quinolinic acid has been researched along with Astrocytosis in 15 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These are astrocytosis, up-regulation of mRNA encoding the neuropeptide somatostatin (SRIF) and an increased expression of MHC Class II antigen." | 2.39 | Neuronal substrates for SIV encephalopathy. ( da Cunha, A; Eiden, LE; Rausch, DM, 1994) |
| "At this time, marked microgliosis (OX-42 marker) and astrogliosis (GFAP marker) were evident in QUIN-injected striatum." | 1.34 | Depletion of neutrophils reduces neuronal degeneration and inflammatory responses induced by quinolinic acid in vivo. ( McLarnon, JG; Ryu, JK; Tran, KC, 2007) |
| "At later time points, a dense astrogliosis with proliferating astrocytes developed in the dorsal and medial striatum." | 1.31 | Time course of glial proliferation and glial apoptosis following excitotoxic CNS injury. ( Block, F; Dihné, M; Korr, H; Töpper, R, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 9 (60.00) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pierozan, P | 1 |
| Colín-González, AL | 1 |
| Biasibetti, H | 1 |
| da Silva, JC | 1 |
| Wyse, A | 1 |
| Wajner, M | 1 |
| Santamaria, A | 2 |
| Ignarro, RS | 1 |
| Vieira, AS | 1 |
| Sartori, CR | 1 |
| Langone, F | 1 |
| Rogério, F | 1 |
| Parada, CA | 1 |
| Kuzdas-Wood, D | 1 |
| Fellner, L | 1 |
| Premstaller, M | 1 |
| Borm, C | 1 |
| Bloem, B | 1 |
| Kirik, D | 1 |
| Wenning, GK | 1 |
| Stefanova, N | 1 |
| Ryu, JK | 4 |
| Jantaratnotai, N | 1 |
| McLarnon, JG | 4 |
| Hanbury, R | 1 |
| Chen, EY | 1 |
| Wuu, J | 1 |
| Kordower, JH | 1 |
| Choi, HB | 1 |
| Walker, DG | 1 |
| Link, J | 1 |
| Lue, LF | 1 |
| Dalsing-Hernandez, JE | 1 |
| Boyes, BE | 1 |
| Tran, KC | 1 |
| Silva-Adaya, D | 1 |
| Pérez-De La Cruz, V | 1 |
| Herrera-Mundo, MN | 1 |
| Mendoza-Macedo, K | 1 |
| Villeda-Hernández, J | 1 |
| Binienda, Z | 1 |
| Ali, SF | 1 |
| Brown, EE | 1 |
| Fibiger, HC | 1 |
| da Cunha, A | 1 |
| Eiden, LE | 1 |
| Rausch, DM | 1 |
| Berger, UV | 1 |
| Tsukaguchi, H | 1 |
| Hediger, MA | 1 |
| Dihné, M | 1 |
| Block, F | 1 |
| Korr, H | 1 |
| Töpper, R | 1 |
| Popoli, P | 1 |
| Pintor, A | 1 |
| Domenici, MR | 1 |
| Frank, C | 1 |
| Tebano, MT | 1 |
| Pèzzola, A | 1 |
| Scarchilli, L | 1 |
| Quarta, D | 1 |
| Reggio, R | 1 |
| Malchiodi-Albedi, F | 1 |
| Falchi, M | 1 |
| Massotti, M | 1 |
1 review available for quinolinic acid and Astrocytosis
| Article | Year |
|---|---|
Neuronal substrates for SIV encephalopathy.
Topics: Animals; Astrocytes; Cognition Disorders; Disease Progression; Encephalitis, Viral; Gene Expression | 1994 |
14 other studies available for quinolinic acid and Astrocytosis
| Article | Year |
|---|---|
Toxic Synergism Between Quinolinic Acid and Glutaric Acid in Neuronal Cells Is Mediated by Oxidative Stress: Insights to a New Toxic Model.
Topics: Animals; Antioxidants; Catalase; Cell Survival; Cerebral Cortex; Coculture Techniques; Dizocilpine M | 2018 |
JAK2 inhibition is neuroprotective and reduces astrogliosis after quinolinic acid striatal lesion in adult mice.
Topics: Animals; Astrocytes; Blotting, Western; Cell Count; Cell Death; Doublecortin Domain Proteins; Enzyme | 2013 |
Overexpression of α-synuclein in oligodendrocytes does not increase susceptibility to focal striatal excitotoxicity.
Topics: alpha-Synuclein; Animals; Cell Death; Corpus Striatum; Disease Models, Animal; Gliosis; Humans; Mice | 2015 |
Thalidomide inhibition of vascular remodeling and inflammatory reactivity in the quinolinic acid-injected rat striatum.
Topics: Angiogenesis Inhibitors; Animals; Astrocytes; Blood Vessels; Cell Survival; Corpus Striatum; Gliosis | 2009 |
Knockout of p75NTR does not alter the viability of striatal neurons following a metabolic or excitotoxic injury.
Topics: Animals; Astrocytes; Brain Injuries; Cell Death; Cell Survival; Energy Metabolism; Gliosis; Immunohi | 2003 |
Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Antineoplastic Agents; Carrier Proteins; Caspases; | 2005 |
Gene expression changes by amyloid beta peptide-stimulated human postmortem brain microglia identify activation of multiple inflammatory processes.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Calgranulin A; Cells, Cultured; C | 2006 |
Depletion of neutrophils reduces neuronal degeneration and inflammatory responses induced by quinolinic acid in vivo.
Topics: Animals; Apomorphine; Blood-Brain Barrier; Cell Survival; Gliosis; Immunohistochemistry; Inflammatio | 2007 |
Excitotoxic damage, disrupted energy metabolism, and oxidative stress in the rat brain: antioxidant and neuroprotective effects of L-carnitine.
Topics: Animals; Antioxidants; Brain; Carnitine; Convulsants; Disease Models, Animal; Dose-Response Relation | 2008 |
VEGF receptor antagonist Cyclo-VEGI reduces inflammatory reactivity and vascular leakiness and is neuroprotective against acute excitotoxic striatal insult.
Topics: Animals; Astrocytes; Blood-Brain Barrier; Corpus Striatum; Drug Evaluation, Preclinical; Endothelial | 2008 |
Differential effects of excitotoxic lesions of the amygdala on cocaine-induced conditioned locomotion and conditioned place preference.
Topics: Amygdala; Animals; Cocaine; Conditioning, Operant; Gliosis; Male; Motor Activity; Oxidopamine; Quino | 1993 |
Distribution of mRNA for the facilitated urea transporter UT3 in the rat nervous system.
Topics: Animals; Astrocytes; Biomarkers; Blotting, Northern; Brain; Carrier Proteins; Female; Ganglia, Spina | 1998 |
Time course of glial proliferation and glial apoptosis following excitotoxic CNS injury.
Topics: Animals; Apoptosis; Astrocytes; Brain Injuries; Cell Count; Cell Division; Glial Fibrillary Acidic P | 2001 |
Blockade of striatal adenosine A2A receptor reduces, through a presynaptic mechanism, quinolinic acid-induced excitotoxicity: possible relevance to neuroprotective interventions in neurodegenerative diseases of the striatum.
Topics: Animals; Behavior, Animal; Calcium; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Dose-R | 2002 |