quinolinic acid has been researched along with Aura in 16 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There was a statistically significant decrease of CSF kynurenic acid in patients with epileptic spasms compared to OND (p<0." | 8.12 | Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids. ( Antony, J; Ardern-Holmes, S; Bandodkar, S; Dale, RC; Gill, D; Guillemin, GJ; Guller, A; Gupta, S; Han, VX; Heng, B; Innes, EA; Jones, HF; Kothur, K; Menezes, MP; Mohammad, S; Patel, S; Pires, AS; Tantsis, E; Troedson, C; Tsang, E; Webster, R; Wienholt, L; Yan, J, 2022) |
| "p." | 5.31 | Guanosine and GMP prevent seizures induced by quinolinic acid in mice. ( da Silveira Perla, A; de Faria Maraschin, J; Lara, DR; Onofre Souza, D; Schmidt, AP, 2000) |
| "There was a statistically significant decrease of CSF kynurenic acid in patients with epileptic spasms compared to OND (p<0." | 4.12 | Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids. ( Antony, J; Ardern-Holmes, S; Bandodkar, S; Dale, RC; Gill, D; Guillemin, GJ; Guller, A; Gupta, S; Han, VX; Heng, B; Innes, EA; Jones, HF; Kothur, K; Menezes, MP; Mohammad, S; Patel, S; Pires, AS; Tantsis, E; Troedson, C; Tsang, E; Webster, R; Wienholt, L; Yan, J, 2022) |
| "We had shown that production of quinolinic acid is high in the brain of epilepsy-prone El mice and that this is due to an increase in the activity of 3-hydroxyanthranilate 3,4-dioxygenase (3-HAO, EC 1." | 3.69 | Increase in the level of mRNA for 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice. ( Asai, H; Kitoh, J; Mori, H; Nakagawa, Y; Nakano, K, 1995) |
| " Several crucial questions remain to be addressed before a case can be made for a 'quinolinic acid hypothesis' of temporal lobe epilepsy." | 3.67 | Quinolinic acid: a pathogen in seizure disorders? ( French, ED; Köhler, C; Okuno, E; Schwarcz, R; Speciale, C, 1986) |
| "Quinolinic acid was not detected in the brain of patients who received antiepileptic drugs other than carbamazepine prior to surgery or in brain endothelial cultures obtained from a control patient." | 1.38 | A pro-convulsive carbamazepine metabolite: quinolinic acid in drug resistant epileptic human brain. ( Alexopoulos, AV; Ghosh, C; Gonzalez-Martinez, J; Hossain, M; Janigro, D; Marchi, N; Rasmussen, P; Yang, H, 2012) |
| "Quinolinic acid (QA) has been used as a model for experimental overstimulation of the glutamatergic system." | 1.32 | Quinolinic acid promotes seizures and decreases glutamate uptake in young rats: reversal by orally administered guanosine. ( de Oliveira, DL; Frizzo, ME; Horn, JF; Moriguchi, E; Rodrigues, JM; Souza, DO; Wofchuk, S, 2004) |
| "p." | 1.31 | Guanosine and GMP prevent seizures induced by quinolinic acid in mice. ( da Silveira Perla, A; de Faria Maraschin, J; Lara, DR; Onofre Souza, D; Schmidt, AP, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (31.25) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 6 (37.50) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Yan, J | 1 |
| Kothur, K | 1 |
| Innes, EA | 1 |
| Han, VX | 1 |
| Jones, HF | 1 |
| Patel, S | 1 |
| Tsang, E | 1 |
| Webster, R | 1 |
| Gupta, S | 1 |
| Troedson, C | 1 |
| Menezes, MP | 1 |
| Antony, J | 1 |
| Ardern-Holmes, S | 1 |
| Tantsis, E | 1 |
| Mohammad, S | 1 |
| Wienholt, L | 1 |
| Pires, AS | 1 |
| Heng, B | 1 |
| Guillemin, GJ | 1 |
| Guller, A | 1 |
| Gill, D | 1 |
| Bandodkar, S | 1 |
| Dale, RC | 1 |
| Ghosh, C | 1 |
| Marchi, N | 1 |
| Hossain, M | 1 |
| Rasmussen, P | 1 |
| Alexopoulos, AV | 1 |
| Gonzalez-Martinez, J | 1 |
| Yang, H | 1 |
| Janigro, D | 1 |
| Juhász, C | 1 |
| Chugani, DC | 1 |
| Padhye, UN | 1 |
| Muzik, O | 1 |
| Shah, A | 1 |
| Asano, E | 1 |
| Mangner, TJ | 1 |
| Chakraborty, PK | 1 |
| Sood, S | 1 |
| Chugani, HT | 1 |
| de Oliveira, DL | 1 |
| Horn, JF | 1 |
| Rodrigues, JM | 1 |
| Frizzo, ME | 2 |
| Moriguchi, E | 1 |
| Souza, DO | 2 |
| Wofchuk, S | 1 |
| Rho, JM | 1 |
| Nakano, K | 2 |
| Takahashi, S | 1 |
| Mizobuchi, M | 1 |
| Kuroda, T | 1 |
| Masuda, K | 1 |
| Kitoh, J | 2 |
| Nakagawa, Y | 1 |
| Asai, H | 1 |
| Mori, H | 1 |
| Schmidt, AP | 2 |
| Lara, DR | 2 |
| de Faria Maraschin, J | 1 |
| da Silveira Perla, A | 1 |
| Onofre Souza, D | 1 |
| Stone, TW | 2 |
| Burgos, JS | 1 |
| Ramírez, G | 1 |
| Manfridi, A | 1 |
| Forloni, GL | 1 |
| Vezzani, A | 2 |
| Fodritto, F | 1 |
| De Simoni, MG | 1 |
| Ben-Ari, Y | 1 |
| Schwarcz, R | 2 |
| Connick, JH | 1 |
| Winn, P | 1 |
| Hastings, MH | 1 |
| English, M | 1 |
| Guiso, G | 1 |
| Caccia, S | 1 |
| Stasi, MA | 1 |
| Salmona, M | 1 |
| Romano, M | 1 |
| Garattini, S | 1 |
| Foster, AC | 1 |
| Speciale, C | 1 |
| Okuno, E | 1 |
| French, ED | 1 |
| Köhler, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prednisolone vs. Vigabatrin in the First-line Treatment of Infantile Spasms[NCT02299115] | Phase 3 | 0 participants (Actual) | Interventional | 2017-09-05 | Withdrawn (stopped due to Most centres are now using oral steroids as 1st line treatment so question of efficacy is no longer of high interest.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for quinolinic acid and Aura
| Article | Year |
|---|---|
Basic science behind the catastrophic epilepsies.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Corticotropin-Releasing Hormone; Epilepsies | 2004 |
Kynurenic acid antagonists and kynurenine pathway inhibitors.
Topics: Brain Ischemia; Epilepsy; Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; Neu | 2001 |
Endogenous excitotoxic agents.
Topics: Animals; Aspartic Acid; Cell Survival; Central Nervous System; Dementia; Epilepsy; Glutamates; Gluta | 1987 |
13 other studies available for quinolinic acid and Aura
| Article | Year |
|---|---|
Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids.
Topics: 3-Hydroxyanthranilic Acid; Adrenal Cortex Hormones; Animals; Biomarkers; Chromatography, Liquid; Epi | 2022 |
A pro-convulsive carbamazepine metabolite: quinolinic acid in drug resistant epileptic human brain.
Topics: Adult; Anticonvulsants; Biotransformation; Brain Chemistry; Carbamazepine; Child; Chromatography, Hi | 2012 |
Evaluation with alpha-[11C]methyl-L-tryptophan positron emission tomography for reoperation after failed epilepsy surgery.
Topics: Adolescent; Adult; Age Factors; Carbon Radioisotopes; Child; Child, Preschool; Electroencephalograph | 2004 |
Quinolinic acid promotes seizures and decreases glutamate uptake in young rats: reversal by orally administered guanosine.
Topics: Administration, Oral; Aging; Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Anim | 2004 |
High levels of quinolinic acid in brain of epilepsy-prone E1 mice.
Topics: Aging; Amino Acids; Animals; Cerebral Cortex; Epilepsy; Escherichia coli; Lipopolysaccharides; Methi | 1993 |
Increase in the level of mRNA for 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Animals; Brain; Dioxygenases; Epilepsy; Genetic Predispositio | 1995 |
Guanosine and GMP prevent seizures induced by quinolinic acid in mice.
Topics: Animals; Anticonvulsants; Central Nervous System; Dose-Response Relationship, Drug; Drug Interaction | 2000 |
Effect of orally administered guanosine on seizures and death induced by glutamatergic agents.
Topics: Animals; Brain; Caffeine; Death; Dizocilpine Maleate; Dose-Response Relationship, Drug; Elapid Venom | 2001 |
Functional and histological consequences of quinolinic and kainic acid-induced seizures on hippocampal somatostatin neurons.
Topics: Animals; Cell Survival; Cysteamine; Electroencephalography; Epilepsy; Hippocampus; Kainic Acid; Male | 1991 |
Seizures and brain damage: are excitatory amino acids involved?
Topics: Action Potentials; Amino Acids; Animals; Brain; Epilepsy; Glutamates; Glutamic Acid; Hippocampus; Ne | 1986 |
Effect of aspartame on seizures in various models of experimental epilepsy.
Topics: Animals; Aspartame; Brain Chemistry; Dipeptides; Electroshock; Epilepsy; Male; Pentylenetetrazole; P | 1988 |
Involvement of excitatory amino acid receptors in the mechanisms underlying excitotoxic phenomena.
Topics: Action Potentials; Amino Acids, Dicarboxylic; Animals; Cell Survival; Dendrites; Epilepsy; Kynurenic | 1986 |
Quinolinic acid: a pathogen in seizure disorders?
Topics: Afferent Pathways; Animals; Brain; Brain Mapping; Cholinergic Fibers; Convulsants; Epilepsy; Kainic | 1986 |