quinolinic acid has been researched along with Brain Disorders in 41 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Quinolinic acid is an agonist at the population of glutamate receptors which are sensitive to N-methyl-D-aspartate (NMDA), and kynurenic acid is an antagonist at several glutamate receptors." | 6.42 | Tryptophan metabolites and brain disorders. ( Clark, CJ; Darlington, LG; Forrest, CM; Mackay, GM; Stone, TW, 2003) |
| "Although some ITES syndromes have recognisable MRI neuroimaging phenotypes, there are otherwise few biomarkers of disease." | 5.91 | CSF neopterin and quinolinic acid are biomarkers of neuroinflammation and neurotoxicity in FIRES and other infection-triggered encephalopathy syndromes. ( Andrews, PI; Ardern-Holmes, S; Bandodkar, S; Calvert, S; Dale, RC; Gill, D; Gupta, S; Han, VX; Kandula, T; Kothur, K; Malone, S; Menezes, MP; Mohammad, S; Patel, S; Subramanian, G; Thomas, T; Troedson, C; Waak, M; Yan, J, 2023) |
| "Quinolinic acid is an agonist at the population of glutamate receptors which are sensitive to N-methyl-D-aspartate (NMDA), and kynurenic acid is an antagonist at several glutamate receptors." | 2.42 | Tryptophan metabolites and brain disorders. ( Clark, CJ; Darlington, LG; Forrest, CM; Mackay, GM; Stone, TW, 2003) |
| "Although some ITES syndromes have recognisable MRI neuroimaging phenotypes, there are otherwise few biomarkers of disease." | 1.91 | CSF neopterin and quinolinic acid are biomarkers of neuroinflammation and neurotoxicity in FIRES and other infection-triggered encephalopathy syndromes. ( Andrews, PI; Ardern-Holmes, S; Bandodkar, S; Calvert, S; Dale, RC; Gill, D; Gupta, S; Han, VX; Kandula, T; Kothur, K; Malone, S; Menezes, MP; Mohammad, S; Patel, S; Subramanian, G; Thomas, T; Troedson, C; Waak, M; Yan, J, 2023) |
| " We need to pay attention to the dosage of ceftazidime and to the appearance of neurological symptoms." | 1.72 | Ceftazidime encephalopathy developed without the elevation of cerebrospinal fluid concentration of ceftazidime: A case report of two cases. ( Fujii, K; Hasegawa, N; Hosoya, K; Kato, A; Kobayashi, E; Komatsu, M; Matsumoto, K; Ryuzaki, M; Taguchi, K; Toda, M; Yoshifuji, A, 2022) |
| "3-Hydroxykynurenine (3-HK) is a tryptophan metabolite whose level in the brain is elevated under several pathological states including Huntington's disease." | 1.29 | 3-Hydroxykynurenine toxicity on the rat striatum in vivo. ( Katsuki, H; Nakagami, Y; Saito, H, 1996) |
| " Lesioned rats showed a cocaine dose-response function that was shifted upwards relative to control subjects." | 1.29 | Excitotoxic lesions of the basolateral amygdala impair the acquisition of cocaine-seeking behaviour under a second-order schedule of reinforcement. ( Everitt, BJ; Markou, A; Robbins, TW; Whitelaw, RB, 1996) |
| "Quinolinic acid (QUIN) is an endogenous N-methyl-D-aspartate receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction." | 1.28 | Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. ( Crowley, JS; Davis, LE; Demitrack, MA; Der, M; Dilling, LA; Elia, J; Heyes, MP; Kruesi, MJ; Lackner, A; Saito, K, 1992) |
| "In patients with encephalopathy, serum QUIN was elevated with corresponding increments in CSF QUIN." | 1.28 | Neuroactive kynurenines in Lyme borreliosis. ( Halperin, JJ; Heyes, MP, 1992) |
| " The antagonistic properties of kynurenate were dose-dependent: equimolar kynurenate had no effect on quinolinate but attenuated the actions of ibotenate, kainate and NMDA; 2 x equimolar kynurenate had no effect on quinolinate or ibotenate but attenuated the toxicity of kainate and NMDA; and 3 x equimolar kynurenate had no effect on the toxicity of kainate or ibotenate, attenuated the actions of NMDA and abolished the toxic action of quinolinate." | 1.28 | A comparison of excitotoxic lesions of the basal forebrain by kainate, quinolinate, ibotenate, N-methyl-D-aspartate or quisqualate, and the effects on toxicity of 2-amino-5-phosphonovaleric acid and kynurenic acid in the rat. ( Clark, AJ; Hastings, MH; Latimer, M; Stone, TW; Winn, P, 1991) |
| "Glutaric aciduria type I is an autosomal recessive metabolic disorder of children associated with severe dystonic motor disturbances and degeneration in the cerebral cortex, striatum and cerebellum." | 1.27 | Hypothesis: a role for quinolinic acid in the neuropathology of glutaric aciduria type I. ( Heyes, MP, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (9.76) | 18.7374 |
| 1990's | 23 (56.10) | 18.2507 |
| 2000's | 11 (26.83) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 3 (7.32) | 2.80 |
| Authors | Studies |
|---|---|
| Toda, M | 1 |
| Yoshifuji, A | 1 |
| Hosoya, K | 1 |
| Taguchi, K | 1 |
| Komatsu, M | 1 |
| Kobayashi, E | 1 |
| Fujii, K | 1 |
| Kato, A | 1 |
| Hasegawa, N | 1 |
| Matsumoto, K | 1 |
| Ryuzaki, M | 1 |
| Phing, AH | 1 |
| Makpol, S | 1 |
| Nasaruddin, ML | 1 |
| Wan Zaidi, WA | 1 |
| Ahmad, NS | 1 |
| Embong, H | 1 |
| Dale, RC | 1 |
| Thomas, T | 1 |
| Patel, S | 1 |
| Han, VX | 1 |
| Kothur, K | 1 |
| Troedson, C | 1 |
| Gupta, S | 1 |
| Gill, D | 1 |
| Malone, S | 1 |
| Waak, M | 1 |
| Calvert, S | 1 |
| Subramanian, G | 1 |
| Andrews, PI | 1 |
| Kandula, T | 1 |
| Menezes, MP | 1 |
| Ardern-Holmes, S | 1 |
| Mohammad, S | 1 |
| Bandodkar, S | 1 |
| Yan, J | 1 |
| Figueiredo, C | 1 |
| Pais, TF | 1 |
| Gomes, JR | 1 |
| Chatterjee, S | 1 |
| Doan, BT | 1 |
| Autret, G | 1 |
| Mispelter, J | 1 |
| Méric, P | 1 |
| Même, W | 1 |
| Montécot-Dubourg, C | 1 |
| Corrèze, JL | 1 |
| Szeremeta, F | 1 |
| Gillet, B | 1 |
| Beloeil, JC | 1 |
| Mering, TA | 1 |
| Olds, ME | 1 |
| Jacques, DB | 1 |
| Kpoyov, O | 1 |
| Stone, TW | 2 |
| Mackay, GM | 1 |
| Forrest, CM | 1 |
| Clark, CJ | 1 |
| Darlington, LG | 1 |
| Block, F | 3 |
| Loos, M | 1 |
| Frohn, C | 1 |
| Schwarz, M | 3 |
| Santiago-López, D | 1 |
| Vázquez-Román, B | 1 |
| Pérez-de La Cruz, V | 1 |
| Barrera, D | 1 |
| Rembao, D | 1 |
| Salinas-Lara, C | 1 |
| Pedraza-Chaverrí, J | 1 |
| Galván-Arzate, S | 1 |
| Ali, SF | 1 |
| Santamaría, A | 2 |
| Moresco, RM | 1 |
| Todde, S | 1 |
| Belloli, S | 1 |
| Simonelli, P | 1 |
| Panzacchi, A | 1 |
| Rigamonti, M | 1 |
| Galli-Kienle, M | 1 |
| Fazio, F | 1 |
| Wolf, G | 1 |
| Henschke, G | 1 |
| Würdig, S | 1 |
| Marston, HM | 1 |
| Faber, ES | 1 |
| Crawford, JH | 1 |
| Butcher, SP | 1 |
| Sharkey, J | 1 |
| Töpper, R | 1 |
| Gehrmann, J | 1 |
| Banati, R | 1 |
| Noth, J | 1 |
| Kreutzberg, GW | 1 |
| Altagracia, M | 1 |
| Solís, F | 1 |
| Kravzov, J | 1 |
| Ordaz, H | 1 |
| Gonzalez, L | 1 |
| Ríos, C | 1 |
| Holzman, D | 1 |
| Schwarcz, R | 6 |
| Kunkel, M | 1 |
| Schapira, AH | 1 |
| Wu, HQ | 3 |
| Ungerstedt, U | 2 |
| Levivier, M | 1 |
| Gash, DM | 1 |
| Przedborski, S | 1 |
| Vogelgesang, SA | 1 |
| Heyes, MP | 4 |
| West, SG | 1 |
| Salazar, AM | 1 |
| Sfikakis, PP | 1 |
| Lipnick, RN | 1 |
| Klipple, GL | 1 |
| Tsokos, GC | 1 |
| Nakagami, Y | 1 |
| Saito, H | 1 |
| Katsuki, H | 1 |
| Whitelaw, RB | 1 |
| Markou, A | 1 |
| Robbins, TW | 1 |
| Everitt, BJ | 1 |
| Sanni, LA | 1 |
| Thomas, SR | 1 |
| Tattam, BN | 1 |
| Moore, DE | 1 |
| Chaudhri, G | 1 |
| Stocker, R | 1 |
| Hunt, NH | 1 |
| O'Neill, AB | 1 |
| Morgan, SJ | 1 |
| Brioni, JD | 1 |
| Henrich-Noack, P | 1 |
| Flor, PJ | 1 |
| Sabelhaus, CF | 1 |
| Prass, K | 1 |
| Dirnagl, U | 1 |
| Gasparini, F | 1 |
| Sauter, A | 1 |
| Rudin, M | 1 |
| Reymann, KG | 1 |
| Lee, SC | 1 |
| Ravikumar, A | 1 |
| Deepadevi, KV | 1 |
| Arun, P | 1 |
| Manojkumar, V | 1 |
| Kurup, PA | 1 |
| Saito, K | 1 |
| Crowley, JS | 1 |
| Davis, LE | 1 |
| Demitrack, MA | 1 |
| Der, M | 1 |
| Dilling, LA | 1 |
| Elia, J | 1 |
| Kruesi, MJ | 1 |
| Lackner, A | 1 |
| Halperin, JJ | 1 |
| Winn, P | 1 |
| Latimer, M | 1 |
| Hastings, MH | 1 |
| Clark, AJ | 1 |
| Du, F | 1 |
| Nash, DR | 1 |
| Kaplan, SM | 1 |
| Norman, AB | 1 |
| Sanberg, PR | 2 |
| Zubrycki, E | 1 |
| Ragozzino, ME | 1 |
| Giordano, M | 1 |
| Shipley, MT | 1 |
| Ng Ying Kin, NM | 1 |
| Chung, D | 1 |
| Wieloch, T | 1 |
| Goldstein, M | 1 |
| Kuga, S | 1 |
| Kusano, N | 1 |
| Meller, E | 1 |
| Dancis, J | 1 |
| Tulipan, N | 1 |
| Luo, SQ | 1 |
| Allen, GS | 1 |
| Whetsell, WO | 1 |
6 reviews available for quinolinic acid and Brain Disorders
| Article | Year |
|---|---|
Altered Tryptophan-Kynurenine Pathway in Delirium: A Review of the Current Literature.
Topics: Aged; Brain Diseases; Delirium; Humans; Immune System; Kynurenine; Quinolinic Acid; Tryptophan | 2023 |
Tryptophan metabolites and brain disorders.
Topics: AIDS Dementia Complex; Brain Diseases; Central Nervous System Diseases; Humans; Huntington Disease; | 2003 |
Metabolism and function of brain kynurenines.
Topics: Animals; Brain; Brain Diseases; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Receptors, N-Me | 1993 |
The use of toxins to elucidate neural function and disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Brain; Brain Diseases; Disease Models, Animal; Humans; | 1993 |
Quinolinic acid and kynurenic acid in the mammalian brain.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; AIDS Dementia Complex; Animals; Aspartic Acid; Biological Tra | 1991 |
Neurochemical correlates to selective neuronal vulnerability.
Topics: Adenosine; Afferent Pathways; Animals; Aspartic Acid; Brain Diseases; Brain Ischemia; Calcium; Chlor | 1985 |
1 trial available for quinolinic acid and Brain Disorders
| Article | Year |
|---|---|
Quinolinic acid in patients with systemic lupus erythematosus and neuropsychiatric manifestations.
Topics: Adult; Brain Diseases; Demography; Electroencephalography; Female; Humans; Lupus Erythematosus, Syst | 1996 |
34 other studies available for quinolinic acid and Brain Disorders
| Article | Year |
|---|---|
Ceftazidime encephalopathy developed without the elevation of cerebrospinal fluid concentration of ceftazidime: A case report of two cases.
Topics: Aged, 80 and over; Brain Diseases; Ceftazidime; Humans; Male; Peritoneal Dialysis; Quinolinic Acid; | 2022 |
CSF neopterin and quinolinic acid are biomarkers of neuroinflammation and neurotoxicity in FIRES and other infection-triggered encephalopathy syndromes.
Topics: Biomarkers; Brain Diseases; Chromatography, Liquid; Encephalitis; Humans; Kynurenine; Neopterin; Neu | 2023 |
Neuron-microglia crosstalk up-regulates neuronal FGF-2 expression which mediates neuroprotection against excitotoxicity via JNK1/2.
Topics: Animals; Brain Diseases; Calcium-Binding Proteins; Cathepsins; Cell Communication; Cell Death; Cells | 2008 |
Simultaneous two-voxel localized (1)H-observed (13)C-edited spectroscopy for in vivo MRS on rat brain at 9.4T: Application to the investigation of excitotoxic lesions.
Topics: Algorithms; Animals; Astrocytes; Brain Chemistry; Brain Diseases; Carbon Radioisotopes; Fluorescent | 2009 |
The action of mexidol on the state of conditioned reflex activity after traumatic brain lesions.
Topics: Algorithms; Animals; Antioxidants; Brain Diseases; Conditioning, Classical; Hippocampus; Picolines; | 2003 |
Behavioral/neurophysiological investigation of effects of combining a quinolinic acid entopeduncular lesion with a fetal mesencephalic tissue transplant in striatum of the 6-OHDA hemilesioned rat.
Topics: Amphetamine; Animals; Apomorphine; Brain Diseases; Brain Tissue Transplantation; Corpus Striatum; Do | 2003 |
Association between inflammation and nigral neuronal damage following striatal excitotoxic lesion.
Topics: Animals; Brain Diseases; Cell Count; Chondroitin Sulfate Proteoglycans; Corpus Striatum; Dizocilpine | 2004 |
Peroxynitrite decomposition catalyst, iron metalloporphyrin, reduces quinolinate-induced neurotoxicity in rats.
Topics: Animals; Antioxidants; Brain Diseases; Corpus Striatum; Iron; Male; Metalloporphyrins; Neurotoxins; | 2004 |
In vivo imaging of adenosine A2A receptors in rat and primate brain using [11C]SCH442416.
Topics: Animals; Brain Diseases; Carbon Radioisotopes; Corpus Striatum; Macaca nemestrina; Male; Metabolic C | 2005 |
Glutamate agonist-induced hippocampal lesion and nitric oxide synthase/NADPH-diaphorase: a light and electron microscopical study in the rat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Oxidoreductases; Animals; Benzo | 1993 |
Behavioural assessment of endothelin-1 induced middle cerebral artery occlusion in the rat.
Topics: Animals; Arterial Occlusive Diseases; Behavior, Animal; Brain Diseases; Caudate Nucleus; Cerebral Ar | 1995 |
Rapid appearance of beta-amyloid precursor protein immunoreactivity in glial cells following excitotoxic brain injury.
Topics: Amyloid beta-Protein Precursor; Animals; Astrocytes; Brain Diseases; Corpus Striatum; Immunohistoche | 1995 |
Kynurenine and probenecid prevent quinolinic acid-induced neurotoxicity in rat corpus striatum.
Topics: Animals; Brain Diseases; gamma-Aminobutyric Acid; Kynurenine; Male; Neostriatum; Probenecid; Quinoli | 1994 |
Inflamed debate over neurotoxin.
Topics: Brain Diseases; Humans; Neurotoxins; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate | 1993 |
Quinolinic acid lesion of the striatum induces impairment in spatial learning and motor performance in rats.
Topics: Animals; Brain Diseases; Corpus Striatum; Learning; Male; Psychomotor Performance; Quinolinic Acid; | 1993 |
L-alpha-aminoadipic acid as a regulator of kynurenic acid production in the hippocampus: a microdialysis study in freely moving rats.
Topics: 2-Aminoadipic Acid; Animals; Brain Diseases; Dialysis; Hippocampus; Kynurenic Acid; Kynurenine; Male | 1995 |
Time course of the neuroprotective effect of transplantation on quinolinic acid-induced lesions of the striatum.
Topics: Adenosine; Animals; Autoradiography; Benzazepines; Brain Diseases; Corpus Striatum; Electron Transpo | 1995 |
3-Hydroxykynurenine toxicity on the rat striatum in vivo.
Topics: Acetylcysteine; Animals; Brain Diseases; Corpus Striatum; Free Radical Scavengers; Injections, Intra | 1996 |
Excitotoxic lesions of the basolateral amygdala impair the acquisition of cocaine-seeking behaviour under a second-order schedule of reinforcement.
Topics: Amygdala; Animals; Behavior, Animal; Brain Diseases; Cocaine; Conditioning, Operant; Male; Narcotics | 1996 |
Dramatic changes in oxidative tryptophan metabolism along the kynurenine pathway in experimental cerebral and noncerebral malaria.
Topics: Animals; Aspartic Acid; Brain; Brain Diseases; Female; Glutamic Acid; Indoleamine-Pyrrole 2,3,-Dioxy | 1998 |
Histological and behavioral protection by (-)-nicotine against quinolinic acid-induced neurodegeneration in the hippocampus.
Topics: Animals; Brain Diseases; Cognition Disorders; Hippocampus; Male; Maze Learning; Memory Disorders; Ne | 1998 |
Distinct influence of the group III metabotropic glutamate receptor agonist (R,S)-4-phosphonophenylglycine [(R,S)-PPG] on different forms of neuronal damage.
Topics: Action Potentials; Animals; Brain Diseases; Brain Ischemia; Cell Hypoxia; Corpus Striatum; Cytoprote | 2000 |
Systemic administration of 4-chlorokynurenine prevents quinolinate neurotoxicity in the rat hippocampus.
Topics: Animals; Brain Diseases; Dialysis Solutions; Hippocampus; Injections, Intraperitoneal; Kynurenic Aci | 2000 |
Tryptophan and tyrosine catabolic pattern in neuropsychiatric disorders.
Topics: Adult; Biogenic Monoamines; Brain Diseases; Brain Neoplasms; Digoxin; Epilepsy, Generalized; Erythro | 2000 |
Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease.
Topics: Aged; Animals; Brain Diseases; Encephalitis; Female; HIV Infections; Humans; Kynurenic Acid; Kynuren | 1992 |
Neuroactive kynurenines in Lyme borreliosis.
Topics: Brain Diseases; Humans; Kynurenine; Lyme Disease; Lymphokines; Multiple Sclerosis; Nervous System Di | 1992 |
Regulation of kynurenic acid synthesis studied by microdialysis in the dorsal hippocampus of unanesthetized rats.
Topics: Aminooxyacetic Acid; Animals; Brain Diseases; Dialysis; Drug Interactions; Hippocampus; Kynurenic Ac | 1992 |
A comparison of excitotoxic lesions of the basal forebrain by kainate, quinolinate, ibotenate, N-methyl-D-aspartate or quisqualate, and the effects on toxicity of 2-amino-5-phosphonovaleric acid and kynurenic acid in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Brain Diseases; Ibotenic Acid; Kainic Acid; Kynurenic A | 1991 |
An evaluation of the possible protective effects of neonatal striatal transplants against kainic acid-induced lesions.
Topics: Animals; Animals, Newborn; Body Weight; Brain Diseases; Brain Tissue Transplantation; Corpus Striatu | 1991 |
Tyrosine hydroxylase-positive fibers and neurons in transplanted striatal tissue in rats with quinolinic acid lesions of the striatum.
Topics: Afferent Pathways; Animals; Brain Diseases; Brain Tissue Transplantation; Corpus Striatum; Fetal Tis | 1990 |
In vivo incorporation of N-acetyl-D-[U-14C]mannosamine into brain gangliosides of rats with quinolinic acid-induced lesions of the forebrain nucleus basalis magnocellularis.
Topics: Animals; Basal Ganglia; Brain Chemistry; Brain Diseases; Carbohydrate Metabolism; Chromatography, Th | 1990 |
Dopamine agonist induced self-mutilative biting behavior in monkeys with unilateral ventromedial tegmental lesions of the brainstem: possible pharmacological model for Lesch-Nyhan syndrome.
Topics: Animals; Brain Diseases; Cercopithecus; Chlorocebus aethiops; Corpus Striatum; Disease Models, Anima | 1986 |
Hypothesis: a role for quinolinic acid in the neuropathology of glutaric aciduria type I.
Topics: Brain Diseases; Child; Glutarates; Glutaryl-CoA Dehydrogenase; Humans; Neurotoxins; Oxidoreductases; | 1987 |
Striatal grafts provide sustained protection from kainic and quinolinic acid-induced damage.
Topics: Animals; Animals, Newborn; Brain Diseases; Cell Count; Corpus Striatum; Kainic Acid; Neurons; Pyridi | 1988 |