quinolinic acid has been researched along with Body Weight in 40 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Evidence has suggested that the activation of indoleamine-2,3-dioxygenase (IDO), the rate-limiting enzyme in the kynurenine pathway (KP), plays a crucial role in inflammation-related diseases." | 3.96 | Involvement of Indoleamine-2,3-Dioxygenase and Kynurenine Pathway in Experimental Autoimmune Encephalomyelitis in Mice. ( Boeira, SP; Cattelan Souza, L; Giacomeli, R; Jesse, CR; Prigol, M; Silva, MRP; Zarzecki, MS, 2020) |
| " Cerebrospinal fluid levels of L-tryptophan, quinolinic acid, kynurenic acid, L-kynurenine, and 5-hydroxyindoleacetic acid were measured in medication-free female patients meeting DSM-III-R criteria for either anorexia nervosa (n = 10) or normal-weight bulimia nervosa (n = 22), studied at varying stages of nutritional recovery." | 3.69 | Cerebrospinal fluid levels of kynurenine pathway metabolites in patients with eating disorders: relation to clinical and biochemical variable. ( Altemus, M; Demitrack, MA; Gold, PW; Heyes, MP; Pigott, TA, 1995) |
| "Huntington disease is hyperkinetic movement disorder characterized by selective and immense degradation of GABAergic medium spiny neurons in striatum." | 1.42 | Protective Effect of Spermidine Against Excitotoxic Neuronal Death Induced by Quinolinic Acid in Rats: Possible Neurotransmitters and Neuroinflammatory Mechanism. ( Jamwal, S; Kaur, N; Kumar, P; Singh, S, 2015) |
| "Treatment with rosiglitazone (5, 10 mg/kg) and VPA (100, 200 mg/kg) for 21 days significantly attenuated these behavioral, biochemical, and cellular alterations as compared to control (QA 200 nmol) group." | 1.40 | Rosiglitazone synergizes the neuroprotective effects of valproic acid against quinolinic acid-induced neurotoxicity in rats: targeting PPARγ and HDAC pathways. ( Chaudhary, T; Kumar, A; Mishra, J, 2014) |
| "Picolinic acid (PiA) is an endogenous metabolite of tryptophan that has been reported to possess a wide range of physiological actions." | 1.40 | Large amounts of picolinic acid are lethal but small amounts increase the conversion of tryptophan-nicotinamide in rats. ( Fukuwatari, T; Shibata, K, 2014) |
| "Huntington disease is a neurodegenerative disease with complex pathophysiology." | 1.37 | Attenuation of proinflammatory cytokines and apoptotic process by verapamil and diltiazem against quinolinic acid induced Huntington like alterations in rats. ( Kalonia, H; Kumar, A; Kumar, P, 2011) |
| "Quinolinic acid is an endogenous excitotoxin that causes neurotoxicity in diverse areas of the brain and produces motor dysfunction." | 1.36 | Protective effect of rofecoxib and nimesulide against intra-striatal quinolinic acid-induced behavioral, oxidative stress and mitochondrial dysfunctions in rats. ( Kalonia, H; Kumar, A; Kumar, P; Nehru, B, 2010) |
| "Quinolinic acid has been reported to induce excitotoxicity by stimulating the N-methyl-D-aspartate receptor, causing calcium overload which in turn leads to the neurodegeneration." | 1.36 | Protective effect of montelukast against quinolinic acid/malonic acid induced neurotoxicity: possible behavioral, biochemical, mitochondrial and tumor necrosis factor-α level alterations in rats. ( Kalonia, H; Kumar, A; Kumar, P; Nehru, B, 2010) |
| "Quinolinic acid (QA) is a well-known excitotoxic agent that could induce behavioral, morphological and biochemical alterations similar with symptoms of Huntington's disease (HD), by stimulating NMDA receptors." | 1.35 | Effects of caffeic acid, rofecoxib, and their combination against quinolinic acid-induced behavioral alterations and disruption in glutathione redox status. ( Kalonia, H; Kumar, A; Kumar, P; Nehru, B, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.50) | 18.7374 |
| 1990's | 6 (15.00) | 18.2507 |
| 2000's | 15 (37.50) | 29.6817 |
| 2010's | 17 (42.50) | 24.3611 |
| 2020's | 1 (2.50) | 2.80 |
| Authors | Studies |
|---|---|
| Zarzecki, MS | 1 |
| Cattelan Souza, L | 1 |
| Giacomeli, R | 1 |
| Silva, MRP | 1 |
| Prigol, M | 1 |
| Boeira, SP | 1 |
| Jesse, CR | 1 |
| Cui, J | 1 |
| Wang, G | 1 |
| Kandhare, AD | 1 |
| Mukherjee-Kandhare, AA | 1 |
| Bodhankar, SL | 1 |
| Terakata, M | 2 |
| Fukuwatari, T | 6 |
| Kadota, E | 1 |
| Sano, M | 2 |
| Kanai, M | 1 |
| Nakamura, T | 1 |
| Funakoshi, H | 1 |
| Shibata, K | 7 |
| Morita, N | 1 |
| Shibata, Y | 1 |
| Mishra, J | 2 |
| Chaudhary, T | 1 |
| Kumar, A | 8 |
| Jamwal, S | 1 |
| Singh, S | 1 |
| Kaur, N | 1 |
| Kumar, P | 7 |
| Lee, DE | 1 |
| Yue, X | 1 |
| Ibrahim, WG | 1 |
| Lentz, MR | 1 |
| Peterson, KL | 1 |
| Jagoda, EM | 1 |
| Kassiou, M | 1 |
| Maric, D | 1 |
| Reid, WC | 1 |
| Hammoud, DA | 1 |
| Morales-Martínez, A | 1 |
| Sánchez-Mendoza, A | 1 |
| Martínez-Lazcano, JC | 1 |
| Pineda-Farías, JB | 1 |
| Montes, S | 1 |
| El-Hafidi, M | 1 |
| Martínez-Gopar, PE | 1 |
| Tristán-López, L | 1 |
| Pérez-Neri, I | 1 |
| Zamorano-Carrillo, A | 1 |
| Castro, N | 1 |
| Ríos, C | 2 |
| Pérez-Severiano, F | 2 |
| Lima, LCF | 1 |
| Saliba, SW | 2 |
| Andrade, JMO | 1 |
| Cunha, ML | 1 |
| Cassini-Vieira, P | 1 |
| Feltenberger, JD | 1 |
| Barcelos, LS | 1 |
| Guimarães, ALS | 1 |
| de-Paula, AMB | 1 |
| de Oliveira, ACP | 1 |
| Santos, SHS | 1 |
| Vieira, EL | 1 |
| Santos, RP | 1 |
| Candelario-Jalil, E | 1 |
| Fiebich, BL | 1 |
| Vieira, LB | 1 |
| Teixeira, AL | 1 |
| de Oliveira, AC | 1 |
| Bezzina, G | 2 |
| Boon, FS | 1 |
| Hampson, CL | 2 |
| Cheung, TH | 2 |
| Body, S | 2 |
| Bradshaw, CM | 2 |
| Szabadi, E | 2 |
| Anderson, IM | 2 |
| Deakin, JF | 2 |
| Kalonia, H | 6 |
| Nehru, B | 3 |
| Nakao, N | 1 |
| Sasaki, R | 2 |
| Fukuoka, S | 2 |
| Suzuki, Y | 1 |
| Sugimoto, E | 1 |
| Santamaría, A | 3 |
| Salvatierra-Sánchez, R | 1 |
| Vázquez-Román, B | 1 |
| Santiago-López, D | 1 |
| Villeda-Hernández, J | 2 |
| Galván-Arzate, S | 3 |
| Jiménez-Capdeville, ME | 2 |
| Ali, SF | 1 |
| Flores-Escartín, A | 1 |
| Martínez, JC | 1 |
| Osorio, L | 1 |
| Pedraza-Chaverrí, J | 2 |
| Chaverrí, JP | 1 |
| Maldonado, PD | 2 |
| Medina-Campos, ON | 2 |
| Manjarrez, J | 1 |
| Ayalon, L | 1 |
| Doron, R | 1 |
| Weiner, I | 1 |
| Joel, D | 1 |
| Popoli, P | 2 |
| Pintor, A | 1 |
| Tebano, MT | 1 |
| Frank, C | 1 |
| Pepponi, R | 1 |
| Nazzicone, V | 1 |
| Grieco, R | 1 |
| Pèzzola, A | 2 |
| Reggio, R | 1 |
| Minghetti, L | 1 |
| De Berardinis, MA | 1 |
| Martire, A | 1 |
| Potenza, RL | 1 |
| Domenici, MR | 2 |
| Massotti, M | 1 |
| Ohsaki, S | 1 |
| Rodríguez-Pérez, M | 1 |
| Ortíz-Plata, A | 1 |
| Sánchez-García, A | 1 |
| Aguilera, P | 1 |
| Egashira, Y | 2 |
| Murotani, G | 1 |
| Tanabe, A | 1 |
| Saito, K | 2 |
| Uehara, K | 1 |
| Morise, A | 1 |
| Sato, M | 2 |
| Sanada, H | 2 |
| Borlongan, CV | 1 |
| Skinner, SJ | 1 |
| Geaney, M | 1 |
| Vasconcellos, AV | 1 |
| Elliott, RB | 1 |
| Emerich, DF | 2 |
| Schweigert, ID | 1 |
| de Oliveira, DL | 1 |
| Scheibel, F | 1 |
| da Costa, F | 1 |
| Wofchuk, ST | 1 |
| Souza, DO | 1 |
| Perry, ML | 1 |
| Acheson, A | 1 |
| Farrar, AM | 1 |
| Patak, M | 1 |
| Hausknecht, KA | 1 |
| Kieres, AK | 1 |
| Choi, S | 1 |
| de Wit, H | 1 |
| Richards, JB | 1 |
| Demitrack, MA | 1 |
| Heyes, MP | 1 |
| Altemus, M | 1 |
| Pigott, TA | 1 |
| Gold, PW | 1 |
| Sagratella, S | 1 |
| Diana, G | 1 |
| Caporali, MG | 1 |
| Bronzetti, E | 1 |
| Vega, J | 1 |
| Scotti de Carolis, A | 1 |
| Dunbar, JS | 1 |
| Hitchcock, K | 1 |
| Latimer, M | 1 |
| Rugg, EL | 1 |
| Ward, N | 1 |
| Winn, P | 1 |
| Vécsei, L | 1 |
| Beal, MF | 1 |
| Nash, DR | 1 |
| Kaplan, SM | 1 |
| Norman, AB | 1 |
| Sanberg, PR | 2 |
| Zubrycki, EM | 1 |
| Murata, K | 1 |
| Hayakawa, T | 1 |
| Iwai, K | 1 |
40 other studies available for quinolinic acid and Body Weight
| Article | Year |
|---|---|
Involvement of Indoleamine-2,3-Dioxygenase and Kynurenine Pathway in Experimental Autoimmune Encephalomyelitis in Mice.
Topics: Animals; Body Weight; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Fem | 2020 |
Neuroprotective effect of naringin, a flavone glycoside in quinolinic acid-induced neurotoxicity: Possible role of PPAR-γ, Bax/Bcl-2, and caspase-3.
Topics: Animals; bcl-2-Associated X Protein; Behavior, Animal; Body Weight; Brain Chemistry; Caspase 3; Corp | 2018 |
The niacin required for optimum growth can be synthesized from L-tryptophan in growing mice lacking tryptophan-2,3-dioxygenase.
Topics: 3-Hydroxyanthranilic Acid; Animals; Body Weight; Diet; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; | 2013 |
Enzymes that control the conversion of L-tryptophan-nicotinamide and the urinary excretion ratio (N(1)-methyl-2-pyridone-5-carboxamide + N(1)-methyl-4-pyridone-3-carboxamide)/N(1)-methylnicotinamide in mice.
Topics: Animals; Body Weight; Eating; Enzymes; Male; Mice; NAD; Niacinamide; Pyridones; Quinolinic Acid; Try | 2013 |
Rosiglitazone synergizes the neuroprotective effects of valproic acid against quinolinic acid-induced neurotoxicity in rats: targeting PPARγ and HDAC pathways.
Topics: Animals; Body Weight; Brain; Disease Models, Animal; Drug Synergism; Histone Deacetylase Inhibitors; | 2014 |
Improvement of mitochondrial function by paliperidone attenuates quinolinic acid-induced behavioural and neurochemical alterations in rats: implications in Huntington's disease.
Topics: Acetylcholinesterase; Animals; Biogenic Amines; Body Weight; Corpus Striatum; Huntington Disease; Is | 2014 |
Large amounts of picolinic acid are lethal but small amounts increase the conversion of tryptophan-nicotinamide in rats.
Topics: Animals; Body Weight; Carboxy-Lyases; Dose-Response Relationship, Drug; Iron Chelating Agents; Kynur | 2014 |
Protective Effect of Spermidine Against Excitotoxic Neuronal Death Induced by Quinolinic Acid in Rats: Possible Neurotransmitters and Neuroinflammatory Mechanism.
Topics: Animals; Body Weight; Cell Death; Corpus Striatum; Disease Models, Animal; Dose-Response Relationshi | 2015 |
Lack of neuroinflammation in the HIV-1 transgenic rat: an [(18)F]-DPA714 PET imaging study.
Topics: Analysis of Variance; Animals; Body Weight; Brain Injuries; Brain Mapping; Cytokines; Encephalitis; | 2015 |
Essential fatty acid-rich diets protect against striatal oxidative damage induced by quinolinic acid in rats.
Topics: Animals; Body Weight; Cholesterol; Corpus Striatum; Disease Models, Animal; Fatty Acids, Essential; | 2017 |
Neurodegeneration Alters Metabolic Profile and Sirt 1 Signaling in High-Fat-Induced Obese Mice.
Topics: Animals; Body Composition; Body Weight; Corpus Striatum; Diet, High-Fat; Male; Metabolic Networks an | 2017 |
Neuroprotective effects of intrastriatal injection of rapamycin in a mouse model of excitotoxicity induced by quinolinic acid.
Topics: Animals; Body Weight; Corpus Striatum; Cytokines; Disease Models, Animal; Dose-Response Relationship | 2017 |
Effect of quinolinic acid-induced lesions of the subthalamic nucleus on performance on a progressive-ratio schedule of reinforcement: a quantitative analysis.
Topics: Animals; Behavior, Animal; Body Weight; Choice Behavior; Conditioning, Operant; Cues; Female; Food D | 2008 |
Effects of caffeic acid, rofecoxib, and their combination against quinolinic acid-induced behavioral alterations and disruption in glutathione redox status.
Topics: Animals; Body Weight; Caffeic Acids; Corpus Striatum; Cyclooxygenase 2 Inhibitors; Disease Models, A | 2009 |
Protective effect of rofecoxib and nimesulide against intra-striatal quinolinic acid-induced behavioral, oxidative stress and mitochondrial dysfunctions in rats.
Topics: Animals; Ataxia; Body Weight; Cell Survival; Corpus Striatum; Cyclooxygenase 2 Inhibitors; Lactones; | 2010 |
Pioglitazone ameliorates behavioral, biochemical and cellular alterations in quinolinic acid induced neurotoxicity: possible role of peroxisome proliferator activated receptor-Upsilon (PPARUpsilon) in Huntington's disease.
Topics: Animals; Antioxidants; Benzhydryl Compounds; Body Weight; Corpus Striatum; Disease Models, Animal; E | 2010 |
Comparative neuroprotective profile of statins in quinolinic acid induced neurotoxicity in rats.
Topics: Analysis of Variance; Animals; Atorvastatin; Behavior, Animal; Body Weight; Corpus Striatum; Fatty A | 2011 |
Protective effect of montelukast against quinolinic acid/malonic acid induced neurotoxicity: possible behavioral, biochemical, mitochondrial and tumor necrosis factor-α level alterations in rats.
Topics: Acetates; Analysis of Variance; Animals; Behavior, Animal; Body Weight; Brain; Brain Chemistry; Cata | 2010 |
Attenuation of proinflammatory cytokines and apoptotic process by verapamil and diltiazem against quinolinic acid induced Huntington like alterations in rats.
Topics: Analysis of Variance; Animals; Apoptosis; Body Weight; Calcium Channel Blockers; Catalase; Cytokines | 2011 |
Establishment of true niacin deficiency in quinolinic acid phosphoribosyltransferase knockout mice.
Topics: Animals; Body Weight; Disease Models, Animal; Eating; Mice; Mice, Inbred C57BL; Mice, Knockout; NAD; | 2012 |
Identification of a toxic mechanism of the plasticizers, phtahlic acid esters, which are putative endocrine disrupters: time-dependent increase in quinolinic acid and its metabolites in rats fed di(2-ethylhexyl)phthalate.
Topics: Animals; Body Weight; Carboxy-Lyases; Diethylhexyl Phthalate; Feeding Behavior; Hexanols; Liver; Nia | 2002 |
Protective effects of the antioxidant selenium on quinolinic acid-induced neurotoxicity in rats: in vitro and in vivo studies.
Topics: Animals; Antioxidants; Behavior, Animal; Body Weight; Brain Chemistry; Corpus Striatum; gamma-Aminob | 2003 |
Copper blocks quinolinic acid neurotoxicity in rats: contribution of antioxidant systems.
Topics: Animals; Antioxidants; Blotting, Western; Body Weight; Ceruloplasmin; Copper; Copper Sulfate; Free R | 2003 |
Amelioration of behavioral deficits in a rat model of Huntington's disease by an excitotoxic lesion to the globus pallidus.
Topics: Amphetamine; Animals; Behavior, Animal; Body Weight; Central Nervous System Stimulants; Cognition; D | 2004 |
Neuroprotective effects of the mGlu5R antagonist MPEP towards quinolinic acid-induced striatal toxicity: involvement of pre- and post-synaptic mechanisms and lack of direct NMDA blocking activity.
Topics: Animals; Body Weight; Calcium; Cells, Cultured; Electroencephalography; Excitatory Amino Acid Antago | 2004 |
Phthalate esters enhance quinolinate production by inhibiting alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD), a key enzyme of the tryptophan pathway.
Topics: Animals; Body Weight; Carboxy-Lyases; Chromatography, High Pressure Liquid; Diet; Diethylhexyl Phtha | 2004 |
S-Allylcysteine, a garlic-derived antioxidant, ameliorates quinolinic acid-induced neurotoxicity and oxidative damage in rats.
Topics: Animals; Antioxidants; Behavior, Animal; Blotting, Western; Body Weight; Cysteine; Garlic; Glutathio | 2004 |
Differential effects of dietary fatty acids on rat liver alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase activity and gene expression.
Topics: Animals; Body Weight; Carboxy-Lyases; Dietary Fats; Eating; Energy Intake; Gene Expression; Linoleic | 2004 |
Neuroprotection by encapsulated choroid plexus in a rodent model of Huntington's disease.
Topics: Alginates; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Body Weight; Brain Tis | 2004 |
Gestational and postnatal malnutrition affects sensitivity of young rats to picrotoxin and quinolinic acid and uptake of GABA by cortical and hippocampal slices.
Topics: Analysis of Variance; Animals; Animals, Newborn; Body Weight; Caseins; Cerebral Cortex; Dose-Respons | 2005 |
Nucleus accumbens lesions decrease sensitivity to rapid changes in the delay to reinforcement.
Topics: Animals; Behavior, Animal; Body Weight; Brain Injuries; Conditioning, Operant; Immunohistochemistry; | 2006 |
Dietary protein level and dietary interaction affect quinolinic acid concentration in rats.
Topics: Analysis of Variance; Animals; Body Weight; Carboxy-Lyases; Caseins; Diet; Dietary Proteins; Dose-Re | 2007 |
Effect of quinolinic acid-induced lesions of the nucleus accumbens core on performance on a progressive ratio schedule of reinforcement: implications for inter-temporal choice.
Topics: Animals; Body Weight; Choice Behavior; Conditioning, Operant; Cues; Data Interpretation, Statistical | 2008 |
Cerebrospinal fluid levels of kynurenine pathway metabolites in patients with eating disorders: relation to clinical and biochemical variable.
Topics: Adolescent; Adult; Anorexia Nervosa; Body Weight; Brain; Bulimia; Female; Humans; Hydroxyindoleaceti | 1995 |
Behavioral and electrophysiological correlates of the quinolinic acid rat model of Huntington's disease in rats.
Topics: Animals; Behavior, Animal; Body Weight; Disease Models, Animal; Electric Stimulation; Electroencepha | 1994 |
Excitotoxic lesions of the pedunculopontine tegmental nucleus of the rat. II. Examination of eating and drinking, rotation, and reaching and grasping following unilateral ibotenate or quinolinate lesions.
Topics: Animals; Behavior, Animal; Body Weight; Choline O-Acetyltransferase; Drinking Behavior; Feeding Beha | 1992 |
Comparative behavioral and neurochemical studies with striatal kainic acid- or quinolinic acid-lesioned rats.
Topics: Animals; Anxiety; Avoidance Learning; Behavior, Animal; Body Weight; Brain Chemistry; Corpus Striatu | 1991 |
An evaluation of the possible protective effects of neonatal striatal transplants against kainic acid-induced lesions.
Topics: Animals; Animals, Newborn; Body Weight; Brain Diseases; Brain Tissue Transplantation; Corpus Striatu | 1991 |
Sex differences in regulatory changes following quinolinic acid-induced striatal lesions.
Topics: Animals; Body Weight; Corpus Striatum; Female; Male; Ovary; Quinolinic Acid; Quinolinic Acids; Rats; | 1990 |
Effect of dietary orotic acid on the levels of liver and blood NAD in rats.
Topics: Animals; Body Weight; Creatinine; Diet; DNA; Fats; Liver; Male; NAD; Niacin; Organ Size; Orotic Acid | 1985 |