quinolinic acid has been researched along with Bipolar Disorder in 6 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Growing evidence suggests that a dysregulation of the kynurenine pathway (KP) occurs in bipolar disorder (BD)." | 9.12 | The kynurenine pathway in bipolar disorder: a meta-analysis on the peripheral blood levels of tryptophan and related metabolites. ( Bartoli, F; Callovini, T; Carrà, G; Cavaleri, D; Cioni, RM; Crocamo, C; Misiak, B; Savitz, JB, 2021) |
| "Inflammation-related changes in the concentrations of kynurenine-pathway metabolites occur in depression secondary to medical conditions but have not been well characterized in primary bipolar disorder (BD), with contradictory results potentially attributable to the presence or absence of psychosis and/or medication effects." | 7.81 | Neuroprotective kynurenine metabolite indices are abnormally reduced and positively associated with hippocampal and amygdalar volume in bipolar disorder. ( Bellgowan, PS; Bodurka, J; Dantzer, R; Drevets, WC; Ford, BN; Savitz, J; Teague, TK; Victor, TA; Wurfel, BE, 2015) |
| "Growing evidence suggests that a dysregulation of the kynurenine pathway (KP) occurs in bipolar disorder (BD)." | 5.12 | The kynurenine pathway in bipolar disorder: a meta-analysis on the peripheral blood levels of tryptophan and related metabolites. ( Bartoli, F; Callovini, T; Carrà, G; Cavaleri, D; Cioni, RM; Crocamo, C; Misiak, B; Savitz, JB, 2021) |
| " Depression is hypothesized to be causally associated with an imbalance in the kynurenine pathway, with an increased metabolism down the 3-hydroxykynurenine (3HK) branch of the pathway leading to increased levels of the neurotoxic metabolite, quinolinic acid (QA), which is a putative N-methyl-d-aspartate (NMDA) receptor agonist." | 3.85 | Serum kynurenic acid is reduced in affective psychosis. ( Bliss, SA; Dantzer, R; Drevets, WC; Ford, BN; McMillin, JR; Morris, HM; Savitz, JB; Suzuki, H; Teague, TK; Wurfel, BE, 2017) |
| "Increased cytokines and kynurenic acid (KYNA) levels in cerebrospinal fluid (CSF) have been reported in patients with schizophrenia and bipolar disorder." | 3.85 | Kynurenic acid and psychotic symptoms and personality traits in twins with psychiatric morbidity. ( Bhat, M; Cannon, TD; Engberg, G; Erhardt, S; Hultman, CM; Johansson, V; Kegel, ME; Landén, M; Schuppe-Koistinen, I; Schwieler, L; Wetterberg, L, 2017) |
| "Inflammation-related changes in the concentrations of kynurenine-pathway metabolites occur in depression secondary to medical conditions but have not been well characterized in primary bipolar disorder (BD), with contradictory results potentially attributable to the presence or absence of psychosis and/or medication effects." | 3.81 | Neuroprotective kynurenine metabolite indices are abnormally reduced and positively associated with hippocampal and amygdalar volume in bipolar disorder. ( Bellgowan, PS; Bodurka, J; Dantzer, R; Drevets, WC; Ford, BN; Savitz, J; Teague, TK; Victor, TA; Wurfel, BE, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Bartoli, F | 1 |
| Misiak, B | 1 |
| Callovini, T | 1 |
| Cavaleri, D | 1 |
| Cioni, RM | 1 |
| Crocamo, C | 1 |
| Savitz, JB | 2 |
| Carrà, G | 1 |
| Wurfel, BE | 2 |
| Drevets, WC | 2 |
| Bliss, SA | 1 |
| McMillin, JR | 1 |
| Suzuki, H | 1 |
| Ford, BN | 2 |
| Morris, HM | 1 |
| Teague, TK | 2 |
| Dantzer, R | 2 |
| Johansson, V | 2 |
| Erhardt, S | 2 |
| Engberg, G | 2 |
| Kegel, M | 1 |
| Bhat, M | 2 |
| Schwieler, L | 2 |
| Blennow, K | 1 |
| Zetterberg, H | 1 |
| Cannon, TD | 2 |
| Wetterberg, L | 2 |
| Hultman, CM | 2 |
| Landén, M | 2 |
| Savitz, J | 1 |
| Victor, TA | 1 |
| Bodurka, J | 1 |
| Bellgowan, PS | 1 |
| Kegel, ME | 1 |
| Schuppe-Koistinen, I | 1 |
| Birner, A | 1 |
| Platzer, M | 1 |
| Bengesser, SA | 1 |
| Dalkner, N | 1 |
| Fellendorf, FT | 1 |
| Queissner, R | 1 |
| Pilz, R | 1 |
| Rauch, P | 1 |
| Maget, A | 1 |
| Hamm, C | 1 |
| Herzog-Eberhard, S | 1 |
| Mangge, H | 1 |
| Fuchs, D | 1 |
| Moll, N | 1 |
| Zelzer, S | 1 |
| Schütze, G | 1 |
| Schwarz, M | 1 |
| Reininghaus, B | 1 |
| Kapfhammer, HP | 1 |
| Reininghaus, EZ | 1 |
1 review available for quinolinic acid and Bipolar Disorder
| Article | Year |
|---|---|
The kynurenine pathway in bipolar disorder: a meta-analysis on the peripheral blood levels of tryptophan and related metabolites.
Topics: Adult; Bipolar Disorder; Humans; Kynurenic Acid; Kynurenine; Observational Studies as Topic; Quinoli | 2021 |
5 other studies available for quinolinic acid and Bipolar Disorder
| Article | Year |
|---|---|
Serum kynurenic acid is reduced in affective psychosis.
Topics: Adult; Affective Disorders, Psychotic; Bipolar Disorder; Corpus Striatum; Cytokines; Depression; Dep | 2017 |
Twin study shows association between monocyte chemoattractant protein-1 and kynurenic acid in cerebrospinal fluid.
Topics: Adult; Aged; Bipolar Disorder; Chemokine CCL2; Cohort Studies; Female; Humans; Kynurenic Acid; Male; | 2020 |
Neuroprotective kynurenine metabolite indices are abnormally reduced and positively associated with hippocampal and amygdalar volume in bipolar disorder.
Topics: Adult; Amygdala; Bipolar Disorder; Female; Hippocampus; Humans; Kynurenic Acid; Kynurenine; Male; Mi | 2015 |
Kynurenic acid and psychotic symptoms and personality traits in twins with psychiatric morbidity.
Topics: Bipolar Disorder; Female; Humans; Interleukin-6; Interleukin-8; Kynurenic Acid; Male; Middle Aged; P | 2017 |
Increased breakdown of kynurenine towards its neurotoxic branch in bipolar disorder.
Topics: Adult; Bipolar Disorder; Brain; Case-Control Studies; Cognition; Depression; Female; Humans; Inflamm | 2017 |