| Vendite, D | 1 |
| Rabinoff, M | 1 |
| Saito, K | 3 |
| Major, EO | 1 |
| Milstien, S | 1 |
| Vickers, JH | 1 |
| Chen, CY | 1 |
| Proescholdt, MG | 2 |
| Nowak, TS | 1 |
| Li, J | 1 |
| Beagles, KE | 1 |
| Proescholdt, MA | 1 |
| Zito, MA | 2 |
| Kawai, K | 1 |
| Koennecke, LA | 1 |
| van Rooijen, N | 1 |
| Chiarugi, A | 1 |
| Calvani, M | 1 |
| Meli, E | 1 |
| Traggiai, E | 1 |
| Moroni, F | 1 |
| Crowley, JS | 1 |
| Davis, LE | 1 |
| Demitrack, MA | 1 |
| Der, M | 1 |
| Dilling, LA | 1 |
| Elia, J | 1 |
| Kruesi, MJ | 1 |
| Lackner, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Role of Kynurenine Pathway Metabolites in Perinatal Depression and Suicidality[NCT02566980] | 209 participants (Actual) | Observational | 2014-10-23 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
19 other studies available for quinolinic acid and Brain Inflammation
| Article | Year |
|---|---|
CSF neopterin and quinolinic acid are biomarkers of neuroinflammation and neurotoxicity in FIRES and other infection-triggered encephalopathy syndromes.
Topics: Biomarkers; Brain Diseases; Chromatography, Liquid; Encephalitis; Humans; Kynurenine; Neopterin; Neu | 2023 |
Effect of wedelolactone and gallic acid on quinolinic acid-induced neurotoxicity and impaired motor function: significance to sporadic amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antioxidants; Apoptosis; Brain; Coumarins; Disease Models, A | 2018 |
Lack of neuroinflammation in the HIV-1 transgenic rat: an [(18)F]-DPA714 PET imaging study.
Topics: Analysis of Variance; Animals; Body Weight; Brain Injuries; Brain Mapping; Cytokines; Encephalitis; | 2015 |
Connecting inflammation with glutamate agonism in suicidality.
Topics: Adult; Aged; Encephalitis; Excitatory Amino Acid Agonists; Female; Follow-Up Studies; Humans; Interl | 2013 |
Effects of systemic and central nervous system localized inflammation on the contributions of metabolic precursors to the L-kynurenine and quinolinic acid pools in brain.
Topics: Animals; Body Fluid Compartments; Brain; Corpus Striatum; Encephalitis; Female; Gerbillinae; Inflamm | 2002 |
Accumulation of quinolinic acid with neuroinflammation: does it mean excitotoxicity?
Topics: Animals; Cerebral Cortex; Encephalitis; Lactic Acid; Male; Membrane Potentials; N-Methylaspartate; N | 2003 |
Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons.
Topics: Astrocytes; Brain; Brain Chemistry; Cells, Cultured; Coculture Techniques; Encephalitis; Humans; Imm | 2005 |
Minocycline in phenotypic models of Huntington's disease.
Topics: Animals; Calpain; Caspases; Cell Death; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Do | 2005 |
Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Antineoplastic Agents; Carrier Proteins; Caspases; | 2005 |
Neuronal localization of indoleamine 2,3-dioxygenase in mice.
Topics: Animals; Encephalitis; Hippocampus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynureni | 2005 |
Gene expression changes by amyloid beta peptide-stimulated human postmortem brain microglia identify activation of multiple inflammatory processes.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Calgranulin A; Cells, Cultured; C | 2006 |
Time course of oxidative events in the hippocampus following intracerebroventricular infusion of quinolinic acid in mice.
Topics: AIDS Dementia Complex; Animals; Antioxidants; Cells, Cultured; Disease Models, Animal; Encephalitis; | 2006 |
Short note: possible role of macrophage metabolic products including quinolinic acid and neopterin in the pathogenesis of inflammatory brain diseases.
Topics: Biopterins; Encephalitis; Folic Acid; Humans; Macrophages; Models, Biological; Neopterin; Quinolinic | 1994 |
A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.
Topics: 3-Hydroxyanthranilic Acid; Animals; Biopterins; Brain; Encephalitis; Fetus; Indoleamine-Pyrrole 2,3, | 1993 |
Species heterogeneity between gerbils and rats: quinolinate production by microglia and astrocytes and accumulations in response to ischemic brain injury and systemic immune activation.
Topics: Animals; Astrocytes; Brain Ischemia; Encephalitis; Gerbillinae; Immune System; Injections, Intraperi | 1997 |
Depletion of systemic macrophages by liposome-encapsulated clodronate attenuates increases in brain quinolinic acid during CNS-localized and systemic immune activation.
Topics: Animals; Brain Chemistry; Cerebellum; Clodronic Acid; Corpus Striatum; Drug Compounding; Encephaliti | 1999 |
Quinolinic acid accumulation during neuroinflammation. Does it imply excitotoxicity?
Topics: Animals; Cerebral Cortex; Cortical Spreading Depression; Encephalitis; Lactic Acid; Male; Potassium; | 2001 |
Synthesis and release of neurotoxic kynurenine metabolites by human monocyte-derived macrophages.
Topics: Cell Death; Cells, Cultured; Culture Media, Conditioned; Cytokines; Encephalitis; Enzyme Inhibitors; | 2001 |
Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease.
Topics: Aged; Animals; Brain Diseases; Encephalitis; Female; HIV Infections; Humans; Kynurenic Acid; Kynuren | 1992 |