quinolinic acid has been researched along with Atrophy in 12 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
Atrophy: Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The influence of embryonic mesencephalic, striatal and mesencephalic/striatal co-grafts on amphetamine- and apomorphine-induced rotation behaviour was assessed in a rat model of multiple system atrophy/striatonigral degeneration type using dopamine D1 ([3H]SCH23390) and D2 ([3H]spiperone) receptor and dopamine re-uptake ([3H]mazindol) autoradiography." | 7.70 | Autoradiographic study of striatal dopamine re-uptake sites and dopamine D1 and D2 receptors in a 6-hydroxydopamine and quinolinic acid double-lesion rat model of striatonigral degeneration (multiple system atrophy) and effects of embryonic ventral mesenc ( Granata, R; Jenner, P; Laboyrie, P; Poewe, W; Puschban, Z; Quinn, NP; Scherfler, C; Wenning, GK, 2000) |
| "The influence of embryonic mesencephalic, striatal and mesencephalic/striatal co-grafts on amphetamine- and apomorphine-induced rotation behaviour was assessed in a rat model of multiple system atrophy/striatonigral degeneration type using dopamine D1 ([3H]SCH23390) and D2 ([3H]spiperone) receptor and dopamine re-uptake ([3H]mazindol) autoradiography." | 3.70 | Autoradiographic study of striatal dopamine re-uptake sites and dopamine D1 and D2 receptors in a 6-hydroxydopamine and quinolinic acid double-lesion rat model of striatonigral degeneration (multiple system atrophy) and effects of embryonic ventral mesenc ( Granata, R; Jenner, P; Laboyrie, P; Poewe, W; Puschban, Z; Quinn, NP; Scherfler, C; Wenning, GK, 2000) |
| "Increased concentrations of the excitotoxin quinolinic acid (QUIN) have been implicated in the neurologic deficits and brain atrophy that may accompany infection with the human immunodeficiency virus type-1." | 3.68 | Relationship of neurologic status in macaques infected with the simian immunodeficiency virus to cerebrospinal fluid quinolinic acid and kynurenic acid. ( Frank, JA; Gravell, M; Heyes, MP; Jordan, EK; Lee, K; Markey, SP; Saito, K; Snoy, PJ, 1992) |
| " The results presented demonstrate that this system can be used for the chronic administration of quinolinic acid with minimal non-specific damage." | 1.28 | A novel device for chronic intracranial drug delivery via microdialysis. ( Albin, RL; Bazzett, TJ; Becker, JB, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (16.67) | 18.7374 |
| 1990's | 7 (58.33) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lelos, MJ | 1 |
| Dunnett, SB | 2 |
| Wiley, CA | 1 |
| Bazzett, TJ | 2 |
| Becker, JB | 2 |
| Kaatz, KW | 1 |
| Albin, RL | 2 |
| Watts, C | 1 |
| Gendelman, HE | 1 |
| Zheng, J | 1 |
| Coulter, CL | 1 |
| Ghorpade, A | 1 |
| Che, M | 1 |
| Thylin, M | 1 |
| Rubocki, R | 1 |
| Persidsky, Y | 1 |
| Hahn, F | 1 |
| Reinhard, J | 1 |
| Swindells, S | 1 |
| Puschban, Z | 1 |
| Scherfler, C | 1 |
| Granata, R | 1 |
| Laboyrie, P | 1 |
| Quinn, NP | 1 |
| Jenner, P | 1 |
| Poewe, W | 1 |
| Wenning, GK | 1 |
| Heyes, MP | 2 |
| Ellis, RJ | 1 |
| Ryan, L | 1 |
| Childers, ME | 1 |
| Grant, I | 1 |
| Wolfson, T | 1 |
| Archibald, S | 1 |
| Jernigan, TL | 1 |
| Jordan, EK | 1 |
| Lee, K | 1 |
| Saito, K | 1 |
| Frank, JA | 1 |
| Snoy, PJ | 1 |
| Markey, SP | 1 |
| Gravell, M | 1 |
| Beal, MF | 1 |
| Ferrante, RJ | 1 |
| Swartz, KJ | 1 |
| Kowall, NW | 1 |
| Roberts, RC | 1 |
| DiFiglia, M | 1 |
| Beskid, M | 1 |
| Markiewicz, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| NMDA-Receptor Blockade in Huntington's Chorea[NCT00001930] | Phase 2 | 25 participants | Interventional | 1999-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for quinolinic acid and Atrophy
| Article | Year |
|---|---|
Quantitative neuropathologic assessment of HIV-1 encephalitis.
Topics: AIDS Dementia Complex; Atrophy; Brain; Brain Chemistry; Cell Count; Encephalitis, Viral; Giant Cells | 1995 |
1 trial available for quinolinic acid and Atrophy
| Article | Year |
|---|---|
Elevated cerebrospinal fluid quinolinic acid levels are associated with region-specific cerebral volume loss in HIV infection.
Topics: Adult; Atrophy; beta 2-Microglobulin; Biomarkers; Brain; Cohort Studies; Corpus Striatum; Cross-Sect | 2001 |
10 other studies available for quinolinic acid and Atrophy
| Article | Year |
|---|---|
Generating Excitotoxic Lesion Models of Huntington's Disease.
Topics: Animals; Atrophy; Disease Models, Animal; Humans; Huntington Disease; Interneurons; Mice; Microinjec | 2018 |
Chronic intrastriatal dialytic administration of quinolinic acid produces selective neural degeneration.
Topics: Amphetamine; Animals; Atrophy; Corpus Striatum; Dialysis; Dose-Response Relationship, Drug; Electron | 1993 |
Effects of severity of host striatal damage on the morphological development of intrastriatal transplants in a rodent model of Huntington's disease: implications for timing of surgical intervention.
Topics: Acetylcholinesterase; Animals; Atrophy; Cell Count; Cell Survival; Cell Transplantation; Corpus Stri | 1998 |
Suppression of inflammatory neurotoxins by highly active antiretroviral therapy in human immunodeficiency virus-associated dementia.
Topics: Adult; AIDS Dementia Complex; Anti-HIV Agents; Atrophy; Brain; Female; Humans; Ibuprofen; Indinavir; | 1998 |
Autoradiographic study of striatal dopamine re-uptake sites and dopamine D1 and D2 receptors in a 6-hydroxydopamine and quinolinic acid double-lesion rat model of striatonigral degeneration (multiple system atrophy) and effects of embryonic ventral mesenc
Topics: Amphetamine; Animals; Apomorphine; Atrophy; Autoradiography; Behavior, Animal; Brain Tissue Transpla | 2000 |
Relationship of neurologic status in macaques infected with the simian immunodeficiency virus to cerebrospinal fluid quinolinic acid and kynurenic acid.
Topics: Animals; Atrophy; Brain; Cisterna Magna; Convulsants; Injections; Kynurenic Acid; Macaca mulatta; Qu | 1992 |
Chronic quinolinic acid lesions in rats closely resemble Huntington's disease.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Atrophy; Biogenic Amines; Cerebra | 1991 |
A novel device for chronic intracranial drug delivery via microdialysis.
Topics: Animals; Atrophy; Brain; Convulsants; Corpus Striatum; Dialysis; Drug Delivery Systems; Infusion Pum | 1991 |
Short- and long-term survival of large neurons in the excitotoxic lesioned rat caudate nucleus: a light and electron microscopic study.
Topics: Animals; Atrophy; Caudate Nucleus; Cell Survival; Male; Microscopy, Electron; Neurons; Pyridines; Qu | 1989 |
[Morphological changes in the rat brain after intracardiac and intraperitoneal administration of quinolinic acid].
Topics: Animals; Atrophy; Brain; Heart Ventricles; Injections; Injections, Intraperitoneal; Male; Pyridines; | 1988 |