quinolinic acid has been researched along with Alzheimer Disease in 34 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cryptotanshinone (CTS), a major constituent from the roots of Salvia miltiorrhiza (Danshen), is widely used in the treatment of coronary heart disease, stroke and less commonly Alzheimer's disease." | 7.74 | Transport of cryptotanshinone, a major active triterpenoid in Salvia miltiorrhiza Bunge widely used in the treatment of stroke and Alzheimer's disease, across the blood-brain barrier. ( Cao, J; Chan, E; Chen, X; Chowbay, B; Duan, W; Li, CG; Liang, J; Lin, SG; Wen, JY; Yu, XY; Zhou, SF; Zhou, ZW, 2007) |
| "The pathomechanism of Alzheimer's disease (AD) certainly involves mitochondrial disturbances, glutamate excitotoxicity, and neuroinflammation." | 6.58 | Alzheimer's Disease: Recent Concepts on the Relation of Mitochondrial Disturbances, Excitotoxicity, Neuroinflammation, and Kynurenines. ( Klivényi, P; Szalárdy, L; Vécsei, L; Veres, G; Zádori, D, 2018) |
| " Low xanthurenic acid occurred in both AD and with aging." | 3.85 | Kynurenine Pathway Metabolites in Alzheimer's Disease. ( Advani, R; Giil, LM; Midttun, Ø; Refsum, H; Smith, AD; Ueland, PM; Ulvik, A, 2017) |
| "Cryptotanshinone (CTS), a major constituent from the roots of Salvia miltiorrhiza (Danshen), is widely used in the treatment of coronary heart disease, stroke and less commonly Alzheimer's disease." | 3.74 | Transport of cryptotanshinone, a major active triterpenoid in Salvia miltiorrhiza Bunge widely used in the treatment of stroke and Alzheimer's disease, across the blood-brain barrier. ( Cao, J; Chan, E; Chen, X; Chowbay, B; Duan, W; Li, CG; Liang, J; Lin, SG; Wen, JY; Yu, XY; Zhou, SF; Zhou, ZW, 2007) |
| "Boosting KYNA levels, through interference with the KP enzymes or through application of prodrugs/analogs with high bioavailability and potency, is a promising clinical approach." | 2.82 | Kynurenic acid in neurodegenerative disorders-unique neuroprotection or double-edged sword? ( Ostapiuk, A; Urbanska, EM, 2022) |
| "The pathomechanism of Alzheimer's disease (AD) certainly involves mitochondrial disturbances, glutamate excitotoxicity, and neuroinflammation." | 2.58 | Alzheimer's Disease: Recent Concepts on the Relation of Mitochondrial Disturbances, Excitotoxicity, Neuroinflammation, and Kynurenines. ( Klivényi, P; Szalárdy, L; Vécsei, L; Veres, G; Zádori, D, 2018) |
| "The kynurenine pathway (KP) is a major route of L-tryptophan catabolism leading to production of a number of biologically active molecules." | 2.41 | Implications of the kynurenine pathway and quinolinic acid in Alzheimer's disease. ( Brew, BJ; Guillemin, GJ, 2002) |
| "The kynurenine pathway (KP) is a major route of tryptophan metabolism." | 1.36 | Kynurenine and its metabolites in Alzheimer's disease patients. ( Bien, B; Gulaj, E; Pawlak, D; Pawlak, K, 2010) |
| "The prevalence of the Alzheimer's disease (AD) is increasing exponentially after the age of 65 and doubles every 5 years." | 1.35 | [The transcription of the amyloid precursor protein and tryptophan 2,3-dioxygenase genes are increased by aging in the rat brain]. ( Bagdy, G; Domokos, A; Garab, D; Kálmán, J; Kálmán, S; Pákáski, M; Puskás, L; Szucs, S; Zelena, D; Zvara, A, 2009) |
| "Quinolinic acid (QA) content was measured in postmortem frontal and temporal cortex, putamen and cerebellum obtained from patients with senile dementia of Alzheimer type (SDAT), Huntington's disease (HD) and controls, using a gas chromatography/mass spectrometry method." | 1.28 | Brain quinolinic acid in Alzheimer's dementia. ( Beckmann, H; Halket, J; Jellinger, K; Przyborowska, A; Riederer, P; Sandler, M; Sofic, E, 1989) |
| "These neurons degenerate in Alzheimer's disease, and there is a corresponding deficiency of cortical choline acetyltransferase activity." | 1.27 | Galanin-like immunoreactivity is unchanged in Alzheimer's disease and Parkinson's disease dementia cerebral cortex. ( Beal, MF; Chattha, GK; Clevens, RA; Gabriel, SM; MacGarvey, UM; Mazurek, MF, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (14.71) | 18.7374 |
| 1990's | 3 (8.82) | 18.2507 |
| 2000's | 10 (29.41) | 29.6817 |
| 2010's | 13 (38.24) | 24.3611 |
| 2020's | 3 (8.82) | 2.80 |
| Authors | Studies |
|---|---|
| Ostapiuk, A | 1 |
| Urbanska, EM | 1 |
| Liang, Y | 1 |
| Xie, S | 1 |
| He, Y | 1 |
| Xu, M | 1 |
| Qiao, X | 1 |
| Zhu, Y | 1 |
| Wu, W | 1 |
| Esmaeili, S | 1 |
| Ghobadi, N | 1 |
| Akbari, V | 1 |
| Moradi, S | 1 |
| Shahlaie, M | 1 |
| Ghobadi, S | 1 |
| Jalalvand, AR | 1 |
| Amani, M | 1 |
| Khodarahmi, R | 1 |
| Busse, M | 1 |
| Hettler, V | 1 |
| Fischer, V | 1 |
| Mawrin, C | 1 |
| Hartig, R | 1 |
| Dobrowolny, H | 1 |
| Bogerts, B | 1 |
| Frodl, T | 1 |
| Busse, S | 1 |
| Giil, LM | 1 |
| Midttun, Ø | 1 |
| Refsum, H | 1 |
| Ulvik, A | 1 |
| Advani, R | 1 |
| Smith, AD | 1 |
| Ueland, PM | 1 |
| Robertson, DS | 1 |
| Zádori, D | 1 |
| Veres, G | 1 |
| Szalárdy, L | 1 |
| Klivényi, P | 1 |
| Vécsei, L | 2 |
| Tavassoly, O | 1 |
| Sade, D | 1 |
| Bera, S | 1 |
| Shaham-Niv, S | 1 |
| Vocadlo, DJ | 1 |
| Gazit, E | 1 |
| Sharma, R | 1 |
| Razdan, K | 1 |
| Bansal, Y | 1 |
| Kuhad, A | 1 |
| Daschil, N | 1 |
| Obermair, GJ | 1 |
| Flucher, BE | 1 |
| Stefanova, N | 1 |
| Hutter-Paier, B | 1 |
| Windisch, M | 1 |
| Humpel, C | 1 |
| Marksteiner, J | 1 |
| Rahman, A | 1 |
| Ting, K | 1 |
| Cullen, KM | 2 |
| Braidy, N | 1 |
| Brew, BJ | 6 |
| Guillemin, GJ | 6 |
| Kálmán, S | 1 |
| Pákáski, M | 1 |
| Szucs, S | 1 |
| Garab, D | 1 |
| Domokos, A | 1 |
| Zvara, A | 1 |
| Puskás, L | 1 |
| Bagdy, G | 1 |
| Zelena, D | 1 |
| Kálmán, J | 1 |
| Ting, KK | 1 |
| Kincses, ZT | 1 |
| Toldi, J | 1 |
| Gulaj, E | 1 |
| Pawlak, K | 1 |
| Bien, B | 1 |
| Pawlak, D | 1 |
| Gong, CY | 1 |
| Li, Z | 1 |
| Wang, HM | 1 |
| Liu, J | 1 |
| Chen, L | 1 |
| Zhang, HW | 1 |
| Wang, X | 1 |
| Yang, J | 1 |
| Fjord-Larsen, L | 1 |
| Kusk, P | 1 |
| Emerich, DF | 1 |
| Thanos, C | 1 |
| Torp, M | 1 |
| Bintz, B | 1 |
| Tornøe, J | 1 |
| Johnsen, AH | 1 |
| Wahlberg, LU | 1 |
| Tan, L | 2 |
| Yu, JT | 1 |
| Schwarz, MJ | 1 |
| Teipel, SJ | 1 |
| Buerger, K | 1 |
| Hampel, H | 1 |
| Zuo, P | 1 |
| Luo, P | 1 |
| Liu, Y | 1 |
| Kurup, RK | 1 |
| Kurup, PA | 1 |
| Williams, KR | 1 |
| Smith, DG | 1 |
| Smythe, GA | 1 |
| Croitoru-Lamoury, J | 1 |
| Noonan, CE | 1 |
| Takikawa, O | 1 |
| Walker, DG | 1 |
| Link, J | 1 |
| Lue, LF | 1 |
| Dalsing-Hernandez, JE | 1 |
| Boyes, BE | 1 |
| Yu, XY | 1 |
| Lin, SG | 1 |
| Chen, X | 1 |
| Zhou, ZW | 1 |
| Liang, J | 1 |
| Duan, W | 1 |
| Chowbay, B | 1 |
| Wen, JY | 1 |
| Chan, E | 1 |
| Cao, J | 1 |
| Li, CG | 1 |
| Zhou, SF | 1 |
| Milstien, S | 1 |
| Sakai, N | 1 |
| Krieger, C | 1 |
| Vickers, JH | 1 |
| Saito, K | 1 |
| Heyes, MP | 2 |
| Misztal, M | 1 |
| Skangiel-Kramska, J | 1 |
| Niewiadomska, G | 1 |
| Danysz, W | 1 |
| Taylor, R | 1 |
| Beal, MF | 1 |
| Clevens, RA | 1 |
| Chattha, GK | 1 |
| MacGarvey, UM | 1 |
| Mazurek, MF | 1 |
| Gabriel, SM | 1 |
| Sofic, E | 1 |
| Halket, J | 1 |
| Przyborowska, A | 1 |
| Riederer, P | 1 |
| Beckmann, H | 1 |
| Sandler, M | 1 |
| Jellinger, K | 1 |
| Mourdian, MM | 1 |
| Pan, JB | 1 |
| Heuser, IJ | 1 |
| Markey, SP | 1 |
| Chase, TN | 1 |
| Mouradian, MM | 1 |
| el-Defrawy, SR | 1 |
| Coloma, F | 1 |
| Jhamandas, K | 1 |
| Boegman, RJ | 1 |
| Beninger, RJ | 1 |
| Wirsching, BA | 1 |
| Lombardi, G | 1 |
| Carlà, V | 1 |
| Moroni, F | 1 |
7 reviews available for quinolinic acid and Alzheimer Disease
| Article | Year |
|---|---|
Kynurenic acid in neurodegenerative disorders-unique neuroprotection or double-edged sword?
Topics: Alzheimer Disease; Animals; Brain; Excitatory Amino Acid Antagonists; Humans; Huntington Disease; Ky | 2022 |
Kynurenine Pathway Metabolites as Biomarkers in Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Humans; Kynurenine; Quinolinic Acid | 2022 |
Alzheimer's Disease: Recent Concepts on the Relation of Mitochondrial Disturbances, Excitotoxicity, Neuroinflammation, and Kynurenines.
Topics: Alzheimer Disease; Animals; Central Nervous System; Disease Models, Animal; Energy Metabolism; Gluta | 2018 |
Rollercoaster ride of kynurenines: steering the wheel towards neuroprotection in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cognitive Dysfunction; Drug Development; Humans; Kynurenic Acid; Kynuren | 2018 |
Kynurenines, neurodegeneration and Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Biosynthetic Pathways; Humans; Kynurenine; Molecular Struc | 2010 |
The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations.
Topics: Aging; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Enzyme Inhibitors; Humans; Hunting | 2012 |
Implications of the kynurenine pathway and quinolinic acid in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Humans; Kynurenine; Quinolinic Acid; Tryptophan | 2002 |
27 other studies available for quinolinic acid and Alzheimer Disease
| Article | Year |
|---|---|
Pyridine-2,3-dicarboxylate, quinolinic acid, induces 1N4R Tau amyloid aggregation in vitro: Another evidence for the detrimental effect of the inescapable endogenous neurotoxin.
Topics: Alzheimer Disease; Amyloid; Humans; Kynurenine; Neurotoxins; Protein Aggregates; Pyridines; Quinolin | 2020 |
Increased quinolinic acid in peripheral mononuclear cells in Alzheimer's dementia.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Female; Humans; Leukocytes, Mononuclear; Male; Mi | 2018 |
Kynurenine Pathway Metabolites in Alzheimer's Disease.
Topics: 3-Hydroxyanthranilic Acid; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Cognition Disorders; C | 2017 |
Proposed biochemistry of Parkinson's and Alzheimer's diseases.
Topics: Aldehydes; Alzheimer Disease; Aspartic Acid; Betaine; Brain; Disease Progression; Humans; Kynurenine | 2017 |
Quinolinic Acid Amyloid-like Fibrillar Assemblies Seed α-Synuclein Aggregation.
Topics: alpha-Synuclein; Alzheimer Disease; Amyloid; Protein Aggregates; Protein Aggregation, Pathological; | 2018 |
CaV1.2 calcium channel expression in reactive astrocytes is associated with the formation of amyloid-β plaques in an Alzheimer's disease mouse model.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Astr | 2013 |
The excitotoxin quinolinic acid induces tau phosphorylation in human neurons.
Topics: Alzheimer Disease; Blotting, Western; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Humans; | 2009 |
[The transcription of the amyloid precursor protein and tryptophan 2,3-dioxygenase genes are increased by aging in the rat brain].
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Mitogen-Activated Protein | 2009 |
Effect of quinolinic acid on human astrocytes morphology and functions: implications in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Cell Proliferation; Cells, Cultured; | 2009 |
Kynurenine and its metabolites in Alzheimer's disease patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Chromatography, High Pressure Liquid; Female; Humans; Ky | 2010 |
Targeting the kynurenine pathway as a potential strategy to prevent and treat Alzheimer's disease.
Topics: Alzheimer Disease; Humans; Inflammation; Kynurenic Acid; Models, Biological; Quinolinic Acid; Recept | 2011 |
Increased encapsulated cell biodelivery of nerve growth factor in the brain by transposon-mediated gene transfer.
Topics: Alzheimer Disease; Animals; Brain; Capsules; Cell Line, Transformed; DNA Transposable Elements; Fema | 2012 |
Increased 3-hydroxykynurenine serum concentrations differentiate Alzheimer's disease patients from controls.
Topics: Aged; Alzheimer Disease; Biomarkers; Blood-Brain Barrier; Brain Chemistry; Chromatography, High Pres | 2013 |
Cholinergic receptor activity after quinolinic acid caused cerebral injury in rats.
Topics: Alzheimer Disease; Animals; Brain; Choline O-Acetyltransferase; Disease Models, Animal; Learning; Ma | 2002 |
Hypothalamic digoxin, hemispheric chemical dominance, and Alzheimer's disease.
Topics: Aged; Albumins; alpha-Tocopherol; Alzheimer Disease; Ceruloplasmin; Digoxin; Dolichols; Dominance, C | 2003 |
Quinolinic acid in the pathogenesis of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Astrocytes; Cells, Cultured; Gene Expression; Humans; Indo | 2003 |
Indoleamine 2,3 dioxygenase and quinolinic acid immunoreactivity in Alzheimer's disease hippocampus.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Astrocytes; Hippocampus; Humans; Immunohistochemistry; I | 2005 |
Gene expression changes by amyloid beta peptide-stimulated human postmortem brain microglia identify activation of multiple inflammatory processes.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Calgranulin A; Cells, Cultured; C | 2006 |
Transport of cryptotanshinone, a major active triterpenoid in Salvia miltiorrhiza Bunge widely used in the treatment of stroke and Alzheimer's disease, across the blood-brain barrier.
Topics: Alzheimer Disease; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Tran | 2007 |
Cerebrospinal fluid nitrite/nitrate levels in neurologic diseases.
Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Biopterins; HIV Infections; Humans; Hunti | 1994 |
Subchronic intraventricular infusion of quinolinic acid produces working memory impairment--a model of progressive excitotoxicity.
Topics: Alzheimer Disease; Animals; Cerebral Ventricles; Disease Models, Animal; Disease Progression; Drug A | 1996 |
A lot of "excitement' about neurodegeneration.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aging; Alzheimer Disease; Animals; Dizocilpine Maleate | 1991 |
Galanin-like immunoreactivity is unchanged in Alzheimer's disease and Parkinson's disease dementia cerebral cortex.
Topics: Aged; Alzheimer Disease; Animals; Cerebral Cortex; Choline O-Acetyltransferase; Chromatography, High | 1988 |
Brain quinolinic acid in Alzheimer's dementia.
Topics: Adult; Aged; Alzheimer Disease; Brain; Cerebellum; Female; Frontal Lobe; Humans; Huntington Disease; | 1989 |
No changes in central quinolinic acid levels in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Humans; In Vitro Techniques; Middle Aged; Quinoli | 1989 |
Functional and neurochemical cortical cholinergic impairment following neurotoxic lesions of the nucleus basalis magnocellularis in the rat.
Topics: Acetylcholine; Acetylcholinesterase; Alzheimer Disease; Animals; Basal Ganglia; Cerebral Cortex; Cho | 1985 |
The physiopathological role of quinolinic acid in the mammalian central nervous system.
Topics: Aging; Alzheimer Disease; Animals; Cerebral Cortex; Gas Chromatography-Mass Spectrometry; Hepatic En | 1988 |