Page last updated: 2024-10-20

quinolinic acid and Benign Psychomotor Epilepsy, Childhood

quinolinic acid has been researched along with Benign Psychomotor Epilepsy, Childhood in 6 studies

Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.

Research Excerpts

ExcerptRelevanceReference
"QUIN seizures showed particular sensitivity to carbamazepine (5 mg/kg) but were resistant to diphenylhydantoin unless a relatively high dose was used (100 mg/kg)."5.27Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments. ( Samanin, R; Tullii, M; Vezzani, A; Wu, HQ, 1986)
"Spontaneous recurrent seizures induced by pilocarpine were monitored behaviorally prior to and after PING or under control conditions."1.62Non-invasive, neurotoxic surgery reduces seizures in a rat model of temporal lobe epilepsy. ( Bertram, EH; Buckmaster, PS; Ghobadi, SN; Habte, FG; Hou, Q; Huang, A; Keunen, O; Lee, KS; Li, N; Narang, S; Qiu, L; Wang, J; Wintermark, M; Zhang, Y, 2021)
"Quinolinic acid was not detected in the brain of patients who received antiepileptic drugs other than carbamazepine prior to surgery or in brain endothelial cultures obtained from a control patient."1.38A pro-convulsive carbamazepine metabolite: quinolinic acid in drug resistant epileptic human brain. ( Alexopoulos, AV; Ghosh, C; Gonzalez-Martinez, J; Hossain, M; Janigro, D; Marchi, N; Rasmussen, P; Yang, H, 2012)
"QUIN seizures showed particular sensitivity to carbamazepine (5 mg/kg) but were resistant to diphenylhydantoin unless a relatively high dose was used (100 mg/kg)."1.27Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments. ( Samanin, R; Tullii, M; Vezzani, A; Wu, HQ, 1986)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19903 (50.00)18.7374
1990's1 (16.67)18.2507
2000's0 (0.00)29.6817
2010's1 (16.67)24.3611
2020's1 (16.67)2.80

Authors

AuthorsStudies
Zhang, Y1
Buckmaster, PS1
Qiu, L1
Wang, J1
Keunen, O1
Ghobadi, SN1
Huang, A1
Hou, Q1
Li, N1
Narang, S1
Habte, FG1
Bertram, EH1
Lee, KS1
Wintermark, M1
Ghosh, C1
Marchi, N1
Hossain, M1
Rasmussen, P1
Alexopoulos, AV1
Gonzalez-Martinez, J1
Yang, H1
Janigro, D1
Schwarcz, R3
Köhler, C2
Foster, AC1
French, ED1
Whetsell, WO1
Du, F1
Vezzani, A1
Wu, HQ1
Tullii, M1
Samanin, R1

Reviews

1 review available for quinolinic acid and Benign Psychomotor Epilepsy, Childhood

ArticleYear
Quinolinic acid and kynurenic acid in the mammalian brain.
    Advances in experimental medicine and biology, 1991, Volume: 294

    Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; AIDS Dementia Complex; Animals; Aspartic Acid; Biological Tra

1991

Other Studies

5 other studies available for quinolinic acid and Benign Psychomotor Epilepsy, Childhood

ArticleYear
Non-invasive, neurotoxic surgery reduces seizures in a rat model of temporal lobe epilepsy.
    Experimental neurology, 2021, Volume: 343

    Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Epilepsy, Temporal Lobe; Intraoperative Neurop

2021
A pro-convulsive carbamazepine metabolite: quinolinic acid in drug resistant epileptic human brain.
    Neurobiology of disease, 2012, Volume: 46, Issue:3

    Topics: Adult; Anticonvulsants; Biotransformation; Brain Chemistry; Carbamazepine; Child; Chromatography, Hi

2012
Differential vulnerability of central neurons of the rat to quinolinic acid.
    Neuroscience letters, 1983, Jul-15, Volume: 38, Issue:1

    Topics: Animals; Brain; Corpus Striatum; Diencephalon; Epilepsy, Temporal Lobe; Hippocampus; Huntington Dise

1983
Excitotoxic models for neurodegenerative disorders.
    Life sciences, 1984, Jul-02, Volume: 35, Issue:1

    Topics: Amino Acids; Animals; Axons; Dendrites; Epilepsy, Temporal Lobe; Hippocampus; Humans; Ibotenic Acid;

1984
Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 239, Issue:1

    Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Chlorpromazine; Diazepam; Disease Models,

1986
chemdatabank.com